To improve the accuracy and speed in cycle-accurate power estimation, this paper uses multiple dimensional coefficients to build a Bayesian inference dynamic power model. By analyzing the power distribution and intern...To improve the accuracy and speed in cycle-accurate power estimation, this paper uses multiple dimensional coefficients to build a Bayesian inference dynamic power model. By analyzing the power distribution and internal node state, we find the deficiency of only using port information. Then, we define the gate level number computing method and the concept of slice, and propose using slice analysis to distill switching density as coefficients in a special circuit stage and participate in Bayesian inference with port information. Experiments show that this method can reduce the power-per-cycle estimation error by 21.9% and the root mean square error by 25.0% compared with the original model, and maintain a 700 + speedup compared with the existing gate-level power analysis technique.展开更多
Rock bolts have been widely used in slopes as a reinforcement measure.Modelling the shear mechanical behaviours of bolted rock joints is very complicated due to the complex factors that affect the axial force and shea...Rock bolts have been widely used in slopes as a reinforcement measure.Modelling the shear mechanical behaviours of bolted rock joints is very complicated due to the complex factors that affect the axial force and shear force on the bolts.Rock bolts under shear action exhibit the guide rail effect;that is,the rock mass slides along the rock bolt as if the rock bolt is a rail.The normal stress can inhibit the guide rail effect and reduce the axial force on bolts.However,this factor is not considered by the existing analysis models.Shear tests of bolted joints under different normal stresses were carried out in the laboratory.During the test,the axial force on each point monitored on the bolt was recorded by a strain gauge,and the attenuation trend of the strain was studied.An analytical model that considers the inhibition of the bolt rail effect due to an increase in the normal stress was proposed to predict the shear mechanical behaviour of rock bolted joints.The new model accommodates the bolt shear behaviours in the elastic stage and plastic stage,and the estimated values agree well with the results of the direct shear tests in the laboratory.The validation shows that the proposed model can effectively describe the deformation characteristics of the bolts in the shear tests.展开更多
A new predictive model for evaluating the vibration of a sawing machine was developed using a new rock classification system. The predictors are machine parameters and a rock sawability index. The new rock classificat...A new predictive model for evaluating the vibration of a sawing machine was developed using a new rock classification system. The predictors are machine parameters and a rock sawability index. The new rock classification system includes four major parameters of the rock: uniaxial compressive strength, abrasiv- ity index, mean MoWs hardness, and Young's modulus. The FAHP approach was used when determining the weights of these parameters by six decision makers. Two groups of carbonate rocks were sawn using a fully-instrumented laboratory sawing rig at different feed rates and depths of cut. During the sawing trials system vibration was monitored as a measure of saw performance. Then, a new statistical model was obtained by multiple regression on the machining parameters and the rock sawability index. The model is very useful for the evaluation of the system vibration, and for selecting suitable machining parameters, from a limited set of mechanical properties.展开更多
Objective To investigate the changes of hipbone biomechanics after the resection of ischiopubic tumors and their relationships with the complications in the convalescent stage, and directing the postoperative pelvic r...Objective To investigate the changes of hipbone biomechanics after the resection of ischiopubic tumors and their relationships with the complications in the convalescent stage, and directing the postoperative pelvic reconstruction. Methods DICOM data were used to create an intact hipbone finite element model and postoperative model. The biomechanical indices on the same region in the two models under the same boundary condition were compared. The differences of displacement, stress, and strain of the two models were analyzed with statistical methods. Results The distribution areas of the hipbone nodes' displacement, stress, and strain were similar before and after the simulated operation. The sacroiliac joint nodes' displacement (P=0.040) and strain (P=0.000), and the acetabular roof nodes' stress (P=0.000) and strain (P=0.005) of two models had significant differences, respectively. But the sacroiliac joint nodes' stress (P=0.076) and the greater sciatic notch nodes' stress (P=0.825) and strain (P=0.506) did not have significant differences. Conclusions The resection of ischiopubic tumors mainly affect the biomechanical states of the homolateral sacroiliac joint and acetabular roof. The complications in the convalescent stage are due to the biomechanical changes of the sacroiliac joint and the acetabular roof and disappearances of the stabilization and connection functions of the pubic symphysis and superior ramus of pubis.展开更多
