Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry. The in-creased importance Of the process is gaining a worldwide interest of research. A growing body of literature has de...Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry. The in-creased importance Of the process is gaining a worldwide interest of research. A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error em-piricism. Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying, material science and mechanisms of heat and mass transfer. This paper presents an overview on freeze ding of aqueous solutions based on publications in the past few decades. The important issuesof the process are analyzed.展开更多
Objective Study of bupropion hydrochloride gel matrix sustained release tablet and the preparation method, test the skeleton material of hydroxypropyl methyl cellulose influencing drug release for evaluation, explore ...Objective Study of bupropion hydrochloride gel matrix sustained release tablet and the preparation method, test the skeleton material of hydroxypropyl methyl cellulose influencing drug release for evaluation, explore the preparation of sustained release tablets of optimization method. Method With hydroxypropyl methyl cellulose as skeleton material, according to the different prescription preparation of bupmpion hydrochloride sustained release tablets. Different HPMC viscosity, Consumption, particle size, compression pressure and slurry rotational speed and other factors, analysis the influence on drug release rate.Through the release of test evaluation of sustained release effect, and the preliminary study on the drug release characteristic. With hydroxypropyl methyl cellulose （ HPMC ） as skeleton material, with citric acid citrate as a porogenic agent, direct powder tabletting method of bupropion hydrochloride sustained release tablets; by using single factor and orthogonal experiment method to investigate HPMC different viscosity, different Consumption, different particle size, different compression pressure, different pulp rotational speed and other factors on the release of delivery rate. Result Select HPMC-K100M for bupropion hydrochloride sustained release tablets of the skeleton materials; reinforcing materials of high viscosity HPMC K100M and main drug quality ratio of 1： 1; HPMC particle diameter of 125p m, make use of these conditions to preparation of bupropion hydrochloride sustained release tablets for optimal prescription conditions. Conclusion bupropion hydroehloride sustained release tablets on the drug release rate is mainly affected by HPMC viscosity and dosage effect. Along with the tablet of HPMC viscosity increased, the drug is released slowly. HPMC viscosity, dosage on the drug release rate has significant influence.展开更多
基金Supported by the National Natural Science Foundation of China(21076042)Research Grants Council of Hong Kong SAR (RGC 600704)
文摘Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry. The in-creased importance Of the process is gaining a worldwide interest of research. A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error em-piricism. Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying, material science and mechanisms of heat and mass transfer. This paper presents an overview on freeze ding of aqueous solutions based on publications in the past few decades. The important issuesof the process are analyzed.
文摘Objective Study of bupropion hydrochloride gel matrix sustained release tablet and the preparation method, test the skeleton material of hydroxypropyl methyl cellulose influencing drug release for evaluation, explore the preparation of sustained release tablets of optimization method. Method With hydroxypropyl methyl cellulose as skeleton material, according to the different prescription preparation of bupmpion hydrochloride sustained release tablets. Different HPMC viscosity, Consumption, particle size, compression pressure and slurry rotational speed and other factors, analysis the influence on drug release rate.Through the release of test evaluation of sustained release effect, and the preliminary study on the drug release characteristic. With hydroxypropyl methyl cellulose （ HPMC ） as skeleton material, with citric acid citrate as a porogenic agent, direct powder tabletting method of bupropion hydrochloride sustained release tablets; by using single factor and orthogonal experiment method to investigate HPMC different viscosity, different Consumption, different particle size, different compression pressure, different pulp rotational speed and other factors on the release of delivery rate. Result Select HPMC-K100M for bupropion hydrochloride sustained release tablets of the skeleton materials; reinforcing materials of high viscosity HPMC K100M and main drug quality ratio of 1： 1; HPMC particle diameter of 125p m, make use of these conditions to preparation of bupropion hydrochloride sustained release tablets for optimal prescription conditions. Conclusion bupropion hydroehloride sustained release tablets on the drug release rate is mainly affected by HPMC viscosity and dosage effect. Along with the tablet of HPMC viscosity increased, the drug is released slowly. HPMC viscosity, dosage on the drug release rate has significant influence.
