广谱强力农药增效剂－害利平

广谱强力农药增效剂－害利平褚茗莉，许国庆，赵琦，顾兰君，赵季秋（辽宁省农业科学院植保所）害利平是刘观兴教授研制的广谱强力增效剂。据资料报道，将害利平混入配好的药液中，防治多种作物或果树病虫害，增效显著。为此，１９９４年我们采用害利平，对棉铃虫、菜青虫...

害利平对卫生杀虫剂增效的实验研究

害利平对卫生杀虫剂增效的实验研究李凡害利平是强力农药增效剂。为了解其对卫生杀虫剂的增效作用，分别进行了实验室和现场实验研究。现将结果报告如下：一、材料：害利平，保定市南市区新兴化工厂提供；８８．５％氯氰菊酯，国家农药测试中心提供；５％奋斗呐（英国），...

广谱农药增效剂─—害利平

广谱农药增效剂─—害利平辽宁省农科院褚茗莉，许国庆，赵奇，顾兰君，赵季秋害利平是一种新研制的广谱强力增效剂。将其混入配好的农药液中，防治多种作物病虫害，增效显著。１９９４年我们应用害利平对棉铃虫、菜青虫、甘蓝夜蛾等进行了室内及田间试验。敌百虫加入害利...

害利平——农药增效的好帮手

害利平是保定市新兴化工厂制造生产、能明显提高农药的利用率及防治效果的一种强力强效剂.其特点:①具有较强的渗透性、展着性和黏附性.②增加农药的杀虫、杀菌、除草速度,加速消除病虫、草害的抗药性.③耐雨水冲刷、药效持久.④明显提高农药的利用率及防治效果.

Development and Validation of Liquid Chromatographic Method for the Determination of the Related Substances of Rifampicin

A number of HPLC methods have been approved for the determination of rifampicin, but no references involved the assay of related substances of rifampicin. In the present paper, a reversed-phase liquid chromatographic method for the determination of related substances of rifampicin is developed and validated. Rifampicin and its related substances, including rifamycin SV, rifampicin N-oxide and 3-formylrifamycin SV were separated using a Zorbax Eclipse C8, 250×4.6 mm(i.d), 5 μm column by isocratic elution at a flow rate of 1 mL·min -1. The detector was set at 254 nm. The mobile phase is a mixture of methanol-acetonitrile -0.075 mol·L -1 monopotassium phosphate -1.0 mol·L -1 citric acid (31:31:35:3, v/v). The method validation included accuracy, precision, linearity, sensitivity and stability. All results are shown to be acceptable.

~1H and ^(13)C NMR Assignments for Amlodipine and Risperidone

Aim To investigate the NMR spectroscopy of amlodipine and risperidone.Methods 1D NMR and 2D NMR experimental techniques of gCOSY, gHSQC and gHMBC were wsed. Results Theassignments of the ~1H and ^(13) C NMR data for the two drugs were performed and confirmed by theevidence of J_(HF) and J_(CF). Conclusion The structures of amlodipine and risperidone wereconfirmed by careful analysis of regular 1D and 2D NMR spectroscopy.

春光照大地 新年全是新

日历翻开新的一页，我们走进了新的一年。新的一年，新的征程，中国欲图强，当有新的风貌，新的精神。聆听新年的钟声，耳边响起了新的号角，眼前形成新的方阵，行舟竞发已张满了风帆，万木逢春已爆绿了希望。

Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats

AIM： To evaluate the hepatoprotective effect of garlic on liver injury induced by isoniazid （INH） and rifarnpicin （RIF）. METHODS： Wistar rats weighing 150-200 g were treated orally with 50 mg/kg of INH and RIF daily each for 28 d. For hepatoprotective studies, 0.25 g/kg per day of freshly prepared garlic hornogenate was administered orally half an hour before the INH＋RIF doses. Serum alanine arninotransferase （AIT）, aspartate aminotransferase （AST） and bilirubin were estimated on d 0, 14, 21, and 28 in all the rats. Histological analysis was carried out to assess the injury to the liver. Lipid peroxidation （1PO） as a marker of oxidative stress and non-protein thiols （glutathione） for antioxidant levels were measured in liver hornogenate. RESULTS： The treatment of rats with INH＋RIF （50 mg/kg per day each） induced hepatotoxicity in all the treated animals as judged by elevated serum ALT, AST, and bilirubin levels, presence of focal hepatocytic necrosis （6/8） and portal triaditis （8/8）. Garlic simultaneously administered at a dose of 0.25 g/kg per day prevented the induction of histopathological injuries in INH＋RIF co-treated animals, except in 4 animals, which showed only moderate portal triaditis. The histological changes correlated with oxidative stress in INH＋RIF treated animals. The group which received 0.25 g/kg per day garlic hornogenate along with INH＋RIF showed higher levels of glutathione （P〈0.05） and low levels of 1PO （P〈 0.05） as compared to INH＋RIF treated group. CONCLUSION： Freshly prepared garlic homogenate protects against INH＋RIF-induced liver injury in experimental animal model.

Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs

AIM: To evaluate and compare the hepatoprotective and immunomodulatory effects of Curcuma longa (CL), Ocimum sanctum (OS), Tinospora cordifolia (TC) and Zizyphus mauritiana (ZM) on liver injury and immunosuppression induced by Isoniazid (INH), Rifampicin (RIF) and Pyrazinamide (PZA). METHODS: Duncan Hartley guinea pigs, weighing 700-1050 g, were treated orally with 50 mg/kg of INH, 100 mg/kg of RIF and 300 mg/Kg of PZA for 21-d. 200 mg/kg (bw) of each herb crude extract was administered to the herb control group and 2-h previous to INH + RIF + PZA (AKT) doses to the Herb + AKT groups. Serum alanine aminotransferase (ALT), aspertate aminotransferase (AST) bilirubin and Alkaline Phosphatase (ALP) were assessed on d 0 and 21 in all the groups. Phagocytic % (P%), Phagocytic Index (PI) and Chemotactic Index (CI) were also measured as immunologic parameters. Histological analysis was carried out to assess injury to the liver. RESULTS: The AKT treated control group showed hepatotoxicity as judged by elevated serum AST 5-fold, AST/ALT ratio 4-fold, ALP 2-fold and hepatological changes, such as focal necrosis, portal triaditis and steatosis. Immune function was suppressed as judged by decreased P% (51.67 ?1.68 vs 40.61 ?1.28, P < 0.01), PI (2.0725±0.05 vs 0.61±0.05, P < 0.001) and CI (1.8525±0.04 vs 0.695±0.07, P < 0.001). All four herb treated groups showed normal liver histology, enzyme levels and increased P%, while PI and CI were enhanced in the TC and ZM treated groups, respectively. CL + AKT, TC + AKT and ZM + AKT showed nearly normal histology with minimal inflammation and microvesicular steatosis, while OS + AKT showed partial protection. Hepatotoxicity was prevented by restricting the rise of AST by 2-fold in CL + AKT and TC + AKT groups and by 3-fold in OS + AKT and ZM + AKT groups, AST/ALT by 2-fold and ALP to normal levels in all four groups. All four herb + AKT groups showed normal to enhanced neutrophil function. CONCLUSION: All four herbs showed hepatoprotective potential and prevented immunosuppression. CL and TC showed the highest hepatoprotective activity, while TC and ZM showed strong immunostimulatory activity.

Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

AIM, To study the role of N-acetylcysteine （NAC） as a protective agent in rifampicin （RMP）-induced oxidative hepatic injury of young rats. METHODS： Hepatic injury was produced by giving 50mg/kg body weight/day of RMP for 3 wk. A dose of NAC （100mg/kg body weight/day） was given in combination with RMP intraperitoneally. Analysis of lipid peroxidation, thiol levels, cytochrome P4se, superoxide dismutase （SOD）, catalase, glutathione peroxidase, reductase and transferase were estimated in liver along with the body weight, liver weight and histological observations. RESULTS： RMP exposure resulted in no change in body and liver weight while antioxidative enzymes were altered but the non protein thiol （GSH） status was well preserved. Cytochrome P450 system and peroxidation of lipids were induced by RMP exposure. Partial protection was observed with NAC against RMP-induced changes in liver, which was evidenced from the prevention of increase in lipid peroxidation and the reduction in SOD and catalase enzyme levels. CONCLUSION. NAC protects young rats against RMP- induced oxidative hepatic injury.

