Objective: The aim of this study was to investigate the efficacy and safety profiles of bevacizumab, the commonly used monoclonal antibody and its safety profiles were challenging, based on Chinese cancer patients. Me...Objective: The aim of this study was to investigate the efficacy and safety profiles of bevacizumab, the commonly used monoclonal antibody and its safety profiles were challenging, based on Chinese cancer patients. Methods: All the papers studied on Chinese cancer patients treated by bevacizumab were found in both databases of Chinese journal database for fulltext and PubMed were collected. The commonly used efficacy index such as disease control rate (CR + PR + SD) and response rate (CR + PR) were analyzed, and the bevacizumab related side effects were analyzed too. Results: (1) There were ten original papers contained total 199 patients who were the candidates to analyze the safety profiles, and 115 patients with colorectal cancer in five papers who were candidates to analyze the efficacy. (2) Nine in ten papers set the dose of bevacizumab in 2.5 mg/kg/week - 5 mg/kg/week, and the biweekly was the standard chemotherapy interval. (3) The disease control rate and response rate in Chinese colorectal cancer patients were 85% (95% CI: 79%-92%) and 61% (95% CI: 52%-70%), respectively. (4) The side effects related to bevacizumab were rare and most of them were grades 1-2, and only one case with grade 4 bleeding was recorded and only two cases with discontinuation of bevacizumab since hemoplysis. Also, the grades 3-4 side effects related cytotoxic agents were not common. Conclusion: This study summarized the data of Chinese cancer patients treated by bevacizumab-contained regimens, and it showed that the monoclonal antibody was effective and safe for Chinese patients as the West patients.展开更多
Since the 1990s, with the in-depth study and understanding of sustainable development, quantitative study of regional sustainable development (RSD) was increasingly hot in China. Based on quantitative study of RSD fro...Since the 1990s, with the in-depth study and understanding of sustainable development, quantitative study of regional sustainable development (RSD) was increasingly hot in China. Based on quantitative study of RSD from Core Periodical in China National Knowledge Infrastructure (1992–2008), statistical analysis on the annual distribution, periodicals distribution and changes of the distribution were made. And from perspectives of social–economic, ecological, systematic and emerging methods, the course, problems and trends of the quantitative study methods on RSD were examined and analyzed to get a clear summary. By the review, the context on the quantitative study of RSD was to be clarified. The study also showed that, primarily, fields involving quantitative study are expanding; second, big progresses and constant development have been made on the systematic method gradually sophisticated, the flourishing ecological method and emerging new methods in the context of cross and integration which has made complex integrated systems a more satisfactory solution; third, the method system has been more multi-angled, and the clues of independent innovation have been observed despite the fact that the introduction of imported method is the main trend. Although many problems exist, multi-scale study, dynamic timeseries study and inter-regional comparative study will be further exploited and increasingly carried out with the progress of spatial information technology, which would boost the development and application of new methods in RSD study.展开更多
OBJECTIVE:To systematically assess the clinical effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis by meta-analysis.METHODS:The articles were mainly retrieved from the "CHKD(...OBJECTIVE:To systematically assess the clinical effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis by meta-analysis.METHODS:The articles were mainly retrieved from the "CHKD(China Hospital Knowledge Database) periodical full text databank",the "China periodical full text databank",the "CHKD doctor's and Master's degree student full text databank",and the "China doctor's degree student thesis databank",and they were selected according to the literature selection standard.The effects of Chinese medicines and Western medicines on radiation esophagitis were compared by meta-analysis.RESULTS:Based on 13 articles,we found that the effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis was superior to Western medicines,with no obvious side effects.Meta-analysis showed that the total odds ratio was 0.426 and the 95% confidence interval was 0.368,0.493.CONCLUSION:Chinese medicines are superior to Western medicines in preventing and treating radiation esophagitis.However,some methodological problems in the literature may have affected the authenticity of the results.Therefore,more rigorous,multi-central,randomized controlled trials with a large sample size should be designed to obtain a more reliable conclusion.展开更多
OBJECTIVE： To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS： We searched online databases： Chinese journal full-text da...OBJECTIVE： To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS： We searched online databases： Chinese journal full-text database, China National Knowledge Infrastructure, Wanfang database, Chinese journal full-text database, Pubmed, ScienceDirect,Embase, and the Cochrane Library with manual-screening of relevant literature. Eligible randomized controlled trials（RCT） on angina pectoris were included. We conducted meta-analysis using the RevMan 5.1 software from The Cochrane Collaboration. We treated the relief rate of angina symptoms and electrocardiograph（ECG） as evaluation.RESULTS： Seven articles, including in 1134 patients, were enrolled after the evaluation. Therewas no significant heterogeneity among the studies（χ2=1.08, df=6, P=0.98, I2=0%）. The safflower yellow injection with conventional therapy has a higher effective rate than the control group in relieving the symptoms of angina pectoris [odds ratio（OR）=2.95, 95%（CI）（1.81, 4.81）] and improving ischemic ECG [OR=2.85, 95% CI（1.67, 4.86）]. The difference was statistically significant in the ＂80 mg dosage＂ and ＂100 mg dosage＂ subgroups（P0.05） for improving clinical symptoms and ECG. The funnel graphic was nearly symmetrical. Sensitivity analysis suggested that the results were stable.CONCLUSION： Safflower yellow injection as an adjunct therapy with conventional drugs shows advantages in easing the clinical symptoms of unstable angina and improving ECG over basic therapy alone. However, the conclusions should be interpreted with care until more high-quality RCTs are reported.展开更多
