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STR-PCR和FISH在监测异性别异基因造血干细胞移植后嵌合状态中意义的比较 被引量:6
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作者 秦尤文 蒋瑛 +3 位作者 王小蕊 万理萍 颜式可 王椿 《中国实验血液学杂志》 CAS CSCD 2009年第4期1016-1020,共5页
本研究比较短串联重复序列PCR(STR-PCR)和荧光原位杂交(FISH)两种方法在异基因造血干细胞移植后血细胞嵌合状态监测中的意义。对38例接受异性别异基因造血干细胞移植的患者,采用STR-PCR和FISH定量测定移植后14、28天和3个月的骨髓或外... 本研究比较短串联重复序列PCR(STR-PCR)和荧光原位杂交(FISH)两种方法在异基因造血干细胞移植后血细胞嵌合状态监测中的意义。对38例接受异性别异基因造血干细胞移植的患者,采用STR-PCR和FISH定量测定移植后14、28天和3个月的骨髓或外周血细胞嵌合状态。结果表明,14天时STR-PCR和FISH同时检测的30例中分别有14例和8例达到完全嵌合(CC,p>0.05)。28天时两者同时检测的31例中分别有26例和15例达到CC(p<0.01)。3个月时两种方法共同监测的24例中分别有22例和17例达到CC(p>0.05)。连续监测3个月以上的28例患者中14例发生移植物被排斥或复发,其中9例由FISH首先检出(p<0.05)。结论:FISH检测比STR-PCR更为准确地反映移植早期造血细胞嵌合状态,有助于监测移植物被排斥和疾病复发。 展开更多
关键词 别异基因造血干细胞移植 短串联重复序列 荧光原位杂交
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气相S-异亮氨酸向R-别异亮氨酸的旋光异构机理及水溶剂化效应 被引量:1
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作者 王丽萍 李晨洁 +3 位作者 王佐成 闫红彦 杨晓翠 佟华 《吉林大学学报(理学版)》 CAS CSCD 北大核心 2017年第3期717-724,共8页
采用密度泛函理论的B3LYP方法,微扰理论的MP2方法及自洽反应场(SCRF)理论的SMD模型方法,研究气相S-异亮氨酸向R-别异亮氨酸的旋光异构机理及水溶剂化效应.结果表明:该反应有a,b,c 3个通道,在通道a和c实现旋光异构反应需经过3个基元反应... 采用密度泛函理论的B3LYP方法,微扰理论的MP2方法及自洽反应场(SCRF)理论的SMD模型方法,研究气相S-异亮氨酸向R-别异亮氨酸的旋光异构机理及水溶剂化效应.结果表明:该反应有a,b,c 3个通道,在通道a和c实现旋光异构反应需经过3个基元反应,在通道b实现旋光异构反应需经过4个基元反应;a为主反应通道,决速步骤Gibbs自由能垒为255.0kJ/mol,由质子从α手性C向氨基N迁移的过渡态产生,决速步骤的反应速率常数为1.25×10-32 s^(-1);水溶剂效应使决速步骤能垒降至114.1kJ/mol,反应速率常数增至2.73×10-7 s^(-1),即水环境对S-异亮氨酸旋光异构具有较好的催化作用. 展开更多
关键词 手性 旋光 亮氨酸 别异亮氨酸 密度泛函理论 过渡态 微扰理论 自洽反应场
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别异烯醇酮对阿尔茨海默病小鼠黑质多巴胺神经元的影响 被引量:6
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作者 王琼仨 戚双双 +4 位作者 周鹏 张驰豪 崔怀瑞 陈世新 孙臣友 《解剖学报》 CAS CSCD 北大核心 2013年第2期176-181,共6页
目的通过分析黑质致密部(SNpc)多巴胺神经元和新生的多巴胺神经元的数目,评估别异烯醇酮(APα)对阿尔茨海默病(AD)小鼠多巴胺神经元的增生是否有影响。方法选用3月龄雄性淀粉样前体蛋白/早老蛋白(APP/PS1)双转基因AD小鼠(2xTg-AD)作为... 目的通过分析黑质致密部(SNpc)多巴胺神经元和新生的多巴胺神经元的数目,评估别异烯醇酮(APα)对阿尔茨海默病(AD)小鼠多巴胺神经元的增生是否有影响。方法选用3月龄雄性淀粉样前体蛋白/早老蛋白(APP/PS1)双转基因AD小鼠(2xTg-AD)作为实验组,背景非转基因小鼠(Non-Tg)作为对照组。2xTg-AD小鼠与Non-Tg小鼠分别行APα和PBS处理,24d后,每组6只小鼠做行为学检测;每组另6只小鼠取出脑组织后固定,通过免疫组织化学、体视测量学和吸光度测定,观察和分析各组小鼠SNpc标记酪氨酸羟化酶(TH)的多巴胺神经元的数目及其表达情况;并通过免疫荧光染色技术计算各组小鼠双标记的TH/5-溴脱氧尿嘧啶核苷(BrdU)阳性神经元的数目。结果与Non-Tg溶剂对照组小鼠相比,2xTg-AD溶剂对照组小鼠开野实验移动格子的数目明显减少(P<0.01);SNpc区域TH的免疫活性强度明显降低(P<0.05);多巴胺神经元的数目明显减少(P<0.05);BrdU/TH双标记神经元的数目均明显降低(P<0.05)。与2xTg-AD溶剂对照组小鼠相比,经APα处理的2xTg-AD小鼠移动格子的数目明显增加(P<0.05);SNpc TH阳性神经元的数目明显增加(P<0.05);BrdU/TH双标记的阳性神经元的数目亦明显增多(P<0.01)。但是,TH免疫活性强度无显著性变化(P>0.05)。结论 APα通过增加AD小鼠SNpc新生的多巴胺的数目达到改善其多巴胺神经元减少和行为学下降的作用,表明APα是一种潜在性的神经增生的促进剂。 展开更多
关键词 别异烯醇酮 多巴胺神经元 神经增生 阿尔茨海默病 免疫组织化学 免疫荧光染色 淀粉样前体 蛋白 早老蛋白双转基因AD小鼠
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认同和别异:散杂居地区回民丧俗文化探析——以山东地方镇为例
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作者 李华 《回族研究》 CSSCI 北大核心 2018年第1期26-32,共7页
山东地方镇是一个典型的回汉散杂居地区,回民丧俗文化展演出与当地汉族及聚居区回族的别异和认同,深受儒学为主的中国传统文化浸润并持守伊斯兰教的地方镇回民,形成了独具特色的散杂居地区回民丧俗,有着重要的社会功能和文化特点,彰显... 山东地方镇是一个典型的回汉散杂居地区,回民丧俗文化展演出与当地汉族及聚居区回族的别异和认同,深受儒学为主的中国传统文化浸润并持守伊斯兰教的地方镇回民,形成了独具特色的散杂居地区回民丧俗,有着重要的社会功能和文化特点,彰显出适应环境、回汉礼俗互动的生活智慧与现实意义。 展开更多
关键词 认同 别异 回民丧俗 山东地方镇
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“唱论”与“琴论”内涵别异之成因 被引量:1
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作者 林纯纯 《中国音乐》 CSSCI 北大核心 2014年第4期162-167,共6页
