The discovery of intrinsically disordered proteins （IDP） （i.e., biologically active proteins that do not possess stable secondary and/or tertiary structures） came as an unexpected surprise, as the existence of suc...The discovery of intrinsically disordered proteins （IDP） （i.e., biologically active proteins that do not possess stable secondary and/or tertiary structures） came as an unexpected surprise, as the existence of such proteins is in contradiction to the traditional ＂sequence →structure →function＂ paradigm. Accurate prediction of a protein＇s predisposition to be intrinsically disordered is a necessary prerequisite for the further understanding of principles and mechanisms of protein folding and function, and is a key for the elaboration of a new structural and functional hierarchy of proteins. Therefore, prediction of IDPs has attracted the attention of many researchers, and a number of prediction tools have been developed. Predictions of disorder, in turn, are playing major roles in directing laboratory experiments that are leading to the discovery of ever more disordered proteins, and thereby leading to a positive feedback loop in the investigation of these proteins. In this review of algorithms for intrinsic disorder prediction, the basic concepts of various prediction methods for IDPs are summarized, the strengths and shortcomings of many of the methods are analyzed, and the difficulties and directions of future development of IDP prediction techniques are discussed.展开更多
Rock drillability reflects the drill bit fragments rock hardly or easily. At present, rock drillability classification indexes have rock single axle compressive strength, point load intensity, fracture stress during c...Rock drillability reflects the drill bit fragments rock hardly or easily. At present, rock drillability classification indexes have rock single axle compressive strength, point load intensity, fracture stress during chiseling, drill speed, chiseling specific work, acoustic parameter, cutting magnitude and so on. Every index reflects rock drillability but isnt overall. It is feasible that using many indexes of fuzzy mathematics method etc. to evaluate rock drillability.展开更多
The purpose of this paper is to present a methodology for optimizing the geometry of the LED （light emitting diode） secondary lens. The research objective is to uniform the illumination distribution on a target plan...The purpose of this paper is to present a methodology for optimizing the geometry of the LED （light emitting diode） secondary lens. The research objective is to uniform the illumination distribution on a target plane for nonimaging application. In order to achieve this, a software that simulates ray tracing is used, in conjunction with a heuristic process for enhancing the optimized parameters that form the geometry of the LED secondary lens. Spherical lenses was opted for optimization due to its lower manufacture complexity.展开更多
Complementing our previous publications, this paper presents the information schema constructs （ISCs） that underpin the programming of specific system manifestation feature （SMF） orientated information management ...Complementing our previous publications, this paper presents the information schema constructs （ISCs） that underpin the programming of specific system manifestation feature （SMF） orientated information management and composing system models. First, we briefly present （1） the general process of pre-embodiment design with SMFs, （2） the procedures of creating genotypes and phenotypes of SMFs, （3） the specific procedure of instantiation of phenotypes of SMFs, and （4） the procedure of system model management and processing. Then, the chunks of information needed for instantiation of phenotypes of SMFs are discussed, and the ISCs designed for instantiation presented. Afterwards, the information management aspects of system modeling are addressed. Methodologically, system modeling involves （1） placement of phenotypes of SMF in the modeling space, （2） combining them towards the desired architecture and operation, （3） assigning values to the parameters and checking the satisfac- tion of constraints, and （4） storing the system model in the SMFs-based warehouse database. The final objective of the reported research is to develop an SMFs-based toolbox to support modeling of cyber-physical systems （CPSs）.展开更多
文摘The discovery of intrinsically disordered proteins （IDP） （i.e., biologically active proteins that do not possess stable secondary and/or tertiary structures） came as an unexpected surprise, as the existence of such proteins is in contradiction to the traditional ＂sequence →structure →function＂ paradigm. Accurate prediction of a protein＇s predisposition to be intrinsically disordered is a necessary prerequisite for the further understanding of principles and mechanisms of protein folding and function, and is a key for the elaboration of a new structural and functional hierarchy of proteins. Therefore, prediction of IDPs has attracted the attention of many researchers, and a number of prediction tools have been developed. Predictions of disorder, in turn, are playing major roles in directing laboratory experiments that are leading to the discovery of ever more disordered proteins, and thereby leading to a positive feedback loop in the investigation of these proteins. In this review of algorithms for intrinsic disorder prediction, the basic concepts of various prediction methods for IDPs are summarized, the strengths and shortcomings of many of the methods are analyzed, and the difficulties and directions of future development of IDP prediction techniques are discussed.
文摘Rock drillability reflects the drill bit fragments rock hardly or easily. At present, rock drillability classification indexes have rock single axle compressive strength, point load intensity, fracture stress during chiseling, drill speed, chiseling specific work, acoustic parameter, cutting magnitude and so on. Every index reflects rock drillability but isnt overall. It is feasible that using many indexes of fuzzy mathematics method etc. to evaluate rock drillability.
文摘The purpose of this paper is to present a methodology for optimizing the geometry of the LED （light emitting diode） secondary lens. The research objective is to uniform the illumination distribution on a target plane for nonimaging application. In order to achieve this, a software that simulates ray tracing is used, in conjunction with a heuristic process for enhancing the optimized parameters that form the geometry of the LED secondary lens. Spherical lenses was opted for optimization due to its lower manufacture complexity.
文摘Complementing our previous publications, this paper presents the information schema constructs （ISCs） that underpin the programming of specific system manifestation feature （SMF） orientated information management and composing system models. First, we briefly present （1） the general process of pre-embodiment design with SMFs, （2） the procedures of creating genotypes and phenotypes of SMFs, （3） the specific procedure of instantiation of phenotypes of SMFs, and （4） the procedure of system model management and processing. Then, the chunks of information needed for instantiation of phenotypes of SMFs are discussed, and the ISCs designed for instantiation presented. Afterwards, the information management aspects of system modeling are addressed. Methodologically, system modeling involves （1） placement of phenotypes of SMF in the modeling space, （2） combining them towards the desired architecture and operation, （3） assigning values to the parameters and checking the satisfac- tion of constraints, and （4） storing the system model in the SMFs-based warehouse database. The final objective of the reported research is to develop an SMFs-based toolbox to support modeling of cyber-physical systems （CPSs）.
