The current corporate finance is based on the theory framework of new classical economics. Therefore, the main contents such as free cash flow, NPV method and capital structure decision-making are still based on the b...The current corporate finance is based on the theory framework of new classical economics. Therefore, the main contents such as free cash flow, NPV method and capital structure decision-making are still based on the balanced price of product and capital markets, they still can＇t reflect the essential character of corporation. The logic paradox, causes the current corporate finance study under a more and more embarrassing circumstance in the front of enterprise financial management practice, with the feature of value management.展开更多
This paper focuses on how to improve aspect-level opinion mining for online customer reviews. We first propose a novel generative topic model, the Joint Aspect/Sentiment (JAS) model, to jointly extract aspects and asp...This paper focuses on how to improve aspect-level opinion mining for online customer reviews. We first propose a novel generative topic model, the Joint Aspect/Sentiment (JAS) model, to jointly extract aspects and aspect-dependent sentiment lexicons from online customer reviews. An aspect-dependent sentiment lexicon refers to the aspect-specific opinion words along with their aspect-aware sentiment polarities with respect to a specific aspect. We then apply the extracted aspectdependent sentiment lexicons to a series of aspect-level opinion mining tasks, including implicit aspect identification, aspect-based extractive opinion summarization, and aspect-level sentiment classification. Experimental results demonstrate the effectiveness of the JAS model in learning aspectdependent sentiment lexicons and the practical values of the extracted lexicons when applied to these practical tasks.展开更多
As is generally known, Newton＇s notion of universal gravitation surpassed various theories of particular gravities in the early modem age, as represented mainly by Kepler and Hooke. In his seminal work Hooke and the ...As is generally known, Newton＇s notion of universal gravitation surpassed various theories of particular gravities in the early modem age, as represented mainly by Kepler and Hooke. In his seminal work Hooke and the Law of Universal Gravitation： A Reappraisal of a Reappraisal Richard S. Westfall argues that Hooke could not reach beyond the concept of spatially bounded particular gravities, as he deployed the method of analogy between the material principle of congruity and incongruity and the extension of gravitational spheres and their action at a distance. However, the doctrine of universal gravitation does not exclude the nature of particular gravities; it is predicated on the notion of an infinite expansion of individual-gravitational spheres and their uniform nature, namely the mutual and centripetal attraction. In my treatise 1 attempt to reinvestigate the nature and structure of gravitation, as established historically in the framework of Newtonian Classical Mechanics, by a method of structural intuition. It examines how the structural intuition, as represented in the celestial-mechanical intuitions of Hooke and Kepler, could unfold into an innovative process within the context of early modem mechanical philosophy, attaining thus a historical siglaificance and legitimacy as against the prevailing Newtonian method of geometric-mathematical axiomatization of mechanical principles. It also explores the actual demonstrative features of the tidal phenomenon with regard to its lunar- and solar-gravitational causation, which has been considered to date to be an important piece of empirical evidence for the theory of universal gravitation.展开更多
Objective： The aim of this study was to observe the expressions and clinical significance of HIF-1a in breast cancer and precancerous lesions, and analyze the relationship between the expressions and clinicopathologi...Objective： The aim of this study was to observe the expressions and clinical significance of HIF-1a in breast cancer and precancerous lesions, and analyze the relationship between the expressions and clinicopathological features in breast cancer. Methods： We analyzed the HIF-1a expression in 128 cases of invasive ductal carcinomas, 146 precancerous lesions patients including 89 cases of ductal carcinoma in situ and 57 cases of atypical ductal hyperplasia. 