Based on the analyses on the quality of educational periodicals and the number of publications and citations in Chinese Social Sciences Citation Index(CSSCI),this paper intends to make an analysis and introduction of ...Based on the analyses on the quality of educational periodicals and the number of publications and citations in Chinese Social Sciences Citation Index(CSSCI),this paper intends to make an analysis and introduction of the general situation of Chinese educational journals and publications during 2000–2004.Results show that the quantity of educational periodicals and papers published in China,their influence,“impact factor”and the quantity of language varieties and quotation types are not completely compatible.展开更多
Objective: To identify the possible safety-influencing factors in use of the tonics of Chinese medicine. Methods: The related case reports published in periodicals published from 1949 to 2006 were analyzed with the bi...Objective: To identify the possible safety-influencing factors in use of the tonics of Chinese medicine. Methods: The related case reports published in periodicals published from 1949 to 2006 were analyzed with the bibliometrics method. Possibility on safety assessment of Chinese materia medica was discussed as well with the method of link analysis. Results: The total number of the tonics selected for the present study was 101, including 44 single drugs and 46 set prescriptions with adverse drug reactions (ADR) found in these tonics. It was found that ADR of 10 single drugs and 29 preparations were not specified in authoritative Chinese materia medica monographs. Among all the set prescriptions, the problem of injection has been standing on the top. Statistical analysis on single factor demonstrates that the most frequently referred ADR come from drug abuse (accounting for 29.20%), and overdose (24.54%). Conclusion: The safety problem of injection remains in a trend of robust growth at least for a period of time, thus reappraisal of the safety issue for the tonics of injection is imperative. It is essential for the public to take doctor’s advice to guarantee safe administration of the tonics, especially for the patients with allergic constitution or those suffering from the liver and heart diseases.展开更多
文摘Objective: The aim of this study was to investigate the efficacy and safety profiles of bevacizumab, the commonly used monoclonal antibody and its safety profiles were challenging, based on Chinese cancer patients. Methods: All the papers studied on Chinese cancer patients treated by bevacizumab were found in both databases of Chinese journal database for fulltext and PubMed were collected. The commonly used efficacy index such as disease control rate (CR + PR + SD) and response rate (CR + PR) were analyzed, and the bevacizumab related side effects were analyzed too. Results: (1) There were ten original papers contained total 199 patients who were the candidates to analyze the safety profiles, and 115 patients with colorectal cancer in five papers who were candidates to analyze the efficacy. (2) Nine in ten papers set the dose of bevacizumab in 2.5 mg/kg/week - 5 mg/kg/week, and the biweekly was the standard chemotherapy interval. (3) The disease control rate and response rate in Chinese colorectal cancer patients were 85% (95% CI: 79%-92%) and 61% (95% CI: 52%-70%), respectively. (4) The side effects related to bevacizumab were rare and most of them were grades 1-2, and only one case with grade 4 bleeding was recorded and only two cases with discontinuation of bevacizumab since hemoplysis. Also, the grades 3-4 side effects related cytotoxic agents were not common. Conclusion: This study summarized the data of Chinese cancer patients treated by bevacizumab-contained regimens, and it showed that the monoclonal antibody was effective and safe for Chinese patients as the West patients.
基金supported by Research Projects of Province-ministry Co-constructing Henan University (Grant no. SBGJ090111)Research Projects of Social Science Plan in Shandong Province (Grant no. 08DJGJ16)Humanities and Social Science Research Projects Authorized by Education Department of Shandong Province (Grant no. J08WE14)
文摘Since the 1990s, with the in-depth study and understanding of sustainable development, quantitative study of regional sustainable development (RSD) was increasingly hot in China. Based on quantitative study of RSD from Core Periodical in China National Knowledge Infrastructure (1992–2008), statistical analysis on the annual distribution, periodicals distribution and changes of the distribution were made. And from perspectives of social–economic, ecological, systematic and emerging methods, the course, problems and trends of the quantitative study methods on RSD were examined and analyzed to get a clear summary. By the review, the context on the quantitative study of RSD was to be clarified. The study also showed that, primarily, fields involving quantitative study are expanding; second, big progresses and constant development have been made on the systematic method gradually sophisticated, the flourishing ecological method and emerging new methods in the context of cross and integration which has made complex integrated systems a more satisfactory solution; third, the method system has been more multi-angled, and the clues of independent innovation have been observed despite the fact that the introduction of imported method is the main trend. Although many problems exist, multi-scale study, dynamic timeseries study and inter-regional comparative study will be further exploited and increasingly carried out with the progress of spatial information technology, which would boost the development and application of new methods in RSD study.
