The phenomenon of anti-symmetrical bifurcation of periodic solutionsoccurring near an integral manifold is the intrinsic cause resulting in harmonic resonanceover-voltage in power systems. Due to this discovery, the p...The phenomenon of anti-symmetrical bifurcation of periodic solutionsoccurring near an integral manifold is the intrinsic cause resulting in harmonic resonanceover-voltage in power systems. Due to this discovery, the principle of eliminating resonance byusing anti-bifurcation technique is presented, which makes that the theoretical bases of verymeasure to eliminate resonance are unified firstly from a point of view of basic theory. Ourdiscussion models depend on a class of nonlinear control model. Using the direct Lyapunov method, acomplete theoretical proof is given in accordance with the measure of eliminating resonance byconnecting nonlinear resistor in series to the neutral point of P. T., and the feedback control lawbeing applied. It comprises the action of parameters of resistor to eliminate resonance and theactual process of eliminating resonance, i.e., to go against bifurcation process which forces thebig harmonic solutions to retreat to the integral manifold gradually and disappear eventually, whichby using the nonlinear controllers. This makes it sure that the intrinsic cause of resonance iseliminated thoroughly. The obtained theory results and computing results are better than thepresented results.展开更多
The eastward-propagation phenomenon from GPS-tracking drifters is characterized by strong Wyrtki Jets（WJs）,with a maximum velocity of over 1.3 m s^（-1）.Based on data gathered during a 2014 spring sea cruise in the...The eastward-propagation phenomenon from GPS-tracking drifters is characterized by strong Wyrtki Jets（WJs）,with a maximum velocity of over 1.3 m s^（-1）.Based on data gathered during a 2014 spring sea cruise in the Indian Ocean,the trajectories show the WJs bifurcate at the equator near the eastern boundary and flow northward and southward in two narrow strong currents.Surface currents reverse and flow westward in the east of the bifurcation longitude.In addition,Aquarius satellite data show the high-salinity water flows eastward from the western Indian Ocean,associated with WJs.Salinity budget analyses in the mixed layer using salinity data from Argo and currents data from OSCAR indicate that the WJs do indeed transport the high-salinity water eastward at the equator,and WJs bifurcation transports high-salinity water away from the equator and suppresses the Bay of Bengal and Java coast from freshening.Therefore,the WJs and WJs bifurcation play an important role in maintaining the salinity balance in the eastern Indian Ocean.展开更多
The relationship of the interannual variability of the transport and bifurcation latitude of the North Equatorial Current （NEC） to the E1 Nifio-Southern Oscillation （ENSO） is investigated. This is done through com...The relationship of the interannual variability of the transport and bifurcation latitude of the North Equatorial Current （NEC） to the E1 Nifio-Southern Oscillation （ENSO） is investigated. This is done through composite analysis of sea surface height （SSH） observed by satellite altimeter during October 1992-July 2009, and correspondingly derived sea surface geostrophic currents. During E1 Nifio/La Nifia years, the SSH in the tropical North Pacific Ocean falls/rises, with maximum changes in the region 0-15~N, 130~E-160~E. The decrease/increase in SSH induces a cyclonic/anticyclonic anomaly in the western tropical gyre. The cyclonic/anticyclonic anomaly in the gyre results in an increase/decrease of NEC transport, and a northward/southward shift of the NEC bifurcation latitude near the Philippine coast. The variations are mainly in response to anomalous wind forcing in the west-central tropical North Pacific Ocean, related to ENSO events.展开更多
Pereutaneous coronary intervention （PCI） for coronary bifurcation lesions has been associated with lower procedural success rates and worse clinical outcomes compared with PCI for simple coronary lesions. Angiograph...Pereutaneous coronary intervention （PCI） for coronary bifurcation lesions has been associated with lower procedural success rates and worse clinical outcomes compared with PCI for simple coronary lesions. Angiographic evaluation alone is sometimes inaccurate and does not reflect the fimctional significance of bifurcation lesions. The fractional flow reserve （FFR） is an easily obtainable, reliable, and reproducible physiologic parameter. This parameter is epicardial lesion specific and reflects both degree of stenosis and the myocardial territory supplied by the specific artery. Recent studies have shown that FFR-guided provisional side branch intervention strategy for bifurcation lesions is feasible and effective and can reduce unnecessary complex interventions and related complications. However, an adequate understanding of coronary physiology and the pitfalls of FFR is essential to properly use FFR for PCI of complex bifurcation lesions.展开更多
As it is well-known, the North Equatorial Current (NEC) bifurcates into the Kuroshio flowing northward and the equatorward Mindanao Current, which is well depicted by Munk's theory in 1950 in terms of its climatol...As it is well-known, the North Equatorial Current (NEC) bifurcates into the Kuroshio flowing northward and the equatorward Mindanao Current, which is well depicted by Munk's theory in 1950 in terms of its climatology. However, Munk's theory is unable to tell the NEC bifurcation variability with time. In the present paper, a time-dependent baroclinic model forced by wind, in which temporal and baroclinic terms are added to Munk's equation, is proposed to examine the seasonal variability of the NEC bifurcation latitude. An analytical solution is obtained, with which the seasonal variability can be well described: NEC bifurcation reaches its northernmost position in December and its southernmost position in June with a range of about 1° in latitude, consistent with previous results with observations. The present solution will degenerate to Munk's one in the case of steady and barotropic state.展开更多