53 cases of usual ductal hyperplasia breast tissues were selected as a control group. The specimens were evaluated for HIF-1a, estrogen receptor （ER） ＆ progesterone receptor （PR）, epidermal growth factor receptor type 2 （HER2/neu） and Ki-67. Immunoreactivity was semi-quantitatively evaluated in at least 1000 cells examined under the microscope at 40 x magnification and recorded as the percentage of positive tumor cells over the total number of cells examined in the same area. The percentage scores were subsequently categorized. The express of HIF-1a and their relationship with multiple biological parameters including ER ＆ PR, HER2/neu and Ki-67, the biomarkers levels of CA153, CA125 TSGF, and CEA in blood serum and nipple discharge, histological grade, region lymph node metastasis, distant metastasis and recurrence on files were also assessed. Results： Compared with usual ductal hyperplasia, the positive expression rate of HIF-1a in atypical ductal hyperplasia, ductal carcinoma in situ and invasive ductal carcinomas group was significantly increased （P 〈 0.01）. The positive rates of HIF-1a in invasive ductal carcinomas were 68.75%, which were significantly higher than that in ductal carcinoma in situ （43.8%）, atypical ductal hyperplasia （31.6%）, usual ductal hyperplasia （9.4%; X2 = 13.44, 22.27, 52.79, respectively, P 〈 0.01）. Statistical analysis showed that difference of abnormal expression rate of HIF-1a between ductal carcinoma in situ and usual ductal hyperplasia （X2 = 18.37, P = 0.00）, atypical ductal hyperplasia and usual ductal hyperplasia （x2 = 8.14, P = 0.00） was significant （P = 0.00）. However, no significant difference in the positive expression rate of HIF-1a was found between atypical ductal hyperplasia and ductal carcinoma in situ tissue （X2 = 2.19, P = 0.14）. There was a significantly difference in the mean HIF-1a frequency between ER ＆ PR positive invasive ductal carcinomas group and negative group, epidermal growth factor receptor type 2 （HER2/neu） positive and negative groups, Ki-67 proliferation index 〈 14% and 〉 14% groups, histological grade （I ＋ II） and grade III invasive ductal carcinomas groups, with lymph node metastasis, distant metastasis and recurrence groups （P 〈 0.05） and without groups （P 〈 0.05）. However, there was not difference in the mean HIF-1a between age （〈 50 years vs 〉 50 years）, tumor diameter （〈 2 cm vs 〉 2 cm; P 〉 0.05）. The nipple discharge and serum levels of CA153, TSGF, CA125 and CEA in invasive ductal carcinomas HIF-1a positive patients were significantly higher than those in the negative patients （P 〈 0.05）. Conclusion： In breast cancer, HIF-1a expressibn was abnormally increased. The aberration of HIF-1a may play a key role during oncogenesis （atypical ductal hyperplasia or ductal carcinoma in situ） and promote breast cellular transformation into malignancy, a finding useful for further understanding of tumorigenesis. The abnormal expression of HIF-1a may be as an early event in the development of breast tumor. The over-expression of HIF-1a might be important biological markers for invasion, metastasis and recurrence of breast cancer.展开更多
The correlation of serum arylesterase(PON1) activity on phenylacetate determined by an integrated method to clas-sical biochemical indexes of liver damage was investigated for the use of PON1 activity to evaluate live...The correlation of serum arylesterase(PON1) activity on phenylacetate determined by an integrated method to clas-sical biochemical indexes of liver damage was investigated for the use of PON1 activity to evaluate liver damage.PON1 reaction curve as absorbance at 270 nm for 0.20 mmol/L phenylacetate hydrolysis was analyzed by the integrated method to determine maximal PON1 reaction rate.Classical biochemical indexes of liver damage were determined routinely.The 95% confidence threshold of PON1 activity in sera from healthy individuals was 2.12 mkat/L [(4.73±1.31) mkat/L,n=105].PON1 activity in clinical sera was closely correlated to serum albumin,total protein and the ratio of albumin to globulins,but was weakly correlated to both direct and total bilirubin in serum.There were no correlations of PON1 activity to γ-glutamyltransferase,alkaline phos-phatase,alanine aminotransferase and aspartate aminotransferase.Among 127 clinical sera with PON1 activity>2.12 mkat/L,there were 92% healthy individuals examined by albumin,90% healthy individuals examined by total protein,88% healthy individuals examined by total bilirubin,86% healthy individuals examined by direct bilirubin and 64% healthy individuals examined by the ratio of albumin to globulins,respectively.In each group of healthy individuals judged by classical biochemical indexes of close correlation to PON1 activity,percentage of healthy individuals examined by PON1 activity was always >80%.These results suggested PON1 activity on phenylacetate estimated by the integrated method was also suitable for the evaluation of liver damage.展开更多
文摘The current corporate finance is based on the theory framework of new classical economics. Therefore, the main contents such as free cash flow, NPV method and capital structure decision-making are still based on the balanced price of product and capital markets, they still can＇t reflect the essential character of corporation. The logic paradox, causes the current corporate finance study under a more and more embarrassing circumstance in the front of enterprise financial management practice, with the feature of value management.
