目的：评价内行患者计划对直肠癌患者 Miles 术后早期生活质量及造口适应水平的影响。方法选择2013年2月—2014年7月直肠癌 Miles 术后患者103例,采用随机数字表法分为干预组52例和对照组51例。干预组参加为期2个月的内行患者计划培训课...目的：评价内行患者计划对直肠癌患者 Miles 术后早期生活质量及造口适应水平的影响。方法选择2013年2月—2014年7月直肠癌 Miles 术后患者103例,采用随机数字表法分为干预组52例和对照组51例。干预组参加为期2个月的内行患者计划培训课程,对照组进行常规门诊随访。干预后2个月,采用欧洲癌症研究与治疗组织生活质量测定量表（QLQ-C30）和造口适应量表（OAS）比较两组患者生活质量及造口适应水平变化。结果干预前两组患者生活质量各维度与造口适应水平得分比较差异均无统计学意义（P 〉0.05）,干预后除疲乏、呼吸困难、食欲减退症状条目外,干预组患者生活质量各维度得分均优于对照组,差异有统计学意义（t =-6.79~9.21,P 〈0.05）,且造口适应水平总分及各维度得分均高于对照组,差异有统计学意义（t =2.60~8.93,P 〈0.05）。结论实施内行患者计划可改善直肠癌患者 Miles 术后早期生活质量及造口适应水平。展开更多
Alzheimer's disease(AD) is a progressive and age-related irreversible neurodegenerative disease. When AD occurs, the relevant amount of zinc ions in brain considerably changes. In this contribution, we have explor...Alzheimer's disease(AD) is a progressive and age-related irreversible neurodegenerative disease. When AD occurs, the relevant amount of zinc ions in brain considerably changes. In this contribution, we have explored the possibility of in vivo rapid fluorescence imaging of AD through accurate targeting biomarker of zinc gluconate. By using the 3- and 6-month-old Alzheimer's model mice(AD-1) as the experimental models, our observations demonstrate that zinc gluconate molecules could pass through the blood–brain barrier and then produce hippocampus region-specific accumulation of fluorescent zinc nanoclusters in vivo, thus allowing kinetically controlled selective imaging of AD by fluorescence bioimaging.展开更多
文摘目的：评价内行患者计划对直肠癌患者 Miles 术后早期生活质量及造口适应水平的影响。方法选择2013年2月—2014年7月直肠癌 Miles 术后患者103例,采用随机数字表法分为干预组52例和对照组51例。干预组参加为期2个月的内行患者计划培训课程,对照组进行常规门诊随访。干预后2个月,采用欧洲癌症研究与治疗组织生活质量测定量表（QLQ-C30）和造口适应量表（OAS）比较两组患者生活质量及造口适应水平变化。结果干预前两组患者生活质量各维度与造口适应水平得分比较差异均无统计学意义（P 〉0.05）,干预后除疲乏、呼吸困难、食欲减退症状条目外,干预组患者生活质量各维度得分均优于对照组,差异有统计学意义（t =-6.79~9.21,P 〈0.05）,且造口适应水平总分及各维度得分均高于对照组,差异有统计学意义（t =2.60~8.93,P 〈0.05）。结论实施内行患者计划可改善直肠癌患者 Miles 术后早期生活质量及造口适应水平。
基金supported by the National Natural Science Foundation of China(81325011)the National High Technology Research and Development Program of China(2015AA020502,2012AA022703)the Major Science and Technology Project of Suzhou(ZXY2012028)
文摘Alzheimer's disease(AD) is a progressive and age-related irreversible neurodegenerative disease. When AD occurs, the relevant amount of zinc ions in brain considerably changes. In this contribution, we have explored the possibility of in vivo rapid fluorescence imaging of AD through accurate targeting biomarker of zinc gluconate. By using the 3- and 6-month-old Alzheimer's model mice(AD-1) as the experimental models, our observations demonstrate that zinc gluconate molecules could pass through the blood–brain barrier and then produce hippocampus region-specific accumulation of fluorescent zinc nanoclusters in vivo, thus allowing kinetically controlled selective imaging of AD by fluorescence bioimaging.
