Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets ...Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets of the TCM were retrieved using the systematic pharmacological analysis platform TCMSP,and the gene name of each target protein was obtained from the UniProtKB network platform.The targets of RA were queried through the CTD database.The protein–protein interaction network was constructed in the STRING database,and the network visualization analysis was performed in Cytoscape.The Gene Ontology and Kyoto Gene and Genomic Encyclopedia pathways enrichment analyses of key target proteins were performed using the DAVID data platform.Results:A total of 472 drug active ingredients were screened from the TCMSP database.Seventy-five disease targets from the CTD database were screened.The compound-target network map contained further screened out 98 components and corresponding 75 targets.The key compounds included quercetin and kaempferol.The key targets were prostaglandin G/H synthase 2 and nitric oxide synthase 2.The protein-protein interaction network consisted of 75 proteins,of which 37 were key proteins,including tumor protein 53,JUN and interleukin-6.There were 260 Gene Ontology entries,of which 246 were biological processes.Fifty-five Kyoto Gene and Genomic Encyclopedia pathways were enriched,mainly the cancer pathway,NOD-like receptor signaling pathway,and Toll-like receptor signaling pathway,which are involved in the action mechanism of FHD.Conclusion:The results of this study preliminarily verified the basic pharmacological action mechanism of FHD in the treatment of RA,laying a foundation for elucidating its mechanism of action.展开更多
Most commentators use the term ＂modern philosophy＂ for the post-Descartes era--an era of unprecedented growth for the modern sciences and, especially the empirical sciences. Even assuming that the feud between the r...Most commentators use the term ＂modern philosophy＂ for the post-Descartes era--an era of unprecedented growth for the modern sciences and, especially the empirical sciences. Even assuming that the feud between the rationalists and the empiricists during this period yielded no other benefits, it was beneficial enough to turn ＂experience＂ into an important pillar of the acquisition of knowledge in the subsequent philosophy. It was this ＂experience-mindedness＂ that drove away the Aristotelian ＂essentialist＂ perspective and replaced it with ＂nominalism.＂ By describing the genesis and emergence of the ＂nominalist-empirical＂ perspective in analytic philosophy as one of the branches of the human sciences, this article strives to advance the claim that philosophical thinking continues to flourish in the absence of ＂realist thinking about universals＂ and that philosophizing does not fundamentally rest on universals.展开更多
Plato＇s lifelong confrontation with Parmenides and his metaphysical mire of believing that nothing （το μη ǒν） does not actually exist, gradually in the Sophist comes into finish, insofar as the philosopher a...Plato＇s lifelong confrontation with Parmenides and his metaphysical mire of believing that nothing （το μη ǒν） does not actually exist, gradually in the Sophist comes into finish, insofar as the philosopher after facing the foe and having the last laugh simmers down. In this paper after giving an interpretation of what Parmenides says, I shall present an analysis of Plato＇s drastic answer to him （Sophist, 259 e4-6） to see how Plato opens the impasse way created by the Eleatic philosopher. Here the intercommunion of Forms is regarded as the final answer by which Plato devastates Parmenides infamous thesis. Since hitherto no in-depth analysis is given by the scholars who are puzzled with the subject, I have tried to analyze the intercommunion of Forms philosophically. Plato＇s Eleatic challenge has always been crucial in Plato himself and philosophical development after him. As while as Parmenides thesis （Sph., 238 a8-9） provides the sophists opportunity to reject the falsehood, Plato＇s theory of Forms in contrast in order to cross off the extremely sly sophists tries to make Parmenides come down. In my opinion, the intercommunion of Forms, as the last step of the theory of Forms, basically determines Plato＇s late ontology tightly knitted with logic. Vindicating this proposal depends on true understanding of the intercommunion of Forms. Since Plato＇s late ontology, in my opinion, is closed to Frege＇s ontology and discussion of language, we are armed to interpret the intercommunion of Forms with recent recent logico-philosophicus achievements, I think. In this respect, this is what I have done in my paper： analyzing sentence from Plato＇s logico-metaphysical point of view. Ultimately, I have tried to show how the aim of the intercommunion of Forms, which Plato himself states, is demonstrating the possibility of dialogue and discourse. This statement explicitly sets forward that the discussion is bound up with several logical approaches, according to which finally full bright light is shed on different implications of the subject such as universals.展开更多