By the use of ANSYS/LS-DYNA FEA software,numerical simulation on the cutting process of cutting plates with a reamer was carried out in the paper. The logical improvement was brought forward and the phenomenon of stre...By the use of ANSYS/LS-DYNA FEA software,numerical simulation on the cutting process of cutting plates with a reamer was carried out in the paper. The logical improvement was brought forward and the phenomenon of stress concentration was deceased by weighted analysis. The effects of different cut velocities and cutting thickness on life-spans of reamers were investigated, and the cutting parameters were optimized to satisfy the cutting precision and cutting efficiency. The study will provide a guide for the practical production.展开更多
AIM: To develop a method of labeling and microdissecting mouse Kupffer cells within an extraordinarily short period of time using laser capture microdissection (LCM). METHODS: Tissues are complex structures compri...AIM: To develop a method of labeling and microdissecting mouse Kupffer cells within an extraordinarily short period of time using laser capture microdissection (LCM). METHODS: Tissues are complex structures comprised of a heterogeneous population of interconnected cells. LCM offers a method of isolating a single cell type from specific regions of a tissue section. LCM is an essential approach used in conjunction with molecular analysis to study the functional interaction of cells in their native tissue environment. The process of labeling and acquiring cells by LCM prior to mRNA isolation can be elaborate, thereby subjecting the RNA to considerable degradation. Kupffer cell labeling is achieved by injecting India ink intravenously, thus circumventing the need for in vitro staining. The significance of this novel approach was validated using a cholestatic liver injury model. RESULTS: mRNA extracted from the microdissected cell population displayed marked increases in colonystimulating factor-1 receptor and Kupffer cell receptor message expression, which demonstrated Kupffer cell enrichment. Gene expression by Kupffer ceils derived from bile-duct-ligated, versus sham-operated, mice was compared. Microarray analysis revealed a significant (2.5-fold, q value 〈 10) change in 493 genes. Based on this fold-change and a standardized PubMed search, 10 genes were identified that were relevant to the ability of Kupffer cells to suppress liver injury. CONCLUSION; The methodology outlined herein provides an approach to isolating high quality RNA from Kupffer cells, without altering the tissue integrity.展开更多
文摘To improve the accuracy and speed in cycle-accurate power estimation, this paper uses multiple dimensional coefficients to build a Bayesian inference dynamic power model. By analyzing the power distribution and internal node state, we find the deficiency of only using port information. Then, we define the gate level number computing method and the concept of slice, and propose using slice analysis to distill switching density as coefficients in a special circuit stage and participate in Bayesian inference with port information. Experiments show that this method can reduce the power-per-cycle estimation error by 21.9% and the root mean square error by 25.0% compared with the original model, and maintain a 700 + speedup compared with the existing gate-level power analysis technique.
基金Projects(41931295,41877258)supported by the National Natural Science Foundation of ChinaProject(2017YFC1501305)supported by the National Key Research and Development Program of China。
文摘Rock bolts have been widely used in slopes as a reinforcement measure.Modelling the shear mechanical behaviours of bolted rock joints is very complicated due to the complex factors that affect the axial force and shear force on the bolts.Rock bolts under shear action exhibit the guide rail effect;that is,the rock mass slides along the rock bolt as if the rock bolt is a rail.The normal stress can inhibit the guide rail effect and reduce the axial force on bolts.However,this factor is not considered by the existing analysis models.Shear tests of bolted joints under different normal stresses were carried out in the laboratory.During the test,the axial force on each point monitored on the bolt was recorded by a strain gauge,and the attenuation trend of the strain was studied.An analytical model that considers the inhibition of the bolt rail effect due to an increase in the normal stress was proposed to predict the shear mechanical behaviour of rock bolted joints.The new model accommodates the bolt shear behaviours in the elastic stage and plastic stage,and the estimated values agree well with the results of the direct shear tests in the laboratory.The validation shows that the proposed model can effectively describe the deformation characteristics of the bolts in the shear tests.
