Since the calcium channel blocker （CCB） has become one of the most prescribed agents for antihypertensive monotherapy in the world, this brief review will focus on the recent research and development of the dihydrop...Since the calcium channel blocker （CCB） has become one of the most prescribed agents for antihypertensive monotherapy in the world, this brief review will focus on the recent research and development of the dihydropyridine （DHP） CCB, addressing pharmacological mecha- nisms for the clinical efficacy of the third and fourth generations of the DHP CCBs, especially on their possible central mechanisms underlying lowering blood pressure.展开更多
Chronic hepatitis B virus infection affects about 400 million people around the globe and causes approximately a million deaths a year. Since the discovery of interferon-α as a therapeutic option the treatment of hep...Chronic hepatitis B virus infection affects about 400 million people around the globe and causes approximately a million deaths a year. Since the discovery of interferon-α as a therapeutic option the treatment of hepatitis B has evolved fast and management has become increasingly complicated. The amount of viral replication reflected in the viral load （HBV-DNA） plays an important role in the development of cirrhosis and hepatocellular carcinoma. The current treatment modalities for chronic hepatitis B are immunomodulatory （interferons） and antiviral suppressants （nucleoside and nucleotide analogues） all with their own advantages and limitations. An overview of the treatment efficacy for both immunomodulatory as antiviral compounds is provided in order to provide the clinician insight into the factors influencing treatment outcome. With nucleoside or nucleotide analogues suppression of viral replication by 5-7 log10 is feasible, but not all patients respond to therapy. Known factors influencing treatment outcome are viral load, ALT levels and compliance. Many other factors which might influence treatment are scarcely investigated. Identifying the factors associated with response might result in stopping rules, so treatment could be adapted in an early stage to provide adequate treatment and avoid the development of resistance. The efficacy of compounds for the treatment of mutant virus and the cross-resistance is largely unknown. However, genotypic and phenotypic testing as well as small clinical trials provided some data on efficacy in this population. Discontinuation of nucleoside or nucleotide analogues frequently results in viral relapse; however, some patients have a sustained response. Data on the risk factors for relapse are necessary in order to determine when treatment can be discontinued safely. In conclusion： chronic hepatitis B has become a treatable disease; however, much research is needed to tailor therapy to an individual patient, to predict the sustainability of response and determine the best treatment for those failing treatment.展开更多
The taxonomic status of the medicinal plants in Jordan is expressed in terms of its diversity, the documentation of the scientific research that is carried out locally over the last many years; to test for the potenti...The taxonomic status of the medicinal plants in Jordan is expressed in terms of its diversity, the documentation of the scientific research that is carried out locally over the last many years; to test for the potential of some medicinal plant species （MPS） in Jordan on different biological aspects is also prepared. This has been reported here by revising and documenting the available literature to the author on this subject. The ecological status of medicinal plants in Jordar is also pointed out. The aim of this research was mainly to evaluate the status of the research on medicinal plants that was carried oul： to test for the different biological potentials of medicinal plants in Jordan and to emphasis the richness of the country of its wild medicinal plants, which are of promising value in whether for use in traditional medicine or in pharmaceutical industry, and certainly need lots of investigations and scientific research. Photographs of some medicinal plants that are common in Jordan and are used in traditional medicine in the urban areas and the Badia region, which is located in the Eastern part of the country and characterized by its dry weather conditions and least amount of rainfall in the country, are also included; the plant photographs are selected from different representative families of the common flowering plants in Jordan.展开更多
PEST （Political, Economic, Social, and Technological） analysis of any industry sector investigates the important factors that are affecting the industry and influencing the companies operating in that sector. The pu...PEST （Political, Economic, Social, and Technological） analysis of any industry sector investigates the important factors that are affecting the industry and influencing the companies operating in that sector. The purpose of this study is to analyze the pharmaceutical sector of Bangladesh using the framework of PEST. This report brings to light the current state of the sector its progress and its problems. Through this study the researchers try to discuss the affect of various macro-economic factors of political, economic, social, and technological aspect on the industry and its related problems and prospects for the future.展开更多
Characterized by their low prevalence, rare diseases are often chronically debilitating or life threatening. Despite their low prevalence, the aggregate number of individuals suffering from a rare disease is estimated...Characterized by their low prevalence, rare diseases are often chronically debilitating or life threatening. Despite their low prevalence, the aggregate number of individuals suffering from a rare disease is estimated to be nearly 400 million worldwide.Over the past decades, efforts from researchers, clinicians, and pharmaceutical industries have been focused on both the diagnosis and therapy of rare diseases. However, because of the lack of data and medical records for individual rare diseases and the high cost of orphan drug development, only limited progress has been achieved. In recent years, the rapid development of next-generation sequencing(NGS)-based technologies, as well as the popularity of precision medicine has facilitated a better understanding of rare diseases and their molecular etiology. As a result, molecular subclassification can be identified within each disease more clearly, significantly improving diagnostic accuracy. However, providing appropriate care for patients with rare diseases is still an enormous challenge. In this review, we provide a brief introduction to the challenges of rare disease research and make suggestions on where and how our efforts should be focused.展开更多
文摘Since the calcium channel blocker （CCB） has become one of the most prescribed agents for antihypertensive monotherapy in the world, this brief review will focus on the recent research and development of the dihydropyridine （DHP） CCB, addressing pharmacological mecha- nisms for the clinical efficacy of the third and fourth generations of the DHP CCBs, especially on their possible central mechanisms underlying lowering blood pressure.
