ZnO nanobelts, hollow microspheres, and urchins have been prepared on copper foil via a simply low temperature evaporation route. The microstructure, morphologies, and photolu-minescence of the ZnO nanostructures were...ZnO nanobelts, hollow microspheres, and urchins have been prepared on copper foil via a simply low temperature evaporation route. The microstructure, morphologies, and photolu-minescence of the ZnO nanostructures were studied with X-ray diffraction, Raman spectra, scanning electron microscopy and photoluminescence spectra. The width of the nanobelts was about 500 nm and the length was longer than 10μm. The diameter of the hollow microspheres was between 5 and 10μm. A possible growth mechanism of the nanobelts, microspheres and urchins was proposed. The photoluminescence spectrum exhibited strong deep level energy emissions and a weak near band edge emission. These ZnO nanostructures on a copper substrate have the advantages of naturally good adhesion and electrical connection between the ZnO nanostructures and the conductive substrate.展开更多
Anterior cruciate ligament （ACL） injuries are common in soccer. Understanding ACL loading mechanisms and risk factors for ACL injury is critical for designing effective prevention programs. The purpose of this revie...Anterior cruciate ligament （ACL） injuries are common in soccer. Understanding ACL loading mechanisms and risk factors for ACL injury is critical for designing effective prevention programs. The purpose of this review is to summarize the relevant literature on ACL loading mechanisms, ACL injury risk factors, and current ACL injury prevention programs for soccer players. Literature has shown that tibial anterior translation due to shear force at the proximal end of tibia is the primary ACL loading mechanism. No evidence has been found showing that knee valgus moment is the primary ACL loading mechanism. ACL loading mechanisms are largely ignored in previous studies on risk factors for ACL injury. Identified risk factors have little connections to ACL loading mechanisms. The results of studies on ACL injury prevention programs for soccer players are inconsistent. Current ACL injury prevention programs for soccer players are clinically ineffective due to low compliance. Future studies are urgently needed to identify risk factors for ACL injury in soccer that are connected to ACL loading mechanisms and have cause-and-effect relationships with injury rate, and to develop new prevention programs to improve compliance.展开更多
In order to save space for storing precision equipments,lower the center of mass of Lander and reduce lunar rover's dimension constraint limited by mechanism of Lander,the locking-releasing mechanism of side-loade...In order to save space for storing precision equipments,lower the center of mass of Lander and reduce lunar rover's dimension constraint limited by mechanism of Lander,the locking-releasing mechanism of side-loaded lunar rover loaded outside Lander is presented,which is a kind of metamorphic mechanism.To ensure the working of this mechanism as the metamorphic process designed,configuration analysis of the locking-releasing mechanism is carried out,and topological structures are described by Huston lower numbered arrays.A kinematic mathematical model of the mechanism is established through homogeneous transformation matrix.The kinematic simulation validates the feasibility of the locking-releasing mechanism when the configurations are shifted from one to the other.展开更多
By using the matrix theory, a 5 parameter grinding mathematical model is established. Based on the properties of feed coal and requirements for size distribution of final product, the model gives the required grinding...By using the matrix theory, a 5 parameter grinding mathematical model is established. Based on the properties of feed coal and requirements for size distribution of final product, the model gives the required grinding probability for various particles and corresponding ball size distribution. By using this model, 3 different sizes of ball mill are designed and put into commercial use for coal water fuel. The forecasted ball mill capacity, the particle sizes and particle size distribution as well as the coal water fuel quality parameters are all in line with industrial operation results, which have proved the suitability of the model.展开更多
With the global warming,the disasters of Glacier Lake Outburst Flood(GLOF) have taken place frequently in Tibet in recent years and attracted more and more attention.A systematic survey was conducted on the 19 GLOFs i...With the global warming,the disasters of Glacier Lake Outburst Flood(GLOF) have taken place frequently in Tibet in recent years and attracted more and more attention.A systematic survey was conducted on the 19 GLOFs in Tibet to study their two main mechanisms.Investigations indicated that all the events occurred in end-moraine lakes,and the outburst occurred partially and instantly.And the breach had the shape of an arc or a trapezoid in overflow outburst and its top width was 3-5 times more than the height.The two main mechanisms of GLOFs in Tibetan end-moraine Lake were overflow and piping,and the overflow mechanism caused by iceberg collapse was dominated in most cases.A formula was proposed to calculate the critical thickness of iceberg tongue that determines the collapse.Granular analysis of the moraine materials revealed that seepage deformation is crucial in the outburst process.Finally,we conducted a case study of the Guangxiecuo Lake to show its possible process of outburst and estimated the peak discharge of the resulted flood.展开更多
As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatmen...As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A (Con A) model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development.展开更多