文摘Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets of the TCM were retrieved using the systematic pharmacological analysis platform TCMSP,and the gene name of each target protein was obtained from the UniProtKB network platform.The targets of RA were queried through the CTD database.The protein–protein interaction network was constructed in the STRING database,and the network visualization analysis was performed in Cytoscape.The Gene Ontology and Kyoto Gene and Genomic Encyclopedia pathways enrichment analyses of key target proteins were performed using the DAVID data platform.Results:A total of 472 drug active ingredients were screened from the TCMSP database.Seventy-five disease targets from the CTD database were screened.The compound-target network map contained further screened out 98 components and corresponding 75 targets.The key compounds included quercetin and kaempferol.The key targets were prostaglandin G/H synthase 2 and nitric oxide synthase 2.The protein-protein interaction network consisted of 75 proteins,of which 37 were key proteins,including tumor protein 53,JUN and interleukin-6.There were 260 Gene Ontology entries,of which 246 were biological processes.Fifty-five Kyoto Gene and Genomic Encyclopedia pathways were enriched,mainly the cancer pathway,NOD-like receptor signaling pathway,and Toll-like receptor signaling pathway,which are involved in the action mechanism of FHD.Conclusion:The results of this study preliminarily verified the basic pharmacological action mechanism of FHD in the treatment of RA,laying a foundation for elucidating its mechanism of action.
文摘Most commentators use the term ＂modern philosophy＂ for the post-Descartes era--an era of unprecedented growth for the modern sciences and, especially the empirical sciences. Even assuming that the feud between the rationalists and the empiricists during this period yielded no other benefits, it was beneficial enough to turn ＂experience＂ into an important pillar of the acquisition of knowledge in the subsequent philosophy. It was this ＂experience-mindedness＂ that drove away the Aristotelian ＂essentialist＂ perspective and replaced it with ＂nominalism.＂ By describing the genesis and emergence of the ＂nominalist-empirical＂ perspective in analytic philosophy as one of the branches of the human sciences, this article strives to advance the claim that philosophical thinking continues to flourish in the absence of ＂realist thinking about universals＂ and that philosophizing does not fundamentally rest on universals.
文摘Plato＇s lifelong confrontation with Parmenides and his metaphysical mire of believing that nothing （το μη ǒν） does not actually exist, gradually in the Sophist comes into finish, insofar as the philosopher after facing the foe and having the last laugh simmers down. In this paper after giving an interpretation of what Parmenides says, I shall present an analysis of Plato＇s drastic answer to him （Sophist, 259 e4-6） to see how Plato opens the impasse way created by the Eleatic philosopher. Here the intercommunion of Forms is regarded as the final answer by which Plato devastates Parmenides infamous thesis. Since hitherto no in-depth analysis is given by the scholars who are puzzled with the subject, I have tried to analyze the intercommunion of Forms philosophically. Plato＇s Eleatic challenge has always been crucial in Plato himself and philosophical development after him. As while as Parmenides thesis （Sph., 238 a8-9） provides the sophists opportunity to reject the falsehood, Plato＇s theory of Forms in contrast in order to cross off the extremely sly sophists tries to make Parmenides come down. In my opinion, the intercommunion of Forms, as the last step of the theory of Forms, basically determines Plato＇s late ontology tightly knitted with logic. Vindicating this proposal depends on true understanding of the intercommunion of Forms. Since Plato＇s late ontology, in my opinion, is closed to Frege＇s ontology and discussion of language, we are armed to interpret the intercommunion of Forms with recent recent logico-philosophicus achievements, I think. In this respect, this is what I have done in my paper： analyzing sentence from Plato＇s logico-metaphysical point of view. Ultimately, I have tried to show how the aim of the intercommunion of Forms, which Plato himself states, is demonstrating the possibility of dialogue and discourse. This statement explicitly sets forward that the discussion is bound up with several logical approaches, according to which finally full bright light is shed on different implications of the subject such as universals.
