Medial orbitofrontal cortex （mOFC） abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined....Medial orbitofrontal cortex （mOFC） abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging （R-fMRI） study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample （NKI-RS） to examine the relationship between the fractional amplitude of low-frequency fluctuation （fALFF） signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity （RSFC） between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.展开更多
基金Project supported by the Natural Science Foundation of Zhejiang Province(No.LY17H180007)the Scientific Research Fund of Zhejiang Education Department(No.Y201431735)the Hangzhou Science and Technology Commission Foundation(No.20170533B06),China
文摘Medial orbitofrontal cortex （mOFC） abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging （R-fMRI） study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample （NKI-RS） to examine the relationship between the fractional amplitude of low-frequency fluctuation （fALFF） signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity （RSFC） between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.
