AIM:To investigate the trend in gastric cancer surgery in the context of rapid therapeutic advancement in Japan and East Asia.METHODS:A retrospective analysis was performed on 4163 patients who underwent gastric resec...AIM:To investigate the trend in gastric cancer surgery in the context of rapid therapeutic advancement in Japan and East Asia.METHODS:A retrospective analysis was performed on 4163 patients who underwent gastric resection for gastric cancer with histological confirmation between 1971 and 2007 at the surgical unit in Kitasato University Hospital,to determine the trend in gastric cancer requiring surgery.RESULTS:Gastric cancer requiring surgical resection increased in our hospital,but the incidence adjusted for population was constant during the observed pe-riod.Interestingly,the ratio of diffuse type/intestinal type gastric cancer was unexpectedly unchanged,and that of advanced/early gastric cancer(EGC)was,however,markedly reduced,while the actual incidence of potentially curative advanced gastric cancer tended to decrease.The incidence of EGC requiring surgery tended to increase as a whole,which is consistent with increased prevalence of endoscopic surveillance.As a result,overall survival and mortality of gastric cancer requiring gastric resection has recently markedly improved.CONCLUSION:In Japan,planned interventions may improve surgical gastric cancer mortality,but an unexpected trend of persistent existence of intestinal type cancer suggests the need for more robust medical intervention.展开更多
AIM： To compare the prognosis of patients who underwent hepatectomy and ablation using the modified Japan Integrated Staging score （mJIS）. METHODS： We examined the clinicopathologic records and patient outcomes in...AIM： To compare the prognosis of patients who underwent hepatectomy and ablation using the modified Japan Integrated Staging score （mJIS）. METHODS： We examined the clinicopathologic records and patient outcomes in 278 HCC patients including 226 undergoing hepatectomy and 52 undergoing ablation therapy. RESULTS： Cirrhosis was more frequent in the ablation group. Tumor size, number and presence of vascular invasion were significantly higher in the operation group compared to the ablation group. The local recurrence rate adjacent to treated lesions was significantly higher in the ablation group compared to the operation group （P 〈 0.05）. The 3- and 5-year survival rates in the ablation and the operation group were 66% and 78%, and 50% and 63%, respectively, but not significantly different. Over 50% survival rates were observed in patients with a m.lIS score of 0-2 in both groups. However, survival rates with a score of 3-5 in both groups were significantly lower. CONCLUSION： According to the mJIS system, both local treatments could be selected for patients with a score of 0-2. However, for patients with a score more than 3, liver transplantation might be a better option in patients with HCC.展开更多
To address large scale industrial processes,a novel Lagrangian scheme is proposed to decompose a refinery scheduling problem with operational transitions in mode switching into a production subproblem and a blending a...To address large scale industrial processes,a novel Lagrangian scheme is proposed to decompose a refinery scheduling problem with operational transitions in mode switching into a production subproblem and a blending and delivery subproblem.To accelerate the convergence of Lagrange multipliers,some auxiliary constraints are added in the blending and delivery subproblem.A speed-up scheme is presented to increase the efficiency for solving the production subproblem.An initialization scheme of Lagrange multipliers and a heuristic algorithm to find feasible solutions are designed.Computational results on three cases with different lengths of time horizons and different numbers of orders show that the proposed Lagrangian scheme is effective and efficient.展开更多
An accurate determination of intedaminar transversal stresses in composite multilayered plates, especially near free-edge, is of great importance in the study of inter-ply damage modes, mainly in the initiation and gr...An accurate determination of intedaminar transversal stresses in composite multilayered plates, especially near free-edge, is of great importance in the study of inter-ply damage modes, mainly in the initiation and growth of delamination. In this paper, interlaminar stresses are determined by layer-wise mixed finite element model. Each layer is analyzed as an isolated one where the displacement continuity is ensured by means of Lagrange multipliers （which represent the statics variables）. This procedure allows the authors to work with any single plate model, obtaining the interlaminar stresses directly without loss of precision. The FSDT （first shear deformation theory） with transverse normal strain effects included is assumed in each layer, but Lagrange polynomials are used to describe the kinematic instead of Taylor＇s polynomial functions of the thickness coordinates, as is common. This expansion allows the authors to pose the interlaminar displacements compatibility simpler than the second one. The in-plane domain of the plate is discretized by four-node quadrilateral elements, both to the field of displacement and to the Lagrange multipliers. The mixed interpolation of tensorial components technique is applied to avoid the shear-locking in the finite element model. Several examples were carried out and the results have been satisfactorily compared with those available in the literature.展开更多
In this paper,the modern geometrical structure of analytical mechanics,the exterior differential forms and the geometrical meaning of dynamic equations are briefly discussed.
