期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
基于网络药理学与分子对接预测的制路路通质量标准研究
1
作者 许世辉 王洪强 +2 位作者 朱雪艳 卜其涛 张成中 《人参研究》 2024年第3期23-31,共9页
目的基于网络药理学分子对接预测制路路通质量标志物,制定制路路通质量标准。方法通过网络药理学的方法构建“制路路通-成分-靶点-通路”网络关系,结合分子对接,预测制路路通潜在的质量标志物。依据《中国药典》2020年版四部通用检测方... 目的基于网络药理学分子对接预测制路路通质量标志物,制定制路路通质量标准。方法通过网络药理学的方法构建“制路路通-成分-靶点-通路”网络关系,结合分子对接,预测制路路通潜在的质量标志物。依据《中国药典》2020年版四部通用检测方法分别测定制路路通的水分、总灰分、酸不溶性灰分、TLC定性鉴别、HPLC定量路路通酸。结果通过网络药理学及分子对接预测发现路路通酸、路路通内酯、枫香脂诺维酸、松柏苷等成分具有较好的药理活性,与ABCB1、SHBG、TERT、NR1H3、CSF1R、G6PD等关键靶点相关,可作用于PI3K-Akt等信号通路,发挥抗癌、抗炎等多种药理活性,是制路路通潜在的质量标志物。结论基于网络药理学与分子对接预测制路路通中的药理活性物质,建立制路路通质量标准。制路路通所含路路通酸,按干燥品计算不得少于0.15%。 展开更多
关键词 制路路通 质量标准 质量标志物 网络药理学 成分-靶点-通路
下载PDF
CONTROL OF VEHICLE PLATOONS FOR HIGHWAY SAFETY AND EFFICIENT UTILITY:CONSENSUS WITH COMMUNICATIONS AND VEHICLE DYNAMICS 被引量:6
2
作者 WANG Le Yi SYED Ali +2 位作者 YIN Gang George PANDYA Abhilash ZHANG Hongwei 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2014年第4期605-631,共27页
Platoon formation of highway vehicles is a critical foundation for autonomous or semiautonomous vehicle control for enhanced safety,improved highway utility,increased fuel economy,and reduced emission toward intellige... Platoon formation of highway vehicles is a critical foundation for autonomous or semiautonomous vehicle control for enhanced safety,improved highway utility,increased fuel economy,and reduced emission toward intelligent transportation systems.Platoon control encounters great challenges from vehicle control,communications,team coordination,and uncertainties.This paper introduces a new method for coordinated control of platoons by using integrated network consensus decisions and vehicle control.To achieve suitable coordination of the team vehicles based on terrain and environmental conditions,the emerging technology of network consensus control is modified to a weighted and constrained consensus-seeking framework.Algorithms are introduced and their convergence properties are established.The methodology employs neighborhood information through on-board sensors and V2 V or V2 I communications,but achieves global coordination of the entire platoon.The ability of the methods in terms of robustness,disturbance rejection,noise attenuation,and cyber-physical interaction is analyzed and demonstrated with simulated case studies. 展开更多
关键词 Collision avoidance COMMUNICATIONS consensus control networked systems platoon con-trol SAFETY vehicle dynamics.
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部