Objective: To determine whether polymorphisms in the genes for coagulation factor II,V, VII could predispose an individual to increase risk for coronary artery disease (CAD) and/or myocardial infarction (MI) in Chines...Objective: To determine whether polymorphisms in the genes for coagulation factor II,V, VII could predispose an individual to increase risk for coronary artery disease (CAD) and/or myocardial infarction (MI) in Chinese. Methods: We screened coagulation factor II(G20210A),V(G1691A),VII (R353Q and HVR4) genotype in 374 patients undergoing coronary angiography by polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) assay. Results: The R353Q and HVR4 genotype of the factor VII distribution was in accordance with Hardy Weinberg equilibrium. The frequencies of FVII genotype or allele did not show statistically significant differences between CAD group and controls or between male and female. The frequencies of the Q allele and (RQ+QQ) genotype were significantly higher among the CAD patients without myocardial infarction (MI) history than among those with MI history ( P <0.05). However, HVR4 polymorphism was not significantly different within groups. We only find one normal control of factorII(G20210A) mutation. No coagulation factor V(G1691A) mutation was found in the CAD patients and controls. Conclusion: The factor II(G20210A),V(G1691A) mutation is absent and may not be a major genetic factor for CAD and/or MI; the Q allele of the R353Q polymorphism of the factor VII gene may be a protective genetic factor against myocardial infarction in Chinese.展开更多
With the further development of socialist market economy, the mobility of factor markets in China, especially the labor market, is strengthened. Externalities interacts with the agglomeration of productive factors. Un...With the further development of socialist market economy, the mobility of factor markets in China, especially the labor market, is strengthened. Externalities interacts with the agglomeration of productive factors. Under the framework of new economic geography, this article presents a theoretical model involving the endogenous population density affected by urban externalities. Results show that the population density is more concentrated around the center because the degree and extent of interaction between individuals intensifies when the distance from the center decreases. When there are several externalities resources, the aggregation of externalities changes the configuration of spatial factor allocation. These results fit well with the empirical facts about the decreasing density of floating population along the cities of Guangzhou, Dongguan and Shenzhen in Guangdong Province which is situated in the eastern coast of the Pearl River Delta. We fred that under the impacts of externalities released from Hong Kong into the coast, floating population was more concentrated around Shenzhen and Dongguan, which are more adjacent to Hong Kong compared with Guangzhou City.展开更多
Ficolins are serum complement lectins,with a structure similar to mannose-binding lectin （MBL） and lung surfactant protein （SP）-A and SP-D.Ficolins activate the lectin complement system and play important roles in...Ficolins are serum complement lectins,with a structure similar to mannose-binding lectin （MBL） and lung surfactant protein （SP）-A and SP-D.Ficolins activate the lectin complement system and play important roles in host innate immunity.Ficolins are members of the collectin family of proteins,which act as pattern recognition receptors （PRRs）.They are soluble oligomeric defense proteins with lectin-like activity,and are able to recognize pathogen-associated molecular patterns （PAMPs）,which are carbohydrate molecules on the surface of pathogens,and of apoptotic,necrotic,and malignant cells.Upon binding to their specific PAMPs,ficolins may trigger activation of the immune system either （1） by initiating activation of complement via the lectin pathway,（2） by a primitive type of opsonophagocytosis,or （3） by stimulating secretion of the inflammatory cytokines interferon （IFN）-γ,interleukin （IL）-17,IL-6,and tumor necrosis factor （TNF）-α,and production of nitric oxide （NO）by macrophages,thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response.Recently,a number of reports have shown that dysfunction or abnormal expression of ficolins may play crucial roles in viral and bacterial diseases and in inflammation.This review summarizes the reports on the roles of ficolins in the infectious diseases,and provides insight into ficolins as novel innate immune therapeutic options to treat these diseases.展开更多
Tetrathiafulvalene (TTF) and its derivatives have been intensively investigated for conducting materials for more than 30 years.As π-electron donors,TTF and its derivatives can be reversibly transformed into the resp...Tetrathiafulvalene (TTF) and its derivatives have been intensively investigated for conducting materials for more than 30 years.As π-electron donors,TTF and its derivatives can be reversibly transformed into the respective TTF.+ and TTF2+.Due to its reversible feature,the TTF unit has been widely employed as the building block for switchable systems.In recent years studies of conducting nanostructures of TTF derivatives have received more and more attention.One simple way to prepare nano-structures is through the gelation processes.In this review,we have discussed recent progress in stimuli-responsive gels and conducting nanostructures based on TTF-based gelators.展开更多
Motivated by the recent experimental achievements in using the Bragg spectroscopy to measure the excitation spectrum of an ultra-cold atomic system with long-range interactions, we investigate the dynamic structure fa...Motivated by the recent experimental achievements in using the Bragg spectroscopy to measure the excitation spectrum of an ultra-cold atomic system with long-range interactions, we investigate the dynamic structure factor of a cigar-shaped dipolar Bose condensate trapped in a one-dimensional optical lattices. Our results show that the Bogoliubov bands of the system, particularly the lowest one, can be significantly influenced when one tunes the dipole orientation. Consequently, the calculated static structure factor of an optically trapped dipolar Bose gas shows marked difference from the non-dipolar one. Moreover, we show that the effects of dipole-dipole interaction on the dynamic structure factor is also strongly affected by the strength of the optical confinement.展开更多
文摘Objective: To determine whether polymorphisms in the genes for coagulation factor II,V, VII could predispose an individual to increase risk for coronary artery disease (CAD) and/or myocardial infarction (MI) in Chinese. Methods: We screened coagulation factor II(G20210A),V(G1691A),VII (R353Q and HVR4) genotype in 374 patients undergoing coronary angiography by polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) assay. Results: The R353Q and HVR4 genotype of the factor VII distribution was in accordance with Hardy Weinberg equilibrium. The frequencies of FVII genotype or allele did not show statistically significant differences between CAD group and controls or between male and female. The frequencies of the Q allele and (RQ+QQ) genotype were significantly higher among the CAD patients without myocardial infarction (MI) history than among those with MI history ( P <0.05). However, HVR4 polymorphism was not significantly different within groups. We only find one normal control of factorII(G20210A) mutation. No coagulation factor V(G1691A) mutation was found in the CAD patients and controls. Conclusion: The factor II(G20210A),V(G1691A) mutation is absent and may not be a major genetic factor for CAD and/or MI; the Q allele of the R353Q polymorphism of the factor VII gene may be a protective genetic factor against myocardial infarction in Chinese.
