Wearable smart devices, such as smart watch, wristband are becoming increasingly popular recently. They generally integrate the MEMS-designed inertial sensors, including accelerometer, gyroscope and compass, which pro...Wearable smart devices, such as smart watch, wristband are becoming increasingly popular recently. They generally integrate the MEMS-designed inertial sensors, including accelerometer, gyroscope and compass, which provide a convenient and inexpensive way to collect motion data of users. Such rich, continuous motion data provide great potential for remote healthcare and decease diagnosis. Information processing algorithms play the critical role in these approaches, which is to extract the motion signatures and to access different kinds of judgements. This paper reviews key algorithms in these areas. In particular, we focus on three kinds of applications: 1) gait analysis; 2) fall detection and 3) sleep monitoring. They are the most popular healthcare applications based on the inertial data. By categorizing and introducing the key algorithms, this paper tries to build a clear map of how the inertial data are processed; how the inertial signatures are defined, extracted, and utilized in different kinds of applications. This will provide a valuable guidance for users to understand the methodologies and to select proper algorithm for specifi c application purpose.展开更多
For its complexity, engineering construction schedule design is limited by various factors.Simulation-based engineering construction schedule takes critical path method (CPM) network as frame and calls complex cyclic ...For its complexity, engineering construction schedule design is limited by various factors.Simulation-based engineering construction schedule takes critical path method (CPM) network as frame and calls complex cyclic operation network (CYCLONE) simulation model enclosed in advance for its simulation nodes. CYCLONE simulation model takes charge of simulating stochastic duration of activity and efficiency of resources, while CPM model performs project scheduling. This combination avoids the shortcomings of both models. Furthermore, geographic information system (GIS) technique is utilized to visualize the construction processes which are otherwise difficult to be understood by static results described. Application in practical project verifies the feasibility and advantage of the technique.展开更多
In mine ventilation networks, the reasonable airflow distribution is very important for the production safety and economy. Three basic problems of the natural, full-controlled and semi-controlled splitting were review...In mine ventilation networks, the reasonable airflow distribution is very important for the production safety and economy. Three basic problems of the natural, full-controlled and semi-controlled splitting were reviewed in the paper. Aiming at the high difficulty semi-controlled splitting problem, the general nonlinear multi-objectives optimization mathematical model with constraints was established based on the theory of mine ventilation networks. A new algorithm, which combined the improved differential evaluation and the critical path method (CPM) based on the multivariable separate solution strategy, was put forward to search for the global optimal solution more efficiently. In each step of evolution, the feasible solutions of air quantity distribution are firstly produced by the improved differential evolu- tion algorithm, and then the optimal solutions of regulator pressure drop are obtained by the CPM. Through finite steps iterations, the optimal solution can be given. In this new algorithm, the population of feasible solutions were sorted and grouped for enhancing the global search ability and the individuals in general group were randomly initialized for keeping diversity. Meanwhile, the individual neighbor- hood in the fine group which may be closely to the optimal solutions were searched locally and slightly for achieving a balance between global searching and local searching, thus improving the convergence rate. The computer program was developed based on this method. Finally, the two ventilation networks with single-fan and multi-fans were solved. The results show that this algorithm has advantages of high effectiveness, fast convergence, good robustness and flexibility. This computer program could be used to solve lar^e-scale ~eneralized ventilation networks o^timization problem in the future.展开更多
A new method for complex activity recognition in videos by key frames was presented. The progressive bisection strategy(PBS) was employed to divide the complex activity into a series of simple activities and the key f...A new method for complex activity recognition in videos by key frames was presented. The progressive bisection strategy(PBS) was employed to divide the complex activity into a series of simple activities and the key frames representing the simple activities were extracted by the self-splitting competitive learning(SSCL) algorithm. A new similarity criterion of complex activities was defined. Besides the regular visual factor, the order factor and the interference factor measuring the timing matching relationship of the simple activities and the discontinuous matching relationship of the simple activities respectively were considered. On these bases, the complex human activity recognition could be achieved by calculating their similarities. The recognition error was reduced compared with other methods when ignoring the recognition of simple activities. The proposed method was tested and evaluated on the self-built broadcast gymnastic database and the dancing database. The experimental results prove the superior efficiency.展开更多
