By elastic-plastic finite deformation finite element analysis (FEA), the conservation of J-integral is investigated in detail for a welded joint with an overmatchingweld in plane stress case. It is indicated that J-in...By elastic-plastic finite deformation finite element analysis (FEA), the conservation of J-integral is investigated in detail for a welded joint with an overmatchingweld in plane stress case. It is indicated that J-integral is path dependent under various conditions at least in the cases studied in this paper. Meanwhile, the above conclusions are verified by the hybrid method results in which combined Moire interferometry with FEA.展开更多
AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to ...AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.展开更多
This article discusses the dynamic state analysis of underwater towed-cable when tow-ship changes its speed in a direction making parabolic profile path. A three-dimensional model of underwater towed system is studied...This article discusses the dynamic state analysis of underwater towed-cable when tow-ship changes its speed in a direction making parabolic profile path. A three-dimensional model of underwater towed system is studied. The established governing equations for the system have been solved using the central implicit finite-difference method. The obtained difference non-linear coupled equations are solved by Newton＇s method and satisfactory results were achieved. The solution of this problem has practical importance in the estimation of dynamic loading and motion, and hence it is directly applicable to the enhancement of safety and the effectiveness of the offshore activities.展开更多
文摘By elastic-plastic finite deformation finite element analysis (FEA), the conservation of J-integral is investigated in detail for a welded joint with an overmatchingweld in plane stress case. It is indicated that J-integral is path dependent under various conditions at least in the cases studied in this paper. Meanwhile, the above conclusions are verified by the hybrid method results in which combined Moire interferometry with FEA.
基金Supported by National Health and Medical Research Council, Australia
文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.
文摘This article discusses the dynamic state analysis of underwater towed-cable when tow-ship changes its speed in a direction making parabolic profile path. A three-dimensional model of underwater towed system is studied. The established governing equations for the system have been solved using the central implicit finite-difference method. The obtained difference non-linear coupled equations are solved by Newton＇s method and satisfactory results were achieved. The solution of this problem has practical importance in the estimation of dynamic loading and motion, and hence it is directly applicable to the enhancement of safety and the effectiveness of the offshore activities.
