基于两级分成机制的物流委托代理问题研究

根据委托代理理论,利用分成机制将物流需求和供应双方之间的委托代理关系模型化,在非对称信息下,分析了委托代理双方在分成机制下各自的努力程度。借鉴存储论中的价格有折扣的模型问题,提出了一种两级分成机制模型,分析了在此机制下物流委托代理双方各自的努力程度,并且比较了两种模式下双方各自的努力程度、效益大小以及全局效益,以推动双方向着全局最优的方向努力。

环境保护税的负担变化和分成机制研究——基于山东省企业排污收费数据的测算

本文从微观角度出发,以2015年山东省微观企业排污收费数据为依据,对比排污费的收费标准和《中华人民共和国环境保护税法》征税标准,得出:费改税后,固体废弃物整体税负平移,水污染以及大气污染整体税负大幅提升,噪声污染税负分等级下降,山东省整体环境保护税收入相比排污费收入有所提高。进一步分析认为,环境保护税的分成机制要分长期和过渡期区别对待:从理论上来看,针对不同的污染物征税应该有不同的划分:水污染征税、大气污染征税应划分为中央地方共享税,而对噪声污染和固体废弃物污染征税划分为地方税;但短期从规模限制和地方激励而言,环境保护税在推出伊始规模有限,适宜留置地方所有,由地方来征收管理。

财政压力、税收转移与增值税分成机制分析

受原产地原则影响,增值税征税过程中低消费可能转移至接收地。本文主要研究财政压力、税收转移和增值税分成,在现行征收方式下,我国增值税财政压力高的地区不断向压力低的地区转移,形成马太效应。社会支出存在负强化问题,财政独立存在正强化问题协调演变。

财政压力、税收转移与增值税分成机制探索

在生产地原则下,增值税税收存在由消费地向征收地转移的现象。本文采用空间动态面板模型,从人口负担、社会性支出负担和财政自给率三个角度对财政压力与增值税税收转移的关系进行检验。研究表明,在现有征收模式下,我国增值税税收由财政压力大的地区向财政压力相对较小的地区转移,形成了税收收入的"马太效应"。其中,社会性支出负担对税收转入存在负向强化,财政自给率对税收转入存在正向强化。进一步研究发现,以人口为分成基数的方案不仅更符合流转税在流通中征收的性质、更符合税收"中性"的要求,也更有利于地区间财政压力的分担和区域的协调发展。

Integrative analysis of bone-formation associated genes and immune cell infiltration in osteoporosis, and the prediction of active ingredients in targeted traditional Chinese medicine

