Objective To establish albumin-creatinine ratio （ACR） reference value of the rural population in Hebei province. Methods This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dys...Objective To establish albumin-creatinine ratio （ACR） reference value of the rural population in Hebei province. Methods This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases, kidney diseases, and overweight condition, as well as those with an estimated glomerular filtration rate （eGFR）（60 ml/（min· 1.73 m^2）, apparently healthy subjects （1168） were selected. Urine albumin was measured by using the immunoturbidimetic method, serum creatinine was measured by using Jaffe＇s kinetic method on a morning spot-urine sample, and ACR was calculated. The 95th percentile of ACR in the healthy subjects was used as the normal upper limit. Results The normal upper limit of ACR was 28.71 mg/g （3.25 mg/retool） for males and 31.85 mg/g （3.60 rag/retool） for females. Based on this ACR reference value, the age-gender standardized prevalence of albuminuria in the rural areas of Hebei province was 12.9%. Conclusion The ACR reference value in the rural of Hebei province is higher than that of the Western population.展开更多
The widespread use of pesticides induces heavy adverse effects on human health,especially for the pregnant women and the newborns.In this study,a screening method has been developed for the determination of multi-pest...The widespread use of pesticides induces heavy adverse effects on human health,especially for the pregnant women and the newborns.In this study,a screening method has been developed for the determination of multi-pesticides in maternal and umbilical cord sera.All pesticides in sera were collected using solid phase extraction(SPE),and analyzed by gas chromatography-quadrupole time of flight mass spectrometry(GC-QTOF MS).To set up the quality criteria,a database of 50 pesticides was created and the accurate masses of 3 up to 5 representative ions with their intensity ratios were included for each pesticide.In addition,a novel"identification points"(IPs)system relying on the accurate MS1 and MS2 spectra was used to interpret the data for each suspected pesticide.The methodology was then applied to a pair of maternal and umbilical cord sera.A total of six pesticide residues were screened out successfully.In conclusion,GC-QTOF MS combined with an accurate mass database seemed to be one of the most efficient tools for systematic pesticide analysis.展开更多
The area along the Grear Wall in northern Shaanxi between the Loess Plateau and the Ordos Desert is one of the major agrarian-pastoral regions of northwest China. Historically, the land was fought over by the nomadic ...The area along the Grear Wall in northern Shaanxi between the Loess Plateau and the Ordos Desert is one of the major agrarian-pastoral regions of northwest China. Historically, the land was fought over by the nomadic and the agrarian peoples of the region. The Yansui section of the Ming Great Wall and thirty-nine fortified encampments along it were built during fighting between the Mongols and the Han people. As all of them were located along communication lines vital to economic development, they played an important role in politics, the economy and transport over three hundred years of Ming and Qing rule. However, they fell into disuse in the late Qing and the Republican period and are now in ruins. The main reason underlying their decline was that the sites had been chosen for their defensive value, so the subsequent northern expansion of China’s borders and structural changes in the border economy hastened their decline. Thus the rise and fall of these fortified towns at the intersection of the agrarian and the pastoral regions was closely related to imperial political and military activity and was in line with ethnic and tribal movements and migrations and the evolution of civilizations. In sum, the reasons behind the demise of these fortified towns and camps were highly complex and usually involved multiple factors.展开更多
基金Supported by the National Basic Research Program of China(973 Program)(2007CB512201)the Program of Health Policy for blindness prevention from China+2 种基金the Key Technologies R&D Program(2006-10903)from the Science and Technology Bureau of Handan City,Hebei Province,Chinaa program from Beijing Tongren Hospitalkey discipline fund of Health Bureau,Handan City,Hebei Province,China
文摘Objective To establish albumin-creatinine ratio （ACR） reference value of the rural population in Hebei province. Methods This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases, kidney diseases, and overweight condition, as well as those with an estimated glomerular filtration rate （eGFR）（60 ml/（min· 1.73 m^2）, apparently healthy subjects （1168） were selected. Urine albumin was measured by using the immunoturbidimetic method, serum creatinine was measured by using Jaffe＇s kinetic method on a morning spot-urine sample, and ACR was calculated. The 95th percentile of ACR in the healthy subjects was used as the normal upper limit. Results The normal upper limit of ACR was 28.71 mg/g （3.25 mg/retool） for males and 31.85 mg/g （3.60 rag/retool） for females. Based on this ACR reference value, the age-gender standardized prevalence of albuminuria in the rural areas of Hebei province was 12.9%. Conclusion The ACR reference value in the rural of Hebei province is higher than that of the Western population.
基金supported by the Science and Technology Commission of Shanghai Municipality(13ZR1448100)
文摘The widespread use of pesticides induces heavy adverse effects on human health,especially for the pregnant women and the newborns.In this study,a screening method has been developed for the determination of multi-pesticides in maternal and umbilical cord sera.All pesticides in sera were collected using solid phase extraction(SPE),and analyzed by gas chromatography-quadrupole time of flight mass spectrometry(GC-QTOF MS).To set up the quality criteria,a database of 50 pesticides was created and the accurate masses of 3 up to 5 representative ions with their intensity ratios were included for each pesticide.In addition,a novel"identification points"(IPs)system relying on the accurate MS1 and MS2 spectra was used to interpret the data for each suspected pesticide.The methodology was then applied to a pair of maternal and umbilical cord sera.A total of six pesticide residues were screened out successfully.In conclusion,GC-QTOF MS combined with an accurate mass database seemed to be one of the most efficient tools for systematic pesticide analysis.
文摘The area along the Grear Wall in northern Shaanxi between the Loess Plateau and the Ordos Desert is one of the major agrarian-pastoral regions of northwest China. Historically, the land was fought over by the nomadic and the agrarian peoples of the region. The Yansui section of the Ming Great Wall and thirty-nine fortified encampments along it were built during fighting between the Mongols and the Han people. As all of them were located along communication lines vital to economic development, they played an important role in politics, the economy and transport over three hundred years of Ming and Qing rule. However, they fell into disuse in the late Qing and the Republican period and are now in ruins. The main reason underlying their decline was that the sites had been chosen for their defensive value, so the subsequent northern expansion of China’s borders and structural changes in the border economy hastened their decline. Thus the rise and fall of these fortified towns at the intersection of the agrarian and the pastoral regions was closely related to imperial political and military activity and was in line with ethnic and tribal movements and migrations and the evolution of civilizations. In sum, the reasons behind the demise of these fortified towns and camps were highly complex and usually involved multiple factors.
