AIM: This prospective study evaluated the effectiveness of 90 W argon plasma coagulation (APC) for the ablation of Barrett's esophagus (BE) that is considered to be the main risk factor for the development of esop...AIM: This prospective study evaluated the effectiveness of 90 W argon plasma coagulation (APC) for the ablation of Barrett's esophagus (BE) that is considered to be the main risk factor for the development of esophageal adenocarcinoma.METHODS: The results from 25 patients, observed at the First Department of General Surgery, University of Verona, Italy, from October 2000 to October 2003, who underwent APC for histologically proven BE were prospectively analyzed.RESULTS: The ablation treatment was completed in all the patients but one (96%). The mean number of APC sessions needed to complete ablation was 1.6 (total number: 40). The eradication was obtained in the majority of cases by one session only (60%), two sessions were required in 24% of the cases and three or more in 16%.About 43% of the sessions were complicated. Retrosternal pain (22.5%) and fever (17.5%) were the most frequent symptoms. Only one major complication occurred, it was an hemorrhage due to ulcer formation on the treated esophagus that required urgent endoscopic sclerosis and admission. The follow-up was accomplished in all the patients with a mean period of 26.3 mo and 20 patients (84%) with a follow-up period longer than 24 mo. Only one patient showed a relapse of metaplastic mucosa 12 mo after the completion of ablation. The patient was hence re-treated and now is free from recurrence 33 mo later.CONCLUSION: High power setting (90 W) APC showed to be safe and effective. The effects persist at a mean follow-up period of two years with a comparable cost in term of complications with respect to standard power settings. Further studies with greater number of patients are required to confirm these results and to assess if ablation reduces the incidence of malignant progression.展开更多
AIM: To identify factors that were related to the short term effectiveness of percutaneous transhepatic biliary drainage in cholangiocarcinoma patients and to evaluate the impact of palliative drainage on their surviv...AIM: To identify factors that were related to the short term effectiveness of percutaneous transhepatic biliary drainage in cholangiocarcinoma patients and to evaluate the impact of palliative drainage on their survival. METHODS: Seventy-four patients with hilar cholangiocarcinoma who underwent percutaneous biliary drainage were enrolled in the study. The demographic and laboratory data as well as the imaging characteristics were retrospectively analyzed to correlate with the bile output and reduction rate of serum bilirubin 1 wk after drainage.RESULTS: Patients with more bile duct visualized on percutaneous transhepatic cholangiography or absence of multiple liver metastases on imaging studies had more bile output after biliary drainage [odds ratio (OR): 8.471, P = 0.010 and OR: 1.959, P = 0.022, respectively]. Patients with prolonged prothrombin time had a slow decrease in serum bilirubin (OR: 0.437, P = 0.005). The median survival time was not signif icantly different in patients with low or high bile output (75 d vs 125 d, P = 0.573) or in patients with slow or rapid reduction of serum bilirubin (88 d vs 94 d, P = 0.576). CONCLUSION: The short term effectiveness of percutaneous biliary drainage was related to patient's prothrombin time or the extent of tumor involvement. It, however, had no impact on survival.展开更多
Based on an engineering background of a deep tunneling in weak rocks, the numerical modeling is used to compare different support schemes of tunnel at great depth in this paper. Focused on the general behaviors of wea...Based on an engineering background of a deep tunneling in weak rocks, the numerical modeling is used to compare different support schemes of tunnel at great depth in this paper. Focused on the general behaviors of weak rocks at great depth, a tunneling scheme with rock bolting and steel fibre reinforced sprayed concrete is proposed. This scheme is practiced successfully at a deep tunnel in weak rocks in Coal Mine No 10 of Hebi Coal Mining Administration.展开更多