基金This paper was supported by National Natural Science Foundation of China (Grant No. 40341008)
文摘With the further development of socialist market economy, the mobility of factor markets in China, especially the labor market, is strengthened. Externalities interacts with the agglomeration of productive factors. Under the framework of new economic geography, this article presents a theoretical model involving the endogenous population density affected by urban externalities. Results show that the population density is more concentrated around the center because the degree and extent of interaction between individuals intensifies when the distance from the center decreases. When there are several externalities resources, the aggregation of externalities changes the configuration of spatial factor allocation. These results fit well with the empirical facts about the decreasing density of floating population along the cities of Guangzhou, Dongguan and Shenzhen in Guangdong Province which is situated in the eastern coast of the Pearl River Delta. We fred that under the impacts of externalities released from Hong Kong into the coast, floating population was more concentrated around Shenzhen and Dongguan, which are more adjacent to Hong Kong compared with Guangzhou City.
基金supported by grants from the National Outstanding Youth Foundation of China(81025008)973 Program of China(2012CB720604)+4 种基金National Natural Science Foundation of China(31221061,31370197)National Grand Program on Key Infectious Disease(2012ZX10003002-015)the Hubei Province's Outstanding Medical Academic Leader Program,Changjiang Scholars and Innovative Research Team,the 211 program(303-581045)the Science and Technology Program of Wuhan(301274075)the FundamentalResearch Funds for the Central Universities
文摘Ficolins are serum complement lectins,with a structure similar to mannose-binding lectin （MBL） and lung surfactant protein （SP）-A and SP-D.Ficolins activate the lectin complement system and play important roles in host innate immunity.Ficolins are members of the collectin family of proteins,which act as pattern recognition receptors （PRRs）.They are soluble oligomeric defense proteins with lectin-like activity,and are able to recognize pathogen-associated molecular patterns （PAMPs）,which are carbohydrate molecules on the surface of pathogens,and of apoptotic,necrotic,and malignant cells.Upon binding to their specific PAMPs,ficolins may trigger activation of the immune system either （1） by initiating activation of complement via the lectin pathway,（2） by a primitive type of opsonophagocytosis,or （3） by stimulating secretion of the inflammatory cytokines interferon （IFN）-γ,interleukin （IL）-17,IL-6,and tumor necrosis factor （TNF）-α,and production of nitric oxide （NO）by macrophages,thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response.Recently,a number of reports have shown that dysfunction or abnormal expression of ficolins may play crucial roles in viral and bacterial diseases and in inflammation.This review summarizes the reports on the roles of ficolins in the infectious diseases,and provides insight into ficolins as novel innate immune therapeutic options to treat these diseases.
基金supported by the National Natural Science Foundation of China,the State Basic Program and Chinese Academy of Sciencessupported by the NSFC-DFG joint project (TRR61)
文摘Tetrathiafulvalene (TTF) and its derivatives have been intensively investigated for conducting materials for more than 30 years.As π-electron donors,TTF and its derivatives can be reversibly transformed into the respective TTF.+ and TTF2+.Due to its reversible feature,the TTF unit has been widely employed as the building block for switchable systems.In recent years studies of conducting nanostructures of TTF derivatives have received more and more attention.One simple way to prepare nano-structures is through the gelation processes.In this review,we have discussed recent progress in stimuli-responsive gels and conducting nanostructures based on TTF-based gelators.
基金Supported by the National Natural Science Foundation of China under Grant Nos.11004200 and 11274315
文摘Motivated by the recent experimental achievements in using the Bragg spectroscopy to measure the excitation spectrum of an ultra-cold atomic system with long-range interactions, we investigate the dynamic structure factor of a cigar-shaped dipolar Bose condensate trapped in a one-dimensional optical lattices. Our results show that the Bogoliubov bands of the system, particularly the lowest one, can be significantly influenced when one tunes the dipole orientation. Consequently, the calculated static structure factor of an optically trapped dipolar Bose gas shows marked difference from the non-dipolar one. Moreover, we show that the effects of dipole-dipole interaction on the dynamic structure factor is also strongly affected by the strength of the optical confinement.
