现代电脑效果图和传统手绘效果图制作的结合

随着科技的发展,制图已成为设计灵感最直观的表现方式。在电脑绘图之前,设计理念和设计构想通过传统手绘效果图呈现出来。但信息技术的出现,电脑效果图以效率高、速度快、直观视觉效果好等优势赢得设计者们的喜爱,而手绘效果图则逐渐被淘汰。但任何一种效果图的呈现都或多或少地有些缺陷,于是,电脑效果图和传统手绘效果图制作的结合,成为未来效果图发展的趋势。

Bonding interface zone of Mg-Gd-Y/Mg-Zn-Gd laminated composite fabricated by equal channel angular extrusion

In order to improve the mechanical properties and corrosion resistance of Mg alloys,the equal channel angular extrusion (ECAE)was employed to fabricate the Mg-5Gd-5Y/Mg-2Zn-1Gd(GW55/ZG21)laminated composites.After fabrication and annealing treatment,the microstructural evolution,phase constitution,microhardness,and bonding strength were investigated on the bonding interface zone of GW55/ZG21 laminated composites.The bonding interface zone of GW55/ZG21 laminated composites comprises a lot of Mg3(Y,Gd)2Zn3 particles along the bonding interface,some rod Mg24(Y,Gd)5 phases on GW55 side,and a precipitation free zone(PFZ)on ZG21 side.After annealing treatment,Mg3(Y,Gd)2Zn3 particles along the bonding interface increase, rod Mg24(Y,Gd)5 phases on GW55 side decrease,and PFZ is broadened.Meanwhile,the hardness on the bonding interface zone decreases and the bonding strength increases from 126 MPa to 162 MPa.

Effect Mechanism of Structure-Changed Water on Heat Stability of Lysozyme

Based on the mechanism of the effect of hydration on the heat stability of lysozyme and the theory of water molecule clusters, the effect of structure-changed water on heat stability of lysozyme has been studied. The results obtained by differential scanning calorimetry (DSC) showed that the thermal denaturation temperature of lysozyme had been elevated 8.47 K through hydration of lysozyme with processed water whose structure had been changed so it was called "structured water" compared to ordinary water. The reason is that structured water changed the dipole moment of water molecules and easily formed cyclic water hexamer or cage-like water hexamer, so that the interacting force of maintaining three-dimensional conformation of lysozyme could be reinforced.

A Family--The Tension and the Satisfaction

Family members solve not only their interests, but make provision for interests of other members of the family, too. The space for the control at a higher level is thus formed. Without notifying, individual members in the process of provision making proceed depending on general rules of the organisation of elements into higher structures, as they exist in all stable objects. This provision making has different forms, starting with the love and ending with an assisted coexistence. The understanding of the role of individual controlling structures allows to improve the functioning of the family. Similarly, as a regular discussion of its functioning in the family and perhaps, their controlled casting by some of partners, too. The submitted work describes roles and the control in the elementary family--in the childless coexistence of partners.

Interaction mechanism between carboxylmethyl cellulose and iron ore concentrates in iron ore agglomeration

Carboxylmethyl cellulose(CMC) has become a commercial organic binder in agglomeration of iron ore concentrates. The relative molecular mass and degree of substitution(DS) of CMC have a large impact on its binding performance. The interaction mechanism between CMC and iron ore particles was analyzed through Zeta potential measurements, adsorption measurements and infrared spectra. The results show that the interaction is chemical adsorption-oriented and the CMC's adsorption performance is related to the properties of CMC as well as the type of iron oxides. CMC has a greater affinity to Fe2O3 than Fe3O4, and CMC with higher relative molecular mass shows a higher adsorption isotherm. Pelletization of practical iron ore concentrates added with CMC further illustrates that CMC with higher relative molecular mass or DS exhibits a better binding performance, which is consistent with the results of adsorption tests.

Ten1p promotes the telomeric DNA-binding activity of Cdc13p： implication for its function in telomere length regulation

In Saccharomyces cerevisiae, the essential gene CDC13 encodes a telomeric single-stranded DNA-binding protein that interacts with Stnlp and Tenlp genetically and physically, and is required for telomere end protection and telomere length control. The molecular mechanism by which Tenl participates in telomere length regulation and chromosome end protection remains elusive. In this work, we observed a weak interaction of Cdc13p and Tenlp in a gelfiltration analysis using purified recombinant Cdc13p and Tenlp. Tenlp itself exhibits a weak DNA-binding activity, but enhances the telomeric TG1-3 DNA-binding ability of Cdc13p. Cdc13p is communoprecipitated with Tenlp. In the mutant ten1-55 or ten1-66 cells, the impaired interaction between Tenlp and Cdc13p results in much longer telomeres, as well as a decreased association of Cdc13p with telomeric DNA. Consistently, the Ten1-55 and Ten1-66 mutant proteins fail to stimulate the telomeric DNA-binding activity of Cdc13p in vitro. These results suggest that Tenlp enhances the telomeric DNA-binding activity of Cdc13p to negatively regulate telomere length.

