Plant development is a process from germination of seed to vegetative growth, flower initiation and development, fertilization and finally to the next generation seed formation. A lot of achievements have been obtai...Plant development is a process from germination of seed to vegetative growth, flower initiation and development, fertilization and finally to the next generation seed formation. A lot of achievements have been obtained in plant developmental biology in China. Since the 1990's, those young generation scientists returned to China from abroad to use molecular and genetic techniques to study morphological, physiological and biochemical process of plant development. The present paper reviews the progress in some research area of plant developmental biology in the past decades and also prospects the chance and future of plant developmental studies, due to the recent advances of plant genome sequencing and functional genomics in China under the international research background.展开更多
We study the Cauchy problem for a nonlinear evolution system with singularintegral differential terms.By means of some a priori estimates of the solution and theLeray-Schauder's fixed point theorem, we prove the e...We study the Cauchy problem for a nonlinear evolution system with singularintegral differential terms.By means of some a priori estimates of the solution and theLeray-Schauder's fixed point theorem, we prove the existence and the uniqueness theoremsof the generalized global solution of the mentioned problem.展开更多
Background:Long non-coding RNAs(lncRNAs)have been applied as biomarkers in many diseases.However,scarce biomarkers are available in single lncRNA differential expression associated with different clinical stages of li...Background:Long non-coding RNAs(lncRNAs)have been applied as biomarkers in many diseases.However,scarce biomarkers are available in single lncRNA differential expression associated with different clinical stages of liver cirrhosis(LC).The aim of the study is to identify some lncRNAs that can serve as non-invasive sensitive biomarkers for early diagnosis and grade of LC.Methods:Blood lncRNA expression was evaluated in three independent cohorts with 305 participants including healthy controls,hepatitis B virus(HBV)carriers,and patients with chronic hepatitis B(CHB)or LC.First,candidate lncRNAs were screened by CapitalBiotech microarray to diagnose cirrhosis.Quantitative reverse-transcriptase polymerase chain reaction was then used to investigate the expression of selected lncRNAs in the whole group of cirrhosis and different Child–Pugh classes.Ultimately,the diagnostic accuracy of the promising biomarker was examined and validated via Mann–Whitney test and receiver-operating characteristics analysis.Results:Lnc-TCL6 was identified as a sensitive biomarker for early diagnosis of LC(Child–Pugh A)compared with healthy controls(area under the ROC curve[AUC]=0.636),HBV carriers(AUC=0.671),and CHB patients(AUC=0.672).Furthermore,lnc-TCL6 showed a favourable capacity in discriminating among different Child–Pugh classes(AUC:0.711–0.837).Compared with healthy controls,HBV carriers,and CHB patients,the expression of lnc-TCL6 was obviously up-regulated in Child–Pugh A patients and,conversely,significantly down-regulated in Child–Pugh C patients.Conclusions:Lnc-TCL6 is a novel potential biomarker for early diagnosis of LC and is a possible predictor of disease progression.展开更多
文摘Plant development is a process from germination of seed to vegetative growth, flower initiation and development, fertilization and finally to the next generation seed formation. A lot of achievements have been obtained in plant developmental biology in China. Since the 1990's, those young generation scientists returned to China from abroad to use molecular and genetic techniques to study morphological, physiological and biochemical process of plant development. The present paper reviews the progress in some research area of plant developmental biology in the past decades and also prospects the chance and future of plant developmental studies, due to the recent advances of plant genome sequencing and functional genomics in China under the international research background.
文摘We study the Cauchy problem for a nonlinear evolution system with singularintegral differential terms.By means of some a priori estimates of the solution and theLeray-Schauder's fixed point theorem, we prove the existence and the uniqueness theoremsof the generalized global solution of the mentioned problem.
基金supported in part by grants from the National Natural Science Foundation of China[U1501224]the Natural Science Foundation Team Project of Guangdong Province[2018B03031200]+1 种基金the Science and Technology Developmental Foundation of Guangdong Province[2017B020226003]the Science and Technology Program of Guangzhou City[201604020118].
文摘Background:Long non-coding RNAs(lncRNAs)have been applied as biomarkers in many diseases.However,scarce biomarkers are available in single lncRNA differential expression associated with different clinical stages of liver cirrhosis(LC).The aim of the study is to identify some lncRNAs that can serve as non-invasive sensitive biomarkers for early diagnosis and grade of LC.Methods:Blood lncRNA expression was evaluated in three independent cohorts with 305 participants including healthy controls,hepatitis B virus(HBV)carriers,and patients with chronic hepatitis B(CHB)or LC.First,candidate lncRNAs were screened by CapitalBiotech microarray to diagnose cirrhosis.Quantitative reverse-transcriptase polymerase chain reaction was then used to investigate the expression of selected lncRNAs in the whole group of cirrhosis and different Child–Pugh classes.Ultimately,the diagnostic accuracy of the promising biomarker was examined and validated via Mann–Whitney test and receiver-operating characteristics analysis.Results:Lnc-TCL6 was identified as a sensitive biomarker for early diagnosis of LC(Child–Pugh A)compared with healthy controls(area under the ROC curve[AUC]=0.636),HBV carriers(AUC=0.671),and CHB patients(AUC=0.672).Furthermore,lnc-TCL6 showed a favourable capacity in discriminating among different Child–Pugh classes(AUC:0.711–0.837).Compared with healthy controls,HBV carriers,and CHB patients,the expression of lnc-TCL6 was obviously up-regulated in Child–Pugh A patients and,conversely,significantly down-regulated in Child–Pugh C patients.Conclusions:Lnc-TCL6 is a novel potential biomarker for early diagnosis of LC and is a possible predictor of disease progression.