"唱论"与"琴论"是我国宋元明清时期文人们一直在探讨和研究的两大论题,二者的别异成因,既有儒道两家不同音乐美学思想的影响,又有文学艺术、书法艺术以及绘画艺术对琴、唱二论的影响;在漫长的音乐实践历史中,歌与... "唱论"与"琴论"是我国宋元明清时期文人们一直在探讨和研究的两大论题,二者的别异成因,既有儒道两家不同音乐美学思想的影响,又有文学艺术、书法艺术以及绘画艺术对琴、唱二论的影响;在漫长的音乐实践历史中,歌与琴价值取向和功能不同,延续下来,唱主"情",琴主"意"也就顺理成章了。 展开更多
关键词 唱论 琴论 别异 成因
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Network analysis of the relationships between depressive symptoms and social participation activities among Chinese older adults and its implications for nursing
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作者 Yebo Yu Hewei Min +3 位作者 Wei Pan Ping Chen Xuxi Zhang Xinying Sun 《International Journal of Nursing Sciences》 CSCD 2024年第4期465-472,I0002,共9页
Objective:Network analysis was used to explore the complex inter-relationships between social participation activities and depressive symptoms among the Chinese older population,and the differences in network structur... Objective:Network analysis was used to explore the complex inter-relationships between social participation activities and depressive symptoms among the Chinese older population,and the differences in network structures among different genders,age groups,and urban-rural residency would be compared.Methods:Based on the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey(CLHLS),12,043 people aged 65 to 105 were included.The 10-item Center for Epidemiologic Studies Depression(CESD)Scale was used to assess depressive symptoms and 10 types of social participation activities were collected,including housework,tai-chi,square dancing,visiting and interacting with friends,garden work,reading newspapers or books,raising domestic animals,playing cards or mahjong,watching TV or listening to radio,and organized social activities.R 4.2.1 software was used to estimate the network model and calculate strength and bridge strength.Results:21.60%(2,601/12,043)of the participants had depressive symptoms.The total social participation score was negatively associated with depressive symptoms after adjusting for sociodemographic factors.The network of social participation and depressive symptoms showed that“D9(Inability to get going)”and“S9(Watching TV and/or listening to the radio)”had the highest strength within depressive symptoms and social participation communities,respectively,and“S1(Housework)”,“S9(Watching TV and/or listening to the radio)”,and“D5(Hopelessness)”were the most prominent bridging nodes between the two communities.Most edges linking the two communities were negative.“S5(Graden work)-D5(Hopelessness)”and“S6(Reading newspapers/books)-D4(Everything was an effort)”were the top 2 strongest negative edges.Older females had significantly denser network structures than older males.Compared to older people aged 65e80,the age group 81e105 showed higher network global strength.Conclusions:This study provides novel insights into the complex relationships between social participation and depressive symptoms.Except for doing housework,other social participation activities were found to be protective for depression levels.Different nursing strategies should be taken to prevent and alleviate depressive symptoms for different genders and older people of different ages. 展开更多
关键词 Depressive symptoms Network analysis Older adults Sex characteristics Social participation
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论“乐”的伦理精神 被引量:1