Gas holdup is one of the key parameters in flotation process. Gas holdup as measured by a differential pressure method was investigated and the relative errors compared to the average gas holdup from the volume expans...Gas holdup is one of the key parameters in flotation process. Gas holdup as measured by a differential pressure method was investigated and the relative errors compared to the average gas holdup from the volume expansion method. The errors were used to establish optimum measurement positions. The results show that the measurement position should be in the middle of the column and in the region half way from the center to the wall (the half-radius). The gas holdup along the axial direction is lower at the bottom and higher at the top of the floatation column. The gas holdup along the radial direction is lower near the wall and higher near the center of the flotation column. The average gas holdup measure- ment can be replaced by regional gas holdup values.展开更多
Objective: The aim of the study was to retrospectively evaluate the outcomes and important prognostic factors for patients with high-grade gliomas (HGG) treated with conventional radiotherapy (RT) followed by IMR...Objective: The aim of the study was to retrospectively evaluate the outcomes and important prognostic factors for patients with high-grade gliomas (HGG) treated with conventional radiotherapy (RT) followed by IMRT as a boost in combination with chemotherapy. Methods: From November 2004 to November 2006, 112 consecutive patients with high-grade gliomas were treated with radiotherapy, which included initial conventional radiotherapy and an IMRT boost to a total dose of 57.5-62.5 Gy, with 27-29 fractions delivered over 37-45 days. All cases received 3-6 cycles of chemotherapy, 63 cases received temozolomide, and another 49 cases received methyI-CCNU and teniposide. The acute and late treatment toxicities and the patterns of treatment failure were recorded. The overall survival (OS) rate and progression-free survival (PFS) rate were calculated, and the prognostic factors were analyzed. Results: Most of the acute radiation reactions were grade 1 or 2. No grade 4 acute reactions were noted. Three cases developed radiation necrosis. Grades Ⅰ, Ⅱ, and Ⅲ myelosuppressions were observed in 5, 32, and 12 cases of 49 patients treated with teniposide and methyl-CCNU, respectively. Grades Ⅰ and Ⅱ myelosuppressions were observed in 15 and 3 of the 63 patients who were treated with temozolomide, respectively. The 57 cases (50.9%) had recurred locally, and 13 cases (11.6%) had intracranial dissemination. The OS rates at 1, 2, and 3 years were 78.9%, 54.7%, and 30.8%, respectively. The PFS rates at 1,2, and 3 years were 63.8%, 38.9%, and 10.5%, respectively. A multivariate analysis showed that only tumor location and KPS were prognostic factors of OS. These same two variables and histopathology were statistically significant predictive factors in a multivariate analysis for PFS. Conclusion: Radiation toxicities were not found to be increased in this retrospective study with 112 consecutive patients of combined modality therapy including an IMRT boost treatment for HGG. Higher rate of local regional dissemination within the brain was observed than before. Tumor location, histopathology and KPS were important prognostic factors.展开更多
Recently, Cai and Su [Phys. Rev. D 81 (2010) 103514] found that the sign of interaction Q in'the dark sector changed in the approximate redshift range of 0.45 ≤ z ≤0.9, by using a modeMndependent method to deal w...Recently, Cai and Su [Phys. Rev. D 81 (2010) 103514] found that the sign of interaction Q in'the dark sector changed in the approximate redshift range of 0.45 ≤ z ≤0.9, by using a modeMndependent method to deal with the observational data. In fact, this result raises a remarkable problem, since most of the familiar interactions cannot change their signs in the whole cosmic history. Motivated by the work of Cai and Su, we have proposed a new type of interaction in a previous work [H. Wei, Nucl. Phys. B 845 (2011) 381]. The key ingredient is the deceleration parameter q in the interaction Q, and hence the interaction Q can change its sign when our universe changes from deceleration (q 〉0) to acceleration (q 〈 0). In the present work, we consider the cosmologicai constraints on this new type of sign-changeable interactions, by using the latest observational data. We find that the cosmological constraints on the model parameters are fairly tight. In particular, the key parameter β can be constrained to a narrow range.展开更多
Many Spoken Term Detection (STD) systems use query expansion to return an increased number of keyword candidates and make posterior probability a confidence feature to reject false alarms. However, some keyword candid...Many Spoken Term Detection (STD) systems use query expansion to return an increased number of keyword candidates and make posterior probability a confidence feature to reject false alarms. However, some keyword candidates hold high posterior probability although these are not recognized correctly. We investigate the Word Activation Force (WAF) model that compatibly encodes syntactical and semantic information into sparse coding directed networks. A high-level confidence feature Keyword Activation Force (KAF) based on WAF is proposed. KAF can be used for detecting false alarms by considering information about the neighbors to provide a more reliable and accurate keyword affinity. Compared with the baseline system, a relative reduction of 30.94% in average error rate could be achieved when KAF is combined with the posterior probability and the language model score.展开更多
This article discussed the mechanisms and precautions of abdominal acupuncture from three different perspectives. First, the relationship between Shénquè (神阙 CV 8) and zang-fu and eight extra meridians s...This article discussed the mechanisms and precautions of abdominal acupuncture from three different perspectives. First, the relationship between Shénquè (神阙 CV 8) and zang-fu and eight extra meridians stated in the ancient literature explained that the theory of CV 8 as the theoretical core of abdominal acupuncture therapy had literature support and theoretical evidence; second, with emphasis on the diagnosis and treatment based on differentiation of syndromes, four methods for selecting the points, including the ones according to hologram, meridians and collaterals, the Ba-kuo (八 廓) and three energizer, meanwhile, the origin of method selecting the points according to Three Energizer and clinical experience was also addressed; third, some problems about the manipulation of abdominal acupuncture therapy were put forward, such as selection of depth, direction, needle tool, as well as personal ideas and precautions, in order to ensure the clinical effect.展开更多
