In order to better understand the general tidal features in the venturi-shaped area between Zhenhai and Shenjiamen in the northern coastal region of Zhejiang Province in the East China Sea, the tidal data were obtaine...In order to better understand the general tidal features in the venturi-shaped area between Zhenhai and Shenjiamen in the northern coastal region of Zhejiang Province in the East China Sea, the tidal data were obtained from both the three permanent tide stations of Zhenhai, Dinghai and Shenjiamen, and four temporary tide stations of Mamu, Chuanshan, Guoju and Liuheng, along with the current speed being observed at Luotou Waterway. Results from harmonic analysis show that: (1) The area was dominated by shallow water tides with irregular semi-diurnal features, and the smallest tidal range occurred in the area near a crossing line between Zhenhai and Dinghai stations, indicating that a tidal node existed in the southern Hangzhou Bay; (2) Formulae, HS2/HM2 >0.4 and gM2-(gK1+gO1)=270° (where H and g are harmonic constants), could be used as judging criteria for high and low tidal level diurnal inequalities; (3) The duration difference between ebb and flood tides could be roughly assessed by the ratio of HM4 vs. HM2; and the larger the ratio is, the bigger the duration difference is. At the same time, the duration period could be assessed by 2gM2-gM4, the epoch difference between M2 and M4 tidal constituents. If 2gM2-gM4 <180°, then the ebb duration is longer than the flood duration; if 180°< 2gM2-gM4 <360°, the result is reversed; (4) Taking Dinghai station as a center point, the highest tidal levels and the average high tidal levels, as well as the average tidal ranges at all stations became higher and larger both southeastwards and northwestwards, while the lowest tidal levels and the average low tidal levels appeared to be lower both southeastwards and northwestwards; and (5) The tidal patterns were not all in line with the tidal current patterns. As a conclusion, the smallest tidal range occurred in the narrow part of the venturi-shaped area. Along the both sides of the area, the highest tidal level and tidal range became higher and larger, while the lowest tidal level became lower with the increase of the distance from the narrow throat area. This is somehow different from the theory that the tidal level increases gradually when it moves towards the top narrow area of a V-shaped bay or estuary.展开更多
AIM:To integrate results from different studies in examining the effectiveness of music in reducing the procedure time and the amount of sedation used during colonoscopic procedure. METHODS: An electronic search in va...AIM:To integrate results from different studies in examining the effectiveness of music in reducing the procedure time and the amount of sedation used during colonoscopic procedure. METHODS: An electronic search in various databases was performed to identify related articles. Study quality was evaluated by the Jadad’s scale. The random effect model was used to pool the effect from individual trials and the Cohen Q-statistic was used to determine heterogeneity. Egger’s regression was used to detect publication bias. RESULTS: Eight studies with 722 subjects were included in this meta-analysis. The combined mean difference for the time taken for the colonoscopy procedure between the music and control groups was -2.84 with 95% CI (-5.61 to -0.08), implying a short time for the music group. The combined mean difference for the use of sedation was -0.46 with 95%CI (-0.91 to -0.01), showing a significant reduction in the use of sedation in the music group. Heterogeneity was observed in both analyses but no publication bias was detected. CONCLUSION: Listening to music is effective in reducing procedure time and amount of sedation during colonoscopy and should be promoted.展开更多
Objectives:To describe and compare fear of childbirth and in-labor pain intensity between primiparas and multiparas and explore the association between the amount of actual pain relief and fear of childbirth.Methods:A...Objectives:To describe and compare fear of childbirth and in-labor pain intensity between primiparas and multiparas and explore the association between the amount of actual pain relief and fear of childbirth.Methods:A convenience sampling method was used.A total of 260 women undergoing spontaneous or induced labor,including 97 primiparas and 163 multiparas,were recruited in a large academic specialized hospital in Guangzhou,China,from February 2018 to August 2019.The clinical data of maternal and neonatal were extracted from a structured electronic medical record system.Other demographic information,such as employment and family monthly income,was collected by a questionnaire.The Numeric Rating Scale(NRS)and the Chinese version of the Childbirth Attitude Questionnaire(C-CAQ)were applied to