从文献类型比较论加强临床医学科研信息服务

目的分析地方临床医学科研文章的文献类型,了解其现状以便有效做好医学信息服务工作。方法从2006—2015年数据库CBM本地版收录的桂林、柳州和南宁等三城市的临床医学18778篇文章整理分析入手。按分析性文章、描述性文章及其他文章逐一分门别类,计数统计及分组进行?2检验。结果本地临床医学研究文章以分析性文章为主,约占68%。(?2=22.7,P<0.01),分析性文章中以临床试验占多(?2=10.2,P<0.01)。描述性文章以综述为多(?2=6.7,P<0.01);其他文献的数量差别无显著性意义(?2=1.4,P>0.05)。结论分析临床科研文献类型可较客观了解本地临床科研成果的体现形式,掌握和分析各类文献的特点,可更有效地做好科技查新工作。

皮试阴性的头孢曲松不良反应文献分析

目的：分析皮试阴后使用头孢曲松而发生不良反应的特点，为临床安全合理用药提供参考。方法：对1998―2015年检索中国生物医学文献数据库、中国期刊全文数据库及万方医学网中报道的头孢曲松皮试阴性的不良反应病例进行统计分析。结果：共收集到45例不良反应报告，大部分发生在开始用药后5~10 min以及连续用药后〉24 h，以呼吸系统（31.54%）、皮肤及附件（19.46%）和心血管系统（18.79%）损害表现为主。结论：头孢曲松的使用和皮试需进一步规范；即使皮试结果为阴性，在使用时仍应做到严密监护，以保证用药安全。

耳穴疗法治疗原发性失眠的现代文献研究

Objective By sorting and analyzing pertinent modern studies targeting auricular point therapy treating primary insomnia(PI),to summarize the point selection rules and clinical efficacy of using auricular points alone or combining it with other therapies in treating PI.Methods A search on China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),PubMed,Springer and Ovid were conducted from January 1,1998 till January 31,2020.Point selection,diagnostic criteria and Pittsburgh sleep quality index(PSQI)in the eligible studies were analyzed and summarized.Results The difference in PSQI before and after using auricular point therapy alone was more significant than that of using Chinese medication alone(P<0.05),but less significant than that of combining auricular point therapy and acupuncture-moxibustion and Chinese therapeutic massage(tuina)(P<0.05).In the included studies,Shenmen(TF_(4))was the most commonly used(370 times),followed by Heart(CO_(15)),which was 344 times,and Subcortex(AT_(4)),which was 325 times.In terms of auricular points distribution,points in the auricular concha were the most commonly used(1500 times),followed by those in the antitragus(474 times)and triangular fossa(387 times).Correlation analysis showed that Shenmen(TF_(4))and Liver(CO_(12)),Sympathetic(AH6a)and Heart(CO_(15))were used together more often,followed by Shenmen(TF_(4)),Liver(CO_(12)),Spleen(CO_(13)),Kidney(CO_(10))and Subcortex(AT_(4)),and then Shenmen(TF_(4)),Liver(CO_(12)),Sympathetic(AH6a),Subcortex(AT_(4))and Heart(CO_(15)).Cluster analysis showed that the auricular points used for PI can be divided into 6 clusters in 2 major groups.One group was Heart(CO_(15)),Subcortex(AT_(4)),Shenmen(TF_(4)),Sympathetic(AH6a),Spleen(CO_(13)),Kidney(CO_(10)),Liver(CO_(12))and Endocrine(CO_(18));the other was Occiput(AT3),Stomach(CO_(4)),Pancrease-gallbladder(CO_(11)),Chuiqian(LO_(4)),Small Intestine(CO_(6)),Central Rim(AT_(2,3,4i))and Sanjiao(CO_(17)).In terms of patterns in traditional Chinese medicine,the pattern of dual deficiency of heart and spleen accounted for the largest proportion in the studies of using auricular points alone or combining it with other treatments to treatment PI,and then it was the pattern of liver depression transforming into fire.Conclusion In treatment of PI with auricular points alone or combo therapy involving auricular points,Shenmen(TF_(4))was commonly used,and the commonly used point group consisted of Shenmen(TF_(4)),Liver(CO_(12)),Sympathetic(AH_(6a))and Heart(CO_(15)).Auricular point therapy can be taken as a complementary therapy in treating PI.

