型腔气体反压智能注射马桶盖模具创新设计

为了解决马桶盖的翘曲变形和表面质量问题,提出一种气体反压注射的方法,通过Moldex3D软件分析预测气体反压工艺塑件存在的可能问题并加以改善。设计了一套气体反压马桶盖模具,利用热流道+冷流道的方式解决了材料浪费和模具偏心问题,采用斜顶+直顶块的联合顶出机构减少了产品变形,同时制定型腔气体反压(GCP)辅助注塑工艺的流程,研发适用于GCP辅助注塑工艺的专用模具型腔气体压力控制系统及控制设备。通过工程实践表明:翘曲变形量减少12.5μm,表面粗糙度减小1.1μm。解决了马桶盖双面高光的问题,具有一定应用价值。

AERODYNAMIC ANALYSIS OF HELICOPTER SHROUDED TAIL ROTOR BY MOMENTUM THEORY

In this paper, in order to clarify the gains of the shroud in the shrouded tail rotor system, a thrust division factor q , which represents the ratio of the shroud thrust to the total thrust of the shrouded tail rotor, is introduced. With the help of q , the slipstream theory for the static and axial flow states of the shrouded tail rotor are fully derived. Based on the sliptream theory, the variations of the thrust, power and disk area against q for different cases are emphatically analysed and the comparisons between a shrouded tail rotor and an isolated one are made. It is shown that, although the shroud can provide as much as 50% of the total thrust of shrouded tail rotor for the static state, the thrust gains of the shroud rapidly decrease for the axial flow state, which depends on the flow velocity ratio.

IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation

IL-23/IL-17 axis is an important regulator in various inflammatory diseases. However, the role of IL-23 in allergic airway inflammation is not well understood. In this study, we show that in an allergen-induced asthma model, mice with transgenic overexpression of IL-23R exhibited increased airway infiltration of eosinophils and Th2 cytokine production, whereas those deficient in IL-23 displayed reduced airway inflammation. In vitro, IL-23-IL-23R signaling promoted GATA-3 expression and enhanced Th2 cytokine expression. Conversely, in the absence of this signal, Th2 cell differentiation was partially inhibited. Therefore, IL-23 signaling may regulate allergic asthma through modulation of Th2 cell differentiation.

Properties of Surface Film on X70 Pipeline Steel in CO_3^(2-)-/HCO_3^- Environment

The electrochemical behavior of X70 pipeline steel in (0.5mol·L-1 Na2CO3+1 mol·L-1 NaHCO3) solution was studied by potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) were used to analyze the composition and microstructure of the surface film. The results showed that there were two anodic peaks at -600 mV and -350 mV. The surface film formed at -600 mV mainly consisted of ferrous carbonates and ferrous hydroxycarbonates. It had a small reaction resistance. It was metastable and possessed poor protective property. Numerous pits and microcracks existed on the film, which could be the active paths for the initiation of stress corrosion cracking. The surface film formed at -350 mV, mainly consisted of ferric oxides. It has high reaction resistance and offered good protection for the substrate.

Avalanche activity and characteristics of its triggering factors in the western Tianshan Mountains,China

Snow avalanche is a serious threat to the safety of roads in alpine mountains. In the western Tianshan Mountains, large scale avalanches occur every year and affect road safety. There is an urgent need to identify the characteristics of triggering factors for avalanche activity in this region to improve road safety and the management of natural hazards. Based on the observation of avalanche activity along the national road G218 in the western Tianshan Mountains, avalanche event data in combination with meteorological, snowpack and earthquake data were collected and analyzed. The snow climate of the mountain range was examined using a recently developed snow climate classification scheme, and triggering conditions of snow avalanche in different snow climate regions were compared. The results show that snowfall is the most common triggering factor for a natural avalanche and there is high probability of avalanche release with snowfall exceeding 20.4 mm during a snowfall period. Consecutive rise in temperature within three days and daily mean temperature reaching 0.5℃ in the following day imply a high probability of temperaturerise-triggered avalanche release. Earthquakes have a significant impact on the formation of large size avalanches in the area. For the period 2011-2017, five cases were identified as a consequence of earthquake with magnitudes of 3.3≤M_L≤5.1 and source-to-site distances of 19~139 km. The Tianshan Mountains are characterized by a continental snow climate with lower snow density, lower snow shear strength and high proportion depth hoar, which explains that both the snowfall and temperature for triggering avalanche release in the continental snow climate of the Tianshan Mountains are lower than that in maritime snow climate and transitional snow climate regions. The findings help forecast avalanche release for mitigating avalanche disaster and assessing the risk of avalanche disaster.