assess maternal in-labor pain intensity and fear of childbirth.The analgesic consumption and the frequency of manual boluses as rescue analgesia were stored and collected from the analgesia pump.Results:Eighty-two(84.5%)primiparas and ninety-nine(60.7%)multiparas received epidural analgesia(P<0.001).In the epidural subgroup,the primiparous average fear of childbirth(36.46±10.93)was higher than that of the multiparas(32.06±10.23)(P¼0.007).However,multiparas reported more intense in-labor pain[8.0(8.0,9.0)vs.8.0(7.0,8.0)],had more successful manual boluses per hour[2.68(1.65,3.85)vs.1.77(0.90,2.47)],more hourly analgesic consumption[23.00(16.00,28.25)vs.17.24(11.52,21.36)mL]and more average analgesic consumption[0.35(0.24,0.45)vs.0.26(0.19,0.35)mL/(h$kg)]than the primiparas(P<0.05).Spearman’s correlation analysis showed that the maximum in-labor pain was weakly positively correlated with fear of childbirth(r¼0.09)(P<0.05),hourly analgesic consumption(r¼0.16)(P<0.01)and average analgesic consumption(r¼0.17)(P<0.05).No statistically significant association was uncovered between analgesic consumption and maternal fear of childbirth.Conclusions:Fear of childbirth is a potential predictor of labor pain intensity.Further study is needed to explore its role and value in pain management during delivery.Parity is not a determinant of pain relief use and should not be a preconceived preference of obstetric care team members to determine the distribution of epidural analgesia,especially when analgesia resources are insufficient.展开更多
AIM: The fears and concerns are associated with gastroscopy (EGD) decrease patient compliance. Conscious sedation (CS) and non-pharmacological interventions have been proposed to reduce anxiety and allow better execut...AIM: The fears and concerns are associated with gastroscopy (EGD) decrease patient compliance. Conscious sedation (CS) and non-pharmacological interventions have been proposed to reduce anxiety and allow better execution of EGD. The aim of this study was to assess whether CS, supplementary information with a videotape, or presence of a relative during the examination could improve the tolerance to EGD. METHODS: Two hundred and twenty-six outpatients (pts), scheduled for a first-time non-emergency EGD were randomly assigned to 4 groups: Co-group (62 pts): throat anaesthesia only; Mi-group (52 pts): CS with i.v. midazolam; Re-group (58 pts): presence of a relative throughout the procedure; Vi-group (54 pts): additional information with a videotape. Anxiety was measured using the “Spielberger State and Trait Anxiety Scales” The patients assessed the overall discomfort during the procedure on an 100-mm visual analogue scale, and their tolerance to EGD answering a questionnaire. The endoscopist evaluated the technical difficulty of the examination and the tolerance of the patients on an 100-mm visual analogue scale and answering a questionnaire. RESULTS: Pre-endoscopy anxiety levels were higher in the Mi-group than in the other groups (P<0.001). On the basis of the patients' evaluation, EGD was well tolerated by 80.7% of patients in Mi-group, 43.5% in Co-group, 58.6% in Regroup, and 50% in Vi-group (P<0.01). The discomfort caused by EGD, evaluated by either the endoscopist or the patients, was lower in Mi-group than in the other groups. The discomfort was correlated with “age” (P<0.001) and “groups of patients” (P<0.05) in the patients' evaluation, and with “gender” (females tolerated better than males, P<0.001) and “groups of patients” (P<0.05) in the endoscopist's evaluation. CONCLUSION: Conscious sedation can improve the tolerance to EGD. Male gender and young age are predictive factors of bad tolerance to the procedure.展开更多
In order to explore the train of thought for China’s urbanizing development and coordinated rural economic development, and to find good ways of solving rural problems through urbanization, this paper absorbs the pus...In order to explore the train of thought for China’s urbanizing development and coordinated rural economic development, and to find good ways of solving rural problems through urbanization, this paper absorbs the push-and-pull forces theory and the systematic dynamic theory in the traditional population migration theories, views urbanization as a dynamic system, makes research on the push-and-pull mechanism of urbanization. The pulling power of urbanization is analyzed according to two aspects, the agglomeration effect and the radiation effect of cities. The agglomeration effect provides continuous propelling force for urbanization, and the radiation effect further accelerates the urbanization process by pushing forward the development of rural economy. Of course, the slow development of urbanization can result in the hindrance to rural economic development.展开更多
