Objective To investigate lipopolysaccharide (LPS) induced acute cerebral inflammatory damage and the therapeutic effect of ginkgolide B (BN52021). Methods Thirty Sprague-Dawley rats were randomly divided into 3 gr...Objective To investigate lipopolysaccharide (LPS) induced acute cerebral inflammatory damage and the therapeutic effect of ginkgolide B (BN52021). Methods Thirty Sprague-Dawley rats were randomly divided into 3 groups (n = 10 for each group): Control group, Model group and Treatment group (treated with BN52021). LPS were injected into the fourth ventricle of rat to make a neuroinflammatory murine model. Morris water maze was used to detect the learning and memory ability of rats; changes of synapse number and subcellular ultrastructures were observed under a transmission electron microscope; OX-42 positive microglia in the brain was detected by immunohistochemical method. Results The average escape latency in the Treatment group were significantly shortened than that in the Model group; and the percentage of swimming distance traveled in platform quadrant accounting for total distance increased markedly. The rough endoplasmic reticulum and polyribosomes in the Treatment group were more than that in the Model group, but the number of synapses seemed to have no obvious change. The number of OX-42 positive microglia in the Treatment group decreased markedly than that in the Model group, and the grey density of OX-42-positive cells increased significantly. Conclusion LPS can induce inflammatory damages to the brain, but the damage could be antagonized by BN52021. Platelet activating factor receptor antagonist may offer an effective therapy for neurodegeneration diseases.展开更多
Changes in tissue structures, rheological properties of cross- and vertical section boiled abalone meat were studied in relation to boiling time. The adductor muscle of abalone Haliotis discus which was removed from t...Changes in tissue structures, rheological properties of cross- and vertical section boiled abalone meat were studied in relation to boiling time. The adductor muscle of abalone Haliotis discus which was removed from the shell, was boiled for 1, 2, and 3 h, respectively. Then it was cut up and separated into cross- and vertical section meat. When observed by a light microscope and a scanning electron microscope, structural changes in the myofibrils were greatest in the cross section meat compared with the vertical section meat. When boiling time was increased from 1 h to 3 h, the instantaneous modulus E 0 and rupture strength of both section meat decreased gradually with increased boiling time, and no significant differences were observed between these two section meat for the same boiling time. When boiled for 1 h, the relaxation time of cross section meat was much longer than that of vertical section meat. There were no significant changes in the relaxation time of vertical section for different boiling time, but the relaxation time of cross section meat was reduced gradually with increasing boiling time. These results confirmed that the difference in rheological properties between the cross- and vertical section meat was mainly due to the denaturation level of myofibrils when heated for 1 h, as well as due to the changes in the amount of denatured proteins, and the manner in which the inner denatured protein components weve exchanged after boiling time was increased from 1 h to 3 h.展开更多
Temporal variations in multimodal structures of diurnal( D_1) and semidiurnal( D_2) internal tides were investigated on the continental slope of the Dongsha Plateau, based on 2-month moored acoustic Doppler current pr...Temporal variations in multimodal structures of diurnal( D_1) and semidiurnal( D_2) internal tides were investigated on the continental slope of the Dongsha Plateau, based on 2-month moored acoustic Doppler current profiler observations. Harmonic analysis indicated that the D_1 components( K_1 and O_1) dominated the internal tide field. The vertical structure of the K_1 constituent presented a first-mode structure while the M_2 constituent seemed to exhibit a high-mode structure. Amplitude spectra analysis of the current data revealed differences in baroclinic current amplitudes between different water depths. Temporal variations in modal structures ware analyzed, based on the D_1 and D_2 baroclinic tides extracted from the baroclinic velocity field with band-pass filters. Analysis showed that the magnitude of the D_1 internal tide current was much larger than the D_2 current, and temporal variations in the modal structure of the D_1 internal tide occurred on an approximately fortnightly cycle. The EOF analyses revealed temporal transformation of multimodal structures for D_1 and D_2 internal tides. The enhancement of the D_1 internal tide was mainly due to the superposition of K_1 and O_1, according to the temporal variation of coherent kinetic energy.展开更多