基金Supported by the National Natural Science Fund(No. 81173195)Capital Medical Development Fund(TCM class) (No.SF-2009-III-45)
文摘OBJECTIVE:To systematically assess the clinical effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis by meta-analysis.METHODS:The articles were mainly retrieved from the "CHKD(China Hospital Knowledge Database) periodical full text databank",the "China periodical full text databank",the "CHKD doctor's and Master's degree student full text databank",and the "China doctor's degree student thesis databank",and they were selected according to the literature selection standard.The effects of Chinese medicines and Western medicines on radiation esophagitis were compared by meta-analysis.RESULTS:Based on 13 articles,we found that the effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis was superior to Western medicines,with no obvious side effects.Meta-analysis showed that the total odds ratio was 0.426 and the 95% confidence interval was 0.368,0.493.CONCLUSION:Chinese medicines are superior to Western medicines in preventing and treating radiation esophagitis.However,some methodological problems in the literature may have affected the authenticity of the results.Therefore,more rigorous,multi-central,randomized controlled trials with a large sample size should be designed to obtain a more reliable conclusion.
基金Supported by Liaoning Province Science and Technology Plan Projects,Traditional Chinese Medicine Efficacy Evaluation Key Technology Research(No.2010225034)and(No.2010ZX09401-304)
文摘OBJECTIVE： To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS： We searched online databases： Chinese journal full-text database, China National Knowledge Infrastructure, Wanfang database, Chinese journal full-text database, Pubmed, ScienceDirect,Embase, and the Cochrane Library with manual-screening of relevant literature. Eligible randomized controlled trials（RCT） on angina pectoris were included. We conducted meta-analysis using the RevMan 5.1 software from The Cochrane Collaboration. We treated the relief rate of angina symptoms and electrocardiograph（ECG） as evaluation.RESULTS： Seven articles, including in 1134 patients, were enrolled after the evaluation. Therewas no significant heterogeneity among the studies（χ2=1.08, df=6, P=0.98, I2=0%）. The safflower yellow injection with conventional therapy has a higher effective rate than the control group in relieving the symptoms of angina pectoris [odds ratio（OR）=2.95, 95%（CI）（1.81, 4.81）] and improving ischemic ECG [OR=2.85, 95% CI（1.67, 4.86）]. The difference was statistically significant in the ＂80 mg dosage＂ and ＂100 mg dosage＂ subgroups（P0.05） for improving clinical symptoms and ECG. The funnel graphic was nearly symmetrical. Sensitivity analysis suggested that the results were stable.CONCLUSION： Safflower yellow injection as an adjunct therapy with conventional drugs shows advantages in easing the clinical symptoms of unstable angina and improving ECG over basic therapy alone. However, the conclusions should be interpreted with care until more high-quality RCTs are reported.
文摘Based on the analyses on the quality of educational periodicals and the number of publications and citations in Chinese Social Sciences Citation Index(CSSCI),this paper intends to make an analysis and introduction of the general situation of Chinese educational journals and publications during 2000–2004.Results show that the quantity of educational periodicals and papers published in China,their influence,“impact factor”and the quantity of language varieties and quotation types are not completely compatible.
基金supported by the Supporting Program of "the National Eleventh Five-year Plan" for Science and Technology Research of China (No.2006BAI08B02-03)
文摘Objective: To identify the possible safety-influencing factors in use of the tonics of Chinese medicine. Methods: The related case reports published in periodicals published from 1949 to 2006 were analyzed with the bibliometrics method. Possibility on safety assessment of Chinese materia medica was discussed as well with the method of link analysis. Results: The total number of the tonics selected for the present study was 101, including 44 single drugs and 46 set prescriptions with adverse drug reactions (ADR) found in these tonics. It was found that ADR of 10 single drugs and 29 preparations were not specified in authoritative Chinese materia medica monographs. Among all the set prescriptions, the problem of injection has been standing on the top. Statistical analysis on single factor demonstrates that the most frequently referred ADR come from drug abuse (accounting for 29.20%), and overdose (24.54%). Conclusion: The safety problem of injection remains in a trend of robust growth at least for a period of time, thus reappraisal of the safety issue for the tonics of injection is imperative. It is essential for the public to take doctor’s advice to guarantee safe administration of the tonics, especially for the patients with allergic constitution or those suffering from the liver and heart diseases.
