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后囊膜混浊相关分子调控通路研究进展 被引量:3
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作者 刘婷婷 包秀丽 《眼科新进展》 CAS 北大核心 2018年第6期592-596,共5页
白内障手术是目前世界上最常见、最成熟的眼科手术之一。手术包括摘除混浊的晶状体及人工晶状体的植入,可以较好地恢复患者视力。后囊膜混浊(posterior capsular opacification,PCO),又称继发性白内障,是白内障手术后常见的并发症之一,... 白内障手术是目前世界上最常见、最成熟的眼科手术之一。手术包括摘除混浊的晶状体及人工晶状体的植入,可以较好地恢复患者视力。后囊膜混浊(posterior capsular opacification,PCO),又称继发性白内障,是白内障手术后常见的并发症之一,严重影响了手术的治疗效果。在白内障手术后2~5 a,由PCO导致的视力下降患者占20%~40%。PCO是一种纤维变性疾病。研究PCO的发生机制已经成为一项重要的医学课题。目前证实手术后晶状体赤道部及前囊下残余的晶状体上皮细胞通过增殖、迁移、上皮间质转化成为成纤维细胞和肌成纤维细胞,伴随细胞外基质的合成最终导致了PCO的发生。一系列生长因子及信号通路参与到PCO的形成和发展过程并发挥了关键作用。本文对与PCO发生相关的分子调控通路的最新知识进行了总结,并探讨了干扰PCO发生的可能途径。 展开更多
关键词 白内障 后囊膜混浊 分子调控通路
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Regulation of innate receptor pathways by microRNAs 被引量:4
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作者 ZHANG Yue LI YingKe 《Science China(Life Sciences)》 SCIE CAS 2013年第1期13-18,共6页
The innate immune response provides the initial defense against infection. This is accomplished by families of pattern recognition receptors (PRRs) that bind to conserved molecules in bacteria, fungi and viruses. PRRs... The innate immune response provides the initial defense against infection. This is accomplished by families of pattern recognition receptors (PRRs) that bind to conserved molecules in bacteria, fungi and viruses. PRRs are finely regulated by elaborate mechanisms to ensure a beneficial outcome in response to foreign invaders. MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs that are emerging as important regulators in immune responses at the post-transcriptional level, through the inhibition of translation, or by inducing mRNA degradation. It has been shown that miRNAs have unique expression profiles in cells of the innate immune systems and play pivotal roles in regulating the signal pathways of innate receptors, including Toll-like receptors, RIG-I-like receptors and Nod-like receptors. We have summarized the recent literature providing new insights into the regulation of innate receptor pathways by miRNAs. 展开更多
关键词 innate receptor MICRORNA immune regulation
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Emerging roles of NudC family: from molecular regulation to clinical implications 被引量:5
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作者 Qiqin Fu Wei Wang +1 位作者 Tianhua Zhou Yuehong Yang 《Science China(Life Sciences)》 SCIE CAS CSCD 2016年第5期455-462,共8页
Nuclear distribution gene C (NudC) was first found in Aspergillus nidulans as an upstream regulator of NudF, whose mamma- lian homolog is Lissencephaly 1 (Lisl). NudC is conserved from fungi to mammals. Vertebrate... Nuclear distribution gene C (NudC) was first found in Aspergillus nidulans as an upstream regulator of NudF, whose mamma- lian homolog is Lissencephaly 1 (Lisl). NudC is conserved from fungi to mammals. Vertebrate NudC has three homologs: NudC, NudC-like protein (NudCL), and NudC-like protein 2 (NudCL2). All members of the NudC family share a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of heat shock protein 90 (Hsp90). Our group and the others found that NudC homologs were involved in cell cycle regulation by stabilizing the components of the LIS l/dynein complex. Additionally, NudC plays important roles in cell migration, ciliogenesis, thrombopoiesis, and the in- flammatory response. It has been reported that NudCL is essential for the stability of the dynein intermediate chain and cilio- genesis via its interaction with the dynein 2 complex. Our data showed that NudCL2 regulates the LISl/dynein pathway by stabilizing LIS 1 with Hsp90 chaperone. The fourth distantly related member of the NudC family, CML66, a tumor-associated antigen in human leukemia, contains a p23 domain and appears to promote oncogenesis by regulating the IGF-1R-MAPK sig- naling pathway. In this review, we summarize our current knowledge of the NudC family and highlight its potential clinical relevance. 展开更多
关键词 nuclear distribution gene C heat shock protein 90 p23 DYNEIN Lissencephaly 1 cell cycle CILIOGENESIS
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