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1516例HLA-A、B、DR分型实验体会
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作者 王庆华 曾章新 +1 位作者 王英 谭建明 《福建医药杂志》 CAS 2002年第6期139-140,共2页
关键词 人白细胞抗原 HLA-A B DR 分型实验
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血清蛋白电泳分析及实验诊断分型 被引量:9
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作者 钟兰 何芳 史林杰 《中国热带医学》 CAS 2007年第11期2102-2104,共3页
目的了解不同疾病患者的血清蛋白电泳图谱的特征。方法采用SH-2020全自动琼脂糖电泳系统对肾病型、肝病型、多发性骨髓瘤及临产妇女等新鲜血清标本进行血清蛋白电泳分析。结果不同疾病在不同病程及不同生理条件下其血清蛋白组分变化均... 目的了解不同疾病患者的血清蛋白电泳图谱的特征。方法采用SH-2020全自动琼脂糖电泳系统对肾病型、肝病型、多发性骨髓瘤及临产妇女等新鲜血清标本进行血清蛋白电泳分析。结果不同疾病在不同病程及不同生理条件下其血清蛋白组分变化均不同。结论新鲜血清蛋白质经电泳后,可精确地显示并定量不同生理及病理条件下血清蛋白成分的特定变化。 展开更多
关键词 蛋白电泳图谱分析 实验诊断分型
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HLA与相关免疫疾病及实验室分型研究进展
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作者 江欣 甘佳 陈嘉林 《医学研究通讯》 2003年第3期47-48,共2页
人类白细胞抗原(HLA)是人类主要组织相容性复合物,随着对HLA在器官移植和疾病的关联等多个领域的深入研究,相关的实验室分型方法的建立,更加推动了HLA的研究进展。
关键词 人类白细胞抗原 相关免疫疾病 实验分型 研究进展
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基于正蛙位双平片的股骨头坏死立体分型系统:广中医生物力学实验室分型 被引量:1
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作者 蔡淼鑫 杨彬 +6 位作者 邓鹏 葛颖杰 郭富明 梁正辉 翟沛 庞智晖 樊粤光 《中国组织工程研究》 CAS 北大核心 2019年第24期3786-3791,共6页
背景:股骨头坏死病灶的三维信息对制定治疗方案极为重要,而过往的生物力学研究更表明股骨头前外侧柱部分几何信息和受力情况左右其塌陷过程。目前使用的平片方法无法呈现相关信息,对治疗方案的制定存在一定的观察盲区。目的:利用双平片... 背景:股骨头坏死病灶的三维信息对制定治疗方案极为重要,而过往的生物力学研究更表明股骨头前外侧柱部分几何信息和受力情况左右其塌陷过程。目前使用的平片方法无法呈现相关信息,对治疗方案的制定存在一定的观察盲区。目的:利用双平片方法呈现立体的坏死部位和范围,改良股骨头的三维分区,制订新分型标准,以提高分型对制定治疗方案的指导意义。方法:根据日常活动中股骨头应力传递方式的数据研究,结合股骨头坏死发病塌陷过程中的应力异常边界及临界值等资料,将股骨头划分为五柱,创立立体五柱分区。并根据正位和蛙位摄片体位下的前外侧柱影像信息,进一步优化立体五柱分区法,成为股骨头前外侧柱分型法,并命名为广中医生物力学实验室分型。结果与结论:详细描述广中医生物力学实验室分型的分型原理、方法和标准,以案例演示操作的方法,并比较传统分型方法,凸显新分型的优点,不但能简便准确判断股骨头坏死的病情及预后,更能有效指导临床治疗方案的选择。 展开更多
关键词 股骨头坏死 前外侧柱 五柱分区 生物力学 广中医药生物力学实验分型 国家自然科学基金
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脑卒中患者TOAST、OCSP分型与外周血DNA甲基转移酶及MeCp2蛋白水平的关系 被引量:3
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作者 张鹏 《检验医学与临床》 CAS 2023年第8期1160-1164,共5页
目的研究脑卒中患者治疗急性卒中实验(TOAST)、牛津郡社区卒中项目(OCSP)分型与外周血DNA甲基转移酶(Dnmt)1、Dnmt3a、Dnmt3b及甲基CpG结合蛋白(MeCp2)水平的关系。方法选取2017年2月至2020年5月该院收治的116例急性缺血性脑卒中患者作... 目的研究脑卒中患者治疗急性卒中实验(TOAST)、牛津郡社区卒中项目(OCSP)分型与外周血DNA甲基转移酶(Dnmt)1、Dnmt3a、Dnmt3b及甲基CpG结合蛋白(MeCp2)水平的关系。方法选取2017年2月至2020年5月该院收治的116例急性缺血性脑卒中患者作为观察组,另选取同期50例健康志愿者作为对照组,采集所有研究对象外周静脉血检测Dnmt1、Dnmt3a、Dnmt3b及MeCp2水平,分析脑卒中患者外周血Dnmt1、Dnmt3a、Dnmt3b及MeCp2水平与TOAST、OCSP分型及脑梗死面积的关系。结果观察组患者外周血Dnmt1、Dnmt3a、Dnmt3b及MeCp2水平均明显高于对照组,差异均有统计学意义(P<0.05)。不同TOAST分型患者外周血Dnmt3a、Dnmt3b及MeCp2水平比较,差异均无统计学意义(P>0.05);而外周血Dnmt1水平比较,差异有统计学意义(P<0.05);其中大动脉粥样硬化型(LAA)组与不明原因型(SUE)组外周血Dnmt1水平均明显高于心源性栓塞型组、小动脉闭塞型组和其他明确病因型组,差异均有统计学意义(P<0.05);而LAA组与SUE组外周血Dnmt1水平比较,差异无统计学意义(P>0.05)。不同OCSP分型患者外周血Dnmt3b水平比较,差异无统计学意义(P>0.05);而外周血Dnmt1、Dnmt3a及MeCp2水平比较,差异均有统计学意义(P<0.05);其中完全前循环梗死(TACI)组外周血Dnmt1、Dnmt3a及MeCp2水平与后循环梗死(POCI)组比较,差异均无统计学意义(P>0.05);TACI组和POCI组外周血Dnmt1、Dnmt3a及MeCp2水平均明显高于部分前循环梗死组和腔隙性梗死组,差异均有统计学意义(P<0.05)。不同梗死面积患者外周血Dnmt1、Dnmt3a、Dnmt3b及MeCp2水平比较,差异均无统计学意义(P>0.05)。结论缺血性脑卒中患者发病24 h内外周血Dnmt1、Dnmt3a、Dnmt3b及MeCp2水平均异常升高,其表达水平与患者TOAST分型有关,而与患者脑梗死面积无关。 展开更多
关键词 脑卒中 外周血DNA甲基转移酶 甲基CpG结合蛋白 治疗急性卒中实验分型 牛津郡社区卒中项目分型
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搞好初中物理实验改革的体会
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作者 白莉 《大庆高等专科学校学报》 2000年第2期110-111,共2页
实验是物理学知识的主要源泉,也是物理学的基本研究方法。初中物理教学大纲明确指出“物理教学要以观察,实验为基础。教学中要重视让学生观察有关的现象,要大力加强演示和学生实验。并且应对学生的实验能力进行考核。”在初中物理教学中... 实验是物理学知识的主要源泉,也是物理学的基本研究方法。初中物理教学大纲明确指出“物理教学要以观察,实验为基础。教学中要重视让学生观察有关的现象,要大力加强演示和学生实验。并且应对学生的实验能力进行考核。”在初中物理教学中,加强实验教学,让学生多动手做,既可以加强对知识的理解,又可以培养学生的实验操作技能,因此。 展开更多
关键词 初中 物理教学 物理实验 改革 分型实验
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陕西地区HLA确认和罕见等位基因及单体型研究
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作者 王天菊 齐珺 +2 位作者 陈利萍 王小芳 王满妮 《中国输血杂志》 北大核心 2017年第11期1238-1242,共5页
目的本研究分析陕西地区1 276例临床血液病患者和供者HLA-A/B/C/DRB1/DQB1高分辨分型结果中确认等位基因(Well-Documented alleles)和罕见等位基因(Rare alleles)的检出情况并且总结确认等位基因相关单体型。方法应用PCR-SBT和PCR-SSOP ... 目的本研究分析陕西地区1 276例临床血液病患者和供者HLA-A/B/C/DRB1/DQB1高分辨分型结果中确认等位基因(Well-Documented alleles)和罕见等位基因(Rare alleles)的检出情况并且总结确认等位基因相关单体型。方法应用PCR-SBT和PCR-SSOP 2种方法对临床血液病患者和供者HLA-A/B/C/DRB1/DQB1 5个位点进行高分辨检测和复核。结果 1 276例患者和供者中共检出48种确认等位基因并且分析总结出11种确认等位基因相关的单体型,检测出5个罕见等位基因HLA-A*11∶140、B*07∶248、C*08∶125、DQB1*06∶103和DQB1*06∶117,其中C*08∶125在同1个家族姐弟中被检出3次。结论在临床检测和分析的过程中,应该不断的记录和统计确认和罕见等位基因,保证中华骨髓库(China Marrow Donor Program,CMDP)HLA基因多态性的不断丰富,有助于中国CWD表的不断完善。对确认和罕见等位基因相关单体型总结和分析,为临床指导非亲缘造血干细胞移植供者的选择提供理论依据,保证携带确认和罕见等位基因的患者最大可能的找到匹配的供者。 展开更多