This paper summarizes the experience that was gained during the construction of the 15.4 km long Ceneri Base Tunnel (CBT), which is the southern part of the fiat railway line crossing the Swiss Alps from north to so...This paper summarizes the experience that was gained during the construction of the 15.4 km long Ceneri Base Tunnel (CBT), which is the southern part of the fiat railway line crossing the Swiss Alps from north to south. The project consisted of a twin tube with a diameter of 9 m interconnected by cross- passages, each 325 m long. In the middle of the alignment and at its southern end, large caverns were excavated for logistical and operational requirements. The total excavation length amounted to approx- imately 40 km. The tunnel crossed Alpine rock formations comprising a variety of rock typologies and several fault zones. The maximum overburden amounted to 850 m. The excavation of the main tunnels and of the cross-passages was executed by means of drill-and-blast (D&B) excavation. The support con- sisted of bolts, meshes, fiber-reinforced shotcrete and, when required, steel ribs. A gripper tunnel boring machine (TBM) was used in order to excavate the access tunnel. The high overburden caused squeezing rock conditions, which are characterized by large anisotropic convergences when crossing weaker rock formations. The latter required the installation of a deformable support. At the north portal, the tunnel (with an enlarged cross-section) passed underneath the A2 Swiss highway (the major road axis connect- ing the north and south of Switzerland) at a small overburden and through soft ground. Vertical and sub- horizontal jet grouting in combination with partial-face excavation was successfully implemented in order to limit the surface settlements. The south portal was located in a dense urban area. The excavation from the south portal included an approximately 220 m long cut-and-cover tunnel, followed by about 300 m of D&B excavation in a bad rock formation. The very low overburden, poor rock quality, and demanding crossing with an existing road tunnel (at a vertical distance of only 4 m) required special excavation methods through reduced sectors and special blasting techniques in order to limit the blast-induced vibrations. The application of a comprehensive risk management procedure, the execution of an intensive surface survey, and the adaptability of the tunnel design to the encountered geological conditions allowed the successful completion of the excavation works.展开更多
Some crude oils with high water cut have the capability to flow below the oil gel point, while the oil particles adhere to the pipe wall in the form of paste, also called "wall sticking". Wall sticking is a ...Some crude oils with high water cut have the capability to flow below the oil gel point, while the oil particles adhere to the pipe wall in the form of paste, also called "wall sticking". Wall sticking is a serious problem during the pipeline transportation, leading to partial or total blockage of the pipeline and energy wastage. In this paper, a series of laboratory flow loop experiments were conducted to observe the wall sticking characteristics of crude oil with high water cut, high viscosity and high gel point at low transportation temperatures. The effects of shear stress and water cut on the wall sticking rate and occurrence temperature were investigated. Experimental results indicated that the wall sticking rate and occurrence temperature were lower under stronger shear stress and higher water cut conditions. A criterion of wall sticking occurrence temperature(WSOT) and a regression model of wall sticking rate were then established. Finally, the software was developed to calculate the pressure drop along the pipelines of crude oils with high water-cut. It was able to predict the wall sticking thickness of gelled oil and then calculate the pressure drop along the pipelines. A typical case study indicated that the prediction results obtained from the software were in agreement with actual measured values.展开更多
Based on a great number of measured data, the author put forward zonal com-pressive and tensile deformation mechanism of soft rock around roadway. By using self-supporting capacity of compressive zone and controlling ...Based on a great number of measured data, the author put forward zonal com-pressive and tensile deformation mechanism of soft rock around roadway. By using self-supporting capacity of compressive zone and controlling rock deformation of tensile zone, the long bolt or short bolt group supporting form was given for different size of rock compressive zone and tensile zone. Finally, studied on the determining method of rational support parameters of bolting and shotcreting with wire mesh in different support technol-ogy.展开更多
Microbiologically induced corrosion of concrete (MICC) and its protective coatings has a high eco-nomic impact on sewer maintenance and rehabilitation. A better understanding of the micro-organisms and the bio- geni...Microbiologically induced corrosion of concrete (MICC) and its protective coatings has a high eco-nomic impact on sewer maintenance and rehabilitation. A better understanding of the micro-organisms and the bio- genie acids that are generated in the sewer is essential in controlling the corrosion of concrete pipes and protective coatings. The role of succession of micro-organisms growth in the corrosion of concrete and protective coatings was evaluated in this study. Examination of various sewer pipe materials exhibiting various extents of degradation, including concrete, cement based and epoxy based coating revealed the presence of both organic and biogenic sulphuric acids. This reflects the activity of fungi and the thiobacilli strains. Organism growth and metabolism were strongly related to the substrate pH. Fungi were found to grow and metabolise organic acids at pH from 2.0-8.0. Whilst the thiobacilli strains grew and generated sulohuric acids at oH below 3.0. The successive growth of the organisms provides an impgrtant bearing in deyeloping improved strateegies.to better manage sewers.展开更多
