In the last several decades, circulating fluidized bed reactors have been studied in many aspects including hydrodynamics, heat and mass transfer and gas–solid two phase contacting. However, despite the abundance of ...In the last several decades, circulating fluidized bed reactors have been studied in many aspects including hydrodynamics, heat and mass transfer and gas–solid two phase contacting. However, despite the abundance of review papers on hydrodynamics, there is no summary paper on gas–solid contact efficiency to date, especially on high density circulating fluidized beds(CFBs). This paper gives an introduction to, and a review of the measurement of contact efficiency in circulating fluidized bed riser. Firstly, the popular testing method of contact efficiency including the method of heating transfer experiment and hot model reaction are discussed, then previous published papers are reviewed based on the discussed methods. Some key results of the experimental work are described and discussed. Gas–solid contact efficiency is affected by the operating conditions as well as the particle size distribution. The result of the contact efficiency shows that the CFB riser is far away from an ideal plug flow reactor due to the characteristics of hydrodynamics in the riser. Lacunae in the available literature have been delineated and recommendations have been made for further work.展开更多
Seepage and stress redistribution are the main factors affecting the stability of surrounding rock in high-pressure hydraulic tunnels.In this work,the effects of the seepage field were firstly simplified as a seepage ...Seepage and stress redistribution are the main factors affecting the stability of surrounding rock in high-pressure hydraulic tunnels.In this work,the effects of the seepage field were firstly simplified as a seepage factor acting on the stress field,and the equilibrium equation of high pressure inner water exosmosis was established based on physical theory.Then,the plane strain theory was used to solve the problem of elasticity,and the analytic expression of surrounding rock stress was obtained.On the basis of criterion of Norway,the influences of seepage,pore water pressure and buried depth on the characteristics of the stress distribution of surrounding rocks were studied.The analyses show that the first water-filling plays a decisive role in the stability of the surrounding rock; the influence of seepage on the stress field around the tunnel is the greatest,and the change of the seepage factor is approximately consistent with the logarithm divergence.With the effects of the rock pore water pressure,the circumferential stress shows the exchange between large and small,but the radial stress does not.Increasing the buried depth can enhance the arching effect of the surrounding rock,thus improving the stability.展开更多
This paper presents an experimental study of the physical characteristic effects of large particles on hydraulic transport in a horizontal pipe.The particles are spherical and are large with respect to the diameter of...This paper presents an experimental study of the physical characteristic effects of large particles on hydraulic transport in a horizontal pipe.The particles are spherical and are large with respect to the diameter of the pipe(8%,10%,16% and 25%).Experiments were done to test the important parameters in solid transport(pressure,velocity,etc.).As a result,the relationship between the pressure gradient forces and the mixture velocity was substantially different from the pure liquid flow.However,in a single-phase flow a monotonous behavior of the pressure drop curve is observed,and the curve of the solid particle flow attains its minimum at the critical velocity.The regimes are characterized with differential pressure measurements and visualizations.展开更多
To research the reinforcement effect of a rock slope with group anchorage cables and the stress characteristics of pre-stressed anchorage cables in the fractured surface, the rock slope calculated model of a wedge blo...To research the reinforcement effect of a rock slope with group anchorage cables and the stress characteristics of pre-stressed anchorage cables in the fractured surface, the rock slope calculated model of a wedge block within the double-slide face was established by using the finite difference software according to the actual slope project combined with indoor model test. The pre-stress loss rule of the anchorage cable and the distribution of axial force and the force-transferring mechanism of the anchorage cable were analyzed during simulation. Also, based on the displacement contour and the safety factor of the calculated results, the quantitative analysis for the reinforcement ef- fect of the rock slope with group pre-stressed anchorage cable was discovered. The results computed by the software conform with the data in the experiment, which can prove the effectiveness and correctness of parameter selection and model building. Keywords group anchorage reinforcement, rock slope, joint fissure, pre-stressed anchorage cable, stress characteristics展开更多
In order to understand and master the dynamic characteristics of sandy soil with different silt contents, the authors carried out many indoor dynamic triaxial tests for five groups of sandy with silt which took from P...In order to understand and master the dynamic characteristics of sandy soil with different silt contents, the authors carried out many indoor dynamic triaxial tests for five groups of sandy with silt which took from Panjin and Xiamen. Under the conditions of consolidation pressure of 100 kPa, 200 kPa, 300 kPa, stationary vibration frequency H=1 and cyclic loading, the authors found that the effective cohesion increases and the effective internal friction angle decreases with the increase of the silt contents. During the liquefied scope, the cementation and the strength have been increased with the increase of the silt contents.展开更多