关键词 人类白细胞抗原 高分辨确认分型实验 确认等位基因 罕见等位基因 单体型
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Effect of crack aperture on P-wave velocity and dispersion 被引量:1
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作者 魏建新 狄帮让 丁拼博 《Applied Geophysics》 SCIE CSCD 2013年第2期125-133,235,共10页
We experimentally studied the effect of crack aperture on P-wave velocity, amplitude, anisotropy and dispersion. Experimental models were constructed based on Hudson's theory. Six crack models were embedded with equa... We experimentally studied the effect of crack aperture on P-wave velocity, amplitude, anisotropy and dispersion. Experimental models were constructed based on Hudson's theory. Six crack models were embedded with equal-radius penny-shaped crack inclusions in each layer. The P-wave velocity and amplitude were measured parallel and perpendicular to the layers of cracks at frequencies of 0.1 MHz to 1 MHz. The experiments show that as the crack aperture increases from 0.l mm to 0.34 mm, the amplitude of the P-waves parallel to the crack layers decreases linearly with increasing frequency and the P-wave velocity dispersion varies from 1.5% to 2.1%, whereas the amplitude of the P-wave perpendicular to the crack layers decreases quadratically with increasing frequency and the velocity dispersion varies from 1.9% to 4.7%. The variation in the velocity dispersion parallel and perpendicular to the cracks intensifies the anisotropy dispersion of the P-waves in the crack models (6.7% to 83%). The P-wave dispersion strongly depends on the scattering characteristics of the crack apertures. 展开更多
关键词 Crack aperture P-wave characteristics DISPERSION ANISOTROPY ultrasonic testing
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血清蛋白电泳的临床意义及实验诊断分型 被引量:11
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作者 王松华 《中国医师杂志》 CAS 2002年第S1期380-381,共2页
关键词 蛋白电泳 血清 临床意义 实验诊断分型
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Dynamic analysis and modal test of long-span cable-stayed bridge based on ambient excitation 被引量:3
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作者 陈常松 颜东煌 《Journal of Central South University of Technology》 EI 2007年第1期135-139,共5页
To study the stiffness distribution of girder and the method to identify modal parameters of cable-stayed bridge, a simplified dynamical finite element method model named three beams model was established for the gird... To study the stiffness distribution of girder and the method to identify modal parameters of cable-stayed bridge, a simplified dynamical finite element method model named three beams model was established for the girder with double ribs. Based on the simplified model four stiffness formulae were deduced according to Hamilton principle. These formulae reflect well the contribution of the flexural, shearing, free torsion and restricted torsion deformation, respectively. An identification method about modal parameters was put forward by combining method of peak value and power spectral density according to modal test under ambient excitation. The dynamic finite element method analysis and modal test were carried out in a long-span concrete cable-stayed bridge. The results show that the errors of frequencies between theoretical analysis and test results are less than 10% mostly, and the most important modal parameters for cable-stayed bridge are determined to be the longitudinal floating mode, the first vertical flexural mode and the first torsional mode, which demonstrate that the method of stiffness distribution for three beams model is accurate and method to identify modal parameters is effective under ambient excitation modal test. 展开更多
关键词 bridge engineering cable-stayed bridge dynamic finite element method ambient excitation modal test
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Experiment and Modeling of Pure and Binary Adsorption of n-Butane and Butene-1 on ZSM-5 Zeolites with Different Si/Al Ratios 被引量:6