Equivalent simplification is an effective method for solving large-scale complex problems. In this paper, the authors simplify a classic project scheduling problem, which is the nonlinear continuous time-cost tradeoff...Equivalent simplification is an effective method for solving large-scale complex problems. In this paper, the authors simplify a classic project scheduling problem, which is the nonlinear continuous time-cost tradeoff problem(TCTP). Simplifying TCTP is a simple path problem in a critical path method(CPM) network. The authors transform TCTP into a simple activity float problem and design a complex polynomial algorithm for its solution. First, the authors discover relationships between activity floats and path lengths by studying activity floats from the perspective of path instead of time.Second, the authors perform simplification and improve the efficiency and accuracy of the solution by deleting redundant activities and narrowing the duration intervals of non-redundant activities. Finally,the authors compare our method with current methods. The relationships between activity floats and path lengths provide new approaches for other path and correlative project problems.展开更多
To solve the resource-constrained multiple project scheduling problem(RCMPSP) more effectively,a method based on timed colored Petri net(TCPN) was proposed.In this methodology,firstly a novel mapping mechanism between...To solve the resource-constrained multiple project scheduling problem(RCMPSP) more effectively,a method based on timed colored Petri net(TCPN) was proposed.In this methodology,firstly a novel mapping mechanism between traditional network diagram such as CPM(critical path method)/PERT(program evaluation and review technique) and TCPN was presented.Then a primary TCPN(PTCPN) for solving RCMPSP was modeled based on the proposed mapping mechanism.Meanwhile,the object PTCPN was used to simulate the multiple projects scheduling and to find the approximately optimal value of RCMPSP.Finally,the performance of the proposed approach for solving RCMPSP was validated by executing a mould manufacturing example.展开更多
Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.H...Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals de-noised according to decomposition in the time-frequency space.The signal was decomposed into various scales,and coefficients were processed based on the properties of each layer.At last,signal was reconstructed based on the new coefficients.The results show that after de-noising,baseline drift is removed and signal-to-noise ratio is increased.It suggests that the neurochip of PC12 cells coupled to LAPS is stable and suitable for long-term and non-invasive measurement of cell electrophysiological properties with wavelet transform,taking advantage of its time-frequency localization analysis to reduce noise.展开更多
Clonal selection feature selection algorithm (CSFS) based on clonal selection algorithm (CSA), a new computational intelligence approach, has been proposed to perform the task of dimensionality reduction in high-d...Clonal selection feature selection algorithm (CSFS) based on clonal selection algorithm (CSA), a new computational intelligence approach, has been proposed to perform the task of dimensionality reduction in high-dimensional images, and has better performance than traditional feature selection algorithms with more computational costs. In this paper, a fast clonal selection feature selection algorithm (FCSFS) for hyperspectral imagery is proposed to improve the convergence rate by using Cauchy mutation instead of non-uniform mutation as the primary immune operator. Two experiments are performed to evaluate the performance of the proposed algorithm in comparison with CSFS using hyperspectral remote sensing imagery acquired by the pushbroom hyperspectral imager (PHI) and the airborne visible/infrared imaging spectrometer (AVlRIS), respectively. Experimental results demonstrate that the FCSFS converges faster than CSFS, hence providing an effective new option for dimensionality reduction of hyperspectral remote sensing imagery.展开更多
基金supported in part by National Natural Science Foundation of China Grant 61202360, 61033001, 61361136003the National Basic Research Program of China Grant 2011CBA00300, 2011CBA00302
文摘Wearable smart devices, such as smart watch, wristband are becoming increasingly popular recently. They generally integrate the MEMS-designed inertial sensors, including accelerometer, gyroscope and compass, which provide a convenient and inexpensive way to collect motion data of users. Such rich, continuous motion data provide great potential for remote healthcare and decease diagnosis. Information processing algorithms play the critical role in these approaches, which is to extract the motion signatures and to access different kinds of judgements. This paper reviews key algorithms in these areas. In particular, we focus on three kinds of applications: 1) gait analysis; 2) fall detection and 3) sleep monitoring. They are the most popular healthcare applications based on the inertial data. By categorizing and introducing the key algorithms, this paper tries to build a clear map of how the inertial data are processed; how the inertial signatures are defined, extracted, and utilized in different kinds of applications. This will provide a valuable guidance for users to understand the methodologies and to select proper algorithm for specifi c application purpose.
