Colorectal cancer(CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interac...Colorectal cancer(CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators(NCo A-1 to 3, NCo A-6, PGC1-α, p300, CREBBP and MED1) and corepressors(N-Co R1 and 2, NRIP1 and MTA1) of nuclear receptors and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.展开更多
Environmental writing has attained a new relevance in the 21st century. In the present scenario, environmental writing becomes a social discourse. This is the result of a new, vibrant and growing environmental constit...Environmental writing has attained a new relevance in the 21st century. In the present scenario, environmental writing becomes a social discourse. This is the result of a new, vibrant and growing environmental constituency in societies such as Brazil, India, Thailand and other Third World Countries. The features of environmental writing include a visible concern for social justice, defence of livelihood and the determining part played by women. This new discourse has emerged with a new focus on redefinition of terms like human rights, common good, democracy and CPRs （common property resources）. Environmental Writing becomes a powerful discourse when it protests against the increasingly intrusive and interventionist developmental projects, implemented by the government, which in turn assert dominion over indigenous people of the land. There is also a strong emphasis on prudence among the poor as contrasted to the ecological profligacy of the rich. This paper is an attempt to examine the voices of dissent and the accountability of postmodern writers and environmental activists in India regarding environmental issues in India.展开更多
基金Supported by SIRIC and the PHC-UTIQUE program,No.16G 0805PHC-UTIQUE program,No.16G 0805+1 种基金Tunisian government(Bourse d’alternance)INSERM,Universitéde Montpellier,INCa,SIRIC Montpellier,the Institut régional du Cancer de Montpellier
文摘Colorectal cancer(CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators(NCo A-1 to 3, NCo A-6, PGC1-α, p300, CREBBP and MED1) and corepressors(N-Co R1 and 2, NRIP1 and MTA1) of nuclear receptors and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.
文摘Environmental writing has attained a new relevance in the 21st century. In the present scenario, environmental writing becomes a social discourse. This is the result of a new, vibrant and growing environmental constituency in societies such as Brazil, India, Thailand and other Third World Countries. The features of environmental writing include a visible concern for social justice, defence of livelihood and the determining part played by women. This new discourse has emerged with a new focus on redefinition of terms like human rights, common good, democracy and CPRs （common property resources）. Environmental Writing becomes a powerful discourse when it protests against the increasingly intrusive and interventionist developmental projects, implemented by the government, which in turn assert dominion over indigenous people of the land. There is also a strong emphasis on prudence among the poor as contrasted to the ecological profligacy of the rich. This paper is an attempt to examine the voices of dissent and the accountability of postmodern writers and environmental activists in India regarding environmental issues in India.