Screening of Prolific Micromonospora carbonacea in Antibiotics Production by Sodium Nitrite Mutagenesis

[Objective] The purpose of the study is to breed Micromonospora car- bonacea highly producing antibiotics and then to improve the antibiotic production. [Method] Sodium Nitrite mutagenesis, combined with rifampicin resistance screening, was used in mutation breeding of M. carbonacea highly producing antibiotics from the strain of M. carbonacea JXNU-I. [Result] The overproducing strain JXNU-1-16- Y65 was screened with the production of antibiotics 266.05% more than that of the original strain. [Conclusion] The effectiveness of sodium nitrite mutation in breeding microorganisms highly producing antibiotic was proved, and the study may lay the foundation on further development and application of the antibiotic from M. car- bonacea JXNU-1.

Principle of Line Configuration and Monte-Carlo Simulation for Shared Multi-Channel System

Based on the steady-state solution of finite-state birth and death process, the principle of line configuration for shared multi-channel system is analyzed. Call congestion ratio equation and channel utilization ratio equation are deduced, and visualized data analysis is presented. The analy-sis indicates that, calculated with the proposed equations, the overestimate for call congestion ratio and channel utilization ratio can be rectified, and thereby the cost of channels can be saved by 2000 in a small system.With MATLAB programming, line configuration methods are provided. In order to generally and intuitively show the dynamic running of the system, and to analyze,promote and improve it, the system is simulated using M/M/n/n/m queuing model and Monte-Carlo method. In addition, the simulation validates the correctness of the theoretical analysis and optimizing configuration method.

Some Problems of Irrigation Water Management in Lower Cheliff Plain （Algeria）

In the Lower Cheliff Plain （northwestern of Algeria）, the waters resources are limited; the adoption of a rational approach in the management of irrigation water in the irrigated perimeter poses an inequality in the balance between supply and demand. The two surface water resources, Gargar and Merdjet Sidi Abed dams, do not satisfy the requirements of agriculture water. According to the National Office of the Irrigation and Drainage data, the quantity of allocated water is never distributed; the difference between allocated water and drop water can also exceed 20%, and then, another problem of management is that the water losses in the distribution can reach 20% again. The shortage irrigation water resource allocated has constrained the farmers to use groundwater. The chemical analysis of 56 simples to this water showed a significant chemical diversity in the compositions. There is a high salinity risk （C3 class） or very high risk （C4 class） of soil salinisation. A space chart distribution to the EC water probability to exceed 2.25 dS/m interpolated by the indicator kriging method showed that 78% of the groundwater surface presents a significant probability to exceed this limit. The average value of the SAR （sodium adsorption ratio） is lower than 10 that indicates a moderate risk of sodisation. This observation is in contradiction with the high values of the SAR measured in the soil solution. The approach of residual alkalinity （RSC） shows that a good number of drillings analyzed presents a positive sign RSC （RSC 〉 0）. This water presents a real danger of sodisation. They have a low salinity, which, for a farmer, does not present any danger.

Evaluation and prediction of blast induced ground vibration using support vector machine

We present the application of Support Vector Machine (SVM) for the prediction of blast induced ground vibration by taking into consideration of maximum charge per delay and distance between blast face to monitoring point. To investigate the suitability of this approach, the predictions by SVM have been compared with conventional predictor equations. Blast vibration study was carried out at Magnesite mine of Pithoragarh, India. Total 170 blast vibrations data sets were recorded at different strate-gic and vulnerable locations in and around to mine. Out of 170 data sets, 150 were used for the training of the SVM network as well as to determine site constants of different conventional predictor equations, whereas, 20 new randomly selected data sets were used to compare the prediction capability of SVM network with conventional predictor equations. Results were compared based on Co-efficient of Determination (CoD) and Mean Absolute Error (MAE) between monitored and predicted values of Peak Particle Veloc-ity (PPV). It was found that SVM gives closer values of predicted PPV as compared to conventional predictor equations. The coef-ficient of determination between measured and predicted PPV by SVM was 0.955, whereas it was 0.262, 0.163, 0.337 and 0.232 by USBM, Langefors-Kihlstrom, Ambraseys-Hendron and Bureau of Indian Standard equations, respectively. The MAE for PPV was 11.13 by SVM, whereas it was 0.973, 1.088, 0.939 and 1.292 by USBM, Langefors-Kihlstrom, Ambraseys-Hendron and Bureau of Indian Standard equations respectively.

