铁路钢桥钢-混凝土结合段整体模块分体式制作施工技术

以新建宁波铁路枢纽北环线甬江(左线)特大桥主桥钢箱梁制作为技术背景,研发新型阶梯状填充混凝土前后承压板式钢-混凝土结合段整体模块分体式制作施工技术。阐述钢混结合段在加工过程中以"整体模块"控制整体外形尺寸,选取合理的分段位置运用"分体"的方式进行制作,并与后续标准梁段进行连续匹配试拼装;分体梁块单元解体后水平运输至桥位架设位置,运用相应吊装设备将分体梁块单元逐一吊装至桥位架设支架上精确定位,复位试拼装桥位线形完成桥位架设。

Computational Simulation of Aptamer-target Binding Mechanisms

Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as biochemical sensors for medicine,food safety and environmental monitoring.However,there is little research on aptamer-target binding mechanisms,which limits their application and development.Computational simulation has gained much attention for revealing aptamer-target binding mechanisms at the atomic level.This work summarizes the main simulation methods used in the mechanistic analysis of aptamer-target complexes,the characteristics of binding between aptamers and different targets(metal ions,small organic molecules,biomacromolecules,cells,bacteria and viruses),the types of aptamer-target interactions and the factors influencing their strength.It provides a reference for further use of simulations in understanding aptamer-target binding mechanisms.

万向联轴器花键套叉头的改进及应用

通过对万向联轴器的部件进行改进，既简化了加工工艺，又满足了使用要求。

仿金地藏王镶嵌式复合铸造工艺探讨

地藏王工艺品总体高2m,其中佛像高1.5m,莲花底座高0.5m,采用熔模精密铸造和砂型铸造相结合的分体、镶嵌式复合铸造工艺,为保证佛像头部的精致,头部、帽冠、两只手、莲花座采用精密铸造,再用精铸佛像头和佛身用镶嵌式复合铸造工艺,采用粘土表干型用砂,在制好的型腔内侧均匀喷涂一层特制快干涂料,浇注出佛像,再拼焊帽冠、两只手、莲花座,经处理后完成地藏王像。

转炉炉壳现场组对焊接技术研究

本文主要通过对炼钢转炉炉壳分体制作、现场组对和焊接技术的研究,成功解决了转炉炉壳在制作中的体积大、重量大、吊装难、运输难等问题。对转炉炉壳制作工艺进行总结、完善成一套适用于转炉炉壳现场组对、焊接的技术,为今后制作同类产品做参考。

九九澳门回归镜铸造工艺

本文介绍了九九澳门回归镜的生产制作过程——通过分体制作,分别采用精密铸造、砂型铸造等工艺手段,并辅以机械加工和表面处理,最后整体装配成形。

Dynamic-static coupling analysis on rockburst mechanism in jointed rock mass

A numerical code called RFPA-Dynamics was used to study the rockburst mechanism under dynamic load based on coupled static-dynamic analysis.The results show that dynamic disturbance has a very distinct triggering effect on rockburst.Under the dynamic load,rockburst is motivated by tensile stress formed by the overlapping of dynamic waves in the form of instantaneous open and cutting through of cracks in weak planes and pre-damaged areas.Meanwhile,the orientation of joint sets has an obvious leading effect on rockburst locations.Finally,a higher initial static stress state before dynamic loading can cause more pre-damaged area,thus leading to a larger rockburst scope.

Empirical Analysis on Influence Mechanism of Cohesiveness and Collective Efficacy of Virtual Community Based on Triadic Reciprocal Determinism

The virtual community has become a new life style as for human,but the public's acceptance is relatively low at present.So the research about the mechanism of the influence on the cohesiveness and the collective efficiency in virtual community has an important theoretical value and practical value.In the paper,the key variables that affect virtual community cohesiveness are extracted from two aspects—self-perception of community members and community environment,and the influence mechanism model of virtual community cohesiveness and community collective efficiency is established based on Triadic Reciprocal Determinism.By means of the questionnaire on the community members and the empirical analysis,the key factors influencing cohesiveness of virtual community are brought up,as well as the mechanism that the four dimensions of cohesiveness work,on collective efficiency.According to the results,it is practically meaningful that the problems and insufficiency in the operation of existing virtual community are discovered,which guides the operating managers of the virtual community to formulate operation policy of the virtual community for operating managers to develop strategies.