Analyzing spatiotemporal dynamics of land use and land cover over time is widely recognized as important to better understand and provide solutions for social, economic, and environmental problems, especially in ecolo...Analyzing spatiotemporal dynamics of land use and land cover over time is widely recognized as important to better understand and provide solutions for social, economic, and environmental problems, especially in ecologically fragile region. In this paper, a case study was taken in Zhenlai County, which is a part of farming-pastoral ecotone of Northeast China. This study seeks to use multi-temporal satellite images and other data from various sources to analyze spatiotemporal changes from 1932 to 2005, and applied a quantitative methodology named intensity analysis in the time scale of decades at three levels: time interval, category, and transition. The findings of the case study are as follows: 1) the interval level of intensity analysis revealed that the annual rate of overall change was relatively fast in 1932–1954 and 1954–1976 time intervals. 2) The category level showed that arable land experienced less intensively gains and losses if the overall change was to have been distributed uniformly across the landscape while the gains and losses of forest land, grassland, water, settlement, wetland and other unused land were not consistent and stationary across the four time intervals. 3) The transition level illustrated that arable land expanded at the expense of grassland before 2000 while it gained intensively from wetland from 2000 to 2005. Settlement targets arable land and avoids grassland, water, wetland and other unused land. Besides, the loss of grassland was intensively targeted by arable land, forest land and wetland in the study period while the loss of wetland was targeted by water except for the time interval of 1976–2000. 4) During the early reclamation period, land use change of the study area was mainly affected by the policy, institutional and political factors, followed by the natural disasters.展开更多
Chromatin structure is important for controlling gene expression, but mechanisms underlying chromatin remodel- ing are not fully understood. Here we report that an FKBP (FK506 binding protein) type immunophilin, AtF...Chromatin structure is important for controlling gene expression, but mechanisms underlying chromatin remodel- ing are not fully understood. Here we report that an FKBP (FK506 binding protein) type immunophilin, AtFKBP53, possesses histone chaperone activity and is required for repressing ribosomal gene expression in Arabidopsis. The At- FKBP53 protein is a multidomain FKBP with a typical peptidylprolyl isomerase (PPIase) domain and several highly charged domains. Using nucleosome assembly assays, we showed that AtFKBP53 has histone chaperone activity and the charged acidic domains are sufficient for the activity. We show that AtFKBP53 interacts with histone H3 through the acidic domains, whereas the PPIase domain is dispensable for histone chaperone activity or histone binding. Ri- bosomal RNA gene (18S rDNA) is overexpressed when AtFKBP53 activity is reduced or eliminated in Arabidopsis plants. Chromatin immunoprecipitation assay showed that AtFKBP53 is associated with the 18S rDNA gene chro- matin, implicating that AtFKBP53 represses rRNA genes at the chromatin level. This study identifies a new histone chaperone in plants that functions in chromatin remodeling and regulation of transcription.展开更多
This paper analyzes the impact of income distribution gap on consumption demand from a theoretical view,and draws the conclusion that there is an inverse relationship between income distribution gap and consumption de...This paper analyzes the impact of income distribution gap on consumption demand from a theoretical view,and draws the conclusion that there is an inverse relationship between income distribution gap and consumption demand.Then,the paper finds that the existing widening income distribution gap in China has a negative impact on consumption demand,but this is not the key factor for the insufficient consumption demand because of the low level of per capital income.At last,it suggests that governments should improve the income level of entire residents and adjust income distribution structure simultaneously.展开更多
