In order to assist the design of short interfering ribonucleic acids (siRNA), 573 non-redundant siRNAs were collected from published literatures and the relationship between siRNAs sequences and RNA interference (R...In order to assist the design of short interfering ribonucleic acids (siRNA), 573 non-redundant siRNAs were collected from published literatures and the relationship between siRNAs sequences and RNA interference (RNAi) effect is analyzed by a support vector machine (SVM) based algorithm relied on a basebase correlation (BBC) feature. The results show that the proposed algorithm has the highest area under curve (AUC) value (0. 73) of the receive operating characteristic (ROC) curve and the greatest r value (0. 43) of the Pearson's correlation coefficient. This indicates that the proposed algorithm is better than the published algorithms on the collected datasets and that more attention should be paid to the base-base correlation information in future siRNA design.展开更多
文摘异类传感器数据关联是数据融合中的一个难点 ,综合利用角度和其他特征信息是改善异类传感器数据关联的一个重要途径。对于雷达在直角坐标系对目标进行跟踪、ESM传感器在修正的极坐标系对目标进行跟踪情况 ,本文综合利用角度、角度变化率和ITG(Inverse Time to Go)信息 ,构建了新的关联统计量 ,并进行了计算机仿真。结果表明 ,本文给出的新关联统计量较之只利用角度和ITG信息的关联统计量有更好的关联性能。
基金The National Natural Science Foundation of China(No60671018,60121101)
文摘In order to assist the design of short interfering ribonucleic acids (siRNA), 573 non-redundant siRNAs were collected from published literatures and the relationship between siRNAs sequences and RNA interference (RNAi) effect is analyzed by a support vector machine (SVM) based algorithm relied on a basebase correlation (BBC) feature. The results show that the proposed algorithm has the highest area under curve (AUC) value (0. 73) of the receive operating characteristic (ROC) curve and the greatest r value (0. 43) of the Pearson's correlation coefficient. This indicates that the proposed algorithm is better than the published algorithms on the collected datasets and that more attention should be paid to the base-base correlation information in future siRNA design.