Since the classical investigation of the Taylor vortex by G. I. Taylor in 1923, many researchers have studied the Taylor vortex as one of the most important vortex types in flow. In this study, the inner cylinder is r...Since the classical investigation of the Taylor vortex by G. I. Taylor in 1923, many researchers have studied the Taylor vortex as one of the most important vortex types in flow. In this study, the inner cylinder is rotating, while the outer cylinder, which is concentric with the inner cylinder, is stationary. In addition, the measurement of the velocity distribution is carried out by the PIV （Particle Image Velocimetry） method. The radius of the inner cylinder is 20 mm, and that of the outer cylinder is 30 mm. In this study, Re = 650-1,200 is assumed. In the upper part of the apparatus, movable ends are fixed to the upper and lower sides of the cylinder to change the aspect ratio. The aspect ratio is defined as the ratio of cylinder height to gap distance. A servo motor to rotate the inner cylinder, a servo-motor control device, a servo amplifier for rotation speed control, and a YAG laser light source are installed in the apparatus. For the visualization of Taylor vortex flow, aluminum powder composed of scale like fine particles is used. As tracer particles used in the PIV method, fluorescent particles with a size of 48 Ixm were used. The governing equations are Navier-Stokes equations with cylindrical coordinates （r, θ, z） and the equations of continuity. Each physical value is nondimensionalized using the angular velocity of the inner cylinder as the representative velocity, and the radius difference between the inner and outer cylinders as the representative length. Discretization of the governing equations is based on the MAC method. The results of EFD and CFD （computational fluid dynamics） are compared. The mode bifurcation is observed, and the flow structure is investigated.展开更多
AIM: To investigate whether the 7-difluoromethoxyl-5, 4'-di-n-octylgenistein (DFOG), a novel synthetic genistein analogue, affects the growth of gastric cancer cells and its mechanisms. METHODS: A series of genist...AIM: To investigate whether the 7-difluoromethoxyl-5, 4'-di-n-octylgenistein (DFOG), a novel synthetic genistein analogue, affects the growth of gastric cancer cells and its mechanisms. METHODS: A series of genistein analogues were prepared by difluoromethylation and alkylation, and human gastric cancer cell lines AGS and SGC-7901 cultured in vitro were treated with various concentrations of genistein and genistein analogues. The cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The cells were incubated by DFOG at different concentrations. The growth inhibitory effects were evaluated using MTT and clonogenic assay. The distribution of the phase in cell cycle was analyzed using flow cytometric analysis with propidium iodide staining. The expression of the transcription factor forkhead box M1 (FOXM1) was analyzed by reverse transcription-polymerase chain reaction and Western blotting. The expression levelsof CDK1, Cdc25B, cyclin B and p27KIP1 protein were detected using Western blotting. RESULTS: Nine of the genistein analogues had more effective antitumor activity than genistein. Among the tested analogues, DFOG possessed the strongest activity against AGS and SGC-7901 cells in vitro. DFOG significantly inhibited the cell viability and colony formation of AGS and SGC-7901 cells. Moreover, DFOG efficaciously arrested the cell cycle in G2/M phase. DFOG decreased the expression of FOXM1 and its downstream genes, such as CDK1, Cdc25B, cyclin B, and increased p27KIP1 at protein levels. Knockdown of FOXM1 by small interfering RNA before DFOG treatment resulted in enhanced cell growth inhibition in AGS cells. Up-regulation of FOXM1 by cDNA transfection attenuated DFOG-induced cell growth inhibition in AGS cells. CONCLUSION: DFOG inhibits the growth of human gastric cancer cells by down-regulating the FOXM1 expression.展开更多
This present paper describes three dimensional computational analysis of complex internal flow in a cross flow fan. A commercial computational fluid dynamics (CFD) software code CFX was used for the computation. RNG k...This present paper describes three dimensional computational analysis of complex internal flow in a cross flow fan. A commercial computational fluid dynamics (CFD) software code CFX was used for the computation. RNG k-ε two equation turbulence model was used to simulate the model with unstructured mesh. Sliding mesh interface was used at the interface between the rotating and stationary domains to capture the unsteady interactions. An accurate assessment of the present investigation is made by comparing various parameters with the available experimental data. Three impeller geometries with different blade angles and radius ratio are used in the present study. Maximum energy transfer through the impeller takes place in the region where the flow follows the blade curvature. Radial velocity is not uniform through blade channels. Some blades work in turbine mode at very low flow coefficients. Static pressure is always negative in and around the impeller region.展开更多
文摘The phenomenon of anti-symmetrical bifurcation of periodic solutionsoccurring near an integral manifold is the intrinsic cause resulting in harmonic resonanceover-voltage in power systems. Due to this discovery, the principle of eliminating resonance byusing anti-bifurcation technique is presented, which makes that the theoretical bases of verymeasure to eliminate resonance are unified firstly from a point of view of basic theory. Ourdiscussion models depend on a class of nonlinear control model. Using the direct Lyapunov method, acomplete theoretical proof is given in accordance with the measure of eliminating resonance byconnecting nonlinear resistor in series to the neutral point of P. T., and the feedback control lawbeing applied. It comprises the action of parameters of resistor to eliminate resonance and theactual process of eliminating resonance, i.e., to go against bifurcation process which forces thebig harmonic solutions to retreat to the integral manifold gradually and disappear eventually, whichby using the nonlinear controllers. This makes it sure that the intrinsic cause of resonance iseliminated thoroughly. The obtained theory results and computing results are better than thepresented results.
