基于碳纳米管的电子器件

碳纳米管有着众多独特的性质 ,尤其是它的电学性质。近几年来 ,碳纳米管的研究已展示出了在纳米电子器件上的应用前景 ,即通过构建尺寸只有几十纳米甚至更小的基于碳纳米管的电子器件和连线 ,实现速度远快于而功耗远小于目前集成电路的碳纳米管集成电路。文中在讨论碳纳米管电学性质的基础上 ,主要介绍基于碳纳米管的结。

Changes of Water Status and Different Responses of Osmoregulants in Jatropha Curcas L. Seedlings to Air-drought Stress

[Objective] The study aimed to investigate the changes of water status and different responses of osmoregulants during air-drought stress,to better understand mechanisms of drought resistance in Jatropha Curcas L. [Methods] The 12-day-old J. curcas seedlings were held in a climate chamber at 25/20 ℃（day/night）,16 hours illumination,and 75% of relative humidity for air-drought treatment,and the changes of water potential,osmotic potential and the content of soluble sugar,proline,betaine were measured. [Results] Water potential and osmotic potential in leaves of J. curcas seedlings dropped significantly,pressure potential lost during air-drought stress,and the contents of osmoregulants soluble sugar,proline and betaine rose significantly to different extent in the leaves and stems. [Conclusion] Osmoregulants in the leaves and stems respond differently to air-drought stress,and in general leaves are much more responsive to the drought than stems of J. curcas seedlings.

Evolution of COP9 Signalosome and Proteasome Lid Complex

The COP9 signalosome and the regulatory lid of the 26S proteasome are both eight-subunit protein complexes which are present in most eukaryotes. There is a one-to-one relationship between the corresponding subunits of the two protein complexes in terms of their size and amino acid sequences. Eight groups of subunits from the COP9 signalosome and the proteasome lid complex of different organisms are collected from all the databases at the NCBI website. The corresponding subunits of COP9 signalosome and proteasome lid complex share at least 12% amino acid identity and some conserved regions, and the conserved sites spread evenly over the entire length of the subunits, suggesting that the two complexes have a common evolutionary ancestor. Phylogenetic analyses based on the amino acid sequences of the corresponding subunits of two protein complexes indicate that every tree consists of two clades. The subunits from one of the two protein complexes of different organisms are grouped into one of the two clades respectively. The sequences of single-cell organisms are always the basal groups to that of multi-cell animal and plant species. These results imply that the duplication/divergence events of COP9 signalosome and regulatory lid of the proteasome genes have occurred before the divergence of single-cell and multi-cell eukaryotes, and the genes of the two complexes are independently evolved. The analyses of dN/dS correlation show significant Pearson's correlations between 21 and 15 pairs of subunit-encoding sequences within the COP9 signalosome and the proteasome lid complex respectively, suggesting that those subunits pairs might have related functions and interacted with one another, and resulted in co-evolution.

Can Campylobacter jejuni play a role in development of celiac disease? A hypothesis

Celiac disease （CD） is an entropathy with malabsortive condition in which an allergic reaction to the cereal grain-protein （gluten） causes small intestine rnucosal injury. CD is a multifactorial disorder in which both genetic and environmental factors contribute to the disease development. Mechanisms have been described to explain the pathology of CD. T cells specific for multiple gluten peptides are found in virtually all patients. Generation of such a broad T cell response may be a prerequisite for disease development. CD is associated with multiple extraintestinal presentations, including neurological deficits. Recent studies have shown a significant correlation between anti-ganglioside antibodies and neurological disorders in patients with underlying CD. Gangliosides are glycosphingolipids which are abundant in nervous system and in other tissues including gastrointestinal tract. It is not known what triggers the release of anti-ganglioside antibodies in people with gluten sensitivity. But, the mechanism is likely to involve the intestinal immune system response to ingested gliadin, a component of wheat gluten. Studies showed that mechanisms different from gluten exposure may be implicated in antibody formation, and other environmental factors may also exist. In addition, considering the fact that genetic predisposition dysregulating mucosal immune responses in the presence of certain environmental triggers like gastrointestinal infections may be strong etiological factors for developing chronic intestinal inflammation including CD, the hypothesis raised in our mind that antiganglioside antibody formation in CD may play a role not only in development of neurological complications in celiac patients, but also in development of CD itself. As presence of Campylobacter jejuni in other diseases with antigangliosides antibody formation has been established, we propose the possible role of Campylobacter jejuni in development of CD in association with other genetic and environmental factors by the mechanism that molecular mimicry of gangliosides-like epitopes common to both lipo-polysacharide coats of certain strains of Campylobacter jejuni and gangliosides in cell structure of gastrointestinal mucosa may cause an autoimmune response and consequently lead to atrophy and degeneration of mucosa possibly by apoptosis.