An analytical model on the normal perforation of reinforced concrete slabs is constructed. The effect of reinforcing bars is further hybridized in a general three-stage model consisting of initial cratering, tunnellin...An analytical model on the normal perforation of reinforced concrete slabs is constructed. The effect of reinforcing bars is further hybridized in a general three-stage model consisting of initial cratering, tunnelling and shear plugging. Besides three dimensionless numbers, i. e., the impact function I, the geometry function of projectile N and the dimensionless thickness of concrete target X, which are employed to predict the ballistic performance of perforation of concrete slabs, the reinforcement ratio Ps of concrete and the tensile strength fs of reinforcing bars are considered as the other main factors influencing the perforation process. Simpler solutions of ballistic performances of normal perforation of reinforced concrete slabs are formulated. Theoretical predictions agree well with individual published experimental data.展开更多
Inflammation and coagulation constantly influence each other and are constantly in balance.Emerging evidence supports this statement in acute inflammatory diseases,such as sepsis,but it also seems to be very important...Inflammation and coagulation constantly influence each other and are constantly in balance.Emerging evidence supports this statement in acute inflammatory diseases,such as sepsis,but it also seems to be very important in chronic inflammatory settings,such as inflammatory bowel disease(IBD).Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events,and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels,where most severe inflammatory abnormalities occur.The aims of this review are to update and classify the type of coagulation system abnormalities in IBD,and analyze the strict and delicate balance between coagulation and inflammation at the mucosal level.Recent studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.展开更多
AIM: Acute gastrointestinal bleeding is a severe complication in patients receiving long-term oral anticoagulant therapy. The purpose of this study was to describe the causes and clinical outcome of these patients. ME...AIM: Acute gastrointestinal bleeding is a severe complication in patients receiving long-term oral anticoagulant therapy. The purpose of this study was to describe the causes and clinical outcome of these patients. METHODS: From January 1999 to October 2003, 111 patients with acute upper gastrointestinal bleeding (AUGIB) were hospitalized while on oral anticoagulants. The causes and clinical outcome of these patients were compared with those of 604 patients hospitalized during 2000-2001 with AUGIB who were not taking warfarin. RESULTS: The most common cause of bleeding was peptic ulcer in 51 patients (45%) receiving anticoagulants compared to 359/604 (59.4%) patients not receiving warfarin (P<0.05). No identifiable source of bleeding could be found in 33 patients (29.7%) compared to 31/604 (5.1%) patients not receiving anticoagulants (P=0.0001). The majority of patients with concurrent use of non-steroidal anti-inflammatory drugs (NSAIDs) (26/35, 74.3%) had a peptic ulcer as a cause of bleeding while 32/76 (40.8%) patients not taking a great dose of NSAIDs had a negative upper and lower gastrointestinal endoscopy. Endoscopic hemostasis was applied and no complication was reported. Six patients (5.4%) were operated due to continuing or recurrent hemorrhage, compared to 23/604 (3.8%) patients not receiving anticoagulants. Four patients died, the overall mortality was 3.6% in patients with AUGIB due to anticoagulants, which was not different from that in patients not receiving anticoagulant therapy. CONCLUSION: Patients with AUGIB while on long-term anticoagulant therapy had a clinical outcome, which is not different from that of patients not taking anticoagulants. Early endoscopy is important for the management of these patients and endoscopic hemostasis can be safely applied.展开更多