基金supported by the National Natural Science Foundation of China(NSFC)[grant numbers 41206018 and41176019]the National Basic Research Program of China[grant number 2012CB956001]+2 种基金the National Program on Global Change and Air-Sea Interaction of the China Meteorological Administration[grant number GYHY201306018]the Strategic Priority Project of Chinese Academy of Sciences[grant numbers XDA11010203]the NSFC-Shandong Joint Fund for Marine Science Research Centers[grant number U1406401]
文摘The eastward-propagation phenomenon from GPS-tracking drifters is characterized by strong Wyrtki Jets（WJs）,with a maximum velocity of over 1.3 m s^（-1）.Based on data gathered during a 2014 spring sea cruise in the Indian Ocean,the trajectories show the WJs bifurcate at the equator near the eastern boundary and flow northward and southward in two narrow strong currents.Surface currents reverse and flow westward in the east of the bifurcation longitude.In addition,Aquarius satellite data show the high-salinity water flows eastward from the western Indian Ocean,associated with WJs.Salinity budget analyses in the mixed layer using salinity data from Argo and currents data from OSCAR indicate that the WJs do indeed transport the high-salinity water eastward at the equator,and WJs bifurcation transports high-salinity water away from the equator and suppresses the Bay of Bengal and Java coast from freshening.Therefore,the WJs and WJs bifurcation play an important role in maintaining the salinity balance in the eastern Indian Ocean.
基金Supported by the National Natural Science Foundation of China Major Project (No. 40890151)the National Basic Research Program of China (973 Program) (No. 2007CB411802)
文摘The relationship of the interannual variability of the transport and bifurcation latitude of the North Equatorial Current （NEC） to the E1 Nifio-Southern Oscillation （ENSO） is investigated. This is done through composite analysis of sea surface height （SSH） observed by satellite altimeter during October 1992-July 2009, and correspondingly derived sea surface geostrophic currents. During E1 Nifio/La Nifia years, the SSH in the tropical North Pacific Ocean falls/rises, with maximum changes in the region 0-15~N, 130~E-160~E. The decrease/increase in SSH induces a cyclonic/anticyclonic anomaly in the western tropical gyre. The cyclonic/anticyclonic anomaly in the gyre results in an increase/decrease of NEC transport, and a northward/southward shift of the NEC bifurcation latitude near the Philippine coast. The variations are mainly in response to anomalous wind forcing in the west-central tropical North Pacific Ocean, related to ENSO events.
文摘Pereutaneous coronary intervention （PCI） for coronary bifurcation lesions has been associated with lower procedural success rates and worse clinical outcomes compared with PCI for simple coronary lesions. Angiographic evaluation alone is sometimes inaccurate and does not reflect the fimctional significance of bifurcation lesions. The fractional flow reserve （FFR） is an easily obtainable, reliable, and reproducible physiologic parameter. This parameter is epicardial lesion specific and reflects both degree of stenosis and the myocardial territory supplied by the specific artery. Recent studies have shown that FFR-guided provisional side branch intervention strategy for bifurcation lesions is feasible and effective and can reduce unnecessary complex interventions and related complications. However, an adequate understanding of coronary physiology and the pitfalls of FFR is essential to properly use FFR for PCI of complex bifurcation lesions.