It is very important to establish cooperative mechanism to guarantee allmembers to develop their e-conomies in the Yellow Sea Rim. In this paper, the development strategiesof shipping centers and transportation networ...It is very important to establish cooperative mechanism to guarantee allmembers to develop their e-conomies in the Yellow Sea Rim. In this paper, the development strategiesof shipping centers and transportation network are discussed based on economic globalizationtendency. The results argue that a united transportation network should be built in order to promotethe economic competition of Northeast Asia in the world. As a key component of the economiccooperation, a hierarchical shipping centers network should be established with Hong Kong, Shanghai,Pusan, Kobe, and Tokyo as cores. The authorities of China, Japan, R. 0. Korea and D. P. R. Koreashould make more efforts to build a set of cooperation institutions based on raising thetransportation efficiency.展开更多
The globalization has experienced three rounds of pushing, or three editions of world system - respectively the globalization of production and trade, government- business mechanism and capital operation. The end of t...The globalization has experienced three rounds of pushing, or three editions of world system - respectively the globalization of production and trade, government- business mechanism and capital operation. The end of the Cold War and China＇s reforms led to the falling of walls between social systems and the globalization with the United States as its representative sample came to its peak. However, administrative systems and ideologies based on nation states have presented barriers to globalization and, obviously due to that, the US is coming to its decline. The new edition of world system calls for breakthrough and change in nation-state system and China is poised to lead the new round of globalization.展开更多
In this study, we compared the transcriptomes of Nannochloropsis oceanica cultured in f/2 medium prepared with seawater and freshwater, respectively, aiming to understand the acclimation mechanism of this alga to fres...In this study, we compared the transcriptomes of Nannochloropsis oceanica cultured in f/2 medium prepared with seawater and freshwater, respectively, aiming to understand the acclimation mechanism of this alga to freshwater. Differentially expressed genes were mainly assigned to the degradation of cell components, ion transportation, and ribosomal biogenesis. These find- ings indicate that the algal cells degrade its components （mainly amino acids and fatty acids） to yield excessive energy （ATP） to maintain cellular ion （mainly K＋ and Ca〉） homeostasis, while the depletion of amino acids and ATP, and the reduction of ribosomes attenuate the protein translation and finally slow down the cell growth.展开更多
The mast cell is an enigmatic cell type whose physiological function has preoccupied large numbers of investigators for decadest. Some have concluded that the absence of mast cells is incompatible with life, at least ...The mast cell is an enigmatic cell type whose physiological function has preoccupied large numbers of investigators for decadest. Some have concluded that the absence of mast cells is incompatible with life, at least in humans, because no human conditions have been documented where these cells are absent from the body. On the other hand, mice harboring specific mutations in certain growth factors, or their receptors, that展开更多
Carcinoid tumors have been reported in a wide range of organs but most frequently involve the gastrointestinal tract; however, duodenal carcinoid tumors are rare. We report a 50-year-old male patient complaining of mu...Carcinoid tumors have been reported in a wide range of organs but most frequently involve the gastrointestinal tract; however, duodenal carcinoid tumors are rare. We report a 50-year-old male patient complaining of multiple melenas for 3 wk. The panendoscopy and endoscopic retrograde cholangiopancreaticography revealed swelling accessory papilla with an ulcer. The biopsy taken showed a carcinoid tumor. The lesion was removed by wide resection. Patient was found to have an abnormal blood cell count during the follow-up period with elevated levels of hemoglobin and hematocrit of 21.2 g/dL and 63.5%,respectively, thrombocytosis of 501 000/μL, and leukocytosis of 20 410/μL. He was diagnosed as a polycythemia vera by a hematologist after further evaluation. He received periodic phlebotomy and hydroxyurea treatment. The response was good and his hematocrit was stabilized by periodic phlebotomy in the range of 44-49% during the last 2 years. The possible origin of UGI bleeding by a duodenal carcinoid tumor, although rare, should be considered. There has been one case report of a duodenal carcinoid tumor that involved accessory papilla of the pancreas divisum and one case report of metastatic carcinoid tumor associated with polycythemia vera. It is different in our patient as compared with the latter report, which mentioned a polycythemia vera patient who was found to have a metastatic carcinoid in the 17 years follow-up period. Chemotherapy had been given before the carcinoid tumor was revealed. Our patient had no previous chemotherapy for polycythemia vera before he was found to have duodenal carcinoid tumor; this excludes the possibility of chemotherapy induced carcinoid tumor, although it had been suspected in the previous report. In our patient, the existence of both diseases may be by predisposition of each other since both diseases have an increased incidence of other neoplasm, or they may be coexistent incidentally.展开更多
基金ACKNOWLEDGMENTS This work was supported by the Natural Science Foundation of Fujian Province of China （No.2007J0317 and No.JB06104） and the Key project of Fujian Provincial Department of Science and Technology （No.2007H0019）.