文摘A new predictive model for evaluating the vibration of a sawing machine was developed using a new rock classification system. The predictors are machine parameters and a rock sawability index. The new rock classification system includes four major parameters of the rock: uniaxial compressive strength, abrasiv- ity index, mean MoWs hardness, and Young's modulus. The FAHP approach was used when determining the weights of these parameters by six decision makers. Two groups of carbonate rocks were sawn using a fully-instrumented laboratory sawing rig at different feed rates and depths of cut. During the sawing trials system vibration was monitored as a measure of saw performance. Then, a new statistical model was obtained by multiple regression on the machining parameters and the rock sawability index. The model is very useful for the evaluation of the system vibration, and for selecting suitable machining parameters, from a limited set of mechanical properties.
基金Supported by Medical Scientific Research Foundation Item of Guangdong Province(A2008800)Science and Technology ProgramItem of Zhongshan City(20082A071and20113A049)
文摘Objective To investigate the changes of hipbone biomechanics after the resection of ischiopubic tumors and their relationships with the complications in the convalescent stage, and directing the postoperative pelvic reconstruction. Methods DICOM data were used to create an intact hipbone finite element model and postoperative model. The biomechanical indices on the same region in the two models under the same boundary condition were compared. The differences of displacement, stress, and strain of the two models were analyzed with statistical methods. Results The distribution areas of the hipbone nodes' displacement, stress, and strain were similar before and after the simulated operation. The sacroiliac joint nodes' displacement (P=0.040) and strain (P=0.000), and the acetabular roof nodes' stress (P=0.000) and strain (P=0.005) of two models had significant differences, respectively. But the sacroiliac joint nodes' stress (P=0.076) and the greater sciatic notch nodes' stress (P=0.825) and strain (P=0.506) did not have significant differences. Conclusions The resection of ischiopubic tumors mainly affect the biomechanical states of the homolateral sacroiliac joint and acetabular roof. The complications in the convalescent stage are due to the biomechanical changes of the sacroiliac joint and the acetabular roof and disappearances of the stabilization and connection functions of the pubic symphysis and superior ramus of pubis.
文摘By the use of ANSYS/LS-DYNA FEA software,numerical simulation on the cutting process of cutting plates with a reamer was carried out in the paper. The logical improvement was brought forward and the phenomenon of stress concentration was deceased by weighted analysis. The effects of different cut velocities and cutting thickness on life-spans of reamers were investigated, and the cutting parameters were optimized to satisfy the cutting precision and cutting efficiency. The study will provide a guide for the practical production.
基金Supported by NIH Grant DK068097funds provided by Rhode Island Hospital+1 种基金the Deutsche Forschungsgemeinschaft grant (DFG) grant GE1193/1-1NIH COBRE Award (RR-P20 RR17695)
文摘AIM: To develop a method of labeling and microdissecting mouse Kupffer cells within an extraordinarily short period of time using laser capture microdissection (LCM). METHODS: Tissues are complex structures comprised of a heterogeneous population of interconnected cells. LCM offers a method of isolating a single cell type from specific regions of a tissue section. LCM is an essential approach used in conjunction with molecular analysis to study the functional interaction of cells in their native tissue environment. The process of labeling and acquiring cells by LCM prior to mRNA isolation can be elaborate, thereby subjecting the RNA to considerable degradation. Kupffer cell labeling is achieved by injecting India ink intravenously, thus circumventing the need for in vitro staining. The significance of this novel approach was validated using a cholestatic liver injury model. RESULTS: mRNA extracted from the microdissected cell population displayed marked increases in colonystimulating factor-1 receptor and Kupffer cell receptor message expression, which demonstrated Kupffer cell enrichment. Gene expression by Kupffer ceils derived from bile-duct-ligated, versus sham-operated, mice was compared. Microarray analysis revealed a significant (2.5-fold, q value 〈 10) change in 493 genes. Based on this fold-change and a standardized PubMed search, 10 genes were identified that were relevant to the ability of Kupffer cells to suppress liver injury. CONCLUSION; The methodology outlined herein provides an approach to isolating high quality RNA from Kupffer cells, without altering the tissue integrity.