Objective To explore the differential expression and mechanisms of bone formation-related genes in osteoporosis(OP)leveraging bioinformatics and machine learning methodologies;and to predict the active ingredients of targeted traditional Chinese medicine(TCM)herbs.Methods The Gene Expression Omnibus(GEO)and GeneCards databases were employed to conduct a comprehensive screening of genes and disease-associated loci pertinent to the pathogenesis of OP.The R package was utilized as the analytical tool for the identification of differentially expressed genes.Least absolute shrinkage and selection operator(LASSO)logis-tic regression analysis and support vector machine-recursive feature elimination(SVM-RFE)algorithm were employed in defining the genetic signature specific to OP.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses for the selected pivotal genes were conducted.The cell-type identification by estimating rela-tive subsets of RNA transcripts(CIBERSORT)algorithm was leveraged to examine the infiltra-tion patterns of immune cells;with Spearman’s rank correlation analysis utilized to assess the relationship between the expression levels of the genes and the presence of immune cells.Coremine Medical Database was used to screen out potential TCM herbs for the treatment of OP.Comparative Toxicogenomics Database(CTD)was employed for forecasting the TCM ac-tive ingredients targeting the key genes.AutoDock Vina 1.2.2 and GROMACS 2020 softwares were employed to conclude analysis results;facilitating the exploration of binding affinity and conformational dynamics between the TCM active ingredients and their biological targets.Results Ten genes were identified by intersecting the results from the GEO and GeneCards databases.Through the application of LASSO regression and SVM-RFE algorithm;four piv-otal genes were selected:coat protein(CP);kallikrein 3(KLK3);polymeraseγ(POLG);and transient receptor potential vanilloid 4(TRPV4).GO and KEGG pathway enrichment analy-ses revealed that these trait genes were predominantly engaged in the regulation of defense response activation;maintenance of cellular metal ion balance;and the production of chemokine ligand 5.These genes were notably associated with signaling pathways such as ferroptosis;porphyrin metabolism;and base excision repair.Immune infiltration analysis showed that key genes were highly correlated with immune cells.Macrophage M0;M1;M2;and resting dendritic cell were significantly different between groups;and there were signifi-cant differences between different groups(P<0.05).The interaction counts of resveratrol;curcumin;and quercetin with KLK3 were 7;3;and 2;respectively.It shows that the interac-tions of resveratrol;curcumin;and quercetin with KLK3 were substantial.Molecular docking and molecular dynamics simulations further confirmed the robust binding affinity of these bioactive compounds to the target genes.Conclusion Pivotal genes including CP;KLK3;POLG;and TRPV4;exhibited commendable significant prognostic value;and played a crucial role in the diagnostic assessment of OP.Resveratrol;curcumin;and quercetin;natural compounds found in TCM;showed promise in their potential to effectively modulate the bone-forming gene KLK3.This study provides a sci-entific basis for the interpretation of the pathogenesis of OP and the development of clinical drugs.

LED节能灯零成本置换模式浅议

调研结果显示:我国LED节能灯普及率较低,主要障碍是其高昂的价格。LED节能灯零成本置换模式具备内生驱动机制,置换产生的现金流收益由节省电费与政府节能补贴构成,在合同期内置换公司和企业按约定比例分享可分配现金流,从而实现零成本置换与合作共赢。

Shape-controlled synthesis of novel precursor for fibrous Ni-Co alloy powders

A novel precursor of nickel-cobalt alloy powders with an appropriate Ni to Co molar ratio was prepared under selectively synthetic conditions. The composition and morphology of the precursor were characterized by X-ray diffractometry （XRD）, scanning electron microscopy （SEM）, Fourier transform infrared spectrometry （FT-IR） and energy dispersive spectrometry （EDS）. The effects of pH value, reaction temperature, metal ion concentrations and surfactant on the morphology and the dispersion of precursor were investigated. The results show that the morphology of precursor depends on ammonia content in the precursor. A fibriform precursor is a complicated ammonia-containing nickel-cobalt oxalate. The uniform shape-controlled fibrous precursor is obtained under the following optimum conditions： ammonia as complex agent as well as pH adjustor, oxalate as coprecipitator, 50-65 °C of reaction temperature, 0.5-0.8 mol/L of total concentration of Ni2＋ and Co2＋, PVP as dispersant, and pH 8.0-8.4.

Does Environmental Regulation Weaken Industrial Competitiveness?Inspirations from China’s Iron and Steel Sector

China＇s economic growth is heavily influenced by exports, while reconciling environmental regulation and economic growth requires handling the relationship between environmental regulation and industrial competitiveness well. The effects of environmental regulation on industrial competitiveness are largely subject to the institutional design of environmental regulation. Despite numerous studies on the relationship between environmental regulation and industrial competitiveness, a consensus has yet to be reached. Aside from differences in research methodology, these studies failed to give sufficient consideration to the impact of environmental regulation on industrial competitiveness. Such effects can be negative or positive depending on the design of environmental regulatory policy. This paper has investigated the relationship between environmental regulation and the competitiveness of China＇s iron and steel industry and discovered that tighter environmental regulation does not diminish the competitiveness of the iron and steel industry since the policy design of environmental regulation accommodates the tolerance of advanced production capacity and includes a reasonable cost sharing mechanism. This discovery is of important reference for China to develop rational policy design to balance the relationship between environmental regulation and industrial competitiveness.