文摘ZnO nanobelts, hollow microspheres, and urchins have been prepared on copper foil via a simply low temperature evaporation route. The microstructure, morphologies, and photolu-minescence of the ZnO nanostructures were studied with X-ray diffraction, Raman spectra, scanning electron microscopy and photoluminescence spectra. The width of the nanobelts was about 500 nm and the length was longer than 10μm. The diameter of the hollow microspheres was between 5 and 10μm. A possible growth mechanism of the nanobelts, microspheres and urchins was proposed. The photoluminescence spectrum exhibited strong deep level energy emissions and a weak near band edge emission. These ZnO nanostructures on a copper substrate have the advantages of naturally good adhesion and electrical connection between the ZnO nanostructures and the conductive substrate.
基金partially supported by Shandong Province Research Development(No.2012G0030039)China Sports Administration Research(No.2012B012)
文摘Anterior cruciate ligament （ACL） injuries are common in soccer. Understanding ACL loading mechanisms and risk factors for ACL injury is critical for designing effective prevention programs. The purpose of this review is to summarize the relevant literature on ACL loading mechanisms, ACL injury risk factors, and current ACL injury prevention programs for soccer players. Literature has shown that tibial anterior translation due to shear force at the proximal end of tibia is the primary ACL loading mechanism. No evidence has been found showing that knee valgus moment is the primary ACL loading mechanism. ACL loading mechanisms are largely ignored in previous studies on risk factors for ACL injury. Identified risk factors have little connections to ACL loading mechanisms. The results of studies on ACL injury prevention programs for soccer players are inconsistent. Current ACL injury prevention programs for soccer players are clinically ineffective due to low compliance. Future studies are urgently needed to identify risk factors for ACL injury in soccer that are connected to ACL loading mechanisms and have cause-and-effect relationships with injury rate, and to develop new prevention programs to improve compliance.
基金Sponsored by the National High Technology Research and Development Program of China(Grant No.2006AA04Z231)Natural Science Foundation of Heilongjiang Province of China(Grant No.ZJG0709)Development Program of the Excellent Youth Scholars of Harbin Institute of Technology(Grant No.CACZ98504837)
文摘In order to save space for storing precision equipments,lower the center of mass of Lander and reduce lunar rover's dimension constraint limited by mechanism of Lander,the locking-releasing mechanism of side-loaded lunar rover loaded outside Lander is presented,which is a kind of metamorphic mechanism.To ensure the working of this mechanism as the metamorphic process designed,configuration analysis of the locking-releasing mechanism is carried out,and topological structures are described by Huston lower numbered arrays.A kinematic mathematical model of the mechanism is established through homogeneous transformation matrix.The kinematic simulation validates the feasibility of the locking-releasing mechanism when the configurations are shifted from one to the other.
文摘By using the matrix theory, a 5 parameter grinding mathematical model is established. Based on the properties of feed coal and requirements for size distribution of final product, the model gives the required grinding probability for various particles and corresponding ball size distribution. By using this model, 3 different sizes of ball mill are designed and put into commercial use for coal water fuel. The forecasted ball mill capacity, the particle sizes and particle size distribution as well as the coal water fuel quality parameters are all in line with industrial operation results, which have proved the suitability of the model.
基金supported by the National Natural Science Foundation of China (Grant No.41201010)the Technology Project of the Ministry of Transport(Grant No.201231879210)+2 种基金the Directional Projectof IMHE (No.SDS-135-1202-02)Opening Fund of State Key Laboratory of Geohazard Prevention and Geoenvironment Protection (Grant No.SKLGP2010K003)Open Research Fund of State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin,China Institute of Water Resources and Hydropower Research (Grant NO.IWHR-SKL-201209)
文摘With the global warming,the disasters of Glacier Lake Outburst Flood(GLOF) have taken place frequently in Tibet in recent years and attracted more and more attention.A systematic survey was conducted on the 19 GLOFs in Tibet to study their two main mechanisms.Investigations indicated that all the events occurred in end-moraine lakes,and the outburst occurred partially and instantly.And the breach had the shape of an arc or a trapezoid in overflow outburst and its top width was 3-5 times more than the height.The two main mechanisms of GLOFs in Tibetan end-moraine Lake were overflow and piping,and the overflow mechanism caused by iceberg collapse was dominated in most cases.A formula was proposed to calculate the critical thickness of iceberg tongue that determines the collapse.Granular analysis of the moraine materials revealed that seepage deformation is crucial in the outburst process.Finally,we conducted a case study of the Guangxiecuo Lake to show its possible process of outburst and estimated the peak discharge of the resulted flood.
