To investigate presence and extent of eosinophilic cholangitis (EC) as well as IgG4-related disease in patients with indeterminate biliary stricture (IBS).METHODSAll patients with diagnosis of sclerosing cholangitis (...To investigate presence and extent of eosinophilic cholangitis (EC) as well as IgG4-related disease in patients with indeterminate biliary stricture (IBS).METHODSAll patients with diagnosis of sclerosing cholangitis (SC) and histopathological samples such as biopsies or surgical specimens at University Hospital Frankfurt from 2005-2015 were included. Histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regarding presence of eosinophilic infiltration and IgG4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing cholangitis.RESULTSone hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30% (3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of IgG4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with IgG4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to IgG4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (n = 27) and patients with primary sclerosing cholangitis (n = 14).CONCLUSIONEC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS.展开更多
Due to possible health effects of electric and magnetic fields, a directive on minimum health and safety requirements regarding the exposure of workers to electromagnetic fields has been disposed by European Parliamen...Due to possible health effects of electric and magnetic fields, a directive on minimum health and safety requirements regarding the exposure of workers to electromagnetic fields has been disposed by European Parliament and Council regarding the exposure of workers to electromagnetic fields. This legislation will be nationally implemented in 2012.The aim of this work was to develop a electromagnetic field exposure measurement method and further a magnetic field hazard evaluation method for exposure of workers in indoor medium to low voltage （MV/LV） distribution substations. Magnetic field exposure was also reflected with BS 8800 general risk classification procedure to accomplish specifications to execute magnetic field measurements and carry our risk assessment procedure for working tasks. The risk assessment procedure is based on magnetic field exposure measurements and dosimetric FEM calculations founded on EU Directive 2004/40/EC. According to field measurements action values were exceeded in several working tasks but limit values were not exceeded.展开更多
In recent years, rapid global urbanization accompanied by rapid economic growth has resulted in increasingly serious eco-environmental problems such as land degradation and pollution. As a society, we are gradually re...In recent years, rapid global urbanization accompanied by rapid economic growth has resulted in increasingly serious eco-environmental problems such as land degradation and pollution. As a society, we are gradually realizing the role of environmental protection and ecologically-focused construction in promoting sustainable development. As an important method for assessing sustainable development, ecological carrying capacity（ECC） has become a powerful tool for investigating sustainable development and assessing eco-environmental problems. Based on results from a large number of previous studies in this discipline, we summarized and generalized the implications, main assessment methods, and key research domains of ECC. Deficiencies and future trends in ECC research are identified. In terms of implications, ECC can be roughly defined into the perspectives of environmental change, human effects on ecological systems, and holistic ecological systems. The primary assessment methods and models can be classified in accordance with these three perspectives, including ecological footprint method, ecosystem-services-based method, net primary productivity method, situation space method, energetic ecological footprint model, system dynamics model, and coupling model. We compared the advantages and disadvantage of different methods and analyzed their applicable conditions. As ECC research has advanced, related studies have gradually extend to land systems, watershed systems, ecologically vulnerable areas, tourism systems, and urban comprehensive systems, which have solved relevant eco-environmental problems based on ECC assessments. Currently, ECC research lacks a standard definition for the ECC index threshold, research related to dynamic monitoring and early warning, sufficient consideration of scientific and technological drivers, and spatial pattern analyses. Future trends in ECC-related research should provide a large-scale assessment of cross-border areas and ecological vulnerable areas, construct an ecological warning platform, and consistently analyze ECC and regional leading industries.展开更多
Biodegradable magnesium（Mg）-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow.Numerous studies have presented in vitro and in viv...Biodegradable magnesium（Mg）-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow.Numerous studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cytocompatibility is a basic and important parameter in the evaluation system. In this review, we summarize the applications and limitations of in vitro evaluation methods including basic characterization methods and direct and indirect cytotoxicity tests. We discuss the influencing factors on cytotoxicity, such as surface roughness, preconditioning of sample surface, cell type for the biocompatibility evaluation in direct contact as well as conditions for the formation of extracts/degradation products for indirect assays. Besides, we highlight the recent in vivo animal tests and clinical trials about Mgbased stents along with some associated results. The aim of this review is to provide a meaningful reference in the further developments and related evaluation methods of Mg-based stents.展开更多
文摘To investigate presence and extent of eosinophilic cholangitis (EC) as well as IgG4-related disease in patients with indeterminate biliary stricture (IBS).METHODSAll patients with diagnosis of sclerosing cholangitis (SC) and histopathological samples such as biopsies or surgical specimens at University Hospital Frankfurt from 2005-2015 were included. Histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regarding presence of eosinophilic infiltration and IgG4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing cholangitis.RESULTSone hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30% (3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of IgG4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with IgG4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to IgG4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (n = 27) and patients with primary sclerosing cholangitis (n = 14).CONCLUSIONEC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS.