The separation method using chiral stationary phase (CSP) for the preparation of enantioselective compound was widely used. In this work, supercritical fluid chromatography(SFC) was proposed to resolve the chiral ...The separation method using chiral stationary phase (CSP) for the preparation of enantioselective compound was widely used. In this work, supercritical fluid chromatography(SFC) was proposed to resolve the chiral mixtures. To determine the optimum operating conditions for the chiral separation of the racemic ibuprofen, the retention factors and resolutions with the change in pressure, temperature and the content of IPA (%, by volume) in supercritical CO2 were investigated. Experiments showed that the retention factor decreased with the increase of pressure and decrease in temperature. The retention factor was also influenced by the content of IPA in mobile phase, as the content of IPA in the supercritical fluid increased, the retention factor decreased. The resolution of the enantiomers became worse with the increase of IPA in the supercritical fluid. Through optimizing the experimental conditions, a SFC procedure with 13MPa, 311.15K and 4% IPA in CO2 was obtained. The peak shape of the enantiomers was symmetric with supercritical fluid chromatography when compared to the asymmetric peak shape obtained by the conventional liquid chromatography. This work demonstrated that the developed supercritical fluid chromatography procedure was suitable for the chiral separation of ibuprofen enantiomers.展开更多
AIM: To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. METHODS: In this prospective study, conducted over a period of three years, 1,104 patients refe...AIM: To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. METHODS: In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 rain intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure. RESULTS: A statistically significant reduction in mean arterial pressure was demonstrated (P〈0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P〈0.001). A critical decrease in oxygen saturation (〈90%) was documented in 27 patients (2.4%). CONCLUSION: Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effelts if carefully titrated. All the patients (and especially ASA Ⅲ group) require monitoring and care of an anesthesiologist.展开更多
The exponential stabilization problem for finite dimensional switched systems is extended to the infinite dimensional distributed parameter systems in the Hilbert space. Based on the semigroup theory, by applying the ...The exponential stabilization problem for finite dimensional switched systems is extended to the infinite dimensional distributed parameter systems in the Hilbert space. Based on the semigroup theory, by applying the multiple Lyapunov function method, the exponential stabilization conditions are derived. These conditions are given in the form of linear operator inequalities where the decision variables are operators in the Hilbert space; while the stabilization properties depend on the switching rule. Being applied to the two-dimensional heat switched propagation equations with the Dirichlet boundary conditions, these linear operator inequalities are transformed into standard linear matrix inequalities. Finally, two examples are given to illustrate the effectiveness of the proposed results.展开更多
AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing colonoscopy.METHODS:Patients referred for colonoscopy were randomized to receive ...AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing colonoscopy.METHODS:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the procedure.Both the colonoscopist and patient were blinded to the type of gas used.During the procedure,insertion and withdrawal times,caecal intubationrates,total sedation given and capnography readings were recorded.The level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale(VAS)(0-3).Patients then graded their level of discomfort and abdominal bloating using a similar VAS.Complications during and after the procedure were recorded.RESULTS:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 arm.Mean age between the two study groups were similar.Insertion time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air(P = 0.0083).The average withdrawal times were not significantly different between the two groups.Caecal intubation rates were 94.4% and 100% in the air and CO2 groups respectively(P = 0.012).The level of discomfort assessed by the nurse was 0.69(air) and 0.39(CO2)(P = 0.0155) and by the patient 0.82(air) and 0.46(CO2)(P = 0.0228).The level of abdominal bloating was 0.97(air) and 0.36(CO2)(P = 0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air insufflation.There were no complications in both arms.CONCLUSION:CO2 insufflation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation rates.Abdominal discomfort and bloating were significantly less with CO2 insufflation.展开更多
