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90锶-90钇敷贴在耳部瘢痕疙瘩术后患者中的应用效果 被引量:1
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作者 张凤真 刘阳 周涛 《长治医学院学报》 2021年第3期200-203,207,共5页
目的:探讨耳部瘢痕疙瘩术后采用90锶-90钇敷贴联合复方倍他米松注射液皮下注射的临床效果。方法:分析85例耳部瘢痕疙瘩行内核切除手术治疗患者的临床资料,按其术后治疗方案不同分组。对照组42例,采用复方倍他米松注射液皮下注射治疗;观... 目的:探讨耳部瘢痕疙瘩术后采用90锶-90钇敷贴联合复方倍他米松注射液皮下注射的临床效果。方法:分析85例耳部瘢痕疙瘩行内核切除手术治疗患者的临床资料,按其术后治疗方案不同分组。对照组42例,采用复方倍他米松注射液皮下注射治疗;观察组43例,在对照组基础上予以90锶-90钇敷贴治疗。比较2组总有效率、治疗前后瘢痕严重程度(VSS评分)、症状(红斑、硬结、瘙痒)积分、局部组织基质金属蛋白酶-1(MMP-1)、基质金属蛋白酶抑制剂-1(TIMP-1)、I型前胶原肽(PINP)表达、治疗期间不良反应情况、治疗后6个月、1年复发率。结果:观察组总有效率(95.35%)高于对照组(66.67%),差异有统计学意义(P<0.05);治疗后观察组VSS评分[(1.58±0.69)vs(2.77±0.81)分]、症状积分[(1.73±0.80)vs(2.91±0.94)分]低于对照组(P<0.05),观察组MMP-1[(20.88±2.54)vs(29.24±2.91)ng·mL^(-1)]、TIMP-1[(32.43±3.16)vs(42.74±3.78)ng·mL^(-1)]、PINP[(7.30±1.57)vs(8.94±1.80)ng·mL^(-1)]水平低于对照组,差异有统计学意义(P<0.05);2组不良反应发生率和治疗后6个月、1年复发率比较差异均无统计学意义(P>0.05)。结论:手术切除耳部瘢痕疙瘩后采用90锶-90钇敷贴联合复方倍他米松注射液皮下注射可有效促进患者瘢痕减退。 展开更多
关键词 耳部瘢痕疙瘩 内核切除手术 90锶-90钇 复方倍他米松 瘢痕改善
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Neoadjuvant peptide receptor radionuclide therapy for an inoperable neuroendocrine pancreatic tumor 被引量:2
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作者 Daniel Kaemmerer Vikas Prasad +4 位作者 Wolfgang Daffner Dieter Hrsch Günter Klppel Merten Hommann Richard P Baum 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第46期5867-5870,共4页
Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen.At diagnosis many of them are already advanced and diff icult to treat.We report on an initially inoperable ma... Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen.At diagnosis many of them are already advanced and diff icult to treat.We report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman,who received neoadjuvant peptide receptor radionuclide therapy(PRRT)as firstline treatment.This resulted in a signif icant downstaging of the tumor and allowed its subsequent complete surgical removal.Follow-up for eighteen months revealed a complete remission.This is the first report on neoadjuvant PRRT in a neuroendocrine neoplasm with subsequent successful complete resection. 展开更多
关键词 Endocrine pancreatic carcinoma Peptidereceptor radionuclide therapy Neodjuvant treatment Pancreatic surgery Molecular imaging Receptor pan-creatic endocrine tumor Computed tomography
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