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作者 黄梦肖 徐嘉 《南通大学学报(社会科学版)》 CSSCI 2023年第4期24-31,共8页
礼乐文明对中国传统伦理产生了深远的影响。“乐”与“礼”所体现的伦理价值既不相同,又相辅相成。“礼”强调等级分明的伦理秩序,“乐”则追求整个社会的“和同”,体现一种“和”的伦理精神。这一独特的伦理精神的历史建构过程复杂而漫... 礼乐文明对中国传统伦理产生了深远的影响。“乐”与“礼”所体现的伦理价值既不相同,又相辅相成。“礼”强调等级分明的伦理秩序,“乐”则追求整个社会的“和同”,体现一种“和”的伦理精神。这一独特的伦理精神的历史建构过程复杂而漫长,在殷商时代呈现为原始先民沟通天人的祭祀仪式,是凝聚群体的集体情感和集体意识;西周的礼乐之治形成了“乐合同,礼别异”的价值格局,“乐”是具有“礼”之规范性的国家制度,通过伦理教化的方式来实现秩序之和;随着西周末年的礼坏乐崩,“乐”在国家制度层面上的伦理规范功能逐渐式微。而孔子赋予“乐”在个体道德层面上的独特价值,是使个体以实现伦理价值为目标、自觉地修养德性的精神动力,由此赓续了“乐”所蕴含的伦理精神的生命力。 展开更多
关键词 别异 乐合同 乐教 伦理精神
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蛇床子化学成分的研究 被引量:39
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作者 张新勇 向仁德 《中草药》 CAS CSCD 北大核心 1997年第10期588-590,共3页
从蛇床子醇提物中经硅胶柱层析分得5个结晶性化合物,经鉴定分别为佛手柑内酯(bergapten,Ⅰ)、蛇床子素(osthol,Ⅱ)、异虎耳草素(isopimpinellin,Ⅲ)、cnidimolB(Ⅳ)和别异欧前胡素(alloisoimperatorin,Ⅴ)。其中cnidimol... 从蛇床子醇提物中经硅胶柱层析分得5个结晶性化合物,经鉴定分别为佛手柑内酯(bergapten,Ⅰ)、蛇床子素(osthol,Ⅱ)、异虎耳草素(isopimpinellin,Ⅲ)、cnidimolB(Ⅳ)和别异欧前胡素(alloisoimperatorin,Ⅴ)。其中cnidimolB为非香豆素成分,其结构为色原酮,化合物Ⅴ是首次从该植物中分得。 展开更多
关键词 蛇床子 香豆素 色原酮 别异 欧前胡素 化学成分
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别与和:中国古代服饰符号中的组合与聚合 被引量:3
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作者 李梅 《社会科学家》 CSSCI 北大核心 2009年第1期38-41,共4页
作为尊卑等级的具体标志,具有聚合关系的不同服饰符号,将社会整体中的人又区分为三六九等,,这是服饰之"别";作为天尊地卑、君尊臣卑的宇宙和社会秩序的象征,上衣下裳的基本组合规则,是天尊地卑、君尊臣卑的宇宙和社会秩序的象... 作为尊卑等级的具体标志,具有聚合关系的不同服饰符号,将社会整体中的人又区分为三六九等,,这是服饰之"别";作为天尊地卑、君尊臣卑的宇宙和社会秩序的象征,上衣下裳的基本组合规则,是天尊地卑、君尊臣卑的宇宙和社会秩序的象征,是社会全体成员都必须遵守的服装组合规则,而共同遵守这一着装规则,便意味着承认这一共同的价值判断体系,相同的服饰基本组合规则,共同的价值判断体系,将不同的社会个体凝聚成一个整体,这又是"别"之前提下的服饰之"和"。 展开更多
关键词 古代服饰符号 组合与聚合关系 别异 乐和同
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P-SV wave elastic impedance and fluid identification factor in weakly anisotropic media 被引量:4
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作者 崔杰 韩立国 +2 位作者 刘前坤 张显文 韩利 《Applied Geophysics》 SCIE CSCD 2010年第2期135-142,193,194,共10页
The P-SV wave reflection coefficients in VTI and HTI media were obtained by approximation of the Jilek(2002a and b)equation in orthotropic anisotropic media.An approximate equation for P-SV wave elastic impedance ca... The P-SV wave reflection coefficients in VTI and HTI media were obtained by approximation of the Jilek(2002a and b)equation in orthotropic anisotropic media.An approximate equation for P-SV wave elastic impedance can be derived from the combination of the new coefficients with S-wave elastic impedance(Duffaut et al.,2000).On this basis, the fluid identification factor in weakly anisotropic media was constructed and used to identify the Castagna and Smith(1994)lithologic combination and achieved good results. Finally,we specifically analyzed the anisotropic parameter impacts P-SV wave elastic impedance and fluid factor trends. 展开更多
关键词 P-SV wave elastic impedance fluid identification factor anisotropic parameter VTI HTI
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A Study of ISA in Chinese Cultural Communication 被引量:1
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作者 周华 韩晓惠 成城 《Sino-US English Teaching》 2007年第3期66-69,共4页
