This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of...This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of methanol on an activated carbon at the molecular level. The adsorption isotherms obtained in the linear region (or adsorption constant) are exploited as a model parameter required for the adsorption process simulation. The adsorption process model described by a set of partial differential equations (PDEs) is solved by using the conservation element and solution element method, which produces a fast and an accurate numerical solution to PDEs. The simulation results obtained from the adsorption constant estimated at the molecular level are in good agreement with the experimental results of the pulse response. The systematical multiscale simulation approach addressed in this study may be useful to accelerate the adsorption process development by reducing the number of experiments.展开更多
Partial epilepsy is characterized by recurrent seizures that arise from a localized pathological brain region. During the onset of partial epilepsy, the seizure evolution commonly exhibits typical timescale separation...Partial epilepsy is characterized by recurrent seizures that arise from a localized pathological brain region. During the onset of partial epilepsy, the seizure evolution commonly exhibits typical timescale separation phenomenon. This timescale separation behavior can be mimicked by a paradigmatic model termed as Epileptor, which consists of coupled fast-slow neural populations via a permittivity variable. By incorporating permittivity noise into the Epileptor model, we show here that stochastic fluctuations of permittivity coupling participate in the modulation of seizure dynamics in partial epilepsy. In particular, introducing a certain level of permittivity noise can make the model produce more comparable seizure-like events that capture the temporal variability in realistic partial seizures. Furthermore, we observe that with the help of permittivity noise our stochastic Epileptor model can trigger the seizure dynamics even when it operates in the theoretical nonepileptogenic regime. These findings establish a deep mechanistic understanding on how stochastic fluctuations of permittivity coupling shape the seizure dynamics in partial epilepsy,and provide insightful biological implications.展开更多
Understanding the interactions(synergies and trade-offs)among the Sustainable Development Goals(SDGs)is crucial for enhancing policy coherence between different sectors.However,spatial differences in the SDG interacti...Understanding the interactions(synergies and trade-offs)among the Sustainable Development Goals(SDGs)is crucial for enhancing policy coherence between different sectors.However,spatial differences in the SDG interactions and their temporal variations at the sub-national scale are still critical gaps that need to be urgently filled.Here,we assess the spatial and temporal variation of the SDG interactions in China based on the systematic classification framework of SDGs.The framework groups the seventeen SDGs into three categories,namely“Essential Needs”“Objectives”,and“Governance”.Spatially,we found that the SDGs in“Essential Needs”&“Objectives”and“Essential Needs”&“Governance”generally show trade-offs in the eastern provinces of China.Synergies among all three SDG categories are observed in some central and western China provinces,which implies that these regions conform to sustainable development patterns.In addition,temporally,the synergies of the three SDG categories have shown a weakening trend in the last decade,mainly due to the regional differences in the progress of SDG7(Affordable and Clean Energy).Overall,our results identify the necessity for provinces to enhance the synergies between SDG12(Responsible Production and Consumption)and other SDGs to tackle the trade-offs between the“Essential Needs”and“Objectives”.Meanwhile,promoting the progress of SDG7 will also contribute to balanced development across provinces.展开更多
Fast Radio Bursts(FRBs)are new transient radio sources discovered recently.Because of the angular resolution restriction in radio surveys,no optical counter part has been identified yet so it is hard to determine the ...Fast Radio Bursts(FRBs)are new transient radio sources discovered recently.Because of the angular resolution restriction in radio surveys,no optical counter part has been identified yet so it is hard to determine the progenitor of FRBs.In this paper we propose to use radio lensing survey to constrain FRB progenitors.We show that,different types of progenitors lead to different probabilities for a FRB to be gravitationally lensed by dark matter halos in foreground galaxies,since different type progenitors result in different redshift distributions of FRBs.For example,the redshift distribution of FRBs arising from double stars shifts toward lower redshift than of the FRBs arising from single stars,because double stars and single stars have different evolution timescales.With detailed calculations,we predict that the FRB sample size for producing one lensing event varies significantly for different FRB progenitor models.We argue that this fact can be used to distinguish different FRB models and also discuss the practical possibility of using lensing observation in radio surveys to constrain FRB progenitors.展开更多
基金the Basic Research Program of the Korea Science & Engineering Foundation (KoSEF, No. R01-2006-000-10786-0).