For the sake of understanding the deterioration behavior of concrete in actual railway tunnel structures subjected to aggressive sulfate medium in practice,detailed field investigations and tested analysis on sprayed ...For the sake of understanding the deterioration behavior of concrete in actual railway tunnel structures subjected to aggressive sulfate medium in practice,detailed field investigations and tested analysis on sprayed concrete linings of approximately 40-year-old railway tunnels in environments containing sulfate ion were carried out,respectively.The results show that the deterioration of concretes in the investigated area is serious,which involves complicated physicochemical process between the sulfate salt and concrete.Among them,the secondary sulfateminerals such as gypsum formation under very high concentration sulfate ion condition by accumulating and evaporation process dominate,followed by the crystallization of sulfate salt and formation of thaumasite.展开更多
We study quantum tunneling of a dipolar Bose-Einstein condensate in optical lattice when the spin system initially is prepared in a squeezed coherent state. It is found that there exists quantum tunneling between latt...We study quantum tunneling of a dipolar Bose-Einstein condensate in optical lattice when the spin system initially is prepared in a squeezed coherent state. It is found that there exists quantum tunneling between lattices l and l + 1, l and l - 1, respectively. In particular, when the optical lattice is infinitely long and the spin excitations are in the long-wavelength limit, quantum tunneling disappears between lattices l and l + 1, and that l and l - 1. Correspondingly, the magnetic soliton appears.展开更多
文摘AIM: This prospective study evaluated the effectiveness of 90 W argon plasma coagulation (APC) for the ablation of Barrett's esophagus (BE) that is considered to be the main risk factor for the development of esophageal adenocarcinoma.METHODS: The results from 25 patients, observed at the First Department of General Surgery, University of Verona, Italy, from October 2000 to October 2003, who underwent APC for histologically proven BE were prospectively analyzed.RESULTS: The ablation treatment was completed in all the patients but one (96%). The mean number of APC sessions needed to complete ablation was 1.6 (total number: 40). The eradication was obtained in the majority of cases by one session only (60%), two sessions were required in 24% of the cases and three or more in 16%.About 43% of the sessions were complicated. Retrosternal pain (22.5%) and fever (17.5%) were the most frequent symptoms. Only one major complication occurred, it was an hemorrhage due to ulcer formation on the treated esophagus that required urgent endoscopic sclerosis and admission. The follow-up was accomplished in all the patients with a mean period of 26.3 mo and 20 patients (84%) with a follow-up period longer than 24 mo. Only one patient showed a relapse of metaplastic mucosa 12 mo after the completion of ablation. The patient was hence re-treated and now is free from recurrence 33 mo later.CONCLUSION: High power setting (90 W) APC showed to be safe and effective. The effects persist at a mean follow-up period of two years with a comparable cost in term of complications with respect to standard power settings. Further studies with greater number of patients are required to confirm these results and to assess if ablation reduces the incidence of malignant progression.
文摘AIM: To identify factors that were related to the short term effectiveness of percutaneous transhepatic biliary drainage in cholangiocarcinoma patients and to evaluate the impact of palliative drainage on their survival. METHODS: Seventy-four patients with hilar cholangiocarcinoma who underwent percutaneous biliary drainage were enrolled in the study. The demographic and laboratory data as well as the imaging characteristics were retrospectively analyzed to correlate with the bile output and reduction rate of serum bilirubin 1 wk after drainage.RESULTS: Patients with more bile duct visualized on percutaneous transhepatic cholangiography or absence of multiple liver metastases on imaging studies had more bile output after biliary drainage [odds ratio (OR): 8.471, P = 0.010 and OR: 1.959, P = 0.022, respectively]. Patients with prolonged prothrombin time had a slow decrease in serum bilirubin (OR: 0.437, P = 0.005). The median survival time was not signif icantly different in patients with low or high bile output (75 d vs 125 d, P = 0.573) or in patients with slow or rapid reduction of serum bilirubin (88 d vs 94 d, P = 0.576). CONCLUSION: The short term effectiveness of percutaneous biliary drainage was related to patient's prothrombin time or the extent of tumor involvement. It, however, had no impact on survival.
文摘Based on an engineering background of a deep tunneling in weak rocks, the numerical modeling is used to compare different support schemes of tunnel at great depth in this paper. Focused on the general behaviors of weak rocks at great depth, a tunneling scheme with rock bolting and steel fibre reinforced sprayed concrete is proposed. This scheme is practiced successfully at a deep tunnel in weak rocks in Coal Mine No 10 of Hebi Coal Mining Administration.