The Kuroshio front to the east of Taiwan: seasonal feature, variability and mechanism

Oceanic front, especially Kuroshio front, is an important phenomenon that is of great significance for scientific research, national economy and military uses. However, Kuroshio front to the east of Taiwan （KFETW in brief） was rare investigated. In this study, reanalysis method is used to study the KFETW＇s temporal and spatial variability and frontogenesis mechanism. It is found that although surface thermal front to the east of Taiwan is not obvious, there is an all-year strong Kuroshio thermal front called KFETW under the surface. The KFETW is connected to the south section of Kuroshio front in the East China Sea （KFECS in brief） and distributes along the east coastline of Taiwan. The KFETW has multi-scale variation feature. It has significant seasonal signal, and its intensity and width reach their maximum in summer. By using the reanalysis results obtained from this study, frontogenesis and changing mechanisms of the KFETW are discussed. It is found that both the Kuroshio and up-welling to the east of Taiwan can affect this front, and the up-welling may be the predominant factor in KFETW＇s frontogenesis and maintenance mechanism.

Formation Mechanism and Binding Energy for Body-Centred Regular Icosahedral Structure of Li_(13) Cluster

The formation mechanism for the body-centred regular icosahedral structure of Li13 cluster is proposed. The curve of the total energy versus the separation R between the nucleus at the centre and nuclei at the apexes for this structure of Li13 has been calculated by using the method of Gou＇s modified arrangement channel quantum mechanics （MACQM）. The result shows that the curve has a minimal energy of-96.951 39 a.u. at R = 5.46ao. When R approaches to infinity, the total energy of thirteen lithium atoms has the value of-96.564 38 a.u. So the binding energy of Lii3 with respect to thirteen lithium atoms is 0.387 01 a.u. Therefore the binding energy per atom for Lii3 is 0.029 77 a.u. or 0.810 eV, which is greater than the binding energy per atom of 0.453 eV for Li2, 0.494 eV for Li3, 0.7878 eV for Li4. 0.632 eV for Lis, and 0.674 eV for Liv calculated by us previously. This means that the Li13 cluster may be formed stably in a body-centred regular icosahedral structure with a greater binding energy.

Atrial fibrosis： an obligatory component of arrhythmia mechanisms in atrial fibrillation？

Advances in clinical and fimdamental research, which have been promoted over last decades have led to a well- established understanding of atrial fibrillation （AF） as an epiphenomenon that despite similar manifestations may have different underlying mechanisms and thus require in- dividualized treatments. With rare exceptions of AF caused by mutations in genes coding ion channels in pa- tients with structurally normal atria, fibrotic replacement of atrial myocardium remains the comer stone of atrial pa- thology in patients with AF.

A novel chloroplast-localized protein EMB1303 is required for chloroplast development in Arabidopsis

To understand the molecular mechanisms underlying chloroplast development, we isolated and characterized the albino mutant emb1303-1 in Arabidopsis. The mutant displayed a severe dwarf phenotype with small albino rosette leaves and short roots on a synthetic medium containing sucrose. It is pigment-deficient and seedling lethal when grown in soil. Embryo development was delayed in the mutant, although seed germination was not significantly impaired. The plastids of embl303-1 were arrested in early developmental stages without the classical stack of thylakoid membrane. Genetic and molecular analyses uncovered that the EMB1303 gene encodes a novel chloroplast-localized protein. Microarray and RT-PCR analyses revealed that a number of nuclear- and plastid-encoded genes involved in photosynthesis and chloroplast biogenesis were substantially downregulated in the mutant. Moreover, the accumulation of several major chloroplast proteins was severely compromised in emb1303-1. These results suggest that EMB1303 is essential for chloroplast development.

