在移动互联网环境下,空间文本skyline查询可以有效支持用户在空间和关键词方面的查询。随着需求的多样性,基于用户经常会同时考虑空间距离、数值型信息、关键词和时间等因素对查询结果的影响,提出了基于时间的空间文本关键词skyline查询...在移动互联网环境下,空间文本skyline查询可以有效支持用户在空间和关键词方面的查询。随着需求的多样性,基于用户经常会同时考虑空间距离、数值型信息、关键词和时间等因素对查询结果的影响,提出了基于时间的空间文本关键词skyline查询(Time based Spatial Text Keyword Skyline Query,TSTKSQ),用来查找在空间、数值、关键词和时间都满足条件的优秀对象,设计了基于时间的空间文本关键词skyline查询的索引结构STTR-Tree,提出了关键词、时间和时空关键词相关性的评价函数,在裁剪策略的基础上提出了skyline查询算法。通过实验结果分析,验证了算法的准确性和有效性。展开更多
Objective:The aim of the study was to investigate the adaptive response of low-dose radiation-induced apoptosis in mouse spleen cells and its related proteins control mechanism. Methods: Kunming male mice were randoml...Objective:The aim of the study was to investigate the adaptive response of low-dose radiation-induced apoptosis in mouse spleen cells and its related proteins control mechanism. Methods: Kunming male mice were randomly divided into sham-irradiation group, attacking dose irradiation group (D2) and low-dose radiation + attacking dose irradiation group (D1+D2). After a week the D1+D2 group was given low-dose radiation (doses were 25,50,75 and 100 mGy, dose rate of 12.5 mGy/min), after 6 hours the D2 group and the D1+D2 group were given attacking dose of radiation (Dose of 1.5 Gy, dose rate of 287 mGy/min). After 18 hours all mice were killed. The spleen cell apoptosis and Caspase-3 expression's changes were detected by flow cytometry (FCM) analysis, and the changes of apoptosis-related proteins Bcl-2 and Bax were detected by immunohistochemical staining semi-quantitative method. Results: The rate of apoptosis, the fluorescence intensity of Caspase-3, and the semi-quantitative results of apoptosis-related proteins Bcl-2 and Bax in every group were significantly different. Of all groups, the apoptosis rate and Caspase-3 fluorescence intensity of D2 group were the highest. Compared with the sham-irradiated group, Bcl-2 protein level of D2 group decreased significantly, and Bax protein level of D2 group increased significantly. But compared with D2 group, the apoptosis rates, the fluorescence intensities of Caspase-3 expression and the Bax protein levels in D1+D2 group were lower in different doses, and the Bcl-2 protein levels in D1+D2 group were higher in different doses. Conclusion: 25-75 mGy low-dose radiation can induce the adaptive response of mouse spleen cells' apoptosis, the expression of Caspase-3, and the apoptosis-related protein Bcl-2 expression increased, Bax reduced, and it leads to the apoptosis of the spleen cells decreased.展开更多
文摘在移动互联网环境下,空间文本skyline查询可以有效支持用户在空间和关键词方面的查询。随着需求的多样性,基于用户经常会同时考虑空间距离、数值型信息、关键词和时间等因素对查询结果的影响,提出了基于时间的空间文本关键词skyline查询(Time based Spatial Text Keyword Skyline Query,TSTKSQ),用来查找在空间、数值、关键词和时间都满足条件的优秀对象,设计了基于时间的空间文本关键词skyline查询的索引结构STTR-Tree,提出了关键词、时间和时空关键词相关性的评价函数,在裁剪策略的基础上提出了skyline查询算法。通过实验结果分析,验证了算法的准确性和有效性。
文摘Objective:The aim of the study was to investigate the adaptive response of low-dose radiation-induced apoptosis in mouse spleen cells and its related proteins control mechanism. Methods: Kunming male mice were randomly divided into sham-irradiation group, attacking dose irradiation group (D2) and low-dose radiation + attacking dose irradiation group (D1+D2). After a week the D1+D2 group was given low-dose radiation (doses were 25,50,75 and 100 mGy, dose rate of 12.5 mGy/min), after 6 hours the D2 group and the D1+D2 group were given attacking dose of radiation (Dose of 1.5 Gy, dose rate of 287 mGy/min). After 18 hours all mice were killed. The spleen cell apoptosis and Caspase-3 expression's changes were detected by flow cytometry (FCM) analysis, and the changes of apoptosis-related proteins Bcl-2 and Bax were detected by immunohistochemical staining semi-quantitative method. Results: The rate of apoptosis, the fluorescence intensity of Caspase-3, and the semi-quantitative results of apoptosis-related proteins Bcl-2 and Bax in every group were significantly different. Of all groups, the apoptosis rate and Caspase-3 fluorescence intensity of D2 group were the highest. Compared with the sham-irradiated group, Bcl-2 protein level of D2 group decreased significantly, and Bax protein level of D2 group increased significantly. But compared with D2 group, the apoptosis rates, the fluorescence intensities of Caspase-3 expression and the Bax protein levels in D1+D2 group were lower in different doses, and the Bcl-2 protein levels in D1+D2 group were higher in different doses. Conclusion: 25-75 mGy low-dose radiation can induce the adaptive response of mouse spleen cells' apoptosis, the expression of Caspase-3, and the apoptosis-related protein Bcl-2 expression increased, Bax reduced, and it leads to the apoptosis of the spleen cells decreased.