PRELIMINARY DISCUSSIONS OF BASIC CLIMATIC CHARACTERISTICS OF PRECIPITATION DURING RAINING SEASONS IN REGIONS SOUTH OF CHANGJIANG RIVER AND ITS RELATIONSHIP WITH SST ANOMALIES

Basic climatic characteristics are analyzed concerning the precipitation anomalies in raining seasons over regions south of the Changjiang River (the Yangtze). It finds that the regions are the earliest in eastern China where raining seasons begin and end. Precipitation there tends to decrease over the past 50 years. Waters bounded by 9(S -1(S, 121(E - 129(E are the key zones of SST anomalies that affect the precipitation in these regions over May ~ July in preceding years. Long-term air-sea interactions make it possible for preceding SST anomalies to affect the general circulation that come afterwards, causing precipitation anomalies in the raining seasons in regions south of the Changjiang River in subsequent years.

Parallelization and performance tuning of molecular dynamics code with OpenMP

An OpenMP approach was proposed to parallelize the sequential molecular dynamics(MD) code on shared memory machines. When a code is converted from the sequential form to the parallel form, data dependence is a main problem. A traditional sequential molecular dynamics code is anatomized to find the data dependence segments in it, and the two different methods, i.e., recover method and backward mapping method were used to eliminate those data dependencies in order to realize the parallelization of this sequential MD code. The performance of the parallelized MD code was analyzed by using some performance analysis tools. The results of the test show that the computing size of this code increases sharply form 1 million atoms before parallelization to 20 million atoms after parallelization, and the wall clock during computing is reduced largely. Some hot-spots in this code are found and optimized by improved algorithm. The efficiency of parallel computing is 30% higher than that of before, and the calculation time is saved and larger scale calculation problems are solved.

The 5'-flanking cis-acting elements of the human ε-globin gene associates with the nuclear matrix and binds to the nuclear matrix proteins

The nucleax mains attachment regions(MARs) and the binding nuclear matrix proteins in the 5’-flalildng cisacting elements of the humanε-globin gene have been examined. Using in vitro DNA-matrix binding assay,it has been shown that the positive stage-specific regulatory element (ε-PREII, -446bp-419bp) upstream of this gene could specifically associate with the nuclear matrix from K562 cells, indicating thatε-PREII mad be an erythroidspecilic facultstive MAR. In gel mobility shift assay and Southwestern blotting assal an eothroid-specific nuclear matrix protein (ε-NMPk) in K562 cells has been revealed to bind to this positive regulatory element (E-PREII). Furthermore, we demonstrated that the silencer (-392hp -177bp) uP8tream of the humanε-globin gene could associate with the nuclear matrices from K562, HEL and Raji cells. In addition, the nucleax matrix proteins prepared from these three cell lines could also bind to this silencer, suggesting that this silencer element linght be a constitutive nuclear mains attachment region (constitutive MAR). Our results demonstrated that the nucleax madrid and nuclear mains proteins lxilght play an important role in the regulation of the human 5-globin gene expression.

HOTAIR:an oncogenic long non-coding RNA in different cancers

Long non-coding RNAs （lncRNAs） refer to a group of RNAs that are usually more than 200 nucleotides and are not involved in protein generation. Instead, lncRNAs are involved in different regulatory processes, such as regulation of gene expression. Different lncRNAs exist throughout the genome. LncRNAs are also known for their roles in different human diseases such as cancer. HOTAIR is an lncRNA that plays a role as an oncogenic molecule in different cancer ceils, such as breast, gastric, colorectal, and cervical cancer cells. Therefore, HOTAIR expression level is a potential biomarker for diagnostic and therapeutic purposes in several cancers. This RNA takes part in epigenetic regulation of genes and plays an important role in different cellular pathways by interacting with Polycomb Repressive Complex 2 （PRC2）. In this review, we describe the molecular function and regulation of HOTAIR and its role in different types of cancers.

Guillain-Barrésyndrome following hepatitis E

Guillain-Barrésyndrome(GBS)is often triggered by a preceding bacterial or viral infection.Occasionally,it has been observed in association with acute hepatitis A,B and C,and three cases have been previously described in India in which GBS was associated with acute hepatitis E.A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents,although the nature of the shared epitopes has not been characterized in most instances,including that in the case of hepatotropic viruses.We report a case of GBS following acute hepatitis E in a European individual.The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E.