A Practical Adaptive TuCM Scheme for Rayleigh Flat Fading Channels

A practical adaptive turbo coded modulation (TuCM) scheme was proposed and its adaptive method was described. With some hardware considerations, a suboptimal optimization algorithm that the number of fading regions is variable was put forward. Furthermore, the cutoff fade depth of power adaptation was modified to reduce the interruption probability. The results show that the proposed adaptive TuCM comes within 3 dB of Rayleigh fading channel capacity, and exhibits about 3 dB power gain relative to the conventional adaptive trellis-coded modulation (TCM), and is easy to realize by hardware.

Regional Differences of China′s Urban Expansion from Late 20th to Early 21st Century Based on Remote Sensing Information

This study investigated the regional differences of China′s urban land expansion from the late 1980s to the year of 2008, based on the spatio-temporal analysis of CLCD (China′s land cover/land use database) datasets which were mainly produced from remote sensing imagery data. A newly defined urbanization level index (UI), based on urban land area, is proposed to describe Chinese urban expansion process at 1 kilometer, provincial, regional, and na-tional scales, together with the absolute urban expansion index (UEa) and the relative urbanization expansion index (UEr). The results indicate that the percentages of total land area occupied by urban in the late 1980s, 1995, 2000, 2005, and 2008 were approximately 0.25%, 0.32%, 0.33%, 0.43% and 0.52% of China′s total land area, respectively. Between the late 1980s and 2008, the total urban expansion in the mainland of China was 2.645 × 104 km2, resulting in an annual urban expansion area of about 1322.7 km2/yr, with the UEr of 111.9%. This study also finds that there has been an obvious spatial gradient of urbanization ratio running from the east coast to the west inland, and the urbanization gaps among different regions have persisted over the past two decades. The study also reveals obvious temporal varia-tions of the urbanization rates. There was very little urban growth during the period of 1995-2000 due to the governmental policy factors.

Changes of Soil Labile Organic Carbon in Different Land Uses in Sanjiang Plain, Heilongjiang Province

In the Sanjiang Plain,Northeast China,the natural wetland is undergoing a rapid conversion into agricultural land,which has resulted in drastic ecological changes in the region. To investigate the effects of different land uses on soil labile organic carbon,soils of Calamagrostis angustifolia wetland,Carex lasiocarpa wetland,dry farmland,paddy field,forest land and abandoned cultivated land were collected for measuring the contents of soil microbial biomass carbon (MBC),dissolved organic carbon (DOC),readily oxidizable carbon (ROC) and carbohydrate carbon (CHC). The results show that soil organic carbon contents follow the order: Carex lasiocarpa wetland>Calamagrostis angustifolia wetland>forest land>paddy field>dry farmland. The contents of MBC and DOC in Calamagrostis angustifolia and Carex lasiocarpa wetlands are significantly higher than those in other land use types. The contents of CHC and ROC are the highest in Calamagrostis angustifolia wetland and the lowest in dry farmland. The contents of all the labile organic carbon increase along with the years of abandonment of cultivated land. The ratios of MBC,DOC and ROC to SOC also follow the order: Carex lasiocarpa wetland>Calamagrostis angustifolia wetland>forest land>paddy field>dry farmland,while the ratio of CHC to SOC is paddy field>forest field>Carex lasiocarpa wetland>Carex lasiocarpa wetland>dry farmland. When natural wetlands were cultivated,the activity of soil organic carbon tends to reduce in some extent due to the disappearance of heterotrophic environment and the reduction of vegetation residue. Thus,the abandonment of cultivated land is an effective way for restoring soil organic carbon.