文摘This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of methanol on an activated carbon at the molecular level. The adsorption isotherms obtained in the linear region (or adsorption constant) are exploited as a model parameter required for the adsorption process simulation. The adsorption process model described by a set of partial differential equations (PDEs) is solved by using the conservation element and solution element method, which produces a fast and an accurate numerical solution to PDEs. The simulation results obtained from the adsorption constant estimated at the molecular level are in good agreement with the experimental results of the pulse response. The systematical multiscale simulation approach addressed in this study may be useful to accelerate the adsorption process development by reducing the number of experiments.
基金supported by the National Natural Science Foundation of China(Grant Nos.81571770,61527815,81371636 and 81330032)
文摘Partial epilepsy is characterized by recurrent seizures that arise from a localized pathological brain region. During the onset of partial epilepsy, the seizure evolution commonly exhibits typical timescale separation phenomenon. This timescale separation behavior can be mimicked by a paradigmatic model termed as Epileptor, which consists of coupled fast-slow neural populations via a permittivity variable. By incorporating permittivity noise into the Epileptor model, we show here that stochastic fluctuations of permittivity coupling participate in the modulation of seizure dynamics in partial epilepsy. In particular, introducing a certain level of permittivity noise can make the model produce more comparable seizure-like events that capture the temporal variability in realistic partial seizures. Furthermore, we observe that with the help of permittivity noise our stochastic Epileptor model can trigger the seizure dynamics even when it operates in the theoretical nonepileptogenic regime. These findings establish a deep mechanistic understanding on how stochastic fluctuations of permittivity coupling shape the seizure dynamics in partial epilepsy,and provide insightful biological implications.
基金supported by the National Natural Science Foundation of China(41991230)the National Key Research and Development Program of China(2017YFA0604701)+1 种基金Prajal Pradhan acknowledges funding from the German Federal Ministry of Education and Research for the BIOCLIMAPATHS project(01LS1906A)under the Axis-ERANET callreviewed by Ministry of Natural Resources of the People’s Republic of China(GS(2021)8701)。
文摘Understanding the interactions(synergies and trade-offs)among the Sustainable Development Goals(SDGs)is crucial for enhancing policy coherence between different sectors.However,spatial differences in the SDG interactions and their temporal variations at the sub-national scale are still critical gaps that need to be urgently filled.Here,we assess the spatial and temporal variation of the SDG interactions in China based on the systematic classification framework of SDGs.The framework groups the seventeen SDGs into three categories,namely“Essential Needs”“Objectives”,and“Governance”.Spatially,we found that the SDGs in“Essential Needs”&“Objectives”and“Essential Needs”&“Governance”generally show trade-offs in the eastern provinces of China.Synergies among all three SDG categories are observed in some central and western China provinces,which implies that these regions conform to sustainable development patterns.In addition,temporally,the synergies of the three SDG categories have shown a weakening trend in the last decade,mainly due to the regional differences in the progress of SDG7(Affordable and Clean Energy).Overall,our results identify the necessity for provinces to enhance the synergies between SDG12(Responsible Production and Consumption)and other SDGs to tackle the trade-offs between the“Essential Needs”and“Objectives”.Meanwhile,promoting the progress of SDG7 will also contribute to balanced development across provinces.
基金supported by the National Basic Research Program of China(Grant No.2014CB845800)\the National Natural Science Foundation of China(Grants No.11373012)
文摘Fast Radio Bursts(FRBs)are new transient radio sources discovered recently.Because of the angular resolution restriction in radio surveys,no optical counter part has been identified yet so it is hard to determine the progenitor of FRBs.In this paper we propose to use radio lensing survey to constrain FRB progenitors.We show that,different types of progenitors lead to different probabilities for a FRB to be gravitationally lensed by dark matter halos in foreground galaxies,since different type progenitors result in different redshift distributions of FRBs.For example,the redshift distribution of FRBs arising from double stars shifts toward lower redshift than of the FRBs arising from single stars,because double stars and single stars have different evolution timescales.With detailed calculations,we predict that the FRB sample size for producing one lensing event varies significantly for different FRB progenitor models.We argue that this fact can be used to distinguish different FRB models and also discuss the practical possibility of using lensing observation in radio surveys to constrain FRB progenitors.