Literature continues to generate controversies as to what it is and what it is for. That is one of the reasons for the proliferation of "literary theories." The notion is here placed between quotation marks because ...Literature continues to generate controversies as to what it is and what it is for. That is one of the reasons for the proliferation of "literary theories." The notion is here placed between quotation marks because it does not mean the same thing to all the scholars in the field. Some regard it in the same way that theory functions in the sciences, where it focuses on the object it is associated with. For example, the atomic theory of matter is concerned with the internal constitution or the characterizing properties of matter. Others, however, are looking beyond the object towards the reader and the extra-textual environment. The approaches to literary studies which look beyond the individual work to outside phenomena are many and increasing all the time as new issues and concerns arrive on the social scene. Issues of climate change are fairly topical now; and criticism is already responding with such ideas as eco-criticism. The question of the identity of the literary object has to be kept in the front burner, so that it is not swamped by the many different interests which attach to literature from time to time. Bringing attention back to the literary work is the central concern of this paper; and we are doing this by way of the metaphors of perception often used with respect to the literary work as these suggest that the work is something to focus on, rather than to see through to something else. Finally, I elaborate the concept of integrity as an appurtenance of the literary text that attracts and holds the gaze.展开更多
We addressed the mesoscale structure variation of the central South China Sea (SCS) with the measurements by a long-lived Argo float and a high-resolution ATLAS buoy during 1998-2002. T-S diagram indicates cooling a...We addressed the mesoscale structure variation of the central South China Sea (SCS) with the measurements by a long-lived Argo float and a high-resolution ATLAS buoy during 1998-2002. T-S diagram indicates cooling and freshening events in 2000 and 2001 with lower salinity (0.5-0.8) and lower temperature (1-1.7℃). Significant decrease in the net heat flux and increase in the precipitation suggest that the cooling and freshening is due to extra forcing by the atmosphere. Additional to large year-to-year changes, intraseasonal variability is moderate in the research area. The axis of the maximum intraseasonal temperature and salinity signals are mainly located on the thermocline, Typically, amplitude and period of intraseasonal temperature is about 2℃ and 40-60 days, and that of salinity is 0.34).5 and 35-60 days. Rapidly-changing winds, heat flux, and precipitation are critical in controlling the intraseasonal fluctuations of the mixed layer of the area. Studies on heat and freshwater balance in the mixed-layer further suggest that horizontal advection plays an important role in intraseasonal fluctuation in the upper ocean. In addition, the energetic mesoscale propagation radiated from the east boundary is linked to the intraseasonal variability in winter.展开更多
To address the increasing demands on pollution control and energy saving, the study of low-emission and high-efficiency burners has been emphasized worldwide. Swirl-induced environmental burners(EV-burners), have nota...To address the increasing demands on pollution control and energy saving, the study of low-emission and high-efficiency burners has been emphasized worldwide. Swirl-induced environmental burners(EV-burners), have notable features aligned with these requirements. In this study, an EV burner is investigated by both an ECT system and an OH-PLIF system. The aim is to detect the structure of a flame and obtain more information about the combustion process in an EV burner. 3D ECT sensitivity maps are generated for the measurement and OH-PLIF images are acquired in the same combustion zone as for the ECT measurements. The experimental images of a flame by ECT are in good agreement with the OH radical distribution pictures captured by OH-PLIF, which provide a mutual verification of the visualization method.展开更多
The gender-based patriarchy of the Huaxia people,consisting of family and state order,inner/outer distinction and gender-based hierarchy,took shape in the period of radical transformation when the Zhou dynasty replace...The gender-based patriarchy of the Huaxia people,consisting of family and state order,inner/outer distinction and gender-based hierarchy,took shape in the period of radical transformation when the Zhou dynasty replaced the Shang dynasty and reached maturity in the Han dynasty,which had been established in the wake of the radical transformation conducted by the Zhou and Qin dynasties.On the basis of the principles of male/female distinction and the integration of family and state,Western Zhou aristocrats abolished the state structure the inner and outer governance systems(nei/waifuzhi内外服制),carried on in part the main patrilineage and surname exogamy of the Shang dynasty,and established the Huaxia patriarchal system.During the Qin and Han dynasties,the patriarchal system evolved into family and state isomorphism characterized by power-sharing between the royal house and its officials and by a two-pronged kinship system in which the male line was inner and the female line was outer.The system thus