Investigation of the active components and mechanism of Sanao Decoction in treating chronic cough by network pharmacology and molecular docking

Objective To investigate the active components and mechanism of Sanao Decoction(三拗汤,SAD)in treating chronic cough based on network pharmacology and molecular docking.Methods Active components and their targets were obtained from the Traditional Chinese Medicine Systems and Pharmacology Database and Analysis Platform(TCMSP),Bioinformatics Analysis Tool for Molecular mech ANism of Traditional Chinese Medicine(BATMAN-TCM)database,and the literature.The component-target regulatory network and protein-protein interaction(PPI)network were constructed by Cytoscape 3.7.2,and a bioinformatics analysis was performed to identify the significant pathways and their relevant targets.Molecular docking of the core active components and relevant targets was performed.Results A total of 98 active components of SAD and the corresponding 113 drug targets were identified.The component-target regulatory network and PPI network were successfully established.Results of the bioinformatics analysis indicated that 2281 Gene Ontology(GO)terms were enriched in chronic cough,including 2062 terms were in biological processes,77 in cellular components,and 142 in molecular functions,and top 20 significant pathways in Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis.Molecular docking study demonstrated that quercetin,luteolin,kaempferol,and naringenin were in good agreement with the corresponding targets.Conclusion The active compounds of SAD,such as quercetin,luteolin,kaempferol,and naringenin,may act on AKT1,MAPK1,RELA,EGFR,and Bcl-2 and regulate the PI3 K-Akt signaling pathway,AGE-RAGE signaling pathway,and fluid shear stress and atherosclerosis pathway to exert the effects of anti-inflammatory,anti-airway remodeling,anti-oxidant stress effects,and repair airway damage,thus treating chronic cough.

Research on Oil/Gas In-pipe Inspection Robot

A new type of in-pipe mobile robot was designed and developed on the basis of w heel in-pipe robot and crawler in-pipe robot. The three sets of driving wheels circumferentially 120° apart in the cross section, both front and rear driving wheels are distributed on the same parallelogram mechanis m. The driving motor drives the three sets of driving wheels by worm couple, the regulating motor makes the three sets of driving wheels push against the pipe inwall with stable and adequate pressing force by the ball screw pair and p ressure sensor, so the in-pipe robot can provide adequate and stable traction force. The robot mechanism is simple and sm all in size and work reliably . It is particularly suitable to the pipe with diameter 400～650 mm.

High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids

AIM： To investigate whether high-fat-feeding is associ- ated with increased intestinal permeability via altera- tions in bile acid metabolism.METHODS： Male C57BI/6J mice were fed on a high-fat （n = 26） or low-fat diet （n = 24） for 15 wk. Intestinal permeability was measured from duodenum, jejunum, ileum and colon in an Ussing chamber system using 4 kDa FITC-labeled dextran as an indicator. Fecal bile ac- ids were analyzed with gas chromatography. Segments of jejunum and colon were analyzed for the expression of farnesoid X receptor （FXR） and tumor necrosis factor

Simulation and analysis of airflow stability during fire in mine belt roadway

According to fluid dynamics analysis during the fire, the criteria k-ε two-equation model for solving three-dimensional turbulence was determined, the pollutants generated in the fire disaster were set by adopting Mixture multiphase flow, and the SIMPLE algorithm was used for solving on the basis of comprehensive consideration on the heat radia- tion and components transmission during fire. By simulating the airflow flowing state inside the tunnel during fire disaster of downward ventilation, drift ventilation, and ascensional ventilation, respectively, with regard to the actual situation of No.l, No.3, and No.5 belt roadway in Kongzhuang Coal Mine, the velocity vector distributions of pollutants under different inlet air volumes were obtained, and the damage degree and influential factors of disaster were also clear, which is helpful to control and avoid disaster during belt roadway fire.

Recent Advances in the Theoretical and Applied Study on Compressible Turbulent Flow over Aerospace Vehicles

This paper focused on the fundamental and applied research of turbulent flows encountered in the hypersonic flight of aerospace vehicles,which take place in the boundary layer and mixing layer.As to the plate boundary layer,LES approach has been used to simulate the flows over compression corners and incident shock waves,revealing that turbulent flows would significantly inhibit the boundary layer separation caused by shock wave-boundary layer interaction(SWBLI).The boundary layer transition over a circular cone has been analyzed through stability analysis and wind-tunnel test,by which the angle-of-attack effect in case of small angle of attack has been studied.Non-linear evolution process and secondary instability structure in the supersonic mixing layer(Mc=0.5) were initially figured out through the study of mixing layer,and knowledge of the flow control mechanism of the boundary layer and mixing enhancement mechanism of the mixing layer has been obtained through this research.Artificial boundary-layer transition technique based on subharmonic resonance has been proposed and applied to the flow control in a scramjet inlet,inhibiting the flow separation of the boundary layer while improving the inlet performance.To guarantee the mixing of kerosene and supersonic airflow in the scramjet combustor,the mixing enhancement method based on subharmonic resonance has been adopted and a concept of combustor with smooth wall and low internal drag has been proposed for ignition and stable combustion.Finally,future turbulence research and technological development of aerospace vehicles is predicted.

Study on application and numerical simulation of the airflow temperature distribution rule in drifting tunnel

According to the law of conservation in the state of turbulent flow, the differential equation describing the airflow temperature distribution in drifting tunnel is derived, By theoretical analysis and field measurement of the airflow and thermal process in mine, theoretical analysis and systematic flow are developed. By PHONENICS program, the numerical simulation is processed, and the changing rule of airflow temperature with various parameters in drifting tunnel is derived. The airflow temperature in drifting tunnel decreases as the airflow velocity increases in a way of negative power exponent, and elevates linearly as the temperature of the incoming airflow elevates.

