Clustered architecture is selected for high level synthesis,and a simultaneous partitioning and scheduling algorithm are proposed.Compared with traditional methods,circuit performance can be improved.Experiments show ...Clustered architecture is selected for high level synthesis,and a simultaneous partitioning and scheduling algorithm are proposed.Compared with traditional methods,circuit performance can be improved.Experiments show the efficiency of the method.展开更多
This paper focuses on the issues of categorical database gen-eralization and emphasizes the roles ofsupporting data model, integrated datamodel, spatial analysis and semanticanalysis in database generalization.The fra...This paper focuses on the issues of categorical database gen-eralization and emphasizes the roles ofsupporting data model, integrated datamodel, spatial analysis and semanticanalysis in database generalization.The framework contents of categoricaldatabase generalization transformationare defined. This paper presents an in-tegrated spatial supporting data struc-ture, a semantic supporting model andsimilarity model for the categorical da-tabase generalization. The concept oftransformation unit is proposed in generalization.展开更多
A novel hybrid self-reconfigurable modular robot is designed to finish the morphing action from line shape to hexagon shape. The robot is composed of many basic modules,each of which consists of a master module and a ...A novel hybrid self-reconfigurable modular robot is designed to finish the morphing action from line shape to hexagon shape. The robot is composed of many basic modules,each of which consists of a master module and a slave module in the shape of triangular prism. There are four connection ports on each basic module. For the master module there are two holes on each connection port,and for the slave one there are two pegs on each connection. The docking process between two neighboring basic modules is analyzed with a peg-in-hole mechanical structure. A small motion's method is presented and the contact forces are derived. According to the force/moment,the pose of a motion module should be adjusted to make two neighboring modules align and finish the docking process.Finally,a simulation of 3 basic modules is shown to finish the morphing and docking process effectively. The system can finish the morphing task from the line shape to the hexagon shape.展开更多
The small GTPase Rap1 induces integrin activation via an inside-out signaling pathway mediated by the Rapl-interacting adaptor mol- ecule （RIAM）. Blocking this pathway may suppress tumor metastasis and other disease...The small GTPase Rap1 induces integrin activation via an inside-out signaling pathway mediated by the Rapl-interacting adaptor mol- ecule （RIAM）. Blocking this pathway may suppress tumor metastasis and other diseases that are related to hyperactive integrins. However, the molecular basis for the specific recognition of RIAM by Rap1 remains largely unknown. Herein we present the crystal structure of an active, GTP-bound GTPase domain of Rap1 in complex with the Ras association （RA）-pleckstrin homology （PH） structural module of RIAM at 1.65 A. The structure reveals that the recognition of RIAM by Rap1 is governed by side-chain interactions. Several side chains are critical in determining specificity of this recognition, particularly the Lys31 residue in Rap1 that is oppositely charged compared with the Glu31/Asp31 residue in other Ras GTPases. Lys31 forms a salt bridge with RIAM residue Glu212, making it the key specificity determinant of the interaction. We also show that disruption of these interactions results in reduction of Rapl：RIAM association, leadingto a loss of co-clustering and cell adhesion. Our findings elucidate the molecular mechanism by which RIAM med- iates Rapl-induced integrin activation. The crystal structure also offers new insight into the structural basis for the specific recruitment of RA-PH module-containing effector proteins by their smaU GTPase partners.展开更多
文摘Clustered architecture is selected for high level synthesis,and a simultaneous partitioning and scheduling algorithm are proposed.Compared with traditional methods,circuit performance can be improved.Experiments show the efficiency of the method.
基金the National Natural Science Foundation (No. 40271088) the Research Fund of International Institute of Geo-information Science and Earth Observation.
文摘This paper focuses on the issues of categorical database gen-eralization and emphasizes the roles ofsupporting data model, integrated datamodel, spatial analysis and semanticanalysis in database generalization.The framework contents of categoricaldatabase generalization transformationare defined. This paper presents an in-tegrated spatial supporting data struc-ture, a semantic supporting model andsimilarity model for the categorical da-tabase generalization. The concept oftransformation unit is proposed in generalization.
基金Supported by the National Natural Science Foundation of China(No.61175069,51075272,51475300)
文摘A novel hybrid self-reconfigurable modular robot is designed to finish the morphing action from line shape to hexagon shape. The robot is composed of many basic modules,each of which consists of a master module and a slave module in the shape of triangular prism. There are four connection ports on each basic module. For the master module there are two holes on each connection port,and for the slave one there are two pegs on each connection. The docking process between two neighboring basic modules is analyzed with a peg-in-hole mechanical structure. A small motion's method is presented and the contact forces are derived. According to the force/moment,the pose of a motion module should be adjusted to make two neighboring modules align and finish the docking process.Finally,a simulation of 3 basic modules is shown to finish the morphing and docking process effectively. The system can finish the morphing task from the line shape to the hexagon shape.
文摘The small GTPase Rap1 induces integrin activation via an inside-out signaling pathway mediated by the Rapl-interacting adaptor mol- ecule （RIAM）. Blocking this pathway may suppress tumor metastasis and other diseases that are related to hyperactive integrins. However, the molecular basis for the specific recognition of RIAM by Rap1 remains largely unknown. Herein we present the crystal structure of an active, GTP-bound GTPase domain of Rap1 in complex with the Ras association （RA）-pleckstrin homology （PH） structural module of RIAM at 1.65 A. The structure reveals that the recognition of RIAM by Rap1 is governed by side-chain interactions. Several side chains are critical in determining specificity of this recognition, particularly the Lys31 residue in Rap1 that is oppositely charged compared with the Glu31/Asp31 residue in other Ras GTPases. Lys31 forms a salt bridge with RIAM residue Glu212, making it the key specificity determinant of the interaction. We also show that disruption of these interactions results in reduction of Rapl：RIAM association, leadingto a loss of co-clustering and cell adhesion. Our findings elucidate the molecular mechanism by which RIAM med- iates Rapl-induced integrin activation. The crystal structure also offers new insight into the structural basis for the specific recruitment of RA-PH module-containing effector proteins by their smaU GTPase partners.
