Folic acid conjugated chitosan was prepared by cross-linking reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC), and then used as a template to prepare folic acid-chitosan(FA-CS) conjugate...Folic acid conjugated chitosan was prepared by cross-linking reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC), and then used as a template to prepare folic acid-chitosan(FA-CS) conjugated nanoparticles and load mitoxantrone nanoparticles(FA-CSNP/MTX). Drug dissolution testing, CCK-8 method, and confocal microscopy were used to detect their controlled-release capability in different situations and the specific uptake by HONE1 cells. The experimental results show that the nanoparticles have uniform size distribution of 48-58 nm. The highest encapsulation rate of the particles on mitoxantrone hydrochloride(MTX) is(77.5±1.9)%, and the drug loading efficiency is(18.4±0.4)%. The sustained release effect, cell growth inhibition activity and targeting effect of the FA-CS/MTX nanoparticles are good in artificial gastric fluid and intestinal fluid. It is demonstrated that the FA-CSNP system is a potentially useful system for the targeted delivery of anticancer drug MTX.展开更多
We report on the ice-templated preparation and sodium storage of ultrasmall SnO2 nanoparticles （3--4 nm） embedded in three-dimensional （3D） graphene （SnO2@3DG）. SnO2@3DG was fabricated by hydrothermal assembly w...We report on the ice-templated preparation and sodium storage of ultrasmall SnO2 nanoparticles （3--4 nm） embedded in three-dimensional （3D） graphene （SnO2@3DG）. SnO2@3DG was fabricated by hydrothermal assembly with ice-templated 3DG and a tin source. The structure and morphology analyses showed that 3DG has an interconnected porous architecture with a large pore volume of 0.578 cm^3·g^-1 and a high surface area of 470.5 m^2·g^-1. In comparison, SnO2@3DG exhibited a pore volume of 0.321 cmg.g^-1 and a surface area of 237.7 m^2·g^-1 with a homogeneous distribution of ultrasmall SnO2 nanoparticles in a 3DG network. SnO2@3DG showed a discharge capacity of 1,155 mA-h·g^-1 in the initial cycle, a reversible capacity of 432 mA·h·g^-1 after 200 cycles at 100 mA·g^-1 （with capacity retention of 85.7% relative to that in the second cycle）, and a discharge capacity of 210 mAh·g^-1 at a high rate of 800 mA·g^-1 This is due to the high distribution of SnO2 nanoparticles in the 3DG network and the enhanced facilitation of electron/ion transport in the electrode.展开更多
基金Projects(31201074,81371013) supported by the National Natural Science Foundation of ChinaProject(2011105102016) supported by the Key Program of Medical Health of Dongguan City,Guangdong Province,ChinaProject(2011108102026) supported by Dongguan Universities Program,China
文摘Folic acid conjugated chitosan was prepared by cross-linking reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC), and then used as a template to prepare folic acid-chitosan(FA-CS) conjugated nanoparticles and load mitoxantrone nanoparticles(FA-CSNP/MTX). Drug dissolution testing, CCK-8 method, and confocal microscopy were used to detect their controlled-release capability in different situations and the specific uptake by HONE1 cells. The experimental results show that the nanoparticles have uniform size distribution of 48-58 nm. The highest encapsulation rate of the particles on mitoxantrone hydrochloride(MTX) is(77.5±1.9)%, and the drug loading efficiency is(18.4±0.4)%. The sustained release effect, cell growth inhibition activity and targeting effect of the FA-CS/MTX nanoparticles are good in artificial gastric fluid and intestinal fluid. It is demonstrated that the FA-CSNP system is a potentially useful system for the targeted delivery of anticancer drug MTX.
文摘We report on the ice-templated preparation and sodium storage of ultrasmall SnO2 nanoparticles （3--4 nm） embedded in three-dimensional （3D） graphene （SnO2@3DG）. SnO2@3DG was fabricated by hydrothermal assembly with ice-templated 3DG and a tin source. The structure and morphology analyses showed that 3DG has an interconnected porous architecture with a large pore volume of 0.578 cm^3·g^-1 and a high surface area of 470.5 m^2·g^-1. In comparison, SnO2@3DG exhibited a pore volume of 0.321 cmg.g^-1 and a surface area of 237.7 m^2·g^-1 with a homogeneous distribution of ultrasmall SnO2 nanoparticles in a 3DG network. SnO2@3DG showed a discharge capacity of 1,155 mA-h·g^-1 in the initial cycle, a reversible capacity of 432 mA·h·g^-1 after 200 cycles at 100 mA·g^-1 （with capacity retention of 85.7% relative to that in the second cycle）, and a discharge capacity of 210 mAh·g^-1 at a high rate of 800 mA·g^-1 This is due to the high distribution of SnO2 nanoparticles in the 3DG network and the enhanced facilitation of electron/ion transport in the electrode.