Effect of androgen withdrawal on activation of ERKs and expression of cell cycle regulation molecules in human prostate carcinoma cells

Objective: To explore the possible mechanisms of growth regression of human androgen dependent prostate carcinoma cells caused by androgen withdrawal. Methods: After 24 h of treatment with 1 × 10-9 mol/L dihydrotestosterone (DHT), the expression of phosphorylated ERK proteins and cell cycle regulation molecules including CDK2, CDK4, CDK6 and P27kip1 in human androgen dependent prostate carcinoma cell line LNCaP was measured by Western blot analysis 0 h, 8 h and 24 h of after androgen withdrawal. Human androgen independent prostate carcinoma cell line PC-3 was also examined as control. Results: Down-regulation of phosphorylated ERK, CDK2, CDK4 and CDK6 and up-regulation of P27kip1 were found initially in LNCaP cell line 8 h after androgen withdrawal. The levels of phosphorylated ERK and CDKs decreased continuously and reached the lowest after 24 h, while continuous elevation of P27kip1 was detected thereafter to 24 h. No expression change of phosphorylated ERK, CDKs and P27kip1 were detected in PC-3 cell line. Conclusion: The androgen withdrawal can cause ERKs activation decrease and cell cycle regulation molecules changes, which may be one of the mechanisms for inhibited growth of androgen dependent prostate carcinoma after androgen ablation by either operative or medicine methods.

Synergistic promotion of HER and OER by alloying ternary Zn‐Co‐Ni nanoparticles in N‐doped carbon interfacial structures

Catalytic water splitting potentially reduce the consumption of fossil fuels and has received intense research attention.Synergy effects in multi‐element transition metal‐based water splitting catalysts have evoked special interests.Studies on catalysts in interfacial structures are especially meaningful due to their pertinence in applications.In this study,we report the synergy effects in promoting catalytic power in the ternary transition metal Zn,Co,Ni alloy nanoparticles that embeds in the carbonized Ppy/CNT multilayered matrix.By comparison with a series of binary or single metal counterparts,the mechanism under the synergy effects are elucidated.Experimental and DFT calculation results indicate that the ternary transition metal catalysts in the N‐doped carbon matrix present special electronic structure,which benefits the reversible transition‐state adsorption in HER and OER and render the catalysts high conductivity in room temperature.We expect our findings inspire further development of efficient transition metal HER and OER catalysts.

CONVERSION RATES OF SURFACE HOX RADICALS IN BEIJING CITY

Surface OH radical concentration in Beijing City was measured by impregnated filter trapping technique-high performance liquid chromatography (IFT-HPLC). The observed concentration of OH radical showed obvious diurnal and seasonal variations, with maximum readings at noon or afternoon, similar to 80x10(6)OH/cm(3) in summer and similar to 20x10(6)-40x10(6)OH/cm(3) in fall. On the basis of measured data, the reaction rates related to the photochemical process of HO(x) (OH+HO(2)) were derived and characteristics of atmospheric chemical processes in the city were analyzed. The results showed that conversion rates of atmospheric OH and HO(2) in the summer of Beijing City were about 700x10(6) molecule/(cm(3) . s) and 600x10(6)molecule/(cm(3) . s), respectively. And the net production of OH in the air of the city mainly originated from the photolysis of the gaseous HNO(2), and the main sink of OH were the photochemical reactions with VOCs, NO(2), HCHO and CO. It was different from the clean area.

Stochastic Differential Game Model for Decentralized Power Control with Wisdom Regulation Factor in Wearable Audio-Oriented BodyNets

In this study, aiming at the characteristics of randomness and dynamics in Wearable Audiooriented BodyNets （WA-BodyNets）, stochastic differential game theory is applied to the investigation of the problem of transmitted power control inconsumer electronic devices. First, astochastic differential game model is proposed for non-cooperative decentralized uplink power control with a wisdom regulation factor over WA-BodyNets with a onehop star topology.This model aims to minimize the cost associated with the novel payoff function of a player, for which two cost functions are defined： functions of inherent power radiation and accumulated power radiation darmge. Second, the feedback Nash equilibrium solution of the proposed model and the constraint of the Quality of Service （QoS） requirement of the player based on the SIR threshold are derived by solving the Fleming-Bellman-Isaacs partial differential equations. Furthermore, the Markov property of the optimal feedback strategies in this model is verified.The simulation results show that the proposed game model is effective and feasible for controlling the transmitted power of WA-BodyNets.