evolved into the Huaxia gender-based patriarchy,which covered spatial spheres,division of responsibilities,the kinship system,values and ethics,and codes of daily interaction and conduct.The distinction between the inner and the outer was not only a core value of the gender-based patriarchy but also its operational strategy.It also engendered such inter-related sub-systems as human functions,ethics and gender and such philosophical systems as the unity of heaven and man and the cosmic binaries of yin-yang(阴阳)and qian-kun(乾坤).The constancy(经jing)/Expedience(权quan)and Continuity(因yin)/Change(变bian)of the gender-based patriarchy,the jing/quan at the heart of the basic system and governance strategy within its constraints jointly ensured the stability and dynamism of the gender-based patriarchy of the Huaxia people.展开更多
We model the interior of Europa using a method by which we set three layers of Europa and the composition of each layer in advance. Comparing the calculated mass and radius related to each model with the data derived ...We model the interior of Europa using a method by which we set three layers of Europa and the composition of each layer in advance. Comparing the calculated mass and radius related to each model with the data derived by the observations, we propose three possible internal structure models for Europa. All models are assumed to be differentiated into a metallic core, a (Mg,Fe)2SiO4 silicate mantle and an outer water shell. The only difference amongst these models are the composition of the core. The core of Model I is composed of Fe, while Model II composed of FeS, and the two models are based on the inferences provided by Europa's external gravitational field. Model III has a core which consists of Fe-FeS alloy, similar to that of Earth's outer core. Model I has a Fe core with a radius of 431 km, a (Mg,Fe)2SiO4 mantle with 999 km and a water shell with 132 km. Model II has a 777 km FeS core, a 619 km (Mg,Fe)2SiO4 mantle and a 167 km water shell. Model III has a 571 km Fe0.8(FeS)0.2 core, a 832 km (Mg,Fe)2SiO4 mantle and a 166 km water shell. In all three models, the density range and the radius of each layer is consistent with those deduced by Anderson et al.展开更多
文摘Objective To investigate lipopolysaccharide (LPS) induced acute cerebral inflammatory damage and the therapeutic effect of ginkgolide B (BN52021). Methods Thirty Sprague-Dawley rats were randomly divided into 3 groups (n = 10 for each group): Control group, Model group and Treatment group (treated with BN52021). LPS were injected into the fourth ventricle of rat to make a neuroinflammatory murine model. Morris water maze was used to detect the learning and memory ability of rats; changes of synapse number and subcellular ultrastructures were observed under a transmission electron microscope; OX-42 positive microglia in the brain was detected by immunohistochemical method. Results The average escape latency in the Treatment group were significantly shortened than that in the Model group; and the percentage of swimming distance traveled in platform quadrant accounting for total distance increased markedly. The rough endoplasmic reticulum and polyribosomes in the Treatment group were more than that in the Model group, but the number of synapses seemed to have no obvious change. The number of OX-42 positive microglia in the Treatment group decreased markedly than that in the Model group, and the grey density of OX-42-positive cells increased significantly. Conclusion LPS can induce inflammatory damages to the brain, but the damage could be antagonized by BN52021. Platelet activating factor receptor antagonist may offer an effective therapy for neurodegeneration diseases.
文摘Changes in tissue structures, rheological properties of cross- and vertical section boiled abalone meat were studied in relation to boiling time. The adductor muscle of abalone Haliotis discus which was removed from the shell, was boiled for 1, 2, and 3 h, respectively. Then it was cut up and separated into cross- and vertical section meat. When observed by a light microscope and a scanning electron microscope, structural changes in the myofibrils were greatest in the cross section meat compared with the vertical section meat. When boiling time was increased from 1 h to 3 h, the instantaneous modulus E 0 and rupture strength of both section meat decreased gradually with increased boiling time, and no significant differences were observed between these two section meat for the same boiling time. When boiled for 1 h, the relaxation time of cross section meat was much longer than that of vertical section meat. There were no significant changes in the relaxation time of vertical section for different boiling time, but the relaxation time of cross section meat was reduced gradually with increasing boiling time. These results confirmed that the difference in rheological properties between the cross- and vertical section meat was mainly due to the denaturation level of myofibrils when heated for 1 h, as well as due to the changes in the amount of denatured proteins, and the manner in which the inner denatured protein components weve exchanged after boiling time was increased from 1 h to 3 h.
