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持续高动力性内毒素血症对禁食和肠道喂养猪空肠动力效应
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作者 杜鹏 《国外医学(外科学分册)》 2004年第2期117-118,共2页
关键词 高动力内毒素 禁食 肠道喂养 空肠动力效应 动物实验 小肠移动运动综合波 腹泻
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枯否细胞NF-κB激活对胆源性内毒素血症大鼠肝部分切除后肝细胞再生的影响 被引量:5
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作者 徐明清 龚建平 +1 位作者 韩本立 薛兰 《中华实验外科杂志》 CAS CSCD 北大核心 2002年第2期147-149,共3页
目的 探讨胆源性内毒素血症 (BE)大鼠肝部分切除 (PH)后枯否细胞 (KCs)核因子 κB(NF κB) )激活对肝细胞再生的影响。方法 将Wistar大鼠分为 4组 (每组 72只 ) :N PH组 (正常大鼠 70 %PH组 ) ;BE PH组 (BE大鼠 70 %PH组 ) ;BE PH白... 目的 探讨胆源性内毒素血症 (BE)大鼠肝部分切除 (PH)后枯否细胞 (KCs)核因子 κB(NF κB) )激活对肝细胞再生的影响。方法 将Wistar大鼠分为 4组 (每组 72只 ) :N PH组 (正常大鼠 70 %PH组 ) ;BE PH组 (BE大鼠 70 %PH组 ) ;BE PH白细胞介素 (IL) 1 0治疗组 ;BE PH治疗对照组。检测 70 %PH后 0、1、6、2 4、48、72hKCsNF κB激活、KCs肿瘤坏死因子α(TNFα)mRNA、IL 1 βmRNA和IL 6mRNA表达以及肝细胞溴脱氧核苷尿嘧啶 (BrdU)标记。 结果 BE PH组KCsNF κB活性高于N PH组 (P <0 .0 0 1 ) ,KCsTNFαmRNA、IL 1 βmRNA及IL 6mR NA表达亦明显高于N PH组 ,而肝细胞BrdU高峰标记指数 (38.82± 9.79)低于N PH组 (64.37±1 3 .69) (P <0 .0 1 ) ;BE PHIL 1 0组KCsNF κB活性低于BE PH组 (P <0 .0 1 ) ,KCsTNFα、IL 1 β及IL 6mRNA表达减少 ,而肝细胞BrdU高峰标记指数高于BE PH组 (P <0 .0 5)。结论 BE PH后KCsNF κB高水平激活导致KCsTNFαmRNA、IL 1 βmRNA及IL 6mRNA表达增高 ,从而抑制肝细胞再生 ,适当调控KCsNF κB活性能促进BE PH后肝细胞再生。 展开更多
关键词 肝再生 胆源内毒素 枯否细胞 NF-ΚB 肝部分切除术 影响 大鼠
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Effect of Efferent Vagus Nerve Excitation by Electrical Stimulation on Acute Liver Injury in Rabbits with Endotoxemia 被引量:7
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作者 ZHENGChong-ming XUXing-rong WANGYong ZUOXiang-rong 《Journal of Nanjing Medical University》 2004年第3期137-140,共4页
Objective:To study the effect of electrical stimulation of efferent vagus nerve on the acute liver injury induced by endotoxemia in rabbits. Methods:Sixteen rabbits were randomly divided into stimulation group(Group ... Objective:To study the effect of electrical stimulation of efferent vagus nerve on the acute liver injury induced by endotoxemia in rabbits. Methods:Sixteen rabbits were randomly divided into stimulation group(Group A,n=8) and control group (Group B,n=8).They were subjected to bilateral cervical vagotomy and intravenously challenged by lipopolysaccharide (LPS) (E.coli 0111:B4,DIFCO,USA) at a dose of 100 μg/kg injected within 30 min.The distal end of the left vagus nerve trunk was placed across bipolar electrodes connected to a stimulation module and controlled by an acquisition system.Stimuli with constant voltage (10V,5Hz,5ms) were applied twice to the nerve for 10 min before and after the administration of LPS in Group A.At the time 30,60,120,180,240,300 min before and after infusion of LPS respectively in each animal,blood samples were taken for late measurement of the serum Alanine aminotransferase (ALT),Aspartate aminotransferase (AST),tumor necrosis factor-α(TNF-α) and interleukin-10 (IL-10).Immediately after the experiment was finished,autopsy was performed and liver samples were taken to pathologic study. Results:Compared with Group B,the electrical stimulation of efferent vagus nerve could significantly decrease the contents of ALT,AST and TNF-α,but increase the contents of IL-10,in serum of Group A.It could also alleviate inflammation of liver tissue after LPS attack. Conclusion:The results suggest that excitation of the efferent vagus nerve can inhibit the inflammation cascade in liver after LPS challenge.Thus,it might have a protective effect on acute liver damage caused by endotoxemia. 展开更多
关键词 ENDOTOXEMIA vagus nerve electrical stimulation
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Effects of preoperatively selected gut decontamination on cardiopulmonary bypass-induced endotoxemia 被引量:1
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作者 余江 肖颖彬 王仙园 《Chinese Journal of Traumatology》 CAS 2007年第3期131-137,共7页
Objective : To evaluate the influence of preoperatively selected gut decontamination (SGD) on intestinally derived endotoxemia (ETM) in patients with rheumatic heart disease undergoing valve replacement operation... Objective : To evaluate the influence of preoperatively selected gut decontamination (SGD) on intestinally derived endotoxemia (ETM) in patients with rheumatic heart disease undergoing valve replacement operation with cardiopulinonary bypass ( CPB ) . Methods : Thirty patients were randomly divided into control group and SGD group. The patients in control group underwent preoperative bowel preparation, i. e, diet preparation and enema. The patients in SGD group were administrated 100 mg Tobramycin, 40 ing garlicin and 20 % Lactulose for 10 ml three times per day for 3 days besides routinely preoperative bowel preparation. Bacteria cultivation and identification and Gram staining of feces in both groups were used to evaluate species of intestinal flora and their ratios. The levds of endotoxin, D-lactate, TNF-α and complement 3 were determined at four time points of anesthetic induction, CPB end, 2 h after CPB, 24 h after CPB. And the related clinical biochemical and clinical markers were recorded. Resnits - Aerobic gram-negative bacilli (AGNB) ratio in post-SGD group decreased significantly as compared with that in control group and pre-SGD group ( P 〈 0.05 ). The level of D-lactate reduced significantly at time points of anesthetic induction and 2 h after CPB (P 〈 0. 05 ). Endotoxin levels of patients in both groups elevated significantly after CPB (P 〈0.05 ), and endotoxin levels of the patients in SGD group decreased significantly at points ofCPBend (P〈0.01) and 24 h after CPB (P〈0.05) compared with those in control group. The levels of TNF-α and complement 3 were similar in both groups as well as clinical and biochemical markers. Conclusions: CPB induces endotoxemia, while the regime of SGD is an effective way to prevent endotoxemia but may not affect activation of inflammatory media and clinical outcomes. 展开更多
关键词 DECONTAMINATION Cardiopulmonary bypass ENDOTOXINS ENDOTOXEMIA
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