C-type natriuretic-peptide-potentiated relaxation response of gastric smooth muscle in streptozotocin-induced diabetic rats

AIM: To study the sensitivity of gastric smooth muscle to C-type natriuretic peptide (CNP) in streptozotocin (STZ)-induced diabetic rats. METHODS: The spontaneous contraction of a gastric smooth muscle strip was recorded by using physiological methods in rats. The expressions of CNP and natriuretic peptide receptor-B (NPR-B) in gastric tissue were examined by using immunohistochemistry techniques in the diabetic rat. RESULTS: At 4 wk after injection of STZ and vehicle, the frequency of spontaneous contraction of gastric smooth muscle was significantly reduced in diabetic rats, and the frequency was decreased from 3.10 ± 0.14 cycle/min in controls to 2.23 ± 0.13 cycle/min (n = 8, P < 0.01). However, the amplitude of spontaneous contraction was not significant different from the normal rat. CNP significantly inhibited spontaneous contraction of gastric smooth muscle in normal and diabetic rats, but the inhibitory effect was significantly potentiated in the diabetic rats. The amplitudes of spontaneous contraction were suppressed by 75.15% ± 0.71% and 58.92% ± 1.32% while the frequencies were decreased by 53.33% ± 2.03% and 26.95% ± 2.82% in diabetic and normal rats, respectively (n = 8, P < 0.01). The expression of CNP in gastric tissue was not changed in diabetic rats, however the expression of NPR-B was significantly increased in diabetic rats, and the staining indexes of NPR-B were 30.67 ± 1.59 and 17.63 ± 1.49 in diabetic and normal rat, respectively (n = 8, P < 0.01).CONCLUSION: The results suggest that CNP induced an inhibitory effect on spontaneous contraction of gastric smooth muscle, potentiated in diabetic rat via up-regulation of the natriuretic peptides-NPR-B-particulate guanylyl cyclase-cyclic GMP signal pathway.

Exhaust Ventilation through a Solar Chimney： A Response to High Hermeticity in Welfare Housing

This research reports on potentiality in the solar chimney as an exhaust ventilation device through a hypothetical statement that convenient weather conditions exist on sub-humid warm climate to enhance the performance ofa SC （solar chimney）, in order to increase ventilation to dissipate metabolic heat from inhabitants of airtight buildings. The methodology used in this research integrates the use of simplified mathematical models that predict in a semi-empirical way a potential volume flow through estimation of kinetic power generation, by natural circulation and stack effect in a typical covered-plate air solar collector. The study was carried out during the warm month of April, an important warm season for Colima, where the prevailing wind is about 6.8 m/s, the average temperature of maximums and minimums oscillates between 15.4℃and 34.4 ℃ with average relative humidity of 65% according to national weather service. A scale model of the SC was installed on environmental chambers. The results showed that this device is capable of generating ventilation conditions around light breeze parameters near between 0.6 m/s and 1.5 m/s width, a better performance at day in 45% approximately than the night values, making ventilation rates up 0.24 ACH （air changes per hour） as average air change rate.

A Distributed Monthly Water Balance Model for Analyzing Impacts of Land Cover Change on Flow Regimes

The Miyun Reservoir is the most important water source for Beijing Municipality, the capital of China with a population of more than 12 million. In recent decades, the inflow to the reservoir has shown a decreasing trend, which has seriously threatened water use in Beijing. In order to analyze the influents of land use and cover change (LUCC) upon inflow to Miyun Reservoir, terrain and land use information from remote sensing were utilized with a revised evapotranspiration estimation formula; a water loss model under conditions of human impacts was introduced; and a distributed monthly water balance model was established and applied to the Chaobai River Basin controlled by the Miyun Reservoir. The model simulation suggested that not only the impact of land cover change on evapotranspiration, but also the extra water loss caused by human activities, such as the water and soil conservation development projects should be considered. Although these development projects were of great benefit to human and ecological protection, they could reallocate water resources in time and space, and in a sense thereby influence the stream flow.