基金Supported by the State Ministry of Science and Technology of China(Nos.2013AA122803,2013AA09A502)the National Natural Science Foundation of China(Nos.41206001,41371496)+1 种基金the Natural Science Foundation of Shandong Province of China(No.ZR2014DM017)National Key Technology Research and Development Program(No.2013BAK05B04)
文摘Temporal variations in multimodal structures of diurnal( D_1) and semidiurnal( D_2) internal tides were investigated on the continental slope of the Dongsha Plateau, based on 2-month moored acoustic Doppler current profiler observations. Harmonic analysis indicated that the D_1 components( K_1 and O_1) dominated the internal tide field. The vertical structure of the K_1 constituent presented a first-mode structure while the M_2 constituent seemed to exhibit a high-mode structure. Amplitude spectra analysis of the current data revealed differences in baroclinic current amplitudes between different water depths. Temporal variations in modal structures ware analyzed, based on the D_1 and D_2 baroclinic tides extracted from the baroclinic velocity field with band-pass filters. Analysis showed that the magnitude of the D_1 internal tide current was much larger than the D_2 current, and temporal variations in the modal structure of the D_1 internal tide occurred on an approximately fortnightly cycle. The EOF analyses revealed temporal transformation of multimodal structures for D_1 and D_2 internal tides. The enhancement of the D_1 internal tide was mainly due to the superposition of K_1 and O_1, according to the temporal variation of coherent kinetic energy.
文摘Literature continues to generate controversies as to what it is and what it is for. That is one of the reasons for the proliferation of "literary theories." The notion is here placed between quotation marks because it does not mean the same thing to all the scholars in the field. Some regard it in the same way that theory functions in the sciences, where it focuses on the object it is associated with. For example, the atomic theory of matter is concerned with the internal constitution or the characterizing properties of matter. Others, however, are looking beyond the object towards the reader and the extra-textual environment. The approaches to literary studies which look beyond the individual work to outside phenomena are many and increasing all the time as new issues and concerns arrive on the social scene. Issues of climate change are fairly topical now; and criticism is already responding with such ideas as eco-criticism. The question of the identity of the literary object has to be kept in the front burner, so that it is not swamped by the many different interests which attach to literature from time to time. Bringing attention back to the literary work is the central concern of this paper; and we are doing this by way of the metaphors of perception often used with respect to the literary work as these suggest that the work is something to focus on, rather than to see through to something else. Finally, I elaborate the concept of integrity as an appurtenance of the literary text that attracts and holds the gaze.
基金Supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (Nos.KZCX1-YW-12-01,KZCX2-YW-BR-04)the Knowledge Innovation Program of the Chinese Academy of Sciences (Nos.SQ200916,SQ200809)+1 种基金the National Natural Science Foundation of China (No.40806003)the National High Technology Research and Development Program of China (863 Program) (No.2008AA09A402)
文摘We addressed the mesoscale structure variation of the central South China Sea (SCS) with the measurements by a long-lived Argo float and a high-resolution ATLAS buoy during 1998-2002. T-S diagram indicates cooling and freshening events in 2000 and 2001 with lower salinity (0.5-0.8) and lower temperature (1-1.7℃). Significant decrease in the net heat flux and increase in the precipitation suggest that the cooling and freshening is due to extra forcing by the atmosphere. Additional to large year-to-year changes, intraseasonal variability is moderate in the research area. The axis of the maximum intraseasonal temperature and salinity signals are mainly located on the thermocline, Typically, amplitude and period of intraseasonal temperature is about 2℃ and 40-60 days, and that of salinity is 0.34).5 and 35-60 days. Rapidly-changing winds, heat flux, and precipitation are critical in controlling the intraseasonal fluctuations of the mixed layer of the area. Studies on heat and freshwater balance in the mixed-layer further suggest that horizontal advection plays an important role in intraseasonal fluctuation in the upper ocean. In addition, the energetic mesoscale propagation radiated from the east boundary is linked to the intraseasonal variability in winter.