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作者 王斐 汪文川 +2 位作者 黄世萍 滕加伟 谢在库 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2007年第3期376-386,共11页
Four ZSM-5 zeolite catalysts with different Si/Al ratios for the catalytic cracking of C4 fractions to produce ethylene and propylene were prepared in this study.First,the adsorption isotherms of pure n-butane and but... Four ZSM-5 zeolite catalysts with different Si/Al ratios for the catalytic cracking of C4 fractions to produce ethylene and propylene were prepared in this study.First,the adsorption isotherms of pure n-butane and butene-1 and their mixtures on these catalysts at 300K and p=0—100kPa were measured using the intelligent gra- vimetric analyzer.The experimental results indicate that the presence of Al can significantly affect the adsorption of butene-1 than that of n-butane on ZSM-5 zeolites.Then,the double Langmuir(DL)model was applied to study the pure gas adsorption on ZSM-5 zeolites for pure n-butane and butene-1.By combining the DL model with the ideal adsorbed solution theory(IAST),the IAST-DL model was applied to model the butene-1(1)/n-butane(2)binary mixture adsorption on ZSM-5 zeolites with different Si/Al ratios.The calculated results are in good agreement with the experimental data,indicating that the IAST-DL model is effective for the present systems.Finally,the adsorp- tion over a wide range of variables was predicted at low pressure and 300K by the model proposed.It is found that the selectivity of butene-1 over n-butane increases linearly with the decrease of Si/Al ratio.A correlation between the selectivity and Si/Al ratio of the sample was proposed at 300K and p=0.08MPa. 展开更多
关键词 ZSM-5 zeolite N-BUTANE BUTENE-1 -adsorption isotherm Si/Al ratio SELECTIVITY
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Novel approach for determining the optimal axial preload of a simulating rotary table spindle system 被引量:7
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作者 SHAN Xiao-biao XIE Tao CHEN Wei-shan 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2007年第5期812-817,共6页
This paper presents a new theoretical model to determine the optimal axial preload of a spindle system, for challenging the traditional method which relies heavily on experience of engineers. The axial preloading stif... This paper presents a new theoretical model to determine the optimal axial preload of a spindle system, for challenging the traditional method which relies heavily on experience of engineers. The axial preloading stiffness was treated as the sum of the spindle modal stiffness and the framework elastic stiffness, based on a novel concept that magnitude of preloads can be controlled by measuring the resonant frequency of a spindle system. By employing an example of a certain type of aircraft simulating rotary table, the modal stiffness was measured on the Agilent 35670A Dynamic Signal Analyzer by experimental modal analysis. The equivalent elastic stiffness was simulated by both finite element analysis in ANSYS? and a curve fitting in MATLAB?. Results showed that the static preloading stiffness of the spindle was 7.2125×107 N/m, and that the optimal preloading force was 120.0848 N. Practical application proved the feasibility of our method. 展开更多
关键词 Three-axis simulating rotary table Axial position preload STIFFNESS Experimental modal analysis Finite elementanalysis
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Investigation of the Relevance Between Electronic Courseware Implementation and Students’ Learning Styles 被引量:1
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作者 Akira KUMAMOTO Hidetaka ITO 《Journal of Measurement Science and Instrumentation》 CAS 2010年第3期262-266,共5页
Currently many methods of implementation are available if we want the com'seware to be used in e-learning interactivly with media rich. This paper focuses the attention to the relevance between various implementation... Currently many methods of implementation are available if we want the com'seware to be used in e-learning interactivly with media rich. This paper focuses the attention to the relevance between various implementations in presentation adopted in the courseware and students' learning styles, in order to consider what kind of implemenation or description is preferable to what kind of students or order to support their leaming. We carded out the canonical correlation analysis for this purpose and investigated this relevance on the basis of the experiments. Main results of the experiment are given with detailed disoussion. 展开更多