Coronary stents are metal coils or mesh tubes delivered to blocked vessels through catheters, whic Recently, special drugs h are expanded by balloons to reopen and scaffold target vessels. are carried by stents (drug...Coronary stents are metal coils or mesh tubes delivered to blocked vessels through catheters, whic Recently, special drugs h are expanded by balloons to reopen and scaffold target vessels. are carried by stents (drug-eluting stents) to further reduce instent restenosis rate after stenting procedure. However, continual study on biomechanical characteristics of stents is necessary provide a more suitable drug loading for better interactions between stents and tissue, or to platform for drug-eluting stents. The purpose of this paper is to show how finite element methods can be used to study cell area and strut distribution changes of bent coronary stents. A same bending deformation was applied to two commercial coronary stent models by a rigid curved vessel. Results show that the stent design influenced the changes of cell area and strut distribution under bending situation. The stent with links had more cell area changes at outer curvature, and the stent with peak-peak ( 〉 〈 ) strut design could have strut contact and overlapping at inner curvature. In conclusion, this finite element method can be used to study and compare cell area and strut distribution changes of bent stents, and to provide a convenient tool for designers in testing and improving biomechanical characteristics of new stents.展开更多
This paper aims at exploring the tectonic characteristics of the South China Continent (SCC) and extracting the universal tec- tonic rules from these characteristics,to help enrich the plate tectonic theory and bett...This paper aims at exploring the tectonic characteristics of the South China Continent (SCC) and extracting the universal tec- tonic rules from these characteristics,to help enrich the plate tectonic theory and better understand the continental dynamic system. For this purpose, here we conduct a multi-disciplinary investigation and combine it with the previous studies to reas- sess the tectonics and evolution of SCC and propose that the tectonic framework of the continent comprises two blocks, three types of tectonic units, four deformation systems, and four evolutionary stages with distinctive mechanism and tectonic characteris- tics since the Neoproterozoic. The four evolutionary stages are: (1) The amalgamation and break-up of the Neoproterozoic plates, typically the intracontinental rifting. (2) The early Paleozoic and Mesozoic intracontinental orogeny confined by plate tectonics, forming two composite tectonic domains. (3) The parallel operation of the Yangtze cratonization and intracontinental orogeny, and multi-phase reactivation of the Yangtze craton. (4) The association and differentiation evolution of plate tectonics and intraconti- nental tectonics, and the dynamic characteristics under the Meso-Cenozoic modem global plate tectonic regime.展开更多
The covalent attachment of protein-resistant polymers to therapeutic proteins is a widely used method for extending their in vivo half-lives; however, the effect of molecular weight of polymer on the in vitro and in v...The covalent attachment of protein-resistant polymers to therapeutic proteins is a widely used method for extending their in vivo half-lives; however, the effect of molecular weight of polymer on the in vitro and in vivo functions of protein-polymer conjugates has not been well elucidated. Herein we report the effect of molecular weight of poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) on the in vitro and in vivo properties of C-termi- nal interferon-alpha (IFN)-POEGMA conjugates. Increasing the molecular weight of POEGMA decreased the in vitro activity of IFN-ct but increased its thermal stability and in vivo pharmacokinetics. Intriguingly, the in vivo antitumor efficacy of IFN-a was increased by increasing the POEGMA molecular weight from ca. 20 to 60 kDa, but was not further increased by increasing the molecular weight of POEGMA from ca. 60 to 100 kDa due to the neutralization of the improved pharmacokinetics and the reduced in vitro activity. This finding offers a new viewpoint on the molecular size rationale for designing next-generation protein-polymer conjugates, which may benefit patients by reducing admin- istration frequency and adverse reactions, and improving therapeutic efficacy.展开更多
基金Supported by the Scientific Research Funds from China University of Petroleum(Beijing)(No.2462014YJRC018)partially supported by the National Natural Science Foundation of China(No.21506253 and No.91534204)
文摘In the last several decades, circulating fluidized bed reactors have been studied in many aspects including hydrodynamics, heat and mass transfer and gas–solid two phase contacting. However, despite the abundance of review papers on hydrodynamics, there is no summary paper on gas–solid contact efficiency to date, especially on high density circulating fluidized beds(CFBs). This paper gives an introduction to, and a review of the measurement of contact efficiency in circulating fluidized bed riser. Firstly, the popular testing method of contact efficiency including the method of heating transfer experiment and hot model reaction are discussed, then previous published papers are reviewed based on the discussed methods. Some key results of the experimental work are described and discussed. Gas–solid contact efficiency is affected by the operating conditions as well as the particle size distribution. The result of the contact efficiency shows that the CFB riser is far away from an ideal plug flow reactor due to the characteristics of hydrodynamics in the riser. Lacunae in the available literature have been delineated and recommendations have been made for further work.