The paper tentatively studies the function of the indirect speech act in Chinese cultural communication, namely, domestic communication. Two aspects are shown in this paper: communication between people of different ... The paper tentatively studies the function of the indirect speech act in Chinese cultural communication, namely, domestic communication. Two aspects are shown in this paper: communication between people of different social status, genders and casual relationships, and communication between people of same social status, genders and close relationships. Therefore, the study result can be concluded like this: whether the use of indirect speech act is successful or not always influences people's communication significantly. 展开更多
关键词 Indirect Speech Act Chinese cultural communication gender difference
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Molecular Biology of Self and Non-self Pollen Recognition in Flowering Plants 被引量:1
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作者 赖钊 崔海洋 +1 位作者 杨慧君 薛勇彪 《Developmental and Reproductive Biology》 1999年第2期65-70,共6页
Fertilization in flowering plants is completed through several recognitionevents, and the first of which is the recognition of pollen by pistil of female reproductivetissue. Self-incompatibility (SI) is an intraspecif... Fertilization in flowering plants is completed through several recognitionevents, and the first of which is the recognition of pollen by pistil of female reproductivetissue. Self-incompatibility (SI) is an intraspecific reproductive barrier to prevent selfferitilization and widely distributed in flowering plants. In many species, SI shows simplegenetics and is controlled by a single multi-allelic locus, called the S locus. In gametophyticSI (GSI) exemplified by the Solanaceae, Scrophulariaceae and Rosaceae, a class ofribonucleases, called S RNases, have been shown to mediate the stylar expression of SI butnot the pollen expression of SI. The latter appears to be determined by a gene differentfrom those encoding S RNases, often referred to as pollen S gene. The pollen S gene is thecrucial missing part in understanding the biochemical and molecular mechanisms of self andnon-self pollen recognition in flowering plants. Recent genetic analysis of mutationsaffecting the pollen expression of SI has suggested a possible model of how the pollen S geneinteracts with S RNases to achieve self and non-self pollen recognition. Furthermore, wewill present two approaches, S-locus directed transposon tagging and map-based cloning, forcloning the pollen S in Antirrhinum. 展开更多
关键词 SELF-INCOMPATIBILITY S RNases pollen S gene
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“仁”的内在张力与从孔子到孟子的话语转型
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作者 韩德民 《北方论丛》 2020年第3期67-75,共9页
仁自身包含的内在精神张力,决定了其作为道德评判尺度在实际运用方式上的复杂性。孟子的主要贡献,是将仁所包含的内在性精神张力,展开成为仁与义之间的外在性范畴对立。仁侧重于主体道德立场的积极性呈现,义侧重于其消极性呈现;仁侧重... 仁自身包含的内在精神张力,决定了其作为道德评判尺度在实际运用方式上的复杂性。孟子的主要贡献,是将仁所包含的内在性精神张力,展开成为仁与义之间的外在性范畴对立。仁侧重于主体道德立场的积极性呈现,义侧重于其消极性呈现;仁侧重于情感瞩望,义侧重于规范约束,仁和义各有侧重,形成相互限制、相互支持的关系,有效提升了儒家道德观念应对矛盾而复杂的现实的能力。这种展开有助于避免"仁"与诸如"兼爱"之类观念的混同。周礼是孔子建构仁学的历史文化依托,从仁到仁和义的分化,与周礼的结构模式之间也存在对应性关系。 展开更多
关键词 张力 和同 别异
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Gender Differences in Non-English Major Graduates' English Compositions——A Study Based on the Use of Oral/Written Register Features
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作者 武蕊 《Sino-US English Teaching》 2007年第1期24-29,共6页