基金Supported by Japanese Foundation for Multidisciplinary Treatment of Cancer
文摘AIM:To investigate the trend in gastric cancer surgery in the context of rapid therapeutic advancement in Japan and East Asia.METHODS:A retrospective analysis was performed on 4163 patients who underwent gastric resection for gastric cancer with histological confirmation between 1971 and 2007 at the surgical unit in Kitasato University Hospital,to determine the trend in gastric cancer requiring surgery.RESULTS:Gastric cancer requiring surgical resection increased in our hospital,but the incidence adjusted for population was constant during the observed pe-riod.Interestingly,the ratio of diffuse type/intestinal type gastric cancer was unexpectedly unchanged,and that of advanced/early gastric cancer(EGC)was,however,markedly reduced,while the actual incidence of potentially curative advanced gastric cancer tended to decrease.The incidence of EGC requiring surgery tended to increase as a whole,which is consistent with increased prevalence of endoscopic surveillance.As a result,overall survival and mortality of gastric cancer requiring gastric resection has recently markedly improved.CONCLUSION:In Japan,planned interventions may improve surgical gastric cancer mortality,but an unexpected trend of persistent existence of intestinal type cancer suggests the need for more robust medical intervention.
文摘AIM： To compare the prognosis of patients who underwent hepatectomy and ablation using the modified Japan Integrated Staging score （mJIS）. METHODS： We examined the clinicopathologic records and patient outcomes in 278 HCC patients including 226 undergoing hepatectomy and 52 undergoing ablation therapy. RESULTS： Cirrhosis was more frequent in the ablation group. Tumor size, number and presence of vascular invasion were significantly higher in the operation group compared to the ablation group. The local recurrence rate adjacent to treated lesions was significantly higher in the ablation group compared to the operation group （P 〈 0.05）. The 3- and 5-year survival rates in the ablation and the operation group were 66% and 78%, and 50% and 63%, respectively, but not significantly different. Over 50% survival rates were observed in patients with a m.lIS score of 0-2 in both groups. However, survival rates with a score of 3-5 in both groups were significantly lower. CONCLUSION： According to the mJIS system, both local treatments could be selected for patients with a score of 0-2. However, for patients with a score more than 3, liver transplantation might be a better option in patients with HCC.
基金Supported by the National Natural Science Foundation of China(61273039,21276137)the National Science Fund for Distinguished Young Scholars of China(61525304)
文摘To address large scale industrial processes,a novel Lagrangian scheme is proposed to decompose a refinery scheduling problem with operational transitions in mode switching into a production subproblem and a blending and delivery subproblem.To accelerate the convergence of Lagrange multipliers,some auxiliary constraints are added in the blending and delivery subproblem.A speed-up scheme is presented to increase the efficiency for solving the production subproblem.An initialization scheme of Lagrange multipliers and a heuristic algorithm to find feasible solutions are designed.Computational results on three cases with different lengths of time horizons and different numbers of orders show that the proposed Lagrangian scheme is effective and efficient.
文摘An accurate determination of intedaminar transversal stresses in composite multilayered plates, especially near free-edge, is of great importance in the study of inter-ply damage modes, mainly in the initiation and growth of delamination. In this paper, interlaminar stresses are determined by layer-wise mixed finite element model. Each layer is analyzed as an isolated one where the displacement continuity is ensured by means of Lagrange multipliers （which represent the statics variables）. This procedure allows the authors to work with any single plate model, obtaining the interlaminar stresses directly without loss of precision. The FSDT （first shear deformation theory） with transverse normal strain effects included is assumed in each layer, but Lagrange polynomials are used to describe the kinematic instead of Taylor＇s polynomial functions of the thickness coordinates, as is common. This expansion allows the authors to pose the interlaminar displacements compatibility simpler than the second one. The in-plane domain of the plate is discretized by four-node quadrilateral elements, both to the field of displacement and to the Lagrange multipliers. The mixed interpolation of tensorial components technique is applied to avoid the shear-locking in the finite element model. Several examples were carried out and the results have been satisfactorily compared with those available in the literature.
基金Work supported by NSF of Henan Education Commission
文摘In this paper,the modern geometrical structure of analytical mechanics,the exterior differential forms and the geometrical meaning of dynamic equations are briefly discussed.