基金Supported by National Natural Science Foundation of China( No. 50179023).
文摘For its complexity, engineering construction schedule design is limited by various factors.Simulation-based engineering construction schedule takes critical path method (CPM) network as frame and calls complex cyclic operation network (CYCLONE) simulation model enclosed in advance for its simulation nodes. CYCLONE simulation model takes charge of simulating stochastic duration of activity and efficiency of resources, while CPM model performs project scheduling. This combination avoids the shortcomings of both models. Furthermore, geographic information system (GIS) technique is utilized to visualize the construction processes which are otherwise difficult to be understood by static results described. Application in practical project verifies the feasibility and advantage of the technique.
基金financially supported by the National Natural Science Foundation of China (No. 51134023)
文摘In mine ventilation networks, the reasonable airflow distribution is very important for the production safety and economy. Three basic problems of the natural, full-controlled and semi-controlled splitting were reviewed in the paper. Aiming at the high difficulty semi-controlled splitting problem, the general nonlinear multi-objectives optimization mathematical model with constraints was established based on the theory of mine ventilation networks. A new algorithm, which combined the improved differential evaluation and the critical path method (CPM) based on the multivariable separate solution strategy, was put forward to search for the global optimal solution more efficiently. In each step of evolution, the feasible solutions of air quantity distribution are firstly produced by the improved differential evolu- tion algorithm, and then the optimal solutions of regulator pressure drop are obtained by the CPM. Through finite steps iterations, the optimal solution can be given. In this new algorithm, the population of feasible solutions were sorted and grouped for enhancing the global search ability and the individuals in general group were randomly initialized for keeping diversity. Meanwhile, the individual neighbor- hood in the fine group which may be closely to the optimal solutions were searched locally and slightly for achieving a balance between global searching and local searching, thus improving the convergence rate. The computer program was developed based on this method. Finally, the two ventilation networks with single-fan and multi-fans were solved. The results show that this algorithm has advantages of high effectiveness, fast convergence, good robustness and flexibility. This computer program could be used to solve lar^e-scale ~eneralized ventilation networks o^timization problem in the future.
基金Project(50808025) supported by the National Natural Science Foundation of ChinaProject(20090162110057) supported by the Doctoral Fund of Ministry of Education,China
文摘A new method for complex activity recognition in videos by key frames was presented. The progressive bisection strategy(PBS) was employed to divide the complex activity into a series of simple activities and the key frames representing the simple activities were extracted by the self-splitting competitive learning(SSCL) algorithm. A new similarity criterion of complex activities was defined. Besides the regular visual factor, the order factor and the interference factor measuring the timing matching relationship of the simple activities and the discontinuous matching relationship of the simple activities respectively were considered. On these bases, the complex human activity recognition could be achieved by calculating their similarities. The recognition error was reduced compared with other methods when ignoring the recognition of simple activities. The proposed method was tested and evaluated on the self-built broadcast gymnastic database and the dancing database. The experimental results prove the superior efficiency.
基金supports for this work provided by the NationalKey Technology R&D Program in the 11th Five-Year Plan of China(No. 2008BAB31B03)
文摘Gas holdup is one of the key parameters in flotation process. Gas holdup as measured by a differential pressure method was investigated and the relative errors compared to the average gas holdup from the volume expansion method. The errors were used to establish optimum measurement positions. The results show that the measurement position should be in the middle of the column and in the region half way from the center to the wall (the half-radius). The gas holdup along the axial direction is lower at the bottom and higher at the top of the floatation column. The gas holdup along the radial direction is lower near the wall and higher near the center of the flotation column. The average gas holdup measure- ment can be replaced by regional gas holdup values.