关键词 rich media oaurseware E-LEARNING learning styles me- dia technology oaurseware implementation
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Structural behaviors of steel roof truss exposed to pool fire 被引量:1
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作者 陈长坤 张威 《Journal of Central South University》 SCIE EI CAS 2012年第7期2054-2060,共7页
Experimental research was conducted to study the structural behaviors of a steel roof truss model without fire-proof coating under pool fire conditions. The data of temperature distribution and displacements of typica... Experimental research was conducted to study the structural behaviors of a steel roof truss model without fire-proof coating under pool fire conditions. The data of temperature distribution and displacements of typical members were obtained. It is found that the temperature distribution of environment inside the structure, which is found to be in accordance with the multi-zone model with height, has a decisive effect on the tempera^tre evolution of steel members. Besides, it can also be observed that due to the restriction and coordination among the truss members in the localized fire, the maximum relative deflection, which occurs at the mid-span of the top chord, is relatively slight and has not exceeded 1 mm under experimental conditions. On the other hand, the column experiences a notable thermal expansion during the test. Then, a finite element model is presented and validated by the test results. 展开更多
关键词 steel roof truss fire test multi-zone model finite element analysis
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Simulating Evolution of a Loess Gully Head with Cellular Automata 被引量:1
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作者 LIU Xiaojing TANG Guo'an +2 位作者 YANG Jianyi SHEN Zhou PAN Ting 《Chinese Geographical Science》 SCIE CSCD 2015年第6期765-774,共10页
This paper presents a new method for simulating the evolution of a gully head in a loess catchment with cellular automata(CA) based on the Fisher discriminant. The experimental site is an indoor loess catchment that w... This paper presents a new method for simulating the evolution of a gully head in a loess catchment with cellular automata(CA) based on the Fisher discriminant. The experimental site is an indoor loess catchment that was constructed in a fixed-intensity rainfall erosion test facility. Nine high-resolution digital elevation model(DEM) data sets were gathered by close range photogrammetry during different phases of the experiment. To simulate the evolution of the catchment gully head, we assumed the following. First, the 5th and 6th DEM data sets were used as a data source for acquiring the location of the catchment gully head and for obtaining spatial variables with GIS spatial analysis tools. Second, the Fisher discriminant was used to calculate the weight of the spatial variables to determine the transition probabilities. Third, CA model was structured to simulate the evolution of the gully head by iterative looping. The status of the cell in the CA models was dynamically updated at the end of each loop to obtain realistic results. Finally, the nearest neighbor, G-function, K-function, Moran′s I and fractal indexes were used to evaluate the model results. Overall, the CA model can be used to simulate the evolution of a loess gully head. The experiment demonstrated the advantages of the CA model which can simulate the dynamic evolution of gully head evolution in a catchment. 展开更多
关键词 cellular automata digital elevation model (DEM) gully head loess catchment point pattem
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Theoretical and experimental study of initial cracking mechanism of an expansive soil due to moisture-change 被引量:11