This article applies the theories of gender differences in language use, makes a survey of non-English major graduates' English writing, and analyzes the gender differences in EFL writing proficiency and particularly... This article applies the theories of gender differences in language use, makes a survey of non-English major graduates' English writing, and analyzes the gender differences in EFL writing proficiency and particularly in the use of oral/written register features, aiming to provide suggestions for gendered teaching in EFL writing. 展开更多
关键词 GENDER DIFFERENCE EFL writing oral and written register feature
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Learning compact binary code based on multiple heterogeneous features
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作者 左欣 罗立民 +1 位作者 沈继锋 于化龙 《Journal of Southeast University(English Edition)》 EI CAS 2013年第4期372-378,共7页
A novel hashing method based on multiple heterogeneous features is proposed to improve the accuracy of the image retrieval system. First, it leverages the imbalanced distribution of the similar and dissimilar samples ... A novel hashing method based on multiple heterogeneous features is proposed to improve the accuracy of the image retrieval system. First, it leverages the imbalanced distribution of the similar and dissimilar samples in the feature space to boost the performance of each weak classifier in the asymmetric boosting framework. Then, the weak classifier based on a novel linear discriminate analysis (LDA) algorithm which is learned from the subspace of heterogeneous features is integrated into the framework. Finally, the proposed method deals with each bit of the code sequentially, which utilizes the samples misclassified in each round in order to learn compact and balanced code. The heterogeneous information from different modalities can be effectively complementary to each other, which leads to much higher performance. The experimental results based on the two public benchmarks demonstrate that this method is superior to many of the state- of-the-art methods. In conclusion, the performance of the retrieval system can be improved with the help of multiple heterogeneous features and the compact hash codes which can be learned by the imbalanced learning method. 展开更多
关键词 hashing code linear discriminate analysis asymmetric boosting heterogeneous feature
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古诗文背诵方法指要
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作者 曹军 《课外语文(下)》 2016年第5期162-164,共3页
古诗文的背诵在语文学习中占有重要地位。积累一定量的古诗文,对学生丰富语言积累,培养语感,传承民族经典大有裨益。学生的先天条件存在着差异,在背诵的落实上有快有慢,但作为教师,我们仍然可以有所作为——我们可以有意识地加强对学生... 古诗文的背诵在语文学习中占有重要地位。积累一定量的古诗文,对学生丰富语言积累,培养语感,传承民族经典大有裨益。学生的先天条件存在着差异,在背诵的落实上有快有慢,但作为教师,我们仍然可以有所作为——我们可以有意识地加强对学生背诵方法的指导,帮助学生提高背诵的速度。本文主要结合具体的初中背诵篇目,谈论了背诵的四种方法:理解记忆法、画结构图法、求同别异法、过度学习法。其中前三种方法着眼于背诵内容的掌握,"过度学习法"着眼于背诵的巩固。 展开更多
关键词 古诗文背诵 理解记忆法 画结构图法 求同别异 过度学习法
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Normalized edge detection, and the horizontal extent and depth of geophysical anomalies 被引量:2
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作者 李丽丽 韩立国 黄大年 《Applied Geophysics》 SCIE CSCD 2014年第2期149-157,252,253,共11页