基金Supported by the Major Program of the National Natural Science Foundation of China (Nos. 40890150, 40890151)the National Basic Research Program of China (973 Program) (No.2007-CB411802)
文摘As it is well-known, the North Equatorial Current (NEC) bifurcates into the Kuroshio flowing northward and the equatorward Mindanao Current, which is well depicted by Munk's theory in 1950 in terms of its climatology. However, Munk's theory is unable to tell the NEC bifurcation variability with time. In the present paper, a time-dependent baroclinic model forced by wind, in which temporal and baroclinic terms are added to Munk's equation, is proposed to examine the seasonal variability of the NEC bifurcation latitude. An analytical solution is obtained, with which the seasonal variability can be well described: NEC bifurcation reaches its northernmost position in December and its southernmost position in June with a range of about 1° in latitude, consistent with previous results with observations. The present solution will degenerate to Munk's one in the case of steady and barotropic state.
文摘Since the classical investigation of the Taylor vortex by G. I. Taylor in 1923, many researchers have studied the Taylor vortex as one of the most important vortex types in flow. In this study, the inner cylinder is rotating, while the outer cylinder, which is concentric with the inner cylinder, is stationary. In addition, the measurement of the velocity distribution is carried out by the PIV （Particle Image Velocimetry） method. The radius of the inner cylinder is 20 mm, and that of the outer cylinder is 30 mm. In this study, Re = 650-1,200 is assumed. In the upper part of the apparatus, movable ends are fixed to the upper and lower sides of the cylinder to change the aspect ratio. The aspect ratio is defined as the ratio of cylinder height to gap distance. A servo motor to rotate the inner cylinder, a servo-motor control device, a servo amplifier for rotation speed control, and a YAG laser light source are installed in the apparatus. For the visualization of Taylor vortex flow, aluminum powder composed of scale like fine particles is used. As tracer particles used in the PIV method, fluorescent particles with a size of 48 Ixm were used. The governing equations are Navier-Stokes equations with cylindrical coordinates （r, θ, z） and the equations of continuity. Each physical value is nondimensionalized using the angular velocity of the inner cylinder as the representative velocity, and the radius difference between the inner and outer cylinders as the representative length. Discretization of the governing equations is based on the MAC method. The results of EFD and CFD （computational fluid dynamics） are compared. The mode bifurcation is observed, and the flow structure is investigated.
基金National Natural Science Foundation of China, No. 81172375Hunan Provincial Natural Science Foundation, No. 03JJY5009
文摘AIM: To investigate whether the 7-difluoromethoxyl-5, 4'-di-n-octylgenistein (DFOG), a novel synthetic genistein analogue, affects the growth of gastric cancer cells and its mechanisms. METHODS: A series of genistein analogues were prepared by difluoromethylation and alkylation, and human gastric cancer cell lines AGS and SGC-7901 cultured in vitro were treated with various concentrations of genistein and genistein analogues. The cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The cells were incubated by DFOG at different concentrations. The growth inhibitory effects were evaluated using MTT and clonogenic assay. The distribution of the phase in cell cycle was analyzed using flow cytometric analysis with propidium iodide staining. The expression of the transcription factor forkhead box M1 (FOXM1) was analyzed by reverse transcription-polymerase chain reaction and Western blotting. The expression levelsof CDK1, Cdc25B, cyclin B and p27KIP1 protein were detected using Western blotting. RESULTS: Nine of the genistein analogues had more effective antitumor activity than genistein. Among the tested analogues, DFOG possessed the strongest activity against AGS and SGC-7901 cells in vitro. DFOG significantly inhibited the cell viability and colony formation of AGS and SGC-7901 cells. Moreover, DFOG efficaciously arrested the cell cycle in G2/M phase. DFOG decreased the expression of FOXM1 and its downstream genes, such as CDK1, Cdc25B, cyclin B, and increased p27KIP1 at protein levels. Knockdown of FOXM1 by small interfering RNA before DFOG treatment resulted in enhanced cell growth inhibition in AGS cells. Up-regulation of FOXM1 by cDNA transfection attenuated DFOG-induced cell growth inhibition in AGS cells. CONCLUSION: DFOG inhibits the growth of human gastric cancer cells by down-regulating the FOXM1 expression.
文摘This present paper describes three dimensional computational analysis of complex internal flow in a cross flow fan. A commercial computational fluid dynamics (CFD) software code CFX was used for the computation. RNG k-ε two equation turbulence model was used to simulate the model with unstructured mesh. Sliding mesh interface was used at the interface between the rotating and stationary domains to capture the unsteady interactions. An accurate assessment of the present investigation is made by comparing various parameters with the available experimental data. Three impeller geometries with different blade angles and radius ratio are used in the present study. Maximum energy transfer through the impeller takes place in the region where the flow follows the blade curvature. Radial velocity is not uniform through blade channels. Some blades work in turbine mode at very low flow coefficients. Static pressure is always negative in and around the impeller region.