文摘This paper summarizes the experience that was gained during the construction of the 15.4 km long Ceneri Base Tunnel (CBT), which is the southern part of the fiat railway line crossing the Swiss Alps from north to south. The project consisted of a twin tube with a diameter of 9 m interconnected by cross- passages, each 325 m long. In the middle of the alignment and at its southern end, large caverns were excavated for logistical and operational requirements. The total excavation length amounted to approx- imately 40 km. The tunnel crossed Alpine rock formations comprising a variety of rock typologies and several fault zones. The maximum overburden amounted to 850 m. The excavation of the main tunnels and of the cross-passages was executed by means of drill-and-blast (D&B) excavation. The support con- sisted of bolts, meshes, fiber-reinforced shotcrete and, when required, steel ribs. A gripper tunnel boring machine (TBM) was used in order to excavate the access tunnel. The high overburden caused squeezing rock conditions, which are characterized by large anisotropic convergences when crossing weaker rock formations. The latter required the installation of a deformable support. At the north portal, the tunnel (with an enlarged cross-section) passed underneath the A2 Swiss highway (the major road axis connect- ing the north and south of Switzerland) at a small overburden and through soft ground. Vertical and sub- horizontal jet grouting in combination with partial-face excavation was successfully implemented in order to limit the surface settlements. The south portal was located in a dense urban area. The excavation from the south portal included an approximately 220 m long cut-and-cover tunnel, followed by about 300 m of D&B excavation in a bad rock formation. The very low overburden, poor rock quality, and demanding crossing with an existing road tunnel (at a vertical distance of only 4 m) required special excavation methods through reduced sectors and special blasting techniques in order to limit the blast-induced vibrations. The application of a comprehensive risk management procedure, the execution of an intensive surface survey, and the adaptability of the tunnel design to the encountered geological conditions allowed the successful completion of the excavation works.
基金the support from the projects of the National Natural Science Foundation of China(No.51374224)for this research
文摘Some crude oils with high water cut have the capability to flow below the oil gel point, while the oil particles adhere to the pipe wall in the form of paste, also called "wall sticking". Wall sticking is a serious problem during the pipeline transportation, leading to partial or total blockage of the pipeline and energy wastage. In this paper, a series of laboratory flow loop experiments were conducted to observe the wall sticking characteristics of crude oil with high water cut, high viscosity and high gel point at low transportation temperatures. The effects of shear stress and water cut on the wall sticking rate and occurrence temperature were investigated. Experimental results indicated that the wall sticking rate and occurrence temperature were lower under stronger shear stress and higher water cut conditions. A criterion of wall sticking occurrence temperature(WSOT) and a regression model of wall sticking rate were then established. Finally, the software was developed to calculate the pressure drop along the pipelines of crude oils with high water-cut. It was able to predict the wall sticking thickness of gelled oil and then calculate the pressure drop along the pipelines. A typical case study indicated that the prediction results obtained from the software were in agreement with actual measured values.
文摘Based on a great number of measured data, the author put forward zonal com-pressive and tensile deformation mechanism of soft rock around roadway. By using self-supporting capacity of compressive zone and controlling rock deformation of tensile zone, the long bolt or short bolt group supporting form was given for different size of rock compressive zone and tensile zone. Finally, studied on the determining method of rational support parameters of bolting and shotcreting with wire mesh in different support technol-ogy.
文摘Microbiologically induced corrosion of concrete (MICC) and its protective coatings has a high eco-nomic impact on sewer maintenance and rehabilitation. A better understanding of the micro-organisms and the bio- genie acids that are generated in the sewer is essential in controlling the corrosion of concrete pipes and protective coatings. The role of succession of micro-organisms growth in the corrosion of concrete and protective coatings was evaluated in this study. Examination of various sewer pipe materials exhibiting various extents of degradation, including concrete, cement based and epoxy based coating revealed the presence of both organic and biogenic sulphuric acids. This reflects the activity of fungi and the thiobacilli strains. Organism growth and metabolism were strongly related to the substrate pH. Fungi were found to grow and metabolise organic acids at pH from 2.0-8.0. Whilst the thiobacilli strains grew and generated sulohuric acids at oH below 3.0. The successive growth of the organisms provides an impgrtant bearing in deyeloping improved strateegies.to better manage sewers.