Edge detection is an image processing technique for finding the boundaries of objects within images. It is typically used to interpret gravity and magnetic data, and find the horizontal boundaries of geological bodies... Edge detection is an image processing technique for finding the boundaries of objects within images. It is typically used to interpret gravity and magnetic data, and find the horizontal boundaries of geological bodies. Large deviations between model and true edges are common because of the interference of depth and errors in computing the derivatives; thus, edge detection methods cannot provide information about the depth of the source. To simultaneously obtain the horizontal extent and depth of geophysical anomalies, we use normalized edge detection filters, which normalize the edge detection function at different depths, and the maxima that correspond to the location of the source. The errors between model and actual edges are minimized as the depth of the source decreases and the normalized edge detection method recognizes the extent of the source based on the maxima, allowing for reliable model results. We demonstrate the applicability of the normalized edge detection filters in defining the horizontal extent and depth using synthetic and actual aeromagnetic data. 展开更多
关键词 geophysical anomalies normalized edge detection normalized total horizontal derivative regularization tilt angle theta map
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Age and Sex-related Dendritic Changes in the Visual Cortex of the Rat
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作者 徐业华 汪浩 +1 位作者 陈勤 周逸峰 《Zoological Research》 CAS CSCD 北大核心 2007年第3期297-302,共6页
Visual functions undergo an age-related degradation. However, the neural mechanisms underlying these changes are not yet clear. This study was designed to investigate the influence of age and sex on the anatomy of the... Visual functions undergo an age-related degradation. However, the neural mechanisms underlying these changes are not yet clear. This study was designed to investigate the influence of age and sex on the anatomy of the rat's visual cortex. Dendritic tree extent and spine density were examined in young adult rats (2-3 months) and aged male and female rats (22-24 months) using a modified Golgi-Cox staining method. A sex difference in dendritic branching of the pyramidal cells was found among young adults. However, this difference disappeared during aging, due to a reduction in branching with age for males but not for females. Moreover, the pyramidal cells of young males also have a greater spine density. Although there was a reduction in spine density with age for both sexes, this reduction was more pronounced for males, resulting in a disappearance of sex difference with age. Thus these results suggest that aging could lead to the degeneration of dendrites, which might contribute to the degradation of age-related visual functions. Also the results indicate that age-related degeneration of dendrites is more severe for males than for females. 展开更多
关键词 Aged Visual cortex DENDRITE Sex difference
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Gender difference in clinicopathologic features and survival of patients with hepatocellular carcinoma 被引量:9
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作者 Pisit Tangkijvanich Varocha Mahachai +1 位作者 Pongspeera Suwangool Yong Poovorawan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第11期1547-1550,共4页
