软胶囊改建车间的初步方案设计

药品车间改建是常见的一种设计内容。改建项目应结合原有车间的实际情况,合理的规划车间的整体布局。结合某软胶囊改建车间的具体实例,从车间的整体布局、车间的总人/物流设计、辅助用室布局、生产区的布局等设计要点分析和探讨了此类车间在初步方案设计中应注意的内容,保证车间布局满足使用需求,符合药品GMP要求,且可最大限度的减少交叉污染,保证人、物流畅通,提高药品生产的质量和效率。

临界实验装置中子毒物系统初步设计研究

为解决钚溶液临界实验装置中子毒物系统初步方案设计中毒物棒布置灵活性和装置密封性的关键难题,本文基于磁吸控制方式,提出了磁吸式无接触布置中子毒物棒的临界实验装置初步设计方案,该方案能够在完全密封无接触的情况下,实现有棒、无棒、不同数量、不同材质、不同排列、不同高度的中子毒物棒布置方案,可以有效解决开展钚溶液带中子毒物棒的临界实验时的放射性气溶胶密封问题、变更中子毒物棒布置的精度不足等问题,相对于传统方法具有较大优势,为开展该类实验装置的详细设计提供了可行思路。

A Signed Digraphs Based Method for Detecting Inherently Unsafe Factors of Chemical Process at Conceptual Design Stage

Digraph-based causal models have been widely used to model the cause and effect behavior of process systems. Signed digraphs （SDG） capture the direction of the effect. It should be mentioned that there are loops in SDG generated from chemical process. From the point of the inherent operability, the worst unsafe factor is the SDG having positive loops that means any disturbance occurring within the loop will propagate through the nodes one by one and are amplified gradually, so the system may lose control, which may lead to an accident. So finding the positive loops in a SDG and treating these unsafe factors in a proper manner can improve the inherent safety of a chemical process. This article proposed a method that can detect the above-mentioned unsafe factors in the proc- ess conceptual design stage automatically through the analysis of the SDG generated from the chemical process. A case study is illustrated to show the working of the algorithm, and then a complicated case from industry is studied to depict the effectiveness of the proposed algorithm.

3R踝关节康复机器人工作空间研究

本文首先对3R踝关节康复训练机器人的工作原理和拓扑构型进行了分析。建立了以D-H法为基础的3R踝关节康复训练器机器人运动学模型。在Inventor软件中完成了3R踝关节康复机器人的初步方案设计工作,借助MATLAB软件仿真分析了脚踏板上一点P在单一康复训练模式和复合康复训练模式下的运动轨迹,进而验证了3R踝关节康复机器人运动学模型的正确性。最后,借助工作原理动画,分析了3R踝关节康复训练机器人在内翻/外翻、背伸/跖屈、内旋/外旋极限位置的工作空间,验证了3R踝关节康复训练机器人初步方案设计的合理性。