Quantitative comparison of the expression of myogenic regulatory factors in flounder(Paralichthys olivaceus) embryos and adult tissues

MyoD, Myf5, and myogenin are myogenic regulatory factors that play important roles during myogenesis. It is thought that MyoD and Myf5 are required for myogenic determination, while myogenin is important for terminal differentiation and lineage maintenance. To better understand the function of myogenic regulatory factors in muscle development of flounder, an important economic fish in Asia, real-time quantitative RT-PCR was used to characterize the expression patterns of MyoD, Myf5, and myogenin at early stages of embryo development, and in different tissues of the adult flounder. The results show that, MyJ5 is the first gene to be expressed during the early stages of flounder development, followed by MyoD and myogenin. The expressions ofMyf5, MyoD, and myogenin at the early stages have a common characteristic： expression gradually increased to a peak level, and then gradually decreased to an extremely low level. In the adult flounder, the expression of the three genes in muscle is much higher than that in other tissues, indicating that they are important for muscle growth and maintenance of grown fish. During embryonic stages, the expression level of MyoD might serve an important role in the balance between muscle cell differentiation and proliferation. When the MyoD expression is over 30% of its highest level, the muscle cells enter the differentiation stage.

Potential Targets and Molecular Mechanism of Quercetin Against Knee Osteoarthritis

Objective The objective of this study was to clarify the potential mechanism of quercetin against knee osteoarthritis(KOA)based on network pharmacology and molecular docking.Methods The targets of quercetin were predicted by PubChem and Swiss Target Prediction databases,and the targets of KOA were obtained by DisGeNET,OMIM,and GeneCards databases.Then,the targets of quercetin and KOA were intersected to find the potential targets of quercetin against KOA.The protein–protein interaction network was constructed through the STRING database,and the core targets were screened.Gene ontology(GO)functions enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed using DAVID database.The drug–target–pathway–disease network was constructed by Cytoscape software,and the molecular docking verification was performed by Vina.Results There were 49 potential targets for quercetin against KOA,including 10 core targets.GO functions enrichment analysis showed that the biological process of quercetin against KOA mainly involved the negative regulation of apoptotic process,collagen catabolic process,and extracellular matrix disassembly.KEGG pathway enrichment analysis showed that quercetin against KOA was closely related to PI3K-Akt signaling pathway,Rap 1 signaling pathway,FoxO signaling pathway,Ras signaling pathway,TNF signaling pathway,and ErbB signaling pathway.The results of molecular docking showed that the binding energies between ligand and receptors were less than−5 kcal·mol−1.Conclusions The molecular mechanism of quercetin against KOA involves many targets and pathways,which can regulate the proliferation and apoptosis of chondrocytes,degradation of extracellular matrix,and inflammatory reaction.Quercetin can stably bind to the active pockets of core target proteins,thereby exerting the effect against KOA.

Changes of Dry-wet Climate in the Dry Season in Yunnan(1961-2007)

Factor analysis was used to investigate the changes of dry-wet climate in the dry season in Yunnan during 1961-2007 based on observed data from 15 stations.Three common factors were extracted from the 9 climatic factors.The results showed that the dry-wet climate has evidently changed since the early 1960s.The general trends in the changes of drywet climate were described as slight decrease in humidity and gradual enhancement in drought intensity.The climate during 1960s-1980s was under weak-medium drought.But since early 1990s,dry conditions have markedly strengthened and continued due to uneven temporal distribution of rainfall and climate warming.

Dynamic Energy Saving Subcarrier, Bit and Power Allocation in OFDMA Relay Networks

To reduce energy consumption while maintaining users＇ Quality of Service （QoS） in Orthogonal Frequency Division Mul- tiplex Access （OFDMA） relay-enhanced net- works, an adaptive energy saving subcarrier, bit and power allocation scheme is presented. The optimal subcarrier, bit and power alloca- tion problems based on discrete adaptive modula- tion and coding scheme have been previously formulated for relay-enhanced networks, and have been reformulated into and solved by integer programming in optimization theory. If the system still has a surplus of subcarriers after resource allocation, we carry out Band- width Exchange （BE） to enable more subcar- riers to participate in transmission to save en- ergy. In addition, as the relay selection scheme is closely linked with heuristic energy saving resource allocation, a relay selection scheme is proposed. Simulation results indicate that the proposed algorithm consumes less energy when transmitting the same number of bits than greedy energy saving schemes, although its spectrum efficiency is worse.