The Mechanism of the Acclimation of Nannochloropsis oceanica to Freshwater Deduced from Its Transcriptome Profiles

In this study, we compared the transcriptomes of Nannochloropsis oceanica cultured in f/2 medium prepared with seawater and freshwater, respectively, aiming to understand the acclimation mechanism of this alga to freshwater. Differentially expressed genes were mainly assigned to the degradation of cell components, ion transportation, and ribosomal biogenesis. These find- ings indicate that the algal cells degrade its components （mainly amino acids and fatty acids） to yield excessive energy （ATP） to maintain cellular ion （mainly K＋ and Ca〉） homeostasis, while the depletion of amino acids and ATP, and the reduction of ribosomes attenuate the protein translation and finally slow down the cell growth.

Atrial fibrosis： an obligatory component of arrhythmia mechanisms in atrial fibrillation？

Atrial fibrosis is common in atrial fibrillation （AF）. Experimental studies have provided convincing evidence that fibrotic transformation of atrial myocardium results in deterioration of atrial conduction, increasing anisotropy of impulse propagation and building of boundaries that promote re-entry in the atrial walls that maybe directly relevant for the mechanisms responsible for maintaining AF. Whether or not fibrosis is a result of structural remodelling caused by persistent AF or a manifestation of occult myocardial process that leads to development of arrhythmia is less clear. Human data indicate the presence of association between persistency of AF and the extent of structural changes in atrial myocardium. The role atrial fibrosis plays in the mechanisms of AF, however, may differ between patients with structurally normal hearts, such as lone AF, and those with advanced cardiovascular comorbidities.

Role and Mechanism of Functional Components in Promoters for Enhancing FCC Propylene Yield

Phosphorus （P） and metal （M） components were incorporated into promoters for enhancing FCC propylene yield, and the reactive behavior of promoters, before and after modification, were investigated. The results showed that both LPG and propylene yields were increased, and propylene selectivity was improved after the incorporation of P or M into the matrix, resulting in an increased C3 to C4 ratio in LPG during FCC process. But the sole incorporation of M into the matrix also led to an increase in coke and H2 yields on the other hand. Simultaneous modification of the matrix by P and M components resulted in more enhancement in propylene yield and selectivity along with little influence on FCC product distribution. Physico-chemical characterizations and model compound reactions were used to assist in analyzing the mechanism for improving propylene selectivity. Two types of active centers could strengthen the oligomerization of C4 olefins in LPG and these oligomers could be further cracked into C3 olefins on ZSM-5 zeolite, therefore maximizing the ratio of C3 to C4 in liquefied petroleum gas obtained during FCC process.

Ab initio Study of Radical-Molecule Reaction： F＋CH2CHCH3

The radical-molecule reaction F＋propene （CH2CHCH3） was studied in detail by using the Becke＇s three parameter Lee-Yang-Parr-B3LYP/6-311G（d,p） and coupled cluster with single, double, and triple excitationsCCSD（T）/6-311＋G（2d,2p）. It is shown that F＋propene reaction mainly occurs through complex-formation mechanism： F attacks the double bond of propene leading to the formation of complex 1 and complex 2. As the two radical complexes are metastable, they can quickly dissociate to H＋C3HsF, CH3＋C2H3F and HF＋C3H5. Based on the ab initio calculations, the CH3＋C2H3F is the main channel, and the H elimination and HF forming channels also provide some contribution to products. The calculated values are in good agreement with the recently reported experimental results.

The research on the thermal destruction of environment and controlling techniques of the No.4 outcrops fire in Haibaoqing

The coal fire is one of very serious disasters in natural, not only amount of coal resources was burned and some ecological environment problems such as ground subsidence, acid rain, pollution and vegetation died were caused serious. The No.4 coal seam outcrops fire in Haibaoqing was take as research object, based on the existing theory of mechanism and characteristics of coal outcrop fires, a new fire-fighting composite gel is applicated which fits in with extinguishment of outcrop coal fires well. The technology has many advantages in extinguishing coal fires including isolating the coal from oxygen and lowering the temperature of the high-temperature coal and rock. The structure and chemical composition as well as fires-fighting properties of the composite gel is analyzed profoundly, as a result, reduce and stop the environment destruction caused by the coal fire.