AIM: To determine the influence of gender on the clinicopathologic characteristics and survival of patients with hepatocellular carcinoma (HCC). METHODS: A retrospective analysis of medical records was performed in 29... AIM: To determine the influence of gender on the clinicopathologic characteristics and survival of patients with hepatocellular carcinoma (HCC). METHODS: A retrospective analysis of medical records was performed in 299 patients with HCC and their clinicopathologic features and survival were compared in relation to gender. RESULTS: There were 260 male (87%) and 39 female patients (13%),with a male-to-female ratio of 6.7:1.Female patients had lower mean serum bilirubin levels (P=0.03), lower proportion of alcohol abuse (P=0.002),smaller mean tumor size (P=0.02),more frequent nodular type but less frequent massive and diffuse types of HCC (P=0.01),were less advanced in Okuda's staging (P=0.04),and less frequently associated with venous invasion (P=0.03).The median survivals in females (14 too) were significantly longer than that of male patients (4 mo) (P=0.004,log-rank test). Multivariate analysis demonstrated that high serum alpha- fetoprotein levels,venous invasion,extrahepatic metastasis and lack of therapy were independent factors related to unfavorable prognosis.However,gender did not constitute a predictive variable associated with patient survival. CONCLUSION: Female patients tend to have higher survival rates than males.These differences were probably due to more favorable pathologic features of HCC at initial diagnosis and greater likelihood to undergo curative therapy in female patients. 展开更多
关键词 ADULT Aged Alcohol Drinking Carcinoma Hepatocellular Female Hepatic Veins Humans Liver Neoplasms Male Middle Aged Portal Vein PREVALENCE Research Support Non-U.S. Gov't Retrospective Studies Risk Factors Sex Distribution Survival Analysis
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Peanut consumption and reduced risk of colorectal cancer in women:A prospective study in Taiwan 被引量:4
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作者 Chih-Ching Yeh San-Lin You +1 位作者 Chien-Jen Chen Fung-Chang Sung 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第2期222-227,共6页
AIM: To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS: In 1990-1992, residents (12026 men and 11917 women aged 3... AIM: To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS: In 1990-1992, residents (12026 men and 11917 women aged 30 to 65 years) in 7 townships, Taiwan, were interviewed and recruited into a cancerscreening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS: During the study period, 107 new colorectal cancer cases (68 men and 39 women) were confirmed. The multivariate Cox's proportional hazard model showed that the relative risk (RR) of peanut consumption was 0.73 [95% confidence interval (CI) = 0.44-1.21] for men and 0.42 (95% CI = 0.21-0.84) for women. However, frequent intake of pickled foodstuffs was harmful for women (RR= 2.15, 95% CI=0.99-4.65). The risk of colorectal cancer was also elevated among cigarette smokers but not significant (P〈 0.05).CONCLUSION: This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake. 展开更多
关键词 Peanuts Colorectal cancer DIET Gender difference Prospective study TAIWAN
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