基金Projects(51374112/E0409,51109084/E090701) supported by the National Natural Science Foundation of ChinaProject(ZQN-PY112) supported by the Promotion Program for Young and Middle-aged Teacher in Science and Technology Research of Huaqiao University,China+1 种基金Project(SKLGP2013K014) supported by the Opening Fund of State Key Laboratory of Geohazard Prevention and Geoenvironment Protection(Chengdu University of Technology),ChinaProject(SKLGDUEK1304) supported by the Open Research Fund of State Key Laboratory for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,China
文摘Seepage and stress redistribution are the main factors affecting the stability of surrounding rock in high-pressure hydraulic tunnels.In this work,the effects of the seepage field were firstly simplified as a seepage factor acting on the stress field,and the equilibrium equation of high pressure inner water exosmosis was established based on physical theory.Then,the plane strain theory was used to solve the problem of elasticity,and the analytic expression of surrounding rock stress was obtained.On the basis of criterion of Norway,the influences of seepage,pore water pressure and buried depth on the characteristics of the stress distribution of surrounding rocks were studied.The analyses show that the first water-filling plays a decisive role in the stability of the surrounding rock; the influence of seepage on the stress field around the tunnel is the greatest,and the change of the seepage factor is approximately consistent with the logarithm divergence.With the effects of the rock pore water pressure,the circumferential stress shows the exchange between large and small,but the radial stress does not.Increasing the buried depth can enhance the arching effect of the surrounding rock,thus improving the stability.
基金the Dyn Fluid Laboratory at Arts et Métiers Paris Tech
文摘This paper presents an experimental study of the physical characteristic effects of large particles on hydraulic transport in a horizontal pipe.The particles are spherical and are large with respect to the diameter of the pipe(8%,10%,16% and 25%).Experiments were done to test the important parameters in solid transport(pressure,velocity,etc.).As a result,the relationship between the pressure gradient forces and the mixture velocity was substantially different from the pure liquid flow.However,in a single-phase flow a monotonous behavior of the pressure drop curve is observed,and the curve of the solid particle flow attains its minimum at the critical velocity.The regimes are characterized with differential pressure measurements and visualizations.
基金Supported by the National Natural Science Foundation of China(50874085)
文摘To research the reinforcement effect of a rock slope with group anchorage cables and the stress characteristics of pre-stressed anchorage cables in the fractured surface, the rock slope calculated model of a wedge block within the double-slide face was established by using the finite difference software according to the actual slope project combined with indoor model test. The pre-stress loss rule of the anchorage cable and the distribution of axial force and the force-transferring mechanism of the anchorage cable were analyzed during simulation. Also, based on the displacement contour and the safety factor of the calculated results, the quantitative analysis for the reinforcement ef- fect of the rock slope with group pre-stressed anchorage cable was discovered. The results computed by the software conform with the data in the experiment, which can prove the effectiveness and correctness of parameter selection and model building. Keywords group anchorage reinforcement, rock slope, joint fissure, pre-stressed anchorage cable, stress characteristics
基金Projects supported by the Natural Science Foundation of China (No.40472134)Survey and evaluation on environmental geology of coastal zone in Liaoning,Institute of Geology and Mineral Resources (No.1212010540502)
文摘In order to understand and master the dynamic characteristics of sandy soil with different silt contents, the authors carried out many indoor dynamic triaxial tests for five groups of sandy with silt which took from Panjin and Xiamen. Under the conditions of consolidation pressure of 100 kPa, 200 kPa, 300 kPa, stationary vibration frequency H=1 and cyclic loading, the authors found that the effective cohesion increases and the effective internal friction angle decreases with the increase of the silt contents. During the liquefied scope, the cementation and the strength have been increased with the increase of the silt contents.