Temperature Profiles in the Flow Channel of a Natural Convection Solar Air Heater

An experimental investigation was conducted to measure the temperature variation across the flow channel and to determine the performance of a natural convection solar air heater at various tilt angles from 15, 30 and 45°. The results of the temperature profile across the air gap showed that heat transfer from the absorber plate to the air stream was mainly by convection. At a particular section, mean air temperature could be calculated from the arithmetic mean of the temperature profile across the air gap to within ± 2 ℃. The axial air temperature distribution was non linear and did not increase much beyond 1 m of collector length. It tended to decrease towards the end of the collector. Overall glass, absorber plate and mean air temperatures over the entire length of the solar air heater could be determined by averaging the mean axial temperatures to within ± 2 ℃. The heater performed better as inclination increased.

Functional mechanism of Pingchuanning Decoction on adjustment of clara cell secretory protein in airway remodeling of asthmatic rats

OBJECTIVE:To study the functional mechanism of Pingchuanning Decoction in treatment of airway remodeling in asthmatic rats.METHODS:Eighty healthy Wistar male rats were randomized into eight groups(n=10 rats each):Normal group,Asthma model group,Dexamethasone group,Guilong Kechuanning group,Xiaoqinglong Decoction group,and Pingchuanning Decoction low-,middle-,and high-dose groups.The rats of all but the Normal group were made into asthma models through intraperitoneal injection and aerosol inhalation of ovalbumin.All treatments were administered at the first stimulation of asthma onset(third week of modeling),and the rats were killed after stimulating asthma attacks for 4 weeks.The general conditions of rats and pathomorphological changes of the lung tissues were observed.The expression of nerve growth factor(NGF) of the lung tissues was measured with immunohistochemical methods,and the content of Clara cell secretory protein(CCSP) mRNA was determined with RT-PCR.RESULTS:Compared with the Normal group,the contents of NGF and CCSP mRNA in the lung tissues of the Model group were significantly changed(P<0.01).Compared with the Model group,the indices of Pingchuanning Decoction and other treatment groups were improved to some extent(P<0.05 or P<0.01).CONCLUSIONS:Pathological changes of airway inflammation and remodeling were present in these rat asthma models.Pingchuanning Decoction had an intervention effect on these experimental models.Its functional mechanism may be related to multiple factors,including alleviation of airway inflammation,relief of bronchial smooth muscle spasm,and inhibition of airway remodeling.

Numerical investigation on synthetic jet flow control inside an S-inlet duct

The high degree of centerline curvature and cross-stream pressure gradient in S-inlet ducts gives rise to boundary layer separation and secondary flows, which result in poor pressure recovery and non-uniform flow in the outlet interface with the engine. The flowfield in ducts is three-dimensional due to the existence of secondary flow, so ordinary two-dimensional actuations have poor effect on reforming the flow. Synthetic jet actuations extended in different spanwise positions were employed to manipulate the flow, and compared with the two-dimensional actuation, The interaction mechanics between flow separation and secondary flow was studied at first. It was found that the secondary flow enhanced Ol~ weakened flow separation depending on the spanwise position of synthetic jet actuators. Moreover, the J flow separation enhanced the secondary flow, thus causing lower pressure recovery and flow distortion in the duct outlet. The actuators located at different spanwise positions will weaken the secondary flows by improving the flow separation to get energetic and uniform main flow.

Performance analysis of quantum key distribution based on air-water channel

Considering the air-water interface and ocean water’s optical attenuation,the performance of quantum key distribution(QKD)based on air-water channel is studied.The effects of photons’various incident angles to air-water interface on quantum bit error rate(QBER)and the maximum secure transmission distance are analyzed.Taking the optical attenuation of ocean water into account,the performance bounds of QKD in different types of ocean water are discussed.The simulation results show that the maximum secure transmission distance of QKD gradually reduces as the incident angle from air to ocean water increases.In the clearest ocean water with the lowest attenuation,the maximum secure transmission distance of photons far exceeds the the working depth of underwater vehicles.In intermediate and murky ocean waters with higher attenuation,the secure transmission distance shortens,but the underwater vehicle can deploy other accessorial methods for QKD with perfect security.So the implementation of OKD between the satellite and the underwater vehicle is feasible.

Fulde-Ferrell-Like Molecular States in Spin-Orbit Coupled Ultracold Fermi Gases

We study the molecular state in three-component Fermi gases with a single impurity of ~6Li immersing in a no-interacting Fermi sea of ^(40)K in the presence of an equal weight combination of Rashba-type and Dresselhaustype spin-orbit coupling. In the region where the Fermi sea has two disjointed Fermi surfaces, we find that there are two Fulde–Ferrell-like molecular states with dominating contributions from the lower helicity branch. Decreasing the scattering length or the spin-orbit coupled Fermi energy, we find the Fulde–Ferrell-like molecular state with small center-of-mass momentum is always energy favored and the other one will suddenly disappear.