Anti-complement constituents of Commelina communis and their targets in complement activation cascade

Anti-complement activity guided fractionation led to the isolation of 24 compounds from Commelina communis.Bioassay showed that six compounds inhibited the classical pathway and alternative pathway with CH 50 values of 0.12-1.44 mM and AP 50 values of 0.28-7.05 mM,respectively.Preliminary mechanism studies demonstrated that quinovic acid acted on C1q,C2,C3,C4,C5 and C9 components of the complement system,β-sitosterol interacted with C3 and C4,（＋）-catechin-3-O-β-Dgluco（2-cinnamoyl）-pyranoside,p-cresol and 6-methoxy-3-methylbenzene-1,2,4-triol blocked C1q,C2,C3,C5 and C9.

Market Transition, Labor Market Segmentation and Organizational Mobility

On the basis of data from the 2008 Chinese General Social Survey, this paper analyzes the changing organizational job mobility patterns of members of society in a segmented labor market. The structure of labor market segmentation is based on differences in the power of different labor sectors to distribute social resources, leading to further differences in their power of ＂attraction＂ or ＂repulsion＂ that influence people＇s organizational mobility. These forces are strongest in the primary labor market, lessening the possibility that workers will leave their jobs and raising the possibility of cross-sector mobility. In the course of China＇s market transition, changes in the power to allocate social resources have entailed changes in the structure of labor market segmentation, changes that have been reflected in organizational mobility. Our examination of changing modes of organizational mobility reveals that the structure of urban labor market segmentation has changed from being mainly systemic at the outset of reform and opening up to the current coexistence of systemic segmentation and market segmentation.

Advances in anti-tumor effects and mechanisms of Pulsatilla Chinensis saponins and its monomers

As a traditional Chinese herbal medicine, Pulsatilla Chinensis(P. Chinensis) is widely used in the clinical practice of traditional Chinese medicine(TCM). Recently, medical research has found that the natural product P. Chinensis saponins and their monomeric compounds extracted from P. Chinensis have a variety of biological activities, especially the triterpenoid saponins, which have significant and broad-spectrum anti-tumor effects. Moreover, its anti-tumor molecular mechanisms include inhibition of the growth and proliferation of tumor cells, repression of the migration, invasion, and metastasis, prevention of tumor cell cycle, regulation of cancer cell energy metabolism, anti-tumor angiogenesis, induction of cancer cell differentiation, apoptosis and autophagy, reversing cancer cell resistance, regulation a variety of related signaling pathways, and improvement of the inflammatory microenvironment of tumor cells. In the present work, we reviewed the related anticancer mechanisms of P. Chinensis saponins and their monomers in different tumors, aiming to provide a theoretical basis for the development and clinical application of new anti-tumor drugs of P. Chinensis saponins and their monomeric compounds.

Molecular basis for rational construction of RVGP modified liposomal delivery system targeting to brain

The rational construction of active targeting liposomes will provide an important structural support for its effective brain targeting.However,there is no clear understanding of the structure-activity relationship of active targeting liposomes.Combining multiscale computational simulation and experimental verification,we established a computational model of RVGP modified PEGylated liposomes(RVGP-PEG-L)and investigated the role of PEG and molecular interaction mechanism of carrier-ligand-receptor.The result indicated that the complex network conformation formed by PEG with 42 monomers(42 PEG)above the density of 8%was the molecular basis for PEG-L to achieve long-circulation function.The lowest monomer number of PEG linker to ensure the targeting ability of RVGP was 42.However,the pose of RVGP binding to nAChR changed after it was linked with PEG-L due to the restraint of PEG chain,leading to a decrease of binding free energy.Increasing the monomer number of PEG linker or improving the non-polarity of polymers was a potential strategy to enhance the combination of RVGP-PEG-L with nAChR on the targeting cell.