基于线性方程组数学分离模型建立光纤传感过程检测复方缬沙坦氢氯噻嗪片溶出度

基于线性方程组数学分离模型建立在线过程检测复方缬沙坦氢氯噻嗪片溶出度方法。分别扫描缬沙坦和氢氯噻嗪的紫外吸收光谱,两组分在最大吸收波长处完全重叠。根据朗伯比尔定律吸光度加和性原理,分别测定两组分在最大吸收波长处的吸光系数,建立线性方程组数学分离模型,采用光纤传感过程分析技术(FODT)检测缬沙坦氢氯噻嗪片的溶出度,并与HPLC法相比较。在规定的溶出介质中,两种成分同时实时测定,并且FODT累积溶出度与HPLC法相比较结果无显著性差异(p>0.05)。不同批次药物的溶出行为一致,说明制剂工艺稳定,均匀度好。溶出曲线显示缬沙坦溶出快于并高于氢氯噻嗪,且30 min时两组分的溶出度均大于80%符合美国药典规定。结果表明,应用线性方程组数学分离模型结合FODT法可实现复方缬沙坦氢氯噻嗪片中双组分溶出度的同时检测,并可提供双组分的溶出过程曲线和全部溶出数据,直观反映各组分在各溶出时段的快慢,为此药建立标准提供依据。与HPLC法单点数据相比优势明显,更有利于药品评价和抽验质量分析。

喷水推进船操纵运动数学建模仿真分析

喷水推进船具有高航速、浅吃水等特点,回转性能优越。该文以喷泵和喷水推进船为研究对象,首先采用称重法,开展喷泵流量标定试验;而后基于裸船体和带四个喷泵的船体,开展水池中约束模平面运动机构模型试验,如斜航运动、横荡运动、摇首运动及自航操舵试验等,获取船体水动力和喷口流量;再采用最小二乘法,回归分析得到相关的水动力导数,建立整体式和分离式操纵运动数学模型,编制喷水推进船的操纵运动程序,数值模拟30°回转运动和10°/10°z形试验,并与外场自由自航模操纵性进行比较。数值模拟结果显示:通过整体式运动数学模型和分离式运动数学方法,战术直径误差在5.5%以内,第一超越角误差为2°左右,这两种方法都能较好地吻合模型试验结果。相较而言,基于整体式运动数学模型的模型试验或CFD数值计算的难度更高且经济成本较大,而在实际工程数值模拟中,基于分离式运动数学模型的数值模拟更容易实施。

基于浮力调节的大负载UUV载荷投放运动分析

研究大负载UUV载荷安全投放技术,不可避免地要分析其载荷投放扰动特性。基于重力解脱方式,建立了载荷投放分离数学模型,通过浮力调节水舱比例-微分的深度控制,仿真研究了UUV载荷投放受扰运动特性。仿真结果表明,载荷投放将导致UUV产生较大幅度纵倾振荡,海流会进一步加大纵倾振荡幅度,对UUV姿态稳定及后续投放产生不利影响。为此,提出了一种纵倾调节布局方案,并对其进行了可行性仿真验证。结果表明,该方案可有效地抑制纵倾振荡,提高了纵倾稳定性。

Mathematic Model of Unsteady Penetration Mass Transfer in Randomly Packed Hollow Fiber Membrane Module

Based on the membrane-based absorption experiment of CO2 into water, shell-side flow distribution and mass transfer in a randomly packed hollow fiber module have been analyzed using subchannel model and unsteady penetration mass transfer theory. The cross section of module is subdivided into many small cells which contains only one hollow-fiber. The cross sectional area distribution of these cells is presented by the normal probability density distribution function. It has been obtained that there was a most serious non-ideal flow in shell side at moderate mean packing density, and the large amount of fluid flowed and transferred mass through a small number of large voids. Thus mass transfer process is dominated by the fluid through the larger void area. The mass transfer process in each cell is described by the unsteady penetration theory. The overall mass transfer coefficient equals to the probability addition of the mean mass transfer coefficient in each cell. The comparisons of the values calculated by the model established with the empirical correlations and the experimental data of this work have been done.The predicted overall mass transfer coefficients are in good agreement with experimental data.

Progress in Pressure Swing Adsorption Models During the Recent 30 Years

The pressure swing adsorption (PSA) models discussed here are divided into three categories: partialdifferential equation model, electrical analogue model and neural network model. The partial differential equationmodel, including equilibrium and kinetic models, has provided an elementary viewpoint for PSA processes. Usingthe simplest equilibrium models, some influential factors, such as pressurization with product, incomplete purge,beds with dead volume and heat effects, are discussed respectively. With several approximate assumptions i.e.,concentration profile in adsorbent, 'frozen' column, symmetry and heat effects of bed wall, the more complexkinetic models can be simplified to a certain degree at the expense of a limited application. It has also been foundthat the electrical analogue model has great flexibility to handle more realistic PSA processes without any additionalhypothesis.

Influence of preload discreteness on air-operated separation process of low-shock separation device

To investigate the influence of design parameters on the performance of separation device,the structure and air-operated test of a low-shock separation device are introduced and analyzed in this paper.According to the law of energy conservation and aerodynamics,a mathematical model is built.Because the preload used to ensure the connection reliability has the discreteness,which will influence the separation process,the influence of preload discreteness on the air-operated separation process is simulated and tested.Simulation results are consistent with the experimental results.It is shown that the change of preload has an obvious influence on the separation process.The study is useful for the design and optimization of separation device.

Separation axioms under crossover operator and its generalized

The purpose of this work is to construct a new crossover operator using the properties of DNA and RNA by using topological concepts in constructing flexible mathematical models in the field of biomathematics. Also, we investigate and study topological prop- erties of the constructed operators and the associated topological spaces of DNA and RNA. Finally we use the process of exchange for sequence of genotypes structures to construct new types of topological concepts to investigate and discuss several examples and some of their properties.