基金Supported by the State Key Lab of Explosion Science and Technology of BIT Under Contract (No. KFJJ04-3)
文摘An analytical model on the normal perforation of reinforced concrete slabs is constructed. The effect of reinforcing bars is further hybridized in a general three-stage model consisting of initial cratering, tunnelling and shear plugging. Besides three dimensionless numbers, i. e., the impact function I, the geometry function of projectile N and the dimensionless thickness of concrete target X, which are employed to predict the ballistic performance of perforation of concrete slabs, the reinforcement ratio Ps of concrete and the tensile strength fs of reinforcing bars are considered as the other main factors influencing the perforation process. Simpler solutions of ballistic performances of normal perforation of reinforced concrete slabs are formulated. Theoretical predictions agree well with individual published experimental data.
基金Supported by Italian Ministry of University,No. PRIN-2007Catholic University School of Medicine,No. Linea D1-2009
文摘Inflammation and coagulation constantly influence each other and are constantly in balance.Emerging evidence supports this statement in acute inflammatory diseases,such as sepsis,but it also seems to be very important in chronic inflammatory settings,such as inflammatory bowel disease(IBD).Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events,and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels,where most severe inflammatory abnormalities occur.The aims of this review are to update and classify the type of coagulation system abnormalities in IBD,and analyze the strict and delicate balance between coagulation and inflammation at the mucosal level.Recent studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.
文摘AIM: Acute gastrointestinal bleeding is a severe complication in patients receiving long-term oral anticoagulant therapy. The purpose of this study was to describe the causes and clinical outcome of these patients. METHODS: From January 1999 to October 2003, 111 patients with acute upper gastrointestinal bleeding (AUGIB) were hospitalized while on oral anticoagulants. The causes and clinical outcome of these patients were compared with those of 604 patients hospitalized during 2000-2001 with AUGIB who were not taking warfarin. RESULTS: The most common cause of bleeding was peptic ulcer in 51 patients (45%) receiving anticoagulants compared to 359/604 (59.4%) patients not receiving warfarin (P<0.05). No identifiable source of bleeding could be found in 33 patients (29.7%) compared to 31/604 (5.1%) patients not receiving anticoagulants (P=0.0001). The majority of patients with concurrent use of non-steroidal anti-inflammatory drugs (NSAIDs) (26/35, 74.3%) had a peptic ulcer as a cause of bleeding while 32/76 (40.8%) patients not taking a great dose of NSAIDs had a negative upper and lower gastrointestinal endoscopy. Endoscopic hemostasis was applied and no complication was reported. Six patients (5.4%) were operated due to continuing or recurrent hemorrhage, compared to 23/604 (3.8%) patients not receiving anticoagulants. Four patients died, the overall mortality was 3.6% in patients with AUGIB due to anticoagulants, which was not different from that in patients not receiving anticoagulant therapy. CONCLUSION: Patients with AUGIB while on long-term anticoagulant therapy had a clinical outcome, which is not different from that of patients not taking anticoagulants. Early endoscopy is important for the management of these patients and endoscopic hemostasis can be safely applied.
基金Project(2008G025-C) supported by the Ministry of Railway of ChinaProject(50708114) supported by the National Natural Science Foundation of China
文摘For the sake of understanding the deterioration behavior of concrete in actual railway tunnel structures subjected to aggressive sulfate medium in practice,detailed field investigations and tested analysis on sprayed concrete linings of approximately 40-year-old railway tunnels in environments containing sulfate ion were carried out,respectively.The results show that the deterioration of concretes in the investigated area is serious,which involves complicated physicochemical process between the sulfate salt and concrete.Among them,the secondary sulfateminerals such as gypsum formation under very high concentration sulfate ion condition by accumulating and evaporation process dominate,followed by the crystallization of sulfate salt and formation of thaumasite.
基金The project partly supported by National Natural Science Foundation of China under Grant No.10574060the Natural Science Foundation of Beijing under Grant No.1072010.
文摘We study quantum tunneling of a dipolar Bose-Einstein condensate in optical lattice when the spin system initially is prepared in a squeezed coherent state. It is found that there exists quantum tunneling between lattices l and l + 1, l and l - 1, respectively. In particular, when the optical lattice is infinitely long and the spin excitations are in the long-wavelength limit, quantum tunneling disappears between lattices l and l + 1, and that l and l - 1. Correspondingly, the magnetic soliton appears.