基金supported by National Natural Science Foundation of China under Grants No.61232010, No.60903139, No.60933005, No.61202215, No.61100083National 242 Project under Grant No.2011F65China Information Technology Security Evaluation Center Program under Grant No.Z1277
文摘This paper focuses on how to improve aspect-level opinion mining for online customer reviews. We first propose a novel generative topic model, the Joint Aspect/Sentiment (JAS) model, to jointly extract aspects and aspect-dependent sentiment lexicons from online customer reviews. An aspect-dependent sentiment lexicon refers to the aspect-specific opinion words along with their aspect-aware sentiment polarities with respect to a specific aspect. We then apply the extracted aspectdependent sentiment lexicons to a series of aspect-level opinion mining tasks, including implicit aspect identification, aspect-based extractive opinion summarization, and aspect-level sentiment classification. Experimental results demonstrate the effectiveness of the JAS model in learning aspectdependent sentiment lexicons and the practical values of the extracted lexicons when applied to these practical tasks.
文摘As is generally known, Newton＇s notion of universal gravitation surpassed various theories of particular gravities in the early modem age, as represented mainly by Kepler and Hooke. In his seminal work Hooke and the Law of Universal Gravitation： A Reappraisal of a Reappraisal Richard S. Westfall argues that Hooke could not reach beyond the concept of spatially bounded particular gravities, as he deployed the method of analogy between the material principle of congruity and incongruity and the extension of gravitational spheres and their action at a distance. However, the doctrine of universal gravitation does not exclude the nature of particular gravities; it is predicated on the notion of an infinite expansion of individual-gravitational spheres and their uniform nature, namely the mutual and centripetal attraction. In my treatise 1 attempt to reinvestigate the nature and structure of gravitation, as established historically in the framework of Newtonian Classical Mechanics, by a method of structural intuition. It examines how the structural intuition, as represented in the celestial-mechanical intuitions of Hooke and Kepler, could unfold into an innovative process within the context of early modem mechanical philosophy, attaining thus a historical siglaificance and legitimacy as against the prevailing Newtonian method of geometric-mathematical axiomatization of mechanical principles. It also explores the actual demonstrative features of the tidal phenomenon with regard to its lunar- and solar-gravitational causation, which has been considered to date to be an important piece of empirical evidence for the theory of universal gravitation.