文摘Objective: The aim of the study was to retrospectively evaluate the outcomes and important prognostic factors for patients with high-grade gliomas (HGG) treated with conventional radiotherapy (RT) followed by IMRT as a boost in combination with chemotherapy. Methods: From November 2004 to November 2006, 112 consecutive patients with high-grade gliomas were treated with radiotherapy, which included initial conventional radiotherapy and an IMRT boost to a total dose of 57.5-62.5 Gy, with 27-29 fractions delivered over 37-45 days. All cases received 3-6 cycles of chemotherapy, 63 cases received temozolomide, and another 49 cases received methyI-CCNU and teniposide. The acute and late treatment toxicities and the patterns of treatment failure were recorded. The overall survival (OS) rate and progression-free survival (PFS) rate were calculated, and the prognostic factors were analyzed. Results: Most of the acute radiation reactions were grade 1 or 2. No grade 4 acute reactions were noted. Three cases developed radiation necrosis. Grades Ⅰ, Ⅱ, and Ⅲ myelosuppressions were observed in 5, 32, and 12 cases of 49 patients treated with teniposide and methyl-CCNU, respectively. Grades Ⅰ and Ⅱ myelosuppressions were observed in 15 and 3 of the 63 patients who were treated with temozolomide, respectively. The 57 cases (50.9%) had recurred locally, and 13 cases (11.6%) had intracranial dissemination. The OS rates at 1, 2, and 3 years were 78.9%, 54.7%, and 30.8%, respectively. The PFS rates at 1,2, and 3 years were 63.8%, 38.9%, and 10.5%, respectively. A multivariate analysis showed that only tumor location and KPS were prognostic factors of OS. These same two variables and histopathology were statistically significant predictive factors in a multivariate analysis for PFS. Conclusion: Radiation toxicities were not found to be increased in this retrospective study with 112 consecutive patients of combined modality therapy including an IMRT boost treatment for HGG. Higher rate of local regional dissemination within the brain was observed than before. Tumor location, histopathology and KPS were important prognostic factors.
基金Supported in part by National Natural Science Foundation of China under Grant No. 10905005the Excellent Young Scholars Research Fund of Beijing Institute of Technologythe Fundamental Research Fund of Beijing Institute of Technology
文摘Recently, Cai and Su [Phys. Rev. D 81 (2010) 103514] found that the sign of interaction Q in'the dark sector changed in the approximate redshift range of 0.45 ≤ z ≤0.9, by using a modeMndependent method to deal with the observational data. In fact, this result raises a remarkable problem, since most of the familiar interactions cannot change their signs in the whole cosmic history. Motivated by the work of Cai and Su, we have proposed a new type of interaction in a previous work [H. Wei, Nucl. Phys. B 845 (2011) 381]. The key ingredient is the deceleration parameter q in the interaction Q, and hence the interaction Q can change its sign when our universe changes from deceleration (q 〉0) to acceleration (q 〈 0). In the present work, we consider the cosmologicai constraints on this new type of sign-changeable interactions, by using the latest observational data. We find that the cosmological constraints on the model parameters are fairly tight. In particular, the key parameter β can be constrained to a narrow range.
基金supported by National Natural Science Foundation of China under Grants No.61005004,No.61175011,No.61171193 the Next-Generation Broadband Wireless Mobile Communications Network Technology Key Project under Grant No.2011ZX03002-005-01+1 种基金 the 111 Project under Grant No.B08004 Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry
文摘Many Spoken Term Detection (STD) systems use query expansion to return an increased number of keyword candidates and make posterior probability a confidence feature to reject false alarms. However, some keyword candidates hold high posterior probability although these are not recognized correctly. We investigate the Word Activation Force (WAF) model that compatibly encodes syntactical and semantic information into sparse coding directed networks. A high-level confidence feature Keyword Activation Force (KAF) based on WAF is proposed. KAF can be used for detecting false alarms by considering information about the neighbors to provide a more reliable and accurate keyword affinity. Compared with the baseline system, a relative reduction of 30.94% in average error rate could be achieved when KAF is combined with the posterior probability and the language model score.
