Quorum sensing, or auto induction, as a cell density dependent signaling mechanism in many microorganisms, is trig- gered via auto inducers which passively diffuse across the bacterial envelope and therefore intracell...Quorum sensing, or auto induction, as a cell density dependent signaling mechanism in many microorganisms, is trig- gered via auto inducers which passively diffuse across the bacterial envelope and therefore intracellulaly accumulate only at higher bacterial densities to regulate specialized processes such as genetic competence, bioluminescence, virulence and sporulation. N-acyl homoserine lactones are the most common type of signal molecules. Aquaculture is one of the fastest-growing food-producing indus- tries, but disease outbreaks caused by pathogenic bacteria are a significant constraint on the development of the sector worldwide. Many of these pathogens have been found to be controlled by their quorum sensing systems. As there is relevance between the pathogenic bacteria＇s virulence factor expression and their auto inducers, quorum quenching is a new effective anti-infective strategy to control infections caused by bacterial pathogens in aquaculture. The techniques used to do this mainly include the following： （1） the inhibition of signal molecule biosynthesis, （2） blocking signal transduction, and （3） chemical inactivation and biodegradation of signal molecules. To provide a basis for finding alternative means of controlling aquatic diseases by quorum quenching instead of treatment by antibiotics and disinfectants, we will discuss the examination, purification and identification of auto inducers in this paper.展开更多
The existence conditions of Hopf bifurcation for a predator prey model based on nutri- tion kinetics are given. The two results may appear as follows： one is that the model has a stable periodic trajectory from Hopf ...The existence conditions of Hopf bifurcation for a predator prey model based on nutri- tion kinetics are given. The two results may appear as follows： one is that the model has a stable periodic trajectory from Hopf bifurcation, which shows the system is in an eco- logical balance; the other is that periodic trajectory from Hopf bifurcation is unstable, which indicates the system is in a sharp or catastrophic loss of stability. For the latter, a bifurcation controller is designed to make the periodic trajectory stable. Finally, some simulations are carried out to prove the results.展开更多
文摘Quorum sensing, or auto induction, as a cell density dependent signaling mechanism in many microorganisms, is trig- gered via auto inducers which passively diffuse across the bacterial envelope and therefore intracellulaly accumulate only at higher bacterial densities to regulate specialized processes such as genetic competence, bioluminescence, virulence and sporulation. N-acyl homoserine lactones are the most common type of signal molecules. Aquaculture is one of the fastest-growing food-producing indus- tries, but disease outbreaks caused by pathogenic bacteria are a significant constraint on the development of the sector worldwide. Many of these pathogens have been found to be controlled by their quorum sensing systems. As there is relevance between the pathogenic bacteria＇s virulence factor expression and their auto inducers, quorum quenching is a new effective anti-infective strategy to control infections caused by bacterial pathogens in aquaculture. The techniques used to do this mainly include the following： （1） the inhibition of signal molecule biosynthesis, （2） blocking signal transduction, and （3） chemical inactivation and biodegradation of signal molecules. To provide a basis for finding alternative means of controlling aquatic diseases by quorum quenching instead of treatment by antibiotics and disinfectants, we will discuss the examination, purification and identification of auto inducers in this paper.
基金Acknowledgments This work was supported by the Science Foundation of Liaoning Province （20092179） and by the National Natural Science Foundation （60974004/F030101）.
文摘The existence conditions of Hopf bifurcation for a predator prey model based on nutri- tion kinetics are given. The two results may appear as follows： one is that the model has a stable periodic trajectory from Hopf bifurcation, which shows the system is in an eco- logical balance; the other is that periodic trajectory from Hopf bifurcation is unstable, which indicates the system is in a sharp or catastrophic loss of stability. For the latter, a bifurcation controller is designed to make the periodic trajectory stable. Finally, some simulations are carried out to prove the results.
