对于真核细胞来说,内质网(endoplasmic reticulum,ER)承担新生蛋白质的折叠、组装和转运。内质网的蛋白折叠机制对了解疾病的发展过程和治疗提供了新的方向,成为当下研究的热点。在蛋白质折叠过程中,由于各种原因会使得未折叠蛋...对于真核细胞来说,内质网(endoplasmic reticulum,ER)承担新生蛋白质的折叠、组装和转运。内质网的蛋白折叠机制对了解疾病的发展过程和治疗提供了新的方向,成为当下研究的热点。在蛋白质折叠过程中,由于各种原因会使得未折叠蛋白或错误折叠蛋白增多。然而,在细胞内存在一种机制,这一机制可以通过调整内质网折叠蛋白的数量和加强内质网的折叠能力,来减少未折叠蛋白或错误折叠蛋白的进一步生成,缓解内质网压力,即未折叠蛋白反应(unfolded protein response,UPR)。展开更多
Efficient functioning of the endoplasmic reticulum(ER) is very important for most cellular activities, such as protein folding and modification. The ER closely interacts with other organelles, including the Golgi body...Efficient functioning of the endoplasmic reticulum(ER) is very important for most cellular activities, such as protein folding and modification. The ER closely interacts with other organelles, including the Golgi body, endosome, membrane, and mitochondria, providing lipids and proteins for the repair of these organelles. ER stress can be induced by various abnormal materials in the cell. ER stress is a compensatory intracellular environment disorder that occurs during areaction. ER can sense the stress and respond to it through translational attenuation, upregulation of the genes for ER chaperones and related proteins, and degradation of unfolded proteins by a quality-control system, but excessive ER activation can cause cell death. The Pubmed and Web of Science databases were searched for full-text articles, and the terms "endoplasmic reticulum stress/unfolded protein response/gynecologic tumor cell apoptosis" were used as key words. Thirty-five studies of ER stress and unfolded protein response published from 2000 to 2016 were analyzed. Stress triggers apoptosis through a variety of signaling pathways. Increasing evidence has shown that the ER plays an important role in tumor cell diseases. The present review discusses the molecular mechanisms underlying unfolded protein response and its ability to promote survival and proliferation in gynecologic tumor cells.展开更多
文摘对于真核细胞来说,内质网(endoplasmic reticulum,ER)承担新生蛋白质的折叠、组装和转运。内质网的蛋白折叠机制对了解疾病的发展过程和治疗提供了新的方向,成为当下研究的热点。在蛋白质折叠过程中,由于各种原因会使得未折叠蛋白或错误折叠蛋白增多。然而,在细胞内存在一种机制,这一机制可以通过调整内质网折叠蛋白的数量和加强内质网的折叠能力,来减少未折叠蛋白或错误折叠蛋白的进一步生成,缓解内质网压力,即未折叠蛋白反应(unfolded protein response,UPR)。
文摘Efficient functioning of the endoplasmic reticulum(ER) is very important for most cellular activities, such as protein folding and modification. The ER closely interacts with other organelles, including the Golgi body, endosome, membrane, and mitochondria, providing lipids and proteins for the repair of these organelles. ER stress can be induced by various abnormal materials in the cell. ER stress is a compensatory intracellular environment disorder that occurs during areaction. ER can sense the stress and respond to it through translational attenuation, upregulation of the genes for ER chaperones and related proteins, and degradation of unfolded proteins by a quality-control system, but excessive ER activation can cause cell death. The Pubmed and Web of Science databases were searched for full-text articles, and the terms "endoplasmic reticulum stress/unfolded protein response/gynecologic tumor cell apoptosis" were used as key words. Thirty-five studies of ER stress and unfolded protein response published from 2000 to 2016 were analyzed. Stress triggers apoptosis through a variety of signaling pathways. Increasing evidence has shown that the ER plays an important role in tumor cell diseases. The present review discusses the molecular mechanisms underlying unfolded protein response and its ability to promote survival and proliferation in gynecologic tumor cells.