文摘This article discussed the mechanisms and precautions of abdominal acupuncture from three different perspectives. First, the relationship between Shénquè (神阙 CV 8) and zang-fu and eight extra meridians stated in the ancient literature explained that the theory of CV 8 as the theoretical core of abdominal acupuncture therapy had literature support and theoretical evidence; second, with emphasis on the diagnosis and treatment based on differentiation of syndromes, four methods for selecting the points, including the ones according to hologram, meridians and collaterals, the Ba-kuo (八 廓) and three energizer, meanwhile, the origin of method selecting the points according to Three Energizer and clinical experience was also addressed; third, some problems about the manipulation of abdominal acupuncture therapy were put forward, such as selection of depth, direction, needle tool, as well as personal ideas and precautions, in order to ensure the clinical effect.
基金supported by the Science and Technology Foundation of Jiangxi Provincial Department of Education in China under Grant No.GJJ161114the Natural Science Foundation of China under Grant No.71271081the Soft Science Research Base of Water Security and Sustainable Development of Jiangxi Province in China
文摘Equivalent simplification is an effective method for solving large-scale complex problems. In this paper, the authors simplify a classic project scheduling problem, which is the nonlinear continuous time-cost tradeoff problem(TCTP). Simplifying TCTP is a simple path problem in a critical path method(CPM) network. The authors transform TCTP into a simple activity float problem and design a complex polynomial algorithm for its solution. First, the authors discover relationships between activity floats and path lengths by studying activity floats from the perspective of path instead of time.Second, the authors perform simplification and improve the efficiency and accuracy of the solution by deleting redundant activities and narrowing the duration intervals of non-redundant activities. Finally,the authors compare our method with current methods. The relationships between activity floats and path lengths provide new approaches for other path and correlative project problems.
文摘To solve the resource-constrained multiple project scheduling problem(RCMPSP) more effectively,a method based on timed colored Petri net(TCPN) was proposed.In this methodology,firstly a novel mapping mechanism between traditional network diagram such as CPM(critical path method)/PERT(program evaluation and review technique) and TCPN was presented.Then a primary TCPN(PTCPN) for solving RCMPSP was modeled based on the proposed mapping mechanism.Meanwhile,the object PTCPN was used to simulate the multiple projects scheduling and to find the approximately optimal value of RCMPSP.Finally,the performance of the proposed approach for solving RCMPSP was validated by executing a mould manufacturing example.
基金Project supported by the National Natural Science Foundation of China (Nos 30700167 and 60725102)the Project of State Key Laboratory of Transducer Technology of China (No SKT0702)+1 种基金the Zhejiang Provincial Natural Science Foundation of China (No Y2080673)the Scientific Research Fund of the Education Department of Zhejiang Province, China (No Y200909323)
文摘Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals de-noised according to decomposition in the time-frequency space.The signal was decomposed into various scales,and coefficients were processed based on the properties of each layer.At last,signal was reconstructed based on the new coefficients.The results show that after de-noising,baseline drift is removed and signal-to-noise ratio is increased.It suggests that the neurochip of PC12 cells coupled to LAPS is stable and suitable for long-term and non-invasive measurement of cell electrophysiological properties with wavelet transform,taking advantage of its time-frequency localization analysis to reduce noise.
基金Supported by the Major State Basic Research Development Program (973 Program) of China (No. 2009CB723905)the National High Technology Research and Development Program (863 Program) of China (Nos.2009AA12Z114, 2007AA12Z148, 2007AA12Z181)+2 种基金the National Natural Sci-ence Foundation of China(Nos. 40771139,40523005, 40721001)the Research Fund for the Doctoral Program of Higher Education of China(No.200804861058)the Foundation of National Laboratory of Pattern Recognition
文摘Clonal selection feature selection algorithm (CSFS) based on clonal selection algorithm (CSA), a new computational intelligence approach, has been proposed to perform the task of dimensionality reduction in high-dimensional images, and has better performance than traditional feature selection algorithms with more computational costs. In this paper, a fast clonal selection feature selection algorithm (FCSFS) for hyperspectral imagery is proposed to improve the convergence rate by using Cauchy mutation instead of non-uniform mutation as the primary immune operator. Two experiments are performed to evaluate the performance of the proposed algorithm in comparison with CSFS using hyperspectral remote sensing imagery acquired by the pushbroom hyperspectral imager (PHI) and the airborne visible/infrared imaging spectrometer (AVlRIS), respectively. Experimental results demonstrate that the FCSFS converges faster than CSFS, hence providing an effective new option for dimensionality reduction of hyperspectral remote sensing imagery.