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作者 吴珺华 袁俊平 吴宏伟 《Journal of Central South University》 SCIE EI CAS 2012年第5期1437-1446,共10页
Swelling and shrinkage due to moisture-change is one of the characteristics of the expansive soil,which is similar to the behavior of most materials under thermal effect,If the deformation is restricted,stress in expa... Swelling and shrinkage due to moisture-change is one of the characteristics of the expansive soil,which is similar to the behavior of most materials under thermal effect,If the deformation is restricted,stress in expansive soil is caused by the swell-shrinking.The stress is defined as "moisture-change stress" and is adopted to analyze swell-shrinkage deformation based on the elasticity mechanics theory.The state when the total stress becomes equal to the soil tensile strength is considered as the cracking criterion as moisture-change increases.Then,the initial cracking mechanism due to evaporation is revealed as follows:Different rates of moisture loss at different depths result in greater shrinkage deformation on the surface while there is smaller shrinkage deformation at the underlayer in expansive soil;cracks will grow when the nonuniform shrinkage deformation increases to a certain degree.A theoretical model is established,which may be used to calculate the stress caused by moisture-change.The depth of initial cracks growing is predicted by the proposed model in expansive soil,A series of laboratory tests are carried out by exposing expansive soil samples with different moisture-changes.The process of crack propagation is investigated by resistivity method.The test results show good consistency with the predicted results by the proposed theoretical model. 展开更多
关键词 expansive soil swell-shrinking deformation moisture-change CRACK RESISTIVITY
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Experimental measurement and numerical analysis of fused taper shape for optical fiber coupler 被引量:2
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作者 帅词俊 段吉安 钟掘 《Journal of Central South University of Technology》 EI 2007年第2期251-254,共4页
To find out the effect of the shape of fused taper region on the optical fiber coupler, the fiber couplers were fabricated at different drawing speeds with a six-axes fiber coupler machine. The results, which were obt... To find out the effect of the shape of fused taper region on the optical fiber coupler, the fiber couplers were fabricated at different drawing speeds with a six-axes fiber coupler machine. The results, which were obtained fi'om the shape of fused taper region measured with microscope, show that there is a close correlation between the cone angle and optical performance of fiber coupler. High-performance fiber coupler cannot be obtained until rheological shape is controlled accurately. The numerical analysis model, which was built based on generalized Maxwell viscoelastic theory, is resolved with ANSYS software. The calculated results accord with the experimental data. It can apply a theoretic basis for forecasting the shape of fiber coupler fabricated under the conditions of different technological parameters. 展开更多
关键词 optical fiber coupler fused biconical taper viscoelastic model rheological shape
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A Fully Flexible Potential Model for Carbon Dioxide 被引量:2
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作者 朱爱梅 张新波 +1 位作者 刘庆林 张秋根 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2009年第2期268-272,共5页
A fully flexible potential model for carbon dioxide has been developed to predict the vapor-liquid coexistence properties using the NVT-Gibbs ensemble Monte Carlo technique(GEMC).The average absolute deviation between... A fully flexible potential model for carbon dioxide has been developed to predict the vapor-liquid coexistence properties using the NVT-Gibbs ensemble Monte Carlo technique(GEMC).The average absolute deviation between our simulation and the literature experimental data for saturated liquid and vapor densities is 0.3% and 2.0%,respectively.Compared with the experimental data,our calculated results of critical properties(7.39 MPa,304.04 