文摘Due to possible health effects of electric and magnetic fields, a directive on minimum health and safety requirements regarding the exposure of workers to electromagnetic fields has been disposed by European Parliament and Council regarding the exposure of workers to electromagnetic fields. This legislation will be nationally implemented in 2012.The aim of this work was to develop a electromagnetic field exposure measurement method and further a magnetic field hazard evaluation method for exposure of workers in indoor medium to low voltage （MV/LV） distribution substations. Magnetic field exposure was also reflected with BS 8800 general risk classification procedure to accomplish specifications to execute magnetic field measurements and carry our risk assessment procedure for working tasks. The risk assessment procedure is based on magnetic field exposure measurements and dosimetric FEM calculations founded on EU Directive 2004/40/EC. According to field measurements action values were exceeded in several working tasks but limit values were not exceeded.
基金National Natural Science Foundation of China(4167117741501192)National Key Research and Development Program(2016YFA0602402)
文摘In recent years, rapid global urbanization accompanied by rapid economic growth has resulted in increasingly serious eco-environmental problems such as land degradation and pollution. As a society, we are gradually realizing the role of environmental protection and ecologically-focused construction in promoting sustainable development. As an important method for assessing sustainable development, ecological carrying capacity（ECC） has become a powerful tool for investigating sustainable development and assessing eco-environmental problems. Based on results from a large number of previous studies in this discipline, we summarized and generalized the implications, main assessment methods, and key research domains of ECC. Deficiencies and future trends in ECC research are identified. In terms of implications, ECC can be roughly defined into the perspectives of environmental change, human effects on ecological systems, and holistic ecological systems. The primary assessment methods and models can be classified in accordance with these three perspectives, including ecological footprint method, ecosystem-services-based method, net primary productivity method, situation space method, energetic ecological footprint model, system dynamics model, and coupling model. We compared the advantages and disadvantage of different methods and analyzed their applicable conditions. As ECC research has advanced, related studies have gradually extend to land systems, watershed systems, ecologically vulnerable areas, tourism systems, and urban comprehensive systems, which have solved relevant eco-environmental problems based on ECC assessments. Currently, ECC research lacks a standard definition for the ECC index threshold, research related to dynamic monitoring and early warning, sufficient consideration of scientific and technological drivers, and spatial pattern analyses. Future trends in ECC-related research should provide a large-scale assessment of cross-border areas and ecological vulnerable areas, construct an ecological warning platform, and consistently analyze ECC and regional leading industries.
基金supported by the National Natural Science Foundation of China (31600766, 21473138 and 81330031)the Fundamental Research Funds for the Central Universities (No. 2682016CX076)
文摘Biodegradable magnesium（Mg）-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow.Numerous studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cytocompatibility is a basic and important parameter in the evaluation system. In this review, we summarize the applications and limitations of in vitro evaluation methods including basic characterization methods and direct and indirect cytotoxicity tests. We discuss the influencing factors on cytotoxicity, such as surface roughness, preconditioning of sample surface, cell type for the biocompatibility evaluation in direct contact as well as conditions for the formation of extracts/degradation products for indirect assays. Besides, we highlight the recent in vivo animal tests and clinical trials about Mgbased stents along with some associated results. The aim of this review is to provide a meaningful reference in the further developments and related evaluation methods of Mg-based stents.