基金Supported by Program for Excellent Talents of Anhui Province,No.2006JQ1196
文摘As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A (Con A) model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development.
文摘It is very important to establish cooperative mechanism to guarantee allmembers to develop their e-conomies in the Yellow Sea Rim. In this paper, the development strategiesof shipping centers and transportation network are discussed based on economic globalizationtendency. The results argue that a united transportation network should be built in order to promotethe economic competition of Northeast Asia in the world. As a key component of the economiccooperation, a hierarchical shipping centers network should be established with Hong Kong, Shanghai,Pusan, Kobe, and Tokyo as cores. The authorities of China, Japan, R. 0. Korea and D. P. R. Koreashould make more efforts to build a set of cooperation institutions based on raising thetransportation efficiency.
文摘The globalization has experienced three rounds of pushing, or three editions of world system - respectively the globalization of production and trade, government- business mechanism and capital operation. The end of the Cold War and China＇s reforms led to the falling of walls between social systems and the globalization with the United States as its representative sample came to its peak. However, administrative systems and ideologies based on nation states have presented barriers to globalization and, obviously due to that, the US is coming to its decline. The new edition of world system calls for breakthrough and change in nation-state system and China is poised to lead the new round of globalization.
基金financially supported by the National Natural Science Foundation of China(31270408)National High Technology Research and Development Program(863 Program)of China(2014AA022001)
文摘In this study, we compared the transcriptomes of Nannochloropsis oceanica cultured in f/2 medium prepared with seawater and freshwater, respectively, aiming to understand the acclimation mechanism of this alga to freshwater. Differentially expressed genes were mainly assigned to the degradation of cell components, ion transportation, and ribosomal biogenesis. These find- ings indicate that the algal cells degrade its components （mainly amino acids and fatty acids） to yield excessive energy （ATP） to maintain cellular ion （mainly K＋ and Ca〉） homeostasis, while the depletion of amino acids and ATP, and the reduction of ribosomes attenuate the protein translation and finally slow down the cell growth.
基金Supported by the grants from the National Institutes of Health,USA (DK33491 and AT01180) and the Crohn's and Colitis Foundation of America
文摘The mast cell is an enigmatic cell type whose physiological function has preoccupied large numbers of investigators for decadest. Some have concluded that the absence of mast cells is incompatible with life, at least in humans, because no human conditions have been documented where these cells are absent from the body. On the other hand, mice harboring specific mutations in certain growth factors, or their receptors, that
文摘Carcinoid tumors have been reported in a wide range of organs but most frequently involve the gastrointestinal tract; however, duodenal carcinoid tumors are rare. We report a 50-year-old male patient complaining of multiple melenas for 3 wk. The panendoscopy and endoscopic retrograde cholangiopancreaticography revealed swelling accessory papilla with an ulcer. The biopsy taken showed a carcinoid tumor. The lesion was removed by wide resection. Patient was found to have an abnormal blood cell count during the follow-up period with elevated levels of hemoglobin and hematocrit of 21.2 g/dL and 63.5%,respectively, thrombocytosis of 501 000/μL, and leukocytosis of 20 410/μL. He was diagnosed as a polycythemia vera by a hematologist after further evaluation. He received periodic phlebotomy and hydroxyurea treatment. The response was good and his hematocrit was stabilized by periodic phlebotomy in the range of 44-49% during the last 2 years. The possible origin of UGI bleeding by a duodenal carcinoid tumor, although rare, should be considered. There has been one case report of a duodenal carcinoid tumor that involved accessory papilla of the pancreas divisum and one case report of metastatic carcinoid tumor associated with polycythemia vera. It is different in our patient as compared with the latter report, which mentioned a polycythemia vera patient who was found to have a metastatic carcinoid in the 17 years follow-up period. Chemotherapy had been given before the carcinoid tumor was revealed. Our patient had no previous chemotherapy for polycythemia vera before he was found to have duodenal carcinoid tumor; this excludes the possibility of chemotherapy induced carcinoid tumor, although it had been suspected in the previous report. In our patient, the existence of both diseases may be by predisposition of each other since both diseases have an increased incidence of other neoplasm, or they may be coexistent incidentally.
