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黄芩苷外用温敏凝胶的处方设计及优化 被引量:9
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作者 梁浩明 龙晓英 卢彬 《中国实验方剂学杂志》 CAS 北大核心 2014年第24期34-38,共5页
目的:通过不同数学模型及评价指标优选黄芩苷外用温敏凝胶的处方。方法:以泊洛沙姆407,188为凝胶基质,以胶凝温度为指标比较全样本多元线性模型及星点设计-效应面法优选的黄芩苷外用温敏凝胶处方。以胶凝时间及凝胶长度为评价指标进行... 目的:通过不同数学模型及评价指标优选黄芩苷外用温敏凝胶的处方。方法:以泊洛沙姆407,188为凝胶基质,以胶凝温度为指标比较全样本多元线性模型及星点设计-效应面法优选的黄芩苷外用温敏凝胶处方。以胶凝时间及凝胶长度为评价指标进行处方优化。结果:星点设计-效应面法优选的处方置信度较高。黄芩苷外用温敏凝胶的最优处方为1%黄芩苷,17%泊洛沙姆407和1.5%泊洛沙姆188;胶凝温度、胶凝时间及凝胶长度分别为(30.3±0.1)℃,(18.9±1.9)s,(0.7±0.6)cm。结论:制备的黄芩苷外用温敏凝胶符合局部迅速富集、提高患者顺应性的要求,指标评价应以人体测定的结果为准,为外用温敏凝胶的处方优选提供参考。 展开更多
关键词 黄芩苷 外用温敏 全样本多元线性模型 温度 凝胶长度
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The separation single-wall carbon nanotubes on length by sepharose gel 被引量:3
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作者 REN LingLing ZHAO MingYuan WANG ZhiHua 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2012年第7期1178-1182,共5页
The separations of single-wall carbon nanotubes on length by sepharose gel were investigated in this work. The solutions of sodium dodecyl sulfate and sodium deoxycholate were applied as the eluent in sequence. SEM an... The separations of single-wall carbon nanotubes on length by sepharose gel were investigated in this work. The solutions of sodium dodecyl sulfate and sodium deoxycholate were applied as the eluent in sequence. SEM and Raman were used to characterize the length of nanotube bundles. The results show that the longer nanotubes were eluted out first, and then the shorter tubes were followed by the sodium dodecyl sulfate. However, the separated order was totally reversed by the sodium deoxycholate. By this method, the process generated nanotube fractions not only were narrower in length distributions, but also could control the separation orders by changing the eluents. Moreover, the separation principle was also discussed. 展开更多
关键词 single-wall carbon nanotubes LENGTH SEPARATION sepharose gel sodium dodecyl sulfate sodium deoxycholate
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