Background/Aims: To assess the effectiveness and the safety of radio-frequenc y thermal ablation (RFTA) in patients with hepatocellular carcinoma(HCC) ≤5 cm in compensated cirrhosis.Methods: A cohort of 202 consecuti...Background/Aims: To assess the effectiveness and the safety of radio-frequenc y thermal ablation (RFTA) in patients with hepatocellular carcinoma(HCC) ≤5 cm in compensated cirrhosis.Methods: A cohort of 202 consecutive patients (165 Chil d-Pughclass A and 37 class B) was prospectively assessed. A single lesion was o bserved in 160/202 (79.2%), two lesions in 29/202(14.3%), and three lesions in 13/202 (6.4%) of patients. Results:Sixty-seven patients died. Survival rates were 80%at 12 months, 67%at 24 months and 57%at 30 months (Child-Pugh A 59% and Child-Pugh B 48%). By Cox regression analysis,survival was independently p redicted by serum albumin levels ≥35 g/L, platelet count ≥100.000/mmc, tumor s ize ≤3 cm, complete response at 1 month and Barcelona Clinic Liver Cancer (BCLC ) staging classification. Overall recurrence rates were 22, 38, and 44%at 12, 2 4, and 30 months, respectively.One procedure-related death occurred. The propor tion of major complications after treatment was 3.9%. Conclusions: A complete r esponse after RFTA significantly increases survival. The longest survival is obt ained in the presence of HCC ≤3 cm and of higher baseline albumin levels and pl atelet counts. BCLC staging classification is able to discriminate patients with good or poor prognosis.展开更多
Objectives: To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine ...Objectives: To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions. Design: Prospective and retrospective observational study. Setting: Dermatology outpatient clinic in a general hospital. Patients: Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period. Interventions: None. Main Outcome Measures: Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing. Results: HLA-DR4 (DRB1.0404) was significantly increased (P < .001; odds ratio, 3.9; 95%confidence interval, 1.86-8.03)-. Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32. Conclusions: The HLA-DRB1.0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.展开更多
文摘Background/Aims: To assess the effectiveness and the safety of radio-frequenc y thermal ablation (RFTA) in patients with hepatocellular carcinoma(HCC) ≤5 cm in compensated cirrhosis.Methods: A cohort of 202 consecutive patients (165 Chil d-Pughclass A and 37 class B) was prospectively assessed. A single lesion was o bserved in 160/202 (79.2%), two lesions in 29/202(14.3%), and three lesions in 13/202 (6.4%) of patients. Results:Sixty-seven patients died. Survival rates were 80%at 12 months, 67%at 24 months and 57%at 30 months (Child-Pugh A 59% and Child-Pugh B 48%). By Cox regression analysis,survival was independently p redicted by serum albumin levels ≥35 g/L, platelet count ≥100.000/mmc, tumor s ize ≤3 cm, complete response at 1 month and Barcelona Clinic Liver Cancer (BCLC ) staging classification. Overall recurrence rates were 22, 38, and 44%at 12, 2 4, and 30 months, respectively.One procedure-related death occurred. The propor tion of major complications after treatment was 3.9%. Conclusions: A complete r esponse after RFTA significantly increases survival. The longest survival is obt ained in the presence of HCC ≤3 cm and of higher baseline albumin levels and pl atelet counts. BCLC staging classification is able to discriminate patients with good or poor prognosis.
文摘Objectives: To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions. Design: Prospective and retrospective observational study. Setting: Dermatology outpatient clinic in a general hospital. Patients: Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period. Interventions: None. Main Outcome Measures: Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing. Results: HLA-DR4 (DRB1.0404) was significantly increased (P < .001; odds ratio, 3.9; 95%confidence interval, 1.86-8.03)-. Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32. Conclusions: The HLA-DRB1.0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.