文摘Coronary stents are metal coils or mesh tubes delivered to blocked vessels through catheters, whic Recently, special drugs h are expanded by balloons to reopen and scaffold target vessels. are carried by stents (drug-eluting stents) to further reduce instent restenosis rate after stenting procedure. However, continual study on biomechanical characteristics of stents is necessary provide a more suitable drug loading for better interactions between stents and tissue, or to platform for drug-eluting stents. The purpose of this paper is to show how finite element methods can be used to study cell area and strut distribution changes of bent coronary stents. A same bending deformation was applied to two commercial coronary stent models by a rigid curved vessel. Results show that the stent design influenced the changes of cell area and strut distribution under bending situation. The stent with links had more cell area changes at outer curvature, and the stent with peak-peak ( 〉 〈 ) strut design could have strut contact and overlapping at inner curvature. In conclusion, this finite element method can be used to study and compare cell area and strut distribution changes of bent stents, and to provide a convenient tool for designers in testing and improving biomechanical characteristics of new stents.
基金supported by the special grant of Ministry of Science and Technology of the People’s Republic of China for State Key Laboratory of Continental Dynamics,Northwest University,the key research project of Sinopec Group(Grant No.YPH08012)the National Natural Science Foundation of China(Grant Nos.41190072,41190073,41190074,41190070)
文摘This paper aims at exploring the tectonic characteristics of the South China Continent (SCC) and extracting the universal tec- tonic rules from these characteristics,to help enrich the plate tectonic theory and better understand the continental dynamic system. For this purpose, here we conduct a multi-disciplinary investigation and combine it with the previous studies to reas- sess the tectonics and evolution of SCC and propose that the tectonic framework of the continent comprises two blocks, three types of tectonic units, four deformation systems, and four evolutionary stages with distinctive mechanism and tectonic characteris- tics since the Neoproterozoic. The four evolutionary stages are: (1) The amalgamation and break-up of the Neoproterozoic plates, typically the intracontinental rifting. (2) The early Paleozoic and Mesozoic intracontinental orogeny confined by plate tectonics, forming two composite tectonic domains. (3) The parallel operation of the Yangtze cratonization and intracontinental orogeny, and multi-phase reactivation of the Yangtze craton. (4) The association and differentiation evolution of plate tectonics and intraconti- nental tectonics, and the dynamic characteristics under the Meso-Cenozoic modem global plate tectonic regime.
基金financially supported by Grants from the National Natural Science Foundation of China (21274043 and 21534006).
文摘The covalent attachment of protein-resistant polymers to therapeutic proteins is a widely used method for extending their in vivo half-lives; however, the effect of molecular weight of polymer on the in vitro and in vivo functions of protein-polymer conjugates has not been well elucidated. Herein we report the effect of molecular weight of poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) on the in vitro and in vivo properties of C-termi- nal interferon-alpha (IFN)-POEGMA conjugates. Increasing the molecular weight of POEGMA decreased the in vitro activity of IFN-ct but increased its thermal stability and in vivo pharmacokinetics. Intriguingly, the in vivo antitumor efficacy of IFN-a was increased by increasing the POEGMA molecular weight from ca. 20 to 60 kDa, but was not further increased by increasing the molecular weight of POEGMA from ca. 60 to 100 kDa due to the neutralization of the improved pharmacokinetics and the reduced in vitro activity. This finding offers a new viewpoint on the molecular size rationale for designing next-generation protein-polymer conjugates, which may benefit patients by reducing admin- istration frequency and adverse reactions, and improving therapeutic efficacy.