The area of interest is located in the South Moravia Region at the confluence of the Jihlava, Oslava and Rokytn^i rivers. Ivan^ice spring area comprises a series of hydrologic boreholes, it is the main water source fo...The area of interest is located in the South Moravia Region at the confluence of the Jihlava, Oslava and Rokytn^i rivers. Ivan^ice spring area comprises a series of hydrologic boreholes, it is the main water source for water supply of Ivan^ice and Rosice towns and provides water for 30,000 inhabitants. The risk analysis was created on the basis of water quality monitoring, hydrogeological assessment and terrain exploration and a revision of protection zones was proposed. The spring area is situated in nitrate vulnerable zones and recently nitrate concentrations have been decreasing. Water quality evaluation results: high concentration of manganese and iron, sometimes higher concentration of ammonium and COD. This area is intensively used for agriculture and it is necessary to make a compromise solution during protection zones proposal, The regime in protection zones can not affect manganese and iron concentration (their origin is in the natural geological environment). Therefore, water treatment plant is in operation and its modernization is proposed. Furthermore, the paper deals with spring area intensification construction of a new hydrologic borehole, and managed and unmanaged infiltration of surface water. The proposal of protection zones revision consists of reduction to a 2nd level protection zone.展开更多
基金Supported by Study on the Temporal and Spatial Distributions of Temperature and Salinity in Xiangshan Bay and the Northern Zhejiang Coastal Waters in the East China Sea of the Education Department of Zhejiang Provincial Government of China (Project No. 20061134)Study on Environment Dynamics and Nutrient Circulation in Xiangshan Bay and its Surrounding Areas in the East China Sea of the Second Institute of Oceanography, State Oceanic Administration, China (Project No. SOED0605)
文摘In order to better understand the general tidal features in the venturi-shaped area between Zhenhai and Shenjiamen in the northern coastal region of Zhejiang Province in the East China Sea, the tidal data were obtained from both the three permanent tide stations of Zhenhai, Dinghai and Shenjiamen, and four temporary tide stations of Mamu, Chuanshan, Guoju and Liuheng, along with the current speed being observed at Luotou Waterway. Results from harmonic analysis show that: (1) The area was dominated by shallow water tides with irregular semi-diurnal features, and the smallest tidal range occurred in the area near a crossing line between Zhenhai and Dinghai stations, indicating that a tidal node existed in the southern Hangzhou Bay; (2) Formulae, HS2/HM2 >0.4 and gM2-(gK1+gO1)=270° (where H and g are harmonic constants), could be used as judging criteria for high and low tidal level diurnal inequalities; (3) The duration difference between ebb and flood tides could be roughly assessed by the ratio of HM4 vs. HM2; and the larger the ratio is, the bigger the duration difference is. At the same time, the duration period could be assessed by 2gM2-gM4, the epoch difference between M2 and M4 tidal constituents. If 2gM2-gM4 <180°, then the ebb duration is longer than the flood duration; if 180°< 2gM2-gM4 <360°, the result is reversed; (4) Taking Dinghai station as a center point, the highest tidal levels and the average high tidal levels, as well as the average tidal ranges at all stations became higher and larger both southeastwards and northwestwards, while the lowest tidal levels and the average low tidal levels appeared to be lower both southeastwards and northwestwards; and (5) The tidal patterns were not all in line with the tidal current patterns. As a conclusion, the smallest tidal range occurred in the narrow part of the venturi-shaped area. Along the both sides of the area, the highest tidal level and tidal range became higher and larger, while the lowest tidal level became lower with the increase of the distance from the narrow throat area. This is somehow different from the theory that the tidal level increases gradually when it moves towards the top narrow area of a V-shaped bay or estuary.
文摘AIM:To integrate results from different studies in examining the effectiveness of music in reducing the procedure time and the amount of sedation used during colonoscopic procedure. METHODS: An electronic search in various databases was performed to identify related articles. Study quality was evaluated by the Jadad’s scale. The random effect model was used to pool the effect from individual trials and the Cohen Q-statistic was used to determine heterogeneity. Egger’s regression was used to detect publication bias. RESULTS: Eight studies with 722 subjects were included in this meta-analysis. The combined mean difference for the time taken for the colonoscopy procedure between the music and control groups was -2.84 with 95% CI (-5.61 to -0.08), implying a short time for the music group. The combined mean difference for the use of sedation was -0.46 with 95%CI (-0.91 to -0.01), showing a significant reduction in the use of sedation in the music group. Heterogeneity was observed in both analyses but no publication bias was detected. CONCLUSION: Listening to music is effective in reducing procedure time and amount of sedation during colonoscopy and should be promoted.