基金sponsored by National Natural Science Foundation of China(61571189,61503137)State Administration of Foreign Experts Affairs for supporting the project‘Overseas Expertise Introduction Programme for Disciplines Innovation in Universities’(ref:B13009)
文摘To address the increasing demands on pollution control and energy saving, the study of low-emission and high-efficiency burners has been emphasized worldwide. Swirl-induced environmental burners(EV-burners), have notable features aligned with these requirements. In this study, an EV burner is investigated by both an ECT system and an OH-PLIF system. The aim is to detect the structure of a flame and obtain more information about the combustion process in an EV burner. 3D ECT sensitivity maps are generated for the measurement and OH-PLIF images are acquired in the same combustion zone as for the ECT measurements. The experimental images of a flame by ECT are in good agreement with the OH radical distribution pictures captured by OH-PLIF, which provide a mutual verification of the visualization method.
文摘The gender-based patriarchy of the Huaxia people,consisting of family and state order,inner/outer distinction and gender-based hierarchy,took shape in the period of radical transformation when the Zhou dynasty replaced the Shang dynasty and reached maturity in the Han dynasty,which had been established in the wake of the radical transformation conducted by the Zhou and Qin dynasties.On the basis of the principles of male/female distinction and the integration of family and state,Western Zhou aristocrats abolished the state structure the inner and outer governance systems(nei/waifuzhi内外服制),carried on in part the main patrilineage and surname exogamy of the Shang dynasty,and established the Huaxia patriarchal system.During the Qin and Han dynasties,the patriarchal system evolved into family and state isomorphism characterized by power-sharing between the royal house and its officials and by a two-pronged kinship system in which the male line was inner and the female line was outer.The system thus evolved into the Huaxia gender-based patriarchy,which covered spatial spheres,division of responsibilities,the kinship system,values and ethics,and codes of daily interaction and conduct.The distinction between the inner and the outer was not only a core value of the gender-based patriarchy but also its operational strategy.It also engendered such inter-related sub-systems as human functions,ethics and gender and such philosophical systems as the unity of heaven and man and the cosmic binaries of yin-yang(阴阳)and qian-kun(乾坤).The constancy(经jing)/Expedience(权quan)and Continuity(因yin)/Change(变bian)of the gender-based patriarchy,the jing/quan at the heart of the basic system and governance strategy within its constraints jointly ensured the stability and dynamism of the gender-based patriarchy of the Huaxia people.
基金supported by the National Natural Science Foundation of China(Grant Nos. 10973044 and 10833001)the Natural Science Foundation of Jiangsu Provincethe Foundation of Minor Planets of Purple Mountain Observatory
文摘We model the interior of Europa using a method by which we set three layers of Europa and the composition of each layer in advance. Comparing the calculated mass and radius related to each model with the data derived by the observations, we propose three possible internal structure models for Europa. All models are assumed to be differentiated into a metallic core, a (Mg,Fe)2SiO4 silicate mantle and an outer water shell. The only difference amongst these models are the composition of the core. The core of Model I is composed of Fe, while Model II composed of FeS, and the two models are based on the inferences provided by Europa's external gravitational field. Model III has a core which consists of Fe-FeS alloy, similar to that of Earth's outer core. Model I has a Fe core with a radius of 431 km, a (Mg,Fe)2SiO4 mantle with 999 km and a water shell with 132 km. Model II has a 777 km FeS core, a 619 km (Mg,Fe)2SiO4 mantle and a 167 km water shell. Model III has a 571 km Fe0.8(FeS)0.2 core, a 832 km (Mg,Fe)2SiO4 mantle and a 166 km water shell. In all three models, the density range and the radius of each layer is consistent with those deduced by Anderson et al.