Oil–water two-phase flow patterns in a horizontal pipe are analyzed with a 16-electrode electrical resistance tomography(ERT) system. The measurement data of the ERT are treated as a multivariate time-series, thus th...Oil–water two-phase flow patterns in a horizontal pipe are analyzed with a 16-electrode electrical resistance tomography(ERT) system. The measurement data of the ERT are treated as a multivariate time-series, thus the information extracted from each electrode represents the local phase distribution and fraction change at that location. The multivariate maximum Lyapunov exponent(MMLE) is extracted from the 16-dimension time-series to demonstrate the change of flow pattern versus the superficial velocity ratio of oil to water. The correlation dimension of the multivariate time-series is further introduced to jointly characterize and finally separate the flow patterns with MMLE. The change of flow patterns with superficial oil velocity at different water superficial velocities is studied with MMLE and correlation dimension, respectively, and the flow pattern transition can also be characterized with these two features. The proposed MMLE and correlation dimension map could effectively separate the flow patterns, thus is an effective tool for flow pattern identification and transition analysis.展开更多
We present a time-resolved two-photon excitation fluorescence spectroscopy and a simultaneous time- and spectrum- resolved multifocal multiphoton microscopy system that is based on a high repetition rate picosecond st...We present a time-resolved two-photon excitation fluorescence spectroscopy and a simultaneous time- and spectrum- resolved multifocal multiphoton microscopy system that is based on a high repetition rate picosecond streak camera for providing time- and spectrum- resolved measurement and imaging in biomedicine. The performance of the system is tested and characterized by the fluorescence spectrum and lifetime analysis of several standard fluorescent dyes and their mixtures. Spectrum-resolved fluorescence lifetime images of fluorescence beads are obtained. Potential applications of the system include clinical diagnostics and cell biology etc.展开更多
A framework is proposed to characterize and forecast the displacement trends of slow-moving landslides, defined as the reactivation stage of phenomena in rocks or fine-grained soils, with movements localized along one...A framework is proposed to characterize and forecast the displacement trends of slow-moving landslides, defined as the reactivation stage of phenomena in rocks or fine-grained soils, with movements localized along one or several existing shear surfaces. The framework is developed based on a thorough analysis of the scientific literature and with reference to significant reported case studies for which a consistent dataset of continuous displacement measurements is available. Three distinct trends of movement are defined to characterize the kinematic behavior of the active stages of slow-moving landslides in a velocity-time plot: a linear trend-type I, which is appropriate for stationary phenomena; a convex shaped trend-type II, which is associated with rapid increases in pore water pressure due to rainfall, followed by a slow decrease in the groundwater level with time; and a concave shaped trend-type III, which denotes a non-stationary process related to the presence of new boundary conditions such as those associated with the development of a newly formed local slip surface that connects with the main existing slip surface. Within the proposed framework, a model is developed to forecast future displacements for active stages of trend-type II based on displacement measurements at the beginning of the stage. The proposed model is validated by application to two case studies.展开更多
AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Coliti...AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.展开更多
基金Projects(61227006,61473206) supported by the National Natural Science Foundation of ChinaProject(13TXSYJC40200) supported by Science and Technology Innovation of Tianjin,China
文摘Oil–water two-phase flow patterns in a horizontal pipe are analyzed with a 16-electrode electrical resistance tomography(ERT) system. The measurement data of the ERT are treated as a multivariate time-series, thus the information extracted from each electrode represents the local phase distribution and fraction change at that location. The multivariate maximum Lyapunov exponent(MMLE) is extracted from the 16-dimension time-series to demonstrate the change of flow pattern versus the superficial velocity ratio of oil to water. The correlation dimension of the multivariate time-series is further introduced to jointly characterize and finally separate the flow patterns with MMLE. The change of flow patterns with superficial oil velocity at different water superficial velocities is studied with MMLE and correlation dimension, respectively, and the flow pattern transition can also be characterized with these two features. The proposed MMLE and correlation dimension map could effectively separate the flow patterns, thus is an effective tool for flow pattern identification and transition analysis.
基金This work was supported by the National Natural Science Foun-dation of China (60627003, 60408011)Guangdong Natural Science Foundation (5010500)was also supported in part by Shenzhen Sci & Tech Program (200516).
文摘We present a time-resolved two-photon excitation fluorescence spectroscopy and a simultaneous time- and spectrum- resolved multifocal multiphoton microscopy system that is based on a high repetition rate picosecond streak camera for providing time- and spectrum- resolved measurement and imaging in biomedicine. The performance of the system is tested and characterized by the fluorescence spectrum and lifetime analysis of several standard fluorescent dyes and their mixtures. Spectrum-resolved fluorescence lifetime images of fluorescence beads are obtained. Potential applications of the system include clinical diagnostics and cell biology etc.
基金partially supported by the University of Salerno (Italy) through the Civil and Environmental Engineering Ph.D. programme and FARB research funding
文摘A framework is proposed to characterize and forecast the displacement trends of slow-moving landslides, defined as the reactivation stage of phenomena in rocks or fine-grained soils, with movements localized along one or several existing shear surfaces. The framework is developed based on a thorough analysis of the scientific literature and with reference to significant reported case studies for which a consistent dataset of continuous displacement measurements is available. Three distinct trends of movement are defined to characterize the kinematic behavior of the active stages of slow-moving landslides in a velocity-time plot: a linear trend-type I, which is appropriate for stationary phenomena; a convex shaped trend-type II, which is associated with rapid increases in pore water pressure due to rainfall, followed by a slow decrease in the groundwater level with time; and a concave shaped trend-type III, which denotes a non-stationary process related to the presence of new boundary conditions such as those associated with the development of a newly formed local slip surface that connects with the main existing slip surface. Within the proposed framework, a model is developed to forecast future displacements for active stages of trend-type II based on displacement measurements at the beginning of the stage. The proposed model is validated by application to two case studies.
基金Supported by Danish Innovation Law Grant,J.nr.3414-06-01530from the Danish Food Industry Agency under the Ministry of Food,Agriculture and FisheriesNordisk Rebalance,who developed and manufactured Profermin,and partly financed the study
文摘AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.