文摘Objectives:To describe and compare fear of childbirth and in-labor pain intensity between primiparas and multiparas and explore the association between the amount of actual pain relief and fear of childbirth.Methods:A convenience sampling method was used.A total of 260 women undergoing spontaneous or induced labor,including 97 primiparas and 163 multiparas,were recruited in a large academic specialized hospital in Guangzhou,China,from February 2018 to August 2019.The clinical data of maternal and neonatal were extracted from a structured electronic medical record system.Other demographic information,such as employment and family monthly income,was collected by a questionnaire.The Numeric Rating Scale(NRS)and the Chinese version of the Childbirth Attitude Questionnaire(C-CAQ)were applied to assess maternal in-labor pain intensity and fear of childbirth.The analgesic consumption and the frequency of manual boluses as rescue analgesia were stored and collected from the analgesia pump.Results:Eighty-two(84.5%)primiparas and ninety-nine(60.7%)multiparas received epidural analgesia(P<0.001).In the epidural subgroup,the primiparous average fear of childbirth(36.46±10.93)was higher than that of the multiparas(32.06±10.23)(P¼0.007).However,multiparas reported more intense in-labor pain[8.0(8.0,9.0)vs.8.0(7.0,8.0)],had more successful manual boluses per hour[2.68(1.65,3.85)vs.1.77(0.90,2.47)],more hourly analgesic consumption[23.00(16.00,28.25)vs.17.24(11.52,21.36)mL]and more average analgesic consumption[0.35(0.24,0.45)vs.0.26(0.19,0.35)mL/(h$kg)]than the primiparas(P<0.05).Spearman’s correlation analysis showed that the maximum in-labor pain was weakly positively correlated with fear of childbirth(r¼0.09)(P<0.05),hourly analgesic consumption(r¼0.16)(P<0.01)and average analgesic consumption(r¼0.17)(P<0.05).No statistically significant association was uncovered between analgesic consumption and maternal fear of childbirth.Conclusions:Fear of childbirth is a potential predictor of labor pain intensity.Further study is needed to explore its role and value in pain management during delivery.Parity is not a determinant of pain relief use and should not be a preconceived preference of obstetric care team members to determine the distribution of epidural analgesia,especially when analgesia resources are insufficient.
文摘AIM: The fears and concerns are associated with gastroscopy (EGD) decrease patient compliance. Conscious sedation (CS) and non-pharmacological interventions have been proposed to reduce anxiety and allow better execution of EGD. The aim of this study was to assess whether CS, supplementary information with a videotape, or presence of a relative during the examination could improve the tolerance to EGD. METHODS: Two hundred and twenty-six outpatients (pts), scheduled for a first-time non-emergency EGD were randomly assigned to 4 groups: Co-group (62 pts): throat anaesthesia only; Mi-group (52 pts): CS with i.v. midazolam; Re-group (58 pts): presence of a relative throughout the procedure; Vi-group (54 pts): additional information with a videotape. Anxiety was measured using the “Spielberger State and Trait Anxiety Scales” The patients assessed the overall discomfort during the procedure on an 100-mm visual analogue scale, and their tolerance to EGD answering a questionnaire. The endoscopist evaluated the technical difficulty of the examination and the tolerance of the patients on an 100-mm visual analogue scale and answering a questionnaire. RESULTS: Pre-endoscopy anxiety levels were higher in the Mi-group than in the other groups (P<0.001). On the basis of the patients' evaluation, EGD was well tolerated by 80.7% of patients in Mi-group, 43.5% in Co-group, 58.6% in Regroup, and 50% in Vi-group (P<0.01). The discomfort caused by EGD, evaluated by either the endoscopist or the patients, was lower in Mi-group than in the other groups. The discomfort was correlated with “age” (P<0.001) and “groups of patients” (P<0.05) in the patients' evaluation, and with “gender” (females tolerated better than males, P<0.001) and “groups of patients” (P<0.05) in the endoscopist's evaluation. CONCLUSION: Conscious sedation can improve the tolerance to EGD. Male gender and young age are predictive factors of bad tolerance to the procedure.
