女性男性化疾病的内分泌测定

本文对51例男性化妇女测定了睾丸酮、游离睾丸酮、雄烯二酮、17α-羟孕酮、硫酸脱氢表雄酮(DHAS)、性激素结合蛋白(SHBG)、雄甾烷二醇和游离雄激素指数(FAI)。男性化妇女伴有高雄激素者92％有明显的SHBG值降低,且FAI明显升高,雄烯二酮和17α-羟孕酮无明显变化,17例雄甾烷二醇值均高于正常,且与睾丸酮和游离睾丸酮有密切相关性(γ=0.78,γ=0.80)。对于女性男性化病例的诊断除测定睾丸酮和DHAS外,还应测定SHBG和FAI。

多囊卵巢综合征诊断与治疗的新进展

现阶段临床医学仍在苦心研究多囊卵巢综合征的发病机制,并致力于其诊断标准的统一划定。由于发病机制不明确、诊断标准缺乏统一,因此使得多囊卵巢综合征的临床诊断与治疗方法相对较多。文章特对多卵巢综合征诊断及治疗进行综述、分析。

子宫内膜增生不孕患者256例临床分析

目的观察子宫内膜增生不孕患者的内分泌特征与子宫内膜的病理结果及治疗效果。方法选择不孕患者256例,进行早期卵泡期超声检查子宫内膜及放免测定血清中的卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、睾酮(T)、雌二醇(E2),并对每个患者进行诊断性刮宫,随机分为2组,分别用克罗米芬及中药治疗。结果子宫内膜增生患者中,单纯增生75.39%、复杂增生14.83%、非典型增生9.75%,其发病率以单纯增生为主(P<0.05)。合并高PRL占16、41%、高雄激素血征占14、45%、高E2占56.64%,高雌二醇高于高催乳素学血症(P<0.05)。结论子宫内膜增生患者中内分泌异常以高PRL及高E2为主,其次为高雄激素血征。此类患者排卵率差,治疗效果无显著差异(P>0.05)。

Determination and Removal of Endocrine Disruptors in Wastewater by Activated Carbon

This study aimed to evaluate the EDC （endocrine disruptors compounds） in the city of Sao Paulo＇s water sources, from samples collected at predetermined sampling points and to evaluate the adsorptive capacity of these compounds in different types of activated carbon. The effects of these EDC on humans are not well established due to the necessary large exposure time for the effect＇s manifestation. After tests using powdered and granular activated carbon, all samples were filtered under vacuum using cellulose acetate membrane （0.45 μm） to remove eventual impurities, and posteriorly carded out the solid-phase extraction SPE （solid-phase extraction） and chromatographic analysis. The results lead to the conclusion that both powdered activated carbon have removal effectiveness of these compounds by adsorption. Furthermore, great amount of endocrine disruptors were found at several sampling points in river and city＇s water reservoirs, which shows different levels of pollution of water sources, some of them responsible for the watersupply of the city of Silo Paulo, Brazil.