Amino Acid and Fatty Acid Profile in Epidermal Mucus of Bluestreak Cleaner Wrasse （Labroides dimidiatus）： Possible Role as Defense Mechanism against Pathogens

Labroides dimidiatus has been proven to remove ectoparasites and monogeneans from client fishes and studies showed that they were not infected with the parasite. Due to this, there is a possibility that a defense mechanism against pathogen and parasitic invasion exist in the epidermal mucus which serves as a mechanical as well as biochemical barrier. The study was performed to identify the amino acid and fatty acid components using GC （gas chromatography） and HPLC （high performance liquid chromatography） in epidermal mucus ofL. dimidiatus. The present study revealed 16 components of amino acid and 22 types of fatty acid in epidermal mucus ofL. dimidiatzts. Linoleic acid （C18：2n6c） was the most prominent PUFA （polyunsaturated fatty acid） which contributed approximately 11.69% of total fatty acids. The other major fatty acids are palmitic acid （C 16：0）, oleic acid （C 18： l n9c）, linoledaidic acid （C18：2n6t）, arachidic acid （C20：0）, Gamma-Linoleic acid （C18：3n6） and gadoleic acid （C20：1） which contained reasonable amounts of 9.52%, 8.06%, 6.26%, 8.33%, 6.21% and 9.05% of total fatty acids, respectively. This present study also demonstrated the presence of various amino acids in skin extract. Glycine, glutamine, arginine, asparagin and alanine were found at high concentration of 8.09%, 6.95%, 5.73%, 4.74%, 4.58% respectively. The most abundance percentage of linoleic acid （C18：2n6c） was found to be the metabolic precursor of arachidonic acid （AA） which inducing platelet aggregation, facilitate the blood clotting process and adhesion in endothelial cells during wound healing and might be responsible for rapid tissue growth in L. dimidiatus. It can be concluded that the amino acid and fatty acid profile from the epidermal mucus ofL. dimidiatus contains most of the essential components required to play a possible role in its defense mechanism. Understanding the biochemical properties of L. dimidiatus epidermal mucus in defense mechanism would enable to determine how this fish protect itself from parasitic infection.

Viral exploitation of actin: force-generation and scaffolding functions in viral infection

As a fundamental component of the host cellular cytoskeleton, actin is routinely engaged by infecting viruses. Furthermore, viruses from diverse groups, and infecting diverse hosts, have convergently evolved an array of mechanisms for manipulating the actin cytoskeleton for efficacious infection. An ongoing chorus of research now indicates that the actin cytoskeleton is critical for viral replication at many stages of the viral life cycle, including binding, entry, nuclear localization, genomic transcription and reverse transcription, assembly, and egress/dissemination. Specifically, viruses subvert the force-generating and macromolecular scaffolding properties of the actin cytoskeleton to propel viral surfing, internalization, and migration within the cell. Additionally, viruses utilize the actin cytoskeleton to support and organize assembly sites, and eject budding virions for cell-to-cell transmission. It is the purpose of this review to provide an overview of current research, focusing on the various mechanisms and themes of virus-mediated actin modulation described therein.

Social Myths： A New Approach

Nowadays, the study of myths is rather neglected as a field of research in sociology. There is a void that this paper would like to contribute to filling. It outlines a theoretical and empirical sociological approach to social myths as a major component of collective imaginaries and a universal sociological mechanism through time and space. The article recalls the major functions performed by myths in every society （modem as well as ＂primitive＂）, introduces new concepts, and sets forth an analytical framework designed to account for the emergence, the reproduction, and the decline of myths, as sacralised collective representations.