文摘In order to explore the train of thought for China’s urbanizing development and coordinated rural economic development, and to find good ways of solving rural problems through urbanization, this paper absorbs the push-and-pull forces theory and the systematic dynamic theory in the traditional population migration theories, views urbanization as a dynamic system, makes research on the push-and-pull mechanism of urbanization. The pulling power of urbanization is analyzed according to two aspects, the agglomeration effect and the radiation effect of cities. The agglomeration effect provides continuous propelling force for urbanization, and the radiation effect further accelerates the urbanization process by pushing forward the development of rural economy. Of course, the slow development of urbanization can result in the hindrance to rural economic development.
基金Under the auspices of National Youth Science Foundation of China(No.41601173)China Postdoctoral Science Foundation(No.2016M600954)
文摘Analyzing spatiotemporal dynamics of land use and land cover over time is widely recognized as important to better understand and provide solutions for social, economic, and environmental problems, especially in ecologically fragile region. In this paper, a case study was taken in Zhenlai County, which is a part of farming-pastoral ecotone of Northeast China. This study seeks to use multi-temporal satellite images and other data from various sources to analyze spatiotemporal changes from 1932 to 2005, and applied a quantitative methodology named intensity analysis in the time scale of decades at three levels: time interval, category, and transition. The findings of the case study are as follows: 1) the interval level of intensity analysis revealed that the annual rate of overall change was relatively fast in 1932–1954 and 1954–1976 time intervals. 2) The category level showed that arable land experienced less intensively gains and losses if the overall change was to have been distributed uniformly across the landscape while the gains and losses of forest land, grassland, water, settlement, wetland and other unused land were not consistent and stationary across the four time intervals. 3) The transition level illustrated that arable land expanded at the expense of grassland before 2000 while it gained intensively from wetland from 2000 to 2005. Settlement targets arable land and avoids grassland, water, wetland and other unused land. Besides, the loss of grassland was intensively targeted by arable land, forest land and wetland in the study period while the loss of wetland was targeted by water except for the time interval of 1976–2000. 4) During the early reclamation period, land use change of the study area was mainly affected by the policy, institutional and political factors, followed by the natural disasters.
基金We thank Veder Garcia (University of California, Berkeley, USA) for critically reading the paper, Zengyong He for providing the AtFKBP53::GUS transgenic line and Masami Horikoshi (The University of Tokyo, Japan) for the pET-6His-SpFkbp39P plasmid. This work was supported by grants from the National Science Foundation and US Department of Energy (toSL).
文摘Chromatin structure is important for controlling gene expression, but mechanisms underlying chromatin remodel- ing are not fully understood. Here we report that an FKBP (FK506 binding protein) type immunophilin, AtFKBP53, possesses histone chaperone activity and is required for repressing ribosomal gene expression in Arabidopsis. The At- FKBP53 protein is a multidomain FKBP with a typical peptidylprolyl isomerase (PPIase) domain and several highly charged domains. Using nucleosome assembly assays, we showed that AtFKBP53 has histone chaperone activity and the charged acidic domains are sufficient for the activity. We show that AtFKBP53 interacts with histone H3 through the acidic domains, whereas the PPIase domain is dispensable for histone chaperone activity or histone binding. Ri- bosomal RNA gene (18S rDNA) is overexpressed when AtFKBP53 activity is reduced or eliminated in Arabidopsis plants. Chromatin immunoprecipitation assay showed that AtFKBP53 is associated with the 18S rDNA gene chro- matin, implicating that AtFKBP53 represses rRNA genes at the chromatin level. This study identifies a new histone chaperone in plants that functions in chromatin remodeling and regulation of transcription.
文摘This paper analyzes the impact of income distribution gap on consumption demand from a theoretical view,and draws the conclusion that there is an inverse relationship between income distribution gap and consumption demand.Then,the paper finds that the existing widening income distribution gap in China has a negative impact on consumption demand,but this is not the key factor for the insufficient consumption demand because of the low level of per capital income.At last,it suggests that governments should improve the income level of entire residents and adjust income distribution structure simultaneously.
