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不同利爪小鼠对戊巴比妥钠药物反应的初步研究 被引量:2
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作者 薛翔 丁冉 曾嵘 《重庆医科大学学报》 CAS CSCD 北大核心 2011年第5期569-571,共3页
目的:研究小鼠是否与人类一样存在着利手(爪)偏侧性现象,比较不同利爪偏侧性小鼠对不同浓度的戊巴比妥钠药物反应,初步探讨利爪分布特点及其对药物反应差异,以及这种差异对临床个性化用药的参考意义。方法:成年昆明鼠96只,雌雄各半,观... 目的:研究小鼠是否与人类一样存在着利手(爪)偏侧性现象,比较不同利爪偏侧性小鼠对不同浓度的戊巴比妥钠药物反应,初步探讨利爪分布特点及其对药物反应差异,以及这种差异对临床个性化用药的参考意义。方法:成年昆明鼠96只,雌雄各半,观察小鼠抓取食物所用左右前爪频次,了解小鼠利爪分布;观察不同利爪小鼠给予非麻醉剂量戊巴比妥钠20 mg/(kg.周)前后10 min内自主活动的次数;观察小鼠给予麻醉剂量戊巴比妥钠60 mg/(kg.周)后翻正反射消失时间及苏醒时间;观察不同利爪小鼠戊巴比妥钠LD50实验;了解不同利爪小鼠对戊巴比妥钠药物反应。结果:小鼠左右利爪比例约为2∶3,不同性别小鼠之间差异无统计学意义;给予非麻醉剂量戊巴比妥钠后,左利小鼠自主活动次数显著低于右利小鼠(P<0.05);给予麻醉剂量戊巴比妥钠后,左利小鼠苏醒时间显著短于右利小鼠(P<0.01),而翻正反射反射消失时间差异无统计学意义;左右利小鼠戊巴比妥钠LD50实验结果差异无统计学意义(P>0.05)。结论:小鼠的利爪差异可能导致生理及药物反应的差异,对该类现象的深入研究将有望为临床的个体化用药提供依据。 展开更多
关键词 戊巴比妥钠 利爪 个体化用药
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左右利爪小鼠自主活动特性的研究
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作者 曹尚涛 项静 +2 位作者 李燕 薛翔 曾嵘 《广东医学》 CAS CSCD 北大核心 2012年第17期2557-2558,共2页
目的比较左右利爪小鼠的自主活动特性差异,为进一步探讨脑不对称性提供实验依据。方法选用雄性昆明小鼠72只,用伸爪取食法将小鼠分为左利鼠、右利鼠和双利鼠,采用条件性位置偏爱(conditionedplace preference,CPP)系统记录分析小鼠自主... 目的比较左右利爪小鼠的自主活动特性差异,为进一步探讨脑不对称性提供实验依据。方法选用雄性昆明小鼠72只,用伸爪取食法将小鼠分为左利鼠、右利鼠和双利鼠,采用条件性位置偏爱(conditionedplace preference,CPP)系统记录分析小鼠自主活动。结果小鼠在暗箱的活动路程明显多于明箱(P<0.05),且左利组、右利组与双利组3组间差异无统计学意义(P>0.05);左利组、双利组在明暗箱之间的穿梭次数均明显多于右利组(P<0.05);3组小鼠在明箱或暗箱的活动时间和总路程上的差异均无统计学意义(P>0.05)。结论左利、右利与双利小鼠均具有喜暗避明的习性且程度相当,但左利、双利小鼠比右利小鼠的自主活性表现更为活跃。 展开更多
关键词 小鼠 利爪 自主活动
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欢乐兽
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作者 沈凯锐 赖昭民(指导) 《创新作文(小学5-6年级)》 2019年第1期47-47,共1页
只听沈凯锐神秘兮兮地吹道:很久很久以前,世界上有许多情绪兽,它们长着松鼠的尾巴,狮子的利爪,尖尖的兽角……一场下了几千年的大雪过后,只有一只情绪兽——欢乐兽因为藏在靠近地心的暖暖的岩洞里,才幸免于难。这天,阳光灿烂,快乐广场... 只听沈凯锐神秘兮兮地吹道:很久很久以前,世界上有许多情绪兽,它们长着松鼠的尾巴,狮子的利爪,尖尖的兽角……一场下了几千年的大雪过后,只有一只情绪兽——欢乐兽因为藏在靠近地心的暖暖的岩洞里,才幸免于难。这天,阳光灿烂,快乐广场上一片快乐,小朋友们在快乐游戏,大人们在愉快地聊天。 展开更多
关键词 地心 利爪 岩洞 狮子 尾巴 小朋友 情绪 兽角 游戏
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Landslide Hazard and Community-based Risk Reduction Effort in Karanganyar and the Surrounding Area,Central Java,Indonesia
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作者 KARNAWATI Dwikorita FATHANI Teuku F +3 位作者 IGNATIUS Sudarno ANDAYANI Budi LEGONO Djoko BURTON Paul W 《Journal of Mountain Science》 SCIE CSCD 2011年第2期149-153,共5页
Karanganyar and the surrounding area are situated in a dynamic volcanic arc region, where landslide frequently occurs during the rainy season. The rain-induced landslide disasters have been resulting in 65 fatalities ... Karanganyar and the surrounding area are situated in a dynamic volcanic arc region, where landslide frequently occurs during the rainy season. The rain-induced landslide disasters have been resulting in 65 fatalities and a substantial socioeconomical loss in last December 2007. Again, in early February 2009, 6 more people died, hundreds of people temporary evacuated and tens of houses damaged due to the rain-induced landslide. Accordingly, inter-disciplinary approach for geological, geotechnical and social investigations were undertaken with the goal for improving community resilience in the landslide vulnerable villages. Landslide hazard mapping and communitybased landslide mitigation were conducted to reduce the risk of landslides. The hazard mapping was carried out based on the susceptibility assessment with respect to the conditions of slope inclination, types and engineering properties of lithology/soil as well as the types of landuse. All of those parameters were analyzed by applying weighing and scoring system which were calculated by semi qualitative approach (Analytical Hierarchical Process). It was found that the weathered andesitic-steep slope (steeper than 30o) was identified as the highest susceptible slope for rapid landslide, whilst the gentle colluvial slope with inter-stratification of tuffaceous clay-silt was found to be the susceptible slope for creeping. Finally, a programme for landslide risk reduction and control were developed with special emphasize on community-based landslide mitigation and early warning system. It should be highlighted that the social approach needs to be properly addressed in order to guarantee the effectiveness of landslide risk reduction. 展开更多
关键词 LANDSLIDE Risk reduction JAVA Indonesia
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