Gynura root induces hepatic veno-occlusive disease:A case report and review of the literature

Gynura root has been used extensively in Chinese folk medicine and plays a role in promoting microcirculation and relieving pain.However,its hepatic toxicity should not be neglected.Recently,we admitted a 62-year old female who developed hepatic veno-occlusive disease(HVOD)after ingestion of Gynura root.Only a few articles on HVOD induced by Gynura root have been reported in the literature.It is suspected that pyrrolizidine alkaloids in Gynura root might be responsible for HVOD.In this paper,we report a case of HVOD and review the literature.

Analysis on the principles of differentiation and prescription of traditional Chinese medicine in the treatment of cancerous fever

To investigate the principles of differentiation and prescription of traditional Chinese medicine(TCM)treatment for cancerous fever by logistic stepwise regression and literature investigation,the following databases were searched(from inception to June 30th 2016):CNKI,CSPD,CBM,PubMed,MEDLINE,EMBASE.According to the inclusion and exclusion criteria,literatures about TCM in the treatment of cancerous fever were screened.The frequency about cancerous fever of differential syndrome types,formulas and herbs were analyzed by logistic multiple regression analysis.The model about syndrome types and formula application of cancerous fever was established.The result showed formula prescriptions used most frequently were Qing-Hao-Bie-Jia decoction,Xiao-Chai-Hu decoction,Xue-Fu-Zhu-Yu decoction,Bai-Hu decoction,San-Ren decoction.The main syndrome types of cancerous fever were as follows:Toxic heat flourishing type,Yin deficiency type,Stagnation of damp-heat type,Qi-Yin deficiency type,Liver meridian depressed-heat type,Blood stasis type and Yang deficiency type.Based on regression equation of the syndrome types,the corresponding herbs of this seven syndrome types were Radix Bupleuri,Radix Paeoniae Alba and Scutellaria Baicalensis Georgi;Radix Bupleuri and Cortex Moutan;Radix Paeoniae Rubra and Radix Angelicae Sinensis;Rhizoma Pinelliae,Cortex Lycii Radicis and Radix Paeoniae Alba;Herba Artemisiae Annuae,Gypsum Fibrosum and Poria Cocos;Rhizoma Anemarrhenae,Scutellaria Baicalensis Georgi and Radix Codonopsis;Radix Bupleuri respectively.The results of Logistic regression analysis and frequency of herbs statistics can provide reference for differentiation and treatment of cancerous fever in clinical.

Meta-analysis on integrative medicine for the treatment of malignant ascites: a comparative study

OBJECTIVE: To compare the efficacy of integrated Chinese and Western Medicine with that of only Western Medicine for the treatment of malignant ascites.METHODS: All randomized controlled trials(January 2004 to March 2013) from the China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, and Wanfang Database were searched with keywords. Meta-analysis was conducted by combining the odds ratios of the individual studies. Review Manager 5.0 was used for the analysis.RESULTS: One thousand one hundred and fifty-six patients from 19 randomized controlled trails were included. Of them, 630 patients were treated with integrated Chinese and Western Medicine(the integrative group), and 526 patients were treated with Western Medicine alone(the control group). The Meta-analysis showed that the total effective rate was 78.73% in the integrated group, and 59.13% in the control group. The effective percentage was sig-nificantly higher in the integrative group than that of the control group [OR = 2.85, 95% CI(2.16,3.74),P < 0.01].CONCLUSION: The short-term curative effect in the integrative group was better than that in the control group. Integrative medicine may be beneficial for malignant ascites.