文摘The separation method using chiral stationary phase (CSP) for the preparation of enantioselective compound was widely used. In this work, supercritical fluid chromatography(SFC) was proposed to resolve the chiral mixtures. To determine the optimum operating conditions for the chiral separation of the racemic ibuprofen, the retention factors and resolutions with the change in pressure, temperature and the content of IPA (%, by volume) in supercritical CO2 were investigated. Experiments showed that the retention factor decreased with the increase of pressure and decrease in temperature. The retention factor was also influenced by the content of IPA in mobile phase, as the content of IPA in the supercritical fluid increased, the retention factor decreased. The resolution of the enantiomers became worse with the increase of IPA in the supercritical fluid. Through optimizing the experimental conditions, a SFC procedure with 13MPa, 311.15K and 4% IPA in CO2 was obtained. The peak shape of the enantiomers was symmetric with supercritical fluid chromatography when compared to the asymmetric peak shape obtained by the conventional liquid chromatography. This work demonstrated that the developed supercritical fluid chromatography procedure was suitable for the chiral separation of ibuprofen enantiomers.
基金Supported by "Bates" Clinic, Svetice 15, Zagreb, Croatia, in the form of grant, equipment and drugs
文摘AIM: To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. METHODS: In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 rain intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure. RESULTS: A statistically significant reduction in mean arterial pressure was demonstrated (P〈0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P〈0.001). A critical decrease in oxygen saturation (〈90%) was documented in 27 patients (2.4%). CONCLUSION: Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effelts if carefully titrated. All the patients (and especially ASA Ⅲ group) require monitoring and care of an anesthesiologist.
基金The National Natural Science Foundation of China(No.61273119,61104068,61374038)the Natural Science Foundation of Jiangsu Province(No.BK2011253)
文摘The exponential stabilization problem for finite dimensional switched systems is extended to the infinite dimensional distributed parameter systems in the Hilbert space. Based on the semigroup theory, by applying the multiple Lyapunov function method, the exponential stabilization conditions are derived. These conditions are given in the form of linear operator inequalities where the decision variables are operators in the Hilbert space; while the stabilization properties depend on the switching rule. Being applied to the two-dimensional heat switched propagation equations with the Dirichlet boundary conditions, these linear operator inequalities are transformed into standard linear matrix inequalities. Finally, two examples are given to illustrate the effectiveness of the proposed results.
文摘AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing colonoscopy.METHODS:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the procedure.Both the colonoscopist and patient were blinded to the type of gas used.During the procedure,insertion and withdrawal times,caecal intubationrates,total sedation given and capnography readings were recorded.The level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale(VAS)(0-3).Patients then graded their level of discomfort and abdominal bloating using a similar VAS.Complications during and after the procedure were recorded.RESULTS:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 arm.Mean age between the two study groups were similar.Insertion time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air(P = 0.0083).The average withdrawal times were not significantly different between the two groups.Caecal intubation rates were 94.4% and 100% in the air and CO2 groups respectively(P = 0.012).The level of discomfort assessed by the nurse was 0.69(air) and 0.39(CO2)(P = 0.0155) and by the patient 0.82(air) and 0.46(CO2)(P = 0.0228).The level of abdominal bloating was 0.97(air) and 0.36(CO2)(P = 0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air insufflation.There were no complications in both arms.CONCLUSION:CO2 insufflation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation rates.Abdominal discomfort and bloating were significantly less with CO2 insufflation.
文摘The area of interest is located in the South Moravia Region at the confluence of the Jihlava, Oslava and Rokytn^i rivers. Ivan^ice spring area comprises a series of hydrologic boreholes, it is the main water source for water supply of Ivan^ice and Rosice towns and provides water for 30,000 inhabitants. The risk analysis was created on the basis of water quality monitoring, hydrogeological assessment and terrain exploration and a revision of protection zones was proposed. The spring area is situated in nitrate vulnerable zones and recently nitrate concentrations have been decreasing. Water quality evaluation results: high concentration of manganese and iron, sometimes higher concentration of ammonium and COD. This area is intensively used for agriculture and it is necessary to make a compromise solution during protection zones proposal, The regime in protection zones can not affect manganese and iron concentration (their origin is in the natural geological environment). Therefore, water treatment plant is in operation and its modernization is proposed. Furthermore, the paper deals with spring area intensification construction of a new hydrologic borehole, and managed and unmanaged infiltration of surface water. The proposal of protection zones revision consists of reduction to a 2nd level protection zone.