K,and 0.4679 g?cm-3) are acceptable and are better than those from the rescaling the potential parameters of elementary physical model(EPM2).The agreement of our simulated densities of supercritical carbon dioxide with the experimental data is acceptable in a wide range of pressure and temperature.The radial distribution function estimated at the supercritical conditions suggests that the carbon dioxide is a nonlinear molecule with the C O bond length of 0.117 nm and the O C O bond angle of 176.4°,which are consistent with Car-Parrinello molecular-dynamics(CPMD),whereas the EPM2 model shows large deviation at supercritical state.The predicted self-diffusion coefficients are in agreement with the experiments. 展开更多
关键词 molecular simulations radial distributions fully flexible potential model carbon dioxide
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Comprehensive evaluation weight-variable identification model of top coal caving effect and its application
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作者 张开智 解品洲 +1 位作者 李大勇 韩承强 《Journal of Coal Science & Engineering(China)》 2007年第4期524-527,共4页
Based on the theory of attribute identification, a weight-variable identification model was put forward on top coal caving effect in fully mechanized top coal caving face. Contribution value of all kinds of evaluation... Based on the theory of attribute identification, a weight-variable identification model was put forward on top coal caving effect in fully mechanized top coal caving face. Contribution value of all kinds of evaluation factor of the caving coal and waste were used to determine weight coefficient. And then comprehensively estimated it by the given credible degree value. This kind of method can not only classify for attribute identification, but also can classify it into sub-classification according to comprehensive score compositor that of the same attribute. The comprehensive estimate result of plane and solid caving experiments shows that the result is true, credible, simple and that is not only one of the effective method of theory study, but also can be regarded as a quantitative examine method of the top coal caving effect in scene. 展开更多
关键词 top coal caving effect weight-variable identification evaluation example analysis
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Dynamic characteristic analysis of whole machine tools based on Kriging model 被引量:2
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作者 高相胜 张以都 +1 位作者 郜浩冬 张洪伟 《Journal of Central South University》 SCIE EI CAS 2013年第11期3094-3102,共9页
In order to study the variation of machine tools’dynamic characteristics in the manufacturing space,a Kriging approximate model is proposed.Finite element method(FEM)is employed on the platform of ANSYS to establish ... In order to study the variation of machine tools’dynamic characteristics in the manufacturing space,a Kriging approximate model is proposed.Finite element method(FEM)is employed on the platform of ANSYS to establish finite element(FE)model with the dynamic characteristic of combined interface for a milling machine,which is newly designed for producing aero engine blades by a certain enterprise group in China.The stiffness and damping of combined interfaces are adjusted by using adaptive simulated annealing algorithm with the optimizing software of iSIGHT in the process of FE model update according to experimental modal analysis(EMA)results.The Kriging approximate model is established according to the finite element analysis results utilizing orthogonal design samples by taking into account of the range of configuration parameters.On the basis of the Kriging approximate model,the response surfaces between key response parameter and configuration parameters are obtained.The results indicate that configuration parameters have great effects on dynamic characteristics of machine tools,and the Kriging approximate model is an effective and rapid method for estimating dynamic characteristics of machine tools in the manufacturing space. 展开更多
关键词 machine tool dynamic characteristic INTERFACE CONFIGURATION Kriging model
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