文摘Chronic hepatitis B virus infection affects about 400 million people around the globe and causes approximately a million deaths a year. Since the discovery of interferon-α as a therapeutic option the treatment of hepatitis B has evolved fast and management has become increasingly complicated. The amount of viral replication reflected in the viral load （HBV-DNA） plays an important role in the development of cirrhosis and hepatocellular carcinoma. The current treatment modalities for chronic hepatitis B are immunomodulatory （interferons） and antiviral suppressants （nucleoside and nucleotide analogues） all with their own advantages and limitations. An overview of the treatment efficacy for both immunomodulatory as antiviral compounds is provided in order to provide the clinician insight into the factors influencing treatment outcome. With nucleoside or nucleotide analogues suppression of viral replication by 5-7 log10 is feasible, but not all patients respond to therapy. Known factors influencing treatment outcome are viral load, ALT levels and compliance. Many other factors which might influence treatment are scarcely investigated. Identifying the factors associated with response might result in stopping rules, so treatment could be adapted in an early stage to provide adequate treatment and avoid the development of resistance. The efficacy of compounds for the treatment of mutant virus and the cross-resistance is largely unknown. However, genotypic and phenotypic testing as well as small clinical trials provided some data on efficacy in this population. Discontinuation of nucleoside or nucleotide analogues frequently results in viral relapse; however, some patients have a sustained response. Data on the risk factors for relapse are necessary in order to determine when treatment can be discontinued safely. In conclusion： chronic hepatitis B has become a treatable disease; however, much research is needed to tailor therapy to an individual patient, to predict the sustainability of response and determine the best treatment for those failing treatment.
文摘The taxonomic status of the medicinal plants in Jordan is expressed in terms of its diversity, the documentation of the scientific research that is carried out locally over the last many years; to test for the potential of some medicinal plant species （MPS） in Jordan on different biological aspects is also prepared. This has been reported here by revising and documenting the available literature to the author on this subject. The ecological status of medicinal plants in Jordar is also pointed out. The aim of this research was mainly to evaluate the status of the research on medicinal plants that was carried oul： to test for the different biological potentials of medicinal plants in Jordan and to emphasis the richness of the country of its wild medicinal plants, which are of promising value in whether for use in traditional medicine or in pharmaceutical industry, and certainly need lots of investigations and scientific research. Photographs of some medicinal plants that are common in Jordan and are used in traditional medicine in the urban areas and the Badia region, which is located in the Eastern part of the country and characterized by its dry weather conditions and least amount of rainfall in the country, are also included; the plant photographs are selected from different representative families of the common flowering plants in Jordan.
文摘PEST （Political, Economic, Social, and Technological） analysis of any industry sector investigates the important factors that are affecting the industry and influencing the companies operating in that sector. The purpose of this study is to analyze the pharmaceutical sector of Bangladesh using the framework of PEST. This report brings to light the current state of the sector its progress and its problems. Through this study the researchers try to discuss the affect of various macro-economic factors of political, economic, social, and technological aspect on the industry and its related problems and prospects for the future.
基金supported by the National High Technology Research and Development Program of China (2015AA020108, 2015AA020104)the National Science Foundation of China (31671377)Shanghai 111 Project (B14019)
文摘Characterized by their low prevalence, rare diseases are often chronically debilitating or life threatening. Despite their low prevalence, the aggregate number of individuals suffering from a rare disease is estimated to be nearly 400 million worldwide.Over the past decades, efforts from researchers, clinicians, and pharmaceutical industries have been focused on both the diagnosis and therapy of rare diseases. However, because of the lack of data and medical records for individual rare diseases and the high cost of orphan drug development, only limited progress has been achieved. In recent years, the rapid development of next-generation sequencing(NGS)-based technologies, as well as the popularity of precision medicine has facilitated a better understanding of rare diseases and their molecular etiology. As a result, molecular subclassification can be identified within each disease more clearly, significantly improving diagnostic accuracy. However, providing appropriate care for patients with rare diseases is still an enormous challenge. In this review, we provide a brief introduction to the challenges of rare disease research and make suggestions on where and how our efforts should be focused.