Heparin-induced thrombocytopenia associated with pulmonary embolism after total knee arthroplasty:a case report and review of literatures

Type II heparin-induced thrombocytopenia （HIT） is a life-threatening adverse drug reaction initiated by heparin administration. We described a rare case of LMWH-induced HIT complicated with proven pulmonary embolism （PE） in a 75-year-old male patient who hospitalized with diagnose of right knee osteoarthritis and was underwent total knee arthroplasty The patient was successfully treated with argatroban. Early recognition and timely altemative therapy are of great importance in the treatment of this severe disorder,

Parameters for Use of BEWAB＋ Programme to Schedule Irrigation of Pea （Pisum sativum L,）

A large portion of irrigation farmers make use of subjective （intuition） irrigation scheduling methods as supposed to objective or scientific irrigation scheduling methods, which need to be changed. The BEsproeiingsWAterbestuursprogram （BEWAB＋） irrigation scheduling programme is based on the water balance equation and needs： （1） a crop production function; （2） a relative consumptive water demand curve and （3） an allowable depletion subroutine. The objective of this paper was to describe research aimed at obtaining information on （1） and （2） for pea and also to describe the effect of water application on yield and water use of pea. BEWAB＋ uses this information to estimate the daily irrigation water requirements for a particular soil-crop-atmosphere system under irrigation. A field experiment, based on published line-source irrigation methodology, was conducted on a 3 m deep loamy fine sand Bainsvlei or Ustic Quartzipsamment soil near Bloemfontein （26°08′S; 29°01′E） in South Africa. Results showed that there is a linear relationship of the form Ys = 8.07ET - 249 （r2 = 0.91）, where Ys is the seed yield of pea （kg/ha） and ET is evapotranspiration for the growing season （mm）. The relative consumptive water demand curve is represented by the following third order polynomial function that describes the relationship between time and relative ET for a pea growing season of 120 days： ETrelx = 0.09419646 - 0.01302413x ＋ 0.00059008x2 - 0.00000371x3. ETrelz denotes relative ET and x denotes time in days. A workable balance between practical problem solving and advanced irrigation science has been established with BEWAB＋. Pre-plant irrigation schedules can be made for semi-arid areas with the BEWAB＋ programme using easily obtainable inputs, like target yield, soil depth and soil particle size distribution information.

Screening and functional evaluation of the glucose-lowering active compounds of total saponins of Baibiandou(Lablab Semen Album)

Objective To screen forα-glucosidase inhibitor active compounds in the total saponins of Baibiandou(Lablab Semen Album)based on UHPLC-Q-Exactive Orbitrap MS technology and to evaluate its hypoglycemic activity in vivo.Methods Acarbose was used as the positive control,and the median inhibitory concentration(IC50)was used as the evaluation index ofα-glucosidase inhibitory activity to establish an in vitroα-glucosidase inhibition model.Further,UHPLC-Q-Exactive Orbitrap MS technology was used to screen and identify the active compounds ofα-glucosidase inhibitors in the total saponins of Baibiandou(Lablab Semen Album)in order to further verify the activity of the main active monomer and to perform homologous modeling and molecular docking of yeast-derivedα-glucosidase and human-derivedα-glucosidase,while the hypoglycemic activity was evaluated in diabetic mice.Results This study successfully identified 15 compounds with potentialα-glucosidase inhibitory activity,including Chikusetsusaponin IVa,from the total saponins of Baibiandou(Lablab Semen Album).Simultaneously,we verified the activity of the main active monomer Chikusetsusaponin IVa,and showed that it has strongα-glucosidase inhibitory activity.Theα-glucosidase inhibitory concentration IC50 was(565.2±1.026)μg/m L,and the IC50 of acarbose,which was lower than the positive control,was(706.6±1.058)μg/m L.The docking energies of Chikusetsusaponin IVa were–6.1 and–7.7 kcal/mol with yeast-derivedα-glucosidase and human-derivedα-glucosidase molecules,respectively.Both showed strong binding activity,and the levels of alanine aminotransaminase(ALT),aspartate aminotransaminase(AST),UREA,Creatinine(CREA),and cholesterol(CHO)were significantly decreased by Chikusetsusaponin IVa(P<0.05).In addition,it could repair damaged liver and pancreas cells of diabetic mice to some extent.Conclusion This study provides a basis for screeningα-glucosidase inhibitors and structural modifications of the total saponins of Baibiandou(Lablab Semen Album).