Expression, purification and evaluation of N-terminal domain of AcAP5 with Factor Xa inhibitory activity

Ancylostoma anticoagulant peptide 5 （AcAP5） is a strong inhibitor of human coagulation factor Xa （FXa）. The N-terminal residues （N40） of AcAP5 contains a domain that could combine with FXa. In order to determine whether N40 protein has FXa inhibitory effect, we cloned, expressed and purified the protein for activity evaluation. The DNA fragment coding N40 was amplified by PCR, cloned into pET-30a to construct recombinant plasmid pET30a-N40, and subsequently transformed into E. coli, BL21 （DE3）. Expression of N40 was induced by isopropyl ~3-D-l-thiogalactopyranoside （IPTG）, and the interest protein was identified by SDS-PAGE and purified using one-step nickel （Ni） affinity chromatography. Under the optimal expres- sion condition （0.05 mM IPTG for 6 h at 37 ℃）, the purity of N40 reached 90%. We also evaluated the inhibition activity of N40 protein on FXa, finding the ICso was 4.58× 10 5 mol/L, This study suggests the N40 of AcAP5 could combine with FXa to inhibit FXa activity.

The Game Theoretical Approach for Multi-phase Complex Systems in Chemical Engineering

This paper explores the application of noncooperative game theory together with the concept of Nash equilibrium to the investigation of some basic problems on multi-scale structure, especially the meso-scale structure in the multi-phase complex systems in chemical engineering. The basis of this work is the energy-minimization-multi-scale （EMMS） model proposed by Li and Kwauk （1994） and Li, et al. （2013） which identifies the multi-scale structure as a result of ＇compromise-in-competition between dominant mechanisms＇ and tries to solve a multi-objective optimization problem. However, the existing methods often integrate it into a problem of single objective optimization, which does not clearly reflect the ＇compromise-in-competition＇ mechanism and causes heavy computation burden as well as uncertainty in choosing suitable weighting factors. This paper will formulate the compromise in competition mechanism in EMMS model as a noncooperative game with constraints, and will describe the desired stable system state as a generalized Nash equilibrium. Then the authors will investigate the game theoretical approach for two typical systems in chemical engineering, the gas-solid fluidiza- tion （GSF） system and turbulent flow in pipe. Two different cases for generalized Nash equilibrinm in such systems will be well defined and distinguished. The generalize Nash equilibrium will be solved accurately for the GSF system and a feasible method will be given for turbulent flow in pipe. These results coincide with the existing computational results and show the feasibility of this approach, which overcomes the disadvantages of the existing methods and provides deep insight into the mechanisms of multi-scale structure in the multi-phase complex systems in chemical engineering.

Stereoselective interactions of chiral dipeptides on amylose based chiral stationary phases

Dipeptides are stereo-specifically involved in several biological functions that are challenging to separate enantiomerically. Elution order of enantiomers is an important issue in chiral chromatography. Amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase(CSP) is the best and most-widely-used CSP in chiral separations, but experimental data of enantiomeric separation of dipeptides on this CSP is lacking. Simulation studies were conducted to determine the order of elution and the chiral recognition mechanism of didpetides on this CSP. Results indicated that the docking energy of SR-enantiomers were higher than SS-antipodes. The range of docking energies for SR-enantiomers was -7.44 to -5.92 kcal/mol with CSP, but -7.15 to -5.87 kcal/mol for SS-stereoisomers. Therefore it is predicted that SS-enantiomer will elute first, followed by SR-antipode. Furthermore, hydrogen bondings, van der Waal's interactions and electrostatic interactions were observed among SR- and SSenantiomers and chiral grooves of CSP. The number of hydrogen bonds was one in each enantiomer binding except S-Ala-R-Tyr, which contained two hydrogen bonds. No hydrogen bond was found in S-Ala-R-Trp, S-Leu-S-Trp, and S-Leu-S-Tyr dipeptides bindings. The chiral recognition mechanisms dictate different strengths of stereoselective bindings of the enantiomers on CSP.