基金Supported by grants from the Application Technology Research and De-velopment Project Foundation in Rizhao City(No.2060402)the Sci-entific Research Projects of Jining Medical College(No,JY2013KJ051)
文摘Objective： The aim of this study was to observe the expressions and clinical significance of HIF-1a in breast cancer and precancerous lesions, and analyze the relationship between the expressions and clinicopathological features in breast cancer. Methods： We analyzed the HIF-1a expression in 128 cases of invasive ductal carcinomas, 146 precancerous lesions patients including 89 cases of ductal carcinoma in situ and 57 cases of atypical ductal hyperplasia. 53 cases of usual ductal hyperplasia breast tissues were selected as a control group. The specimens were evaluated for HIF-1a, estrogen receptor （ER） ＆ progesterone receptor （PR）, epidermal growth factor receptor type 2 （HER2/neu） and Ki-67. Immunoreactivity was semi-quantitatively evaluated in at least 1000 cells examined under the microscope at 40 x magnification and recorded as the percentage of positive tumor cells over the total number of cells examined in the same area. The percentage scores were subsequently categorized. The express of HIF-1a and their relationship with multiple biological parameters including ER ＆ PR, HER2/neu and Ki-67, the biomarkers levels of CA153, CA125 TSGF, and CEA in blood serum and nipple discharge, histological grade, region lymph node metastasis, distant metastasis and recurrence on files were also assessed. Results： Compared with usual ductal hyperplasia, the positive expression rate of HIF-1a in atypical ductal hyperplasia, ductal carcinoma in situ and invasive ductal carcinomas group was significantly increased （P 〈 0.01）. The positive rates of HIF-1a in invasive ductal carcinomas were 68.75%, which were significantly higher than that in ductal carcinoma in situ （43.8%）, atypical ductal hyperplasia （31.6%）, usual ductal hyperplasia （9.4%; X2 = 13.44, 22.27, 52.79, respectively, P 〈 0.01）. Statistical analysis showed that difference of abnormal expression rate of HIF-1a between ductal carcinoma in situ and usual ductal hyperplasia （X2 = 18.37, P = 0.00）, atypical ductal hyperplasia and usual ductal hyperplasia （x2 = 8.14, P = 0.00） was significant （P = 0.00）. However, no significant difference in the positive expression rate of HIF-1a was found between atypical ductal hyperplasia and ductal carcinoma in situ tissue （X2 = 2.19, P = 0.14）. There was a significantly difference in the mean HIF-1a frequency between ER ＆ PR positive invasive ductal carcinomas group and negative group, epidermal growth factor receptor type 2 （HER2/neu） positive and negative groups, Ki-67 proliferation index 〈 14% and 〉 14% groups, histological grade （I ＋ II） and grade III invasive ductal carcinomas groups, with lymph node metastasis, distant metastasis and recurrence groups （P 〈 0.05） and without groups （P 〈 0.05）. However, there was not difference in the mean HIF-1a between age （〈 50 years vs 〉 50 years）, tumor diameter （〈 2 cm vs 〉 2 cm; P 〉 0.05）. The nipple discharge and serum levels of CA153, TSGF, CA125 and CEA in invasive ductal carcinomas HIF-1a positive patients were significantly higher than those in the negative patients （P 〈 0.05）. Conclusion： In breast cancer, HIF-1a expressibn was abnormally increased. The aberration of HIF-1a may play a key role during oncogenesis （atypical ductal hyperplasia or ductal carcinoma in situ） and promote breast cellular transformation into malignancy, a finding useful for further understanding of tumorigenesis. The abnormal expression of HIF-1a may be as an early event in the development of breast tumor. The over-expression of HIF-1a might be important biological markers for invasion, metastasis and recurrence of breast cancer.
基金Project (No. 30200266) supported by the National Natural Science Foundation of China
文摘The correlation of serum arylesterase(PON1) activity on phenylacetate determined by an integrated method to clas-sical biochemical indexes of liver damage was investigated for the use of PON1 activity to evaluate liver damage.PON1 reaction curve as absorbance at 270 nm for 0.20 mmol/L phenylacetate hydrolysis was analyzed by the integrated method to determine maximal PON1 reaction rate.Classical biochemical indexes of liver damage were determined routinely.The 95% confidence threshold of PON1 activity in sera from healthy individuals was 2.12 mkat/L [(4.73±1.31) mkat/L,n=105].PON1 activity in clinical sera was closely correlated to serum albumin,total protein and the ratio of albumin to globulins,but was weakly correlated to both direct and total bilirubin in serum.There were no correlations of PON1 activity to γ-glutamyltransferase,alkaline phos-phatase,alanine aminotransferase and aspartate aminotransferase.Among 127 clinical sera with PON1 activity>2.12 mkat/L,there were 92% healthy individuals examined by albumin,90% healthy individuals examined by total protein,88% healthy individuals examined by total bilirubin,86% healthy individuals examined by direct bilirubin and 64% healthy individuals examined by the ratio of albumin to globulins,respectively.In each group of healthy individuals judged by classical biochemical indexes of close correlation to PON1 activity,percentage of healthy individuals examined by PON1 activity was always >80%.These results suggested PON1 activity on phenylacetate